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ShareScore release 0.9.0
Dataset results
145 results for “Cytochrome P450”
The expression profile of cytochromes P450 (CYPs) and aldo-keto reductases (AKRs) in post-treatment breast carcinomas
GEO Series GSE56259. Homo sapiens. 111 samples. Type: Expression profiling by RT-PCR.
A cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
GEO Series GSE224014. Digitalis lanata. 12 samples. Type: Expression profiling by high throughput sequencing.
Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450, family 21, subfamily A, polypeptide 2 (CYP21A2) expression in the bovine corpus luteum
GEO Series GSE128706. Bos taurus. 12 samples. Type: Expression profiling by array.
Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
GEO Series GSE49012. Homo sapiens. 34 samples. Type: Non-coding RNA profiling by array.
Over-expression of a Cytochrome P450 is Associated with Resistance to Pyriproxyfen in the Greenhouse Whitefly Trialeurodes vaporariorum
GEO Series GSE31316. Trialeurodes vaporariorum. 8 samples. Type: Expression profiling by array.
Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression
GEO Series GSE47698. Mus musculus. 28 samples. Type: Expression profiling by array.
Identification and developmental expression of the full complement of cytochrome P450 genes in zebrafish
GEO Series GSE24840. Danio rerio. 24 samples. Type: Expression profiling by array.
Alteration of the expression and 17, 20 lyase activity of cytochrome P450 17-hydroxylase/17, 20 lyase and of the expression of other Leydig cells genes in the rat fetal testis directly exposed to Mono
GEO Series GSE22218. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
Cytochrome P450 induction reverses mitochondrial dysfunction in a parkinsonian model of neurodegeneration
<p><strong>Supplementary material 1. </strong>Mitochondrial fusion dynamics in SH-SY5Y cells. PA-GFP is gradually spread in mitochondria over the 45 minutes of assay. The intensity of fluorescence in the photo-activated area consistently decreases until 15-20% at minute 45. Ds-Red was used as a mitochondrial marker and calibrator. Data represent the normalized pixel intensity (%) ± SEM of at least 3 independent experiments.</p>
Data from: Differential sensitivity to in vitro inhibition of cytochrome P450 aromatase (CYP19) activity among 18 freshwater fishes
There is significant concern regarding potential impairment of fish reproduction associated with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme involved in the conversion of androgens to estrogens. Inhibition of aromatase by chemicals can result in reduced concentrations of estrogens leading to adverse reproductive effects. These effects have been extensively investigated in a small number of laboratory model fishes, such as fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes), and zebrafish (Danio rerio). But, differences in sensitivity among species is largely unknown. Therefore, this study took a first step towards understanding potential differences in sensitivity to aromatase inhibitors among fishes. Specifically, a standard in vitro aromatase inhibition assay using subcellular fractions of whole tissue homogenates was used to evaluate the potential sensitivity of eighteen phylogenetically diverse species of freshwater fish to the nonsteroidal aromatase inhibitor fadrozole. Sensitivity to fadrozole ranged by more than 52-fold among these species. Five species were further investigated for sensitivity to up to four additional nonsteroidal aromatase inhibitors, letrozole, imazalil, prochloraz, and propiconazole. Potencies of each of these chemicals relative to fadrozole ranged by up to two orders of magnitude among the five species. Fathead minnow, Japanese medaka, and zebrafish were among the least sensitive to all the investigated chemicals; therefore, ecological risks of aromatase inhibitors derived from these species might not be adequately protective of more sensitive native fishes. This information could guide more objective ecological risk assessments of native fishes to chemicals that inhibit aromatase.
Investigation of the Etiology of Hypertension and Endothelial Damage in Patients With Cytochrome P450 Oxidoreductase Deficiency
ClinicalTrials.gov study NCT06756620. IPD Sharing: NO. Countries: 1. Publications: 0.
Cytochrome P450 2D6 (CYP 450 2D6) Genotype and Flecainide Efficacy
ClinicalTrials.gov study NCT00945867. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis
ClinicalTrials.gov study NCT05891119. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol
ClinicalTrials.gov study NCT03547024. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Evaluate the Effects of a Cytochrome P450 2C19 Inhibitor on the Pharmacokinetics of Miricorilant
ClinicalTrials.gov study NCT05712265. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants
ClinicalTrials.gov study NCT06363630. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects
ClinicalTrials.gov study NCT01402076. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cytochrome P450 2C19 Variant is Related to Pharmacokinetics of Glipizide Extended Release Tablet in Chinese Subjects
ClinicalTrials.gov study NCT01082796. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of ARQ 197 in Healthy Volunteers to Assess the Pharmacokinetic (PK) Profile in Extensive and Poor Metabolizers as Defined by Cytochrome P450 2C19 (CYP 2C19) Genotype
ClinicalTrials.gov study NCT00651638. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Drug-Drug Interaction Study of MLC1501 Using Cocktail of Drugs Acting as Sensitive Clinical Probes/Substrates of Cytochrome P450 Isoenzymes and Transporters in Healthy Subjects
ClinicalTrials.gov study NCT04233437. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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