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2,450 results for “CD4 T cells”
Efficacy of Seluang Fish Oil (Rasbora Argyrotaenia) and Synbiotics Supplementation on CD4+CD25+ Foxp3+ T-regulator Cells, IL17/IL-10 Ratio, and Disease Activity in Systemic Lupus Erythematosus Patient
ClinicalTrials.gov study NCT06659068. IPD Sharing: Not stated. Countries: 1. Publications: 2.
RNAseq of tolerized auroreactive RBC-specific CD4 T cells, HODxOTII murine model of autoimmune hemolytic anemia (AIHA)
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Timing of blood sample processing affects the transcriptomic and epigenomic profiles in CD4+ T-cells of atopic subjects
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Data from: Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function.
<p>Thymic regulatory T cells (tTreg) are potent inhibitors of autoreactive immune responses and loss of tTreg function results in fatal autoimmune disease. Defects in Treg number or function are also implicated in multiple autoimmune diseases, leading to growing interest in use of Treg as cell therapies to establish immune tolerance. Because tTreg are present at low numbers in circulating blood and may be challenging to purify and expand, and also inherently defective in some subjects, we designed an alternative strategy to creating autologous Treg-like cells from bulk CD4+ T cells. We utilized homology-directed-repair (HDR)-based gene-editing to enforce FOXP3 expression. Targeted insertion of a robust enhancer/promoter proximal to the first coding exon bypassed epigenetic silencing, permitting stable, high level endogenous FOXP3 expression. HDR-edited T cells, edTreg, manifested a transcriptional program leading to sustained expression of canonical markers and suppressive activity of tTreg. Both human and murine edTreg mediated immunosuppression in vivo in models of inflammatory disease. Further, this engineering strategy permitted generation of antigen-specific edTreg with robust in vitro and in vivo functional activity. Finally, edTreg could be enriched and expanded at scale using clinically-relevant methods. Together, these finding suggest edTreg production may permit broad future clinical application.</p>
Figure 2 from: Hartati FK, Nafisah W, Sutanto A, Saati EA, Khairoh M, Sjamsiah (2024) Aqueous black rice (Oryza sativa L. indica) extract enhanced the activation of CD4+ and CD8+ T cells in mouse breast cancer model. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e113442
Figure 2 Aqueous black rice (ABR) extract reduced the relative number of CD4+IL17+, CD4+TNFα+, and CD4+IFNγ+ cytokine production. A, C, E. were flow cytometry diagram; B, D, F. were the graph of flow cytometry results. The bar in the graph shows the calculation results as the mean ± SD of the relative number of cytokine production. *P<0.05, indicate significant different. The group in this study were normal group; Cancer, DMBA 15 mg/kg BW; Cis, DMBA 15 mg/kg BW + Cisplatin 5 mg/kg BW; ABR1, DMBA 15 mg/kg BW + aqueous black rice extract 0.2 g/kg BW; ABR2, DMBA 15 mg/kg BW + aqueous black rice extract 0.3 g/kg BW; ABR3, DMBA 15 mg/kg BW + aqueous black rice extract 0.4 g/kg BW; ABR4, DMBA 15 mg/kg BW + aqueous black rice extract 0.5 g/kg BW.
Figure 1 from: Hartati FK, Nafisah W, Sutanto A, Saati EA, Khairoh M, Sjamsiah (2024) Aqueous black rice (Oryza sativa L. indica) extract enhanced the activation of CD4+ and CD8+ T cells in mouse breast cancer model. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e113442
Figure 1 Aqueous black rice (ABR) extract increased the relative number of CD4+CD62L- cells and CD8+CD62L- cells. A, C. Show flow cytometry diagrams, and B, D. Show graphs of the flow cytometry results. The bars in the graphs show the calculated results as the mean ± SD of the relative number of CD4+ and CD8+ cell activations. *P<0.05 indicates a significant difference. The groups in this study included the following groups: Normal; Cancer, DMBA 15 mg/kg BW; Cis, DMBA 15 mg/kg BW + Cisplatin 5 mg/kg BW; ABR1, DMBA 15 mg/kg BW + ABR extract 0.2 g/kg BW; ABR2, DMBA 15 mg/kg BW + ABR extract 0.3 g/kg BW; ABR3, DMBA 15 mg/kg BW + ABR extract 0.4 g/kg BW; and ABR4, DMBA 15 mg/kg BW + ABR extract 0.5 g/kg BW.
Figure 3 from: Hartati FK, Nafisah W, Sutanto A, Saati EA, Khairoh M, Sjamsiah (2024) Aqueous black rice (Oryza sativa L. indica) extract enhanced the activation of CD4+ and CD8+ T cells in mouse breast cancer model. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e113442
Figure 3 Aqueous black rice (ABR) extract effect on mammary mice histology based on Hematoxylin & Eosin staining (M: 400x). D, ductal; AT, adipose tissue; arrow, cancer cell. The group in this study were normal group; Cancer, DMBA 15 mg/kg BW; Cis, DMBA 15 mg/kg BW + Cisplatin 5 mg/kg BW; ABR1, DMBA 15 mg/kg BW + aqueous black rice extract 0.2 g/kg BW; ABR2, DMBA 15 mg/kg BW + aqueous black rice extract 0.3 g/kg BW; ABR3, DMBA 15 mg/kg BW + aqueous black rice extract 0.4 g/kg BW; ABR4, DMBA 15 mg/kg BW + aqueous black rice extract 0.5 g/kg BW.
Raw data to: "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection"
<p>Raw data underlying the publication by Narr et al. entitled "Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection".</p>
Phosphoproteomics analysis of antibody-based stimulation of TCR in CD4+ T cells
<p>Code associated with the paper "LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions" published in Molecular Systems Biology in 2020.</p> <p>abstract: <br> T-cell receptor (TCR) ligation-mediated protein phosphorylation regulates the activation, cellular responses, and fates of T cells. Here, we used time-resolved high-resolution phosphoproteomics to identify, quantify, and characterize the phosphorylation dynamics of thousands of phosphorylation sites in primary T cells during the first 10 min after TCR stimulation. Bioinformatic analysis of the data revealed a coherent orchestration of biological processes underlying T-cell activation. In particular, functional modules associated with cytoskeletal remodeling, transcription, translation, and metabolic processes were mobilized within seconds after TCR engagement. Among proteins whose phosphorylation was regulated by TCR stimulation, we demonstrated, using a fast-track gene inactivation approach in primary lymphocytes, that the ITSN2 adaptor protein regulated T-cell effector functions. This resource, called LymphoAtlas, represents an integrated pipeline to further decipher the organization of the signaling network encoding T-cell activation. LymphoAtlas is accessible to the community at: <a href="https://bmm-lab.github.io/LymphoAtlas">https://bmm-lab.github.io/LymphoAtlas</a>.</p>
COVID-19: SARS-CoV-2 Specific Memory B and T-CD4+ Cells
ClinicalTrials.gov study NCT04402892. IPD Sharing: NO. Countries: 0. Publications: 2.
An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients With HIV Infection (CD4+ Cell Count < 40
ClinicalTrials.gov study NCT00000649. IPD Sharing: Not stated. Countries: 1. Publications: 1.
HuMax-CD4 in Non-Cutaneous T-Cell Lymphoma
ClinicalTrials.gov study NCT00877656. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Autologous CD4 T-Cells in HIV (C34-CXCR4)
ClinicalTrials.gov study NCT03020524. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery
ClinicalTrials.gov study NCT00925756. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure
ClinicalTrials.gov study NCT06889142. IPD Sharing: NO. Countries: 0. Publications: 11.
FTC/RPV/TDF on T-Cell Activation, CD4+ T-Cell Count, Inflammatory Biomarkers and Viral Reservoir
ClinicalTrials.gov study NCT01777997. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts
ClinicalTrials.gov study NCT00000908. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Immunological and Viral Response to Antiretrovirals in HIV Patients With CD4 Cell Count Below 100
ClinicalTrials.gov study NCT00385957. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery
ClinicalTrials.gov study NCT01969058. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Data from: Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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