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2,800 results for “CD8+ T cells”
Figure 3 from: Hartati FK, Nafisah W, Sutanto A, Saati EA, Khairoh M, Sjamsiah (2024) Aqueous black rice (Oryza sativa L. indica) extract enhanced the activation of CD4+ and CD8+ T cells in mouse breast cancer model. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e113442
Figure 3 Aqueous black rice (ABR) extract effect on mammary mice histology based on Hematoxylin & Eosin staining (M: 400x). D, ductal; AT, adipose tissue; arrow, cancer cell. The group in this study were normal group; Cancer, DMBA 15 mg/kg BW; Cis, DMBA 15 mg/kg BW + Cisplatin 5 mg/kg BW; ABR1, DMBA 15 mg/kg BW + aqueous black rice extract 0.2 g/kg BW; ABR2, DMBA 15 mg/kg BW + aqueous black rice extract 0.3 g/kg BW; ABR3, DMBA 15 mg/kg BW + aqueous black rice extract 0.4 g/kg BW; ABR4, DMBA 15 mg/kg BW + aqueous black rice extract 0.5 g/kg BW.
Blockade of LAG3 and PD1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
<p>This is the data necessary to reproduce the figures from "<em>Blockade of LAG3 and PD1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity</em>" by Cillo et al.</p>
Dataset #2 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
<p><span>CD8<sup>+</sup> T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8<sup>+</sup> T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regression. NaCl supplementation during CD8<sup>+</sup> T-cell culture induced potent effector differentiation, IFN-</span><span>g</span><span> production and cytotoxicity while maintaining gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized model. In mice, high-salt diet reduced growth of experimental tumors in a CD8<sup>+</sup> T cell-dependent manner, by inhibiting terminal differentiation, and by enhancing the effector potency of CD8<sup>+</sup> T cells. Mechanistically, NaCl enhanced glutamine consumption that was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8<sup>+</sup> T cells undergoing antigen recognition in tumors and predicting favorable response to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a major regulator of CD8<sup>+</sup> T-cell effector function, with potential translation in cancer immunotherapy.</span></p>
Additional Datasets for: Integrative Mapping of Human CD8+ T Cell in Inflammation and Cancer
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Data from: Identification and validation of a novel immune-related signature associated with macrophages and CD8 T cell infiltration predicting overall survival for hepatocellular carcinoma
<p><b>Background:</b> Although the effects of macrophages and CD8 T cell infiltration on clinical outcomes have been widely reported, the association between immunity-associated gene with them for hepatocellular carcinoma (HCC) remains unclear.</p> <p><b>Materials and methods: </b>The ssGSEA served for quantifying the macrophages as well as CD8 T cell infiltration in the HCC samples obtained from TCGA database. Kaplan-Meier(KM) survival assay was used to determine the associations between macrophages and CD8 T cell infiltration with OS. LASSO Cox regressive method assisted in developing an immune gene signature as well as building a risk score. The performance was evaluated by the time-dependent ROC together with the KM survival analysis. The ICGC database were adopted for external verification. CIBERSORT was applied to the correlation analysis on the immune-related signature and the immunocyte infiltration. GSEA were employed exploring the underlying molecular mechanisms.</p> <p><b>Results:</b> Increased CD8+ T cell infiltration was associated with longer OS, whereas a greater infiltration of macrophages was related to shorter OS. There were 398 differential expression genes (DEGs) between the high- and low infiltration groups with the "edgeR" package. A prognostic signature consisted of 10 immune genes was built in TCGA and examined in ICGC. The uniform cutoff (0.927) was adopted for separating sufferers into the high-risk(HR) and low-risk(LR) groups. The ROC curves revealed that the AUC data for this signature predicting 1,2,3,4 and 5 year were all above 0.7 in both TCGA and ICGC cohort and patients in the HR<sub> </sub>group exhibited evidently weaker prognostic results compared with the LR group. The HR<sub> </sub>group presented evidently greater Tregs and Macrophage M0 relative to the LR group, whereas the LR group saw the enrichment of CD8 T cells.</p> <p><b>Conclusion:</b> The immune signature associated with macrophages as well as CD8 T cell infiltration has reliable prognostic and predictive value for HCC patients.</p>
Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
<p><span>CD8<sup>+</sup> T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8<sup>+</sup> T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regression. NaCl supplementation during CD8<sup>+</sup> T-cell culture induced potent effector differentiation, IFN-</span><span>g</span><span> production and cytotoxicity while maintaining gene networks responsible for stem-like plasticity. Accordingly, adoptive transfer of tumor-specific T cells resulted in superior anti-tumor immunity in a humanized model. In mice, high-salt diet reduced growth of experimental tumors in a CD8<sup>+</sup> T cell-dependent manner, by inhibiting terminal differentiation, and by enhancing the effector potency of CD8<sup>+</sup> T cells. Mechanistically, NaCl enhanced glutamine consumption that was critical for transcriptional, epigenetic and functional reprogramming. In humans, CD8<sup>+</sup> T cells undergoing antigen recognition in tumors and predicting favorable response to checkpoint blockade immunotherapy resembled those induced by NaCl. Thus, NaCl metabolism is a major regulator of CD8<sup>+</sup> T-cell effector function, with potential translation in cancer immunotherapy.</span></p>
CD8+ T Cell Imaging During Pre-surgery Immunotherapy in People With Melanoma
ClinicalTrials.gov study NCT05289193. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study of CD8+ T Cell Imaging During Treatment in People With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT06863233. IPD Sharing: YES. Countries: 1. Publications: 0.
CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma
ClinicalTrials.gov study NCT02424968. IPD Sharing: NO. Countries: 1. Publications: 0.
Laboratory-Treated (Central Memory/Naive) CD8+ T Cells in Treating Patients With Newly Diagnosed or Relapsed Acute Myeloid Leukemia
ClinicalTrials.gov study NCT02770820. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CD8+ Antigen-Specific T Cells, Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Melanoma
ClinicalTrials.gov study NCT02027935. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Identification and validation of a novel immune-related signature associated with macrophages and CD8 T cell infiltration predicting overall survival for hepatocellular carcinoma
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Prolonged and coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during convalescence
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mRNA-seq of Tgfbr2 KO CD8 T cells (d8/d15)
GEO Series GSE209598. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Sequencing of tumor associated (B16f10-OVA) mir-155 Wt or deficient CD4+ and CD8+ T cells
GEO Series GSE101690. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile analysis of CD8+ T cells isolated from splenic red and white pulp upon LCMV infection
GEO Series GSE87561. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
NKG2D blockade impairs cytotoxic CD8+ tissue resident memory T cell accumulation and attenuates severity of chronic lung allograft dysfunction after transplantation
GEO Series GSE285515. Homo sapiens. 15 samples. Type: Other; Expression profiling by high throughput sequencing.
Mint-ChIP-seq from stimulated activated naive CD8-positive, alpha-beta T cell (ENCSR651PFT)
GEO Series GSE209385. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene expression data in CD4+ and CD8+ cells in sarcoidosis patients following antimycobacterial therapy
GEO Series GSE39606. Homo sapiens. 20 samples. Type: Expression profiling by array.
Mint-ChIP-seq from CD8-positive, alpha-beta T cell (ENCSR367EKE)
GEO Series GSE177293. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.