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407
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Dataset results
407 results for “Biological activity”
Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-
ClinicalTrials.gov study NCT04134728. IPD Sharing: YES. Countries: 15. Publications: 1.
Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs
ClinicalTrials.gov study NCT01578850. IPD Sharing: Not stated. Countries: 19. Publications: 3.
Safety and Biological Activity of Vesatolimod in HIV-1 Infected, Virologically Suppressed Adults
ClinicalTrials.gov study NCT02858401. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study Of Tocilizumab in Patients With Moderate to Severe Active Rheumatoid Arthritis Who Have an Inadequate Response to or Are Unable to Tolerate Biologic and Non-Biologic Disease-modifying Antirheu
ClinicalTrials.gov study NCT00891020. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response t
ClinicalTrials.gov study NCT02046603. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study in Healthy Adults to Evaluate Gene Activation After Vaccination With GlaxoSmithKline (GSK) Biologicals' Candidate Tuberculosis (TB) Vaccine GSK 692342
ClinicalTrials.gov study NCT01669096. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic
ClinicalTrials.gov study NCT03104374. IPD Sharing: YES. Countries: 19. Publications: 14.
Filgotinib Versus Placebo in Adults With Active Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Biologic Disease-modifying Anti-rheumatic Drug(s) (DMARDs) Treatment
ClinicalTrials.gov study NCT02873936. IPD Sharing: NO. Countries: 15. Publications: 7.
A Study of the Safety and Efficacy of Golimumab (CNTO 148) in Subjects With Active Rheumatoid Arthritis Previously Treated With Biologic Anti-TNFa Agent(s)
ClinicalTrials.gov study NCT00299546. IPD Sharing: Not stated. Countries: 10. Publications: 4.
The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST).
ClinicalTrials.gov study NCT00385203. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Study to Investigate the Biological Activity, Safety, Tolerability, and Pharmacokinetics of ACT-334441 in Subjects With Systemic Lupus Erythematosus
ClinicalTrials.gov study NCT02472795. IPD Sharing: NO. Countries: 6. Publications: 1.
Data for: Using faecal cortisol metabolites to assess adrenocortical activity in wild-living Alpine marmot Marmota marmota: A biological validation experiment
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A major locus controls a biologically active pheromone component in Heliconius melpomene
<p>Understanding the production, response, and genetics of signals used in mate choice can inform our understanding of the evolution of both intraspecific mate choice and reproductive isolation. Sex pheromones are important for courtship and mate choice in many insects, but we know relatively little of their role in butterflies. The butterfly <i>Heliconius</i> <i>melpomene</i> uses a complex blend of wing androconial compounds during courtship. Electroantennography in <i>H. melpomene </i>and its close relative <i>H. cydno</i> showed that responses to androconial extracts were not species-specific. Females of both species responded equally strongly to<i> </i>extracts of both species, suggesting conservation of peripheral nervous system elements across the two species. Individual blend components provoked little to no response, with the exception of octadecanal, a major component of the <i>H. melpomene </i>blend. Supplementing octadecanal on the wings of octadecanal-rich <i>H. melpomene </i>males led to an increase in the time until mating, demonstrating the bioactivity of octadecanal in <i>Heliconius</i>. Using quantitative trait locus (QTL) mapping, we identified a single locus on chromosome 20 responsible for 41% of the parental species' difference in octadecanal production. This QTL does not overlap with any of the major wing color or mate choice loci, nor does it overlap with known regions of elevated or reduced <i>F</i><sub>ST</sub>. A set of 16 candidate fatty acid biosynthesis genes lies underneath the QTL. Pheromones in <i>Heliconius </i>carry information relevant for mate choice and are under simple genetic control, suggesting they could be important during speciation.</p>
FIGURE 2 in A new solar powered species of the genus Phyllodesmium Ehrenberg, 1831 (Mollusca: Nudibranchia: Aeolidoidea) from Indonesia with analysis of its photosynthetic activity and notes on biology
FIGURE 2: Phyllodesmium jakobsenae, morphology: A: General outline of organs in situ. B: Digestive tract (oral glands omitted). C: Right jaw seen from the interior side. D: Distal genital system. E: Schematic cross section of apical part of ceras. The upper side represents the part which is exposed to light, when resting on the food coral. F: Central nervous system. Abbreviations: a anus, am ampulla, au auricle, bg buccal ganglion, ca capsule gland, cplg cerebropleural ganglion, dgl digestive gland, e eye, i intestine, mu mucous gland, og oral glands, ot oral tentacles, pg pedal ganglion, ph pharynx, pr prostate, rec receptaculum seminis, rh rhinophore, rhg rhinophoral ganglion, sy syrinx, ve ventricle.
FIGURE 3 in A new solar powered species of the genus Phyllodesmium Ehrenberg, 1831 (Mollusca: Nudibranchia: Aeolidoidea) from Indonesia with analysis of its photosynthetic activity and notes on biology
FIGURE 3: Phyllodesmium jakobsenae, hard structures in digestive system: A: Right jaw seen from the outside. B: Left jaw from the inside, denticles at the masticatory border seen from the inside. C: Distal part of radula of specimen No. 5. D: Closeup of distal part of radula of specimen No. 5; note the worn denticles on the edge of the rhachidian teeth.. E: Distal part of radula of specimen No. 3. F: Different angle of view of rhachidian cusps from No. 3. G: Part of the radula of specimen No. 3.
FIGURE 4 in A new solar powered species of the genus Phyllodesmium Ehrenberg, 1831 (Mollusca: Nudibranchia: Aeolidoidea) from Indonesia with analysis of its photosynthetic activity and notes on biology
FIGURE 4: Phyllodesmium jakobsenae, histology: A: View of ceras from side orientated to light. Note the dense branches along the whole ceras. B: View of ceras from side orientated away from light. Note the main branch of digestive gland and the fewer ramifications. C: Cnidosac of large ceras with no nematocysts. D: Digestive glandular branches beneath epidermis in large ceras. Note the many zooxanthellae especially in the digestive glandular tissue. E: Longitudinal section of small ceras with cnidosac. The digestive glandular duct is not branching, and shows glandular cells. The cnidosac is filled with many tiny nematocysts. The epidermis shows many glandular cells, beneath the epidermis a layer of "cellules spéciales" can be seen. F: Section trough eye and statocyst with one statolith. G: Small part of the oral gland with outleading duct. Abbreviations: cn cnidosac, cs "cellules spéciales", e eye, mc mucous cells, st statocyst.
FIGURE 1 in A new solar powered species of the genus Phyllodesmium Ehrenberg, 1831 (Mollusca: Nudibranchia: Aeolidoidea) from Indonesia with analysis of its photosynthetic activity and notes on biology
FIGURE 1: Phyllodesmium jakobsenae, living animals from North Sulawesi: A: Specimen laying eggs in an aquarium. B: Two specimens sitting in their food coral Xenia: on the right side a specimen with more brownish cerata and to the left a bigger specimen with more whitish cerata. Polyps of Xenia surround both individuals. C: Bigger specimen from B; please note the smaller cerata in the anterior part of body and the oral tentacles stretched to the lateral sides. D: Animal sitting inactive and mimicking Xenia polyps. E: Specimen starting to crawl.
Enhanced accumulation of biologically active compounds in lichens with potential functional food applications
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CONTAM Project Files and Exposure Data for An In Silico Investigation of Activity-Related Physical, Chemical, and Biological Pollutant Exposure in Basements Using CONTAM
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Data explanation for Manuscript "'An optimized hydroponic pipeline for large-scale identification of wheat genotypes with resilient biological nitrification inhibition (BNI) activity'"
<p>Data explanation for Manuscript "'An optimized hydroponic pipeline for large-scale identification of wheat genotypes with resilient biological nitrification inhibition (BNI) activity'"</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.