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613 results for “Dengue”
Dataset for attitude measures towards Dengue control efforts with the potential of digital technology during COVID-19
<div class="J0lOec"><span class="VIiyi"><span class="JLqJ4b ChMk0b"><span class="Q4iAWc">This data contains a questionnaire and a data set of structural equation modeling for Attitude Towards Dengue Control Efforts with the Potential of Digital Technology.</span></span> <span class="JLqJ4b ChMk0b"><span class="Q4iAWc">The variables are grouped into six namely the need for digital information systems, perceptions of being threatened with dengue, the benefits of dengue control programs, program constraints on environmental factors and attitudes in dengue control.</span></span> <span class="JLqJ4b ChMk0b"><span class="Q4iAWc">Data was collected online using Google Forms.</span></span></span></div>
Postural fall in systolic blood pressure is an useful warning sign in Dengue fever
<p><strong>Purpose</strong>: Capillary leak is the hallmark of development of severe dengue. A rise in hematocrit has been a major warning sign in WHO guidelines. Postural hypotension, which could reflect the intravascular volume reduction in capillary leak, has been noted as a warning sign in CDC and Pan American Health Organisation guidelines. We evaluated the diagnostic accuracy of Postural hypotension as a marker of development of severe dengue.</p> <p><strong>Methods</strong>: 150 patients admitted with dengue fever were recruited in this prospective observational study. Diagnostic accuracy of conventional warning signs (<span>abdominal pain, persistent vomiting, fluid accumulation, mucosal bleeding, lethargy, liver enlargement, increasing hematocrit with decreasing platelets)</span> and postural hypotension was evaluated.</p> <p><strong>Result</strong>: 23 (15.3%) subjects developed severe dengue. Multiple logistic regression analysis showed that Ascites/Pleural effusion and postural fall in systolic blood pressure of >10.33% had an odds ratio of 5.024(95%CI:1.11 – 22.75) and 11.369 (95% CI:2.27 – 56.87) respectively. Other parameters did not reach statistical significance. Sensitivity and specificity of Ascites/Pleural effusion were 82.6% and 88.2% for development of severe dengue, whereas postural fall in systolic blood pressure had sensitivity and specificity of 87% and 82.7%.</p> <p><strong>Conclusion</strong>: These findings present a strong case for including postural hypotension as a warning sign in patients with dengue fever, especially in resource-limited settings.</p>
Mechanical transmission of Dengue Virus by Aedes aegypti may influence disease transmission dynamics during outbreaks data
<strong><span>Summary</span></strong> <p class="MsoNormal"><em><span>Background</span></em><span>: Dengue virus outbreaks are increasing in number and severity worldwide. Viral transmission is assumed to require a minimum time period of viral replication within the mosquito midgut. It is unknown if alternative transmission periods not requiring replication are possible.</span></p> <p class="MsoNormal"><em><span>Methods</span></em><span>: We used a mouse model of dengue virus transmission to investigate the potential of mechanical transmission of dengue virus. We investigated minimal viral titres necessary for development of symptoms in bitten mice and used resulting parameters to inform a new model of dengue virus transmission within a susceptible population.</span></p> <p class="MsoNormal"><em><span>Findings</span></em><span>: Naïve mice bitten by mosquitoes immediately after they took partial blood meals from dengue infected mice showed symptoms of dengue virus, followed by mortality. Incorporation of mechanical transmission into mathematical models of dengue virus transmission suggests that this supplemental transmission route could result in larger outbreaks which peak sooner.</span></p> <p class="MsoNormal"><em><span>Interpretation</span></em><span>: The potential of dengue transmission routes independent of midgut viral replication has implications for vector control strategies that target mosquito lifespan and suggest the possibility of similar mechanical transmission routes in other disease-carrying mosquitoes.</span></p>
The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses
<p>This is the corresponding data of the Publication in Plos Neglected tropical diseases.</p> <p>Zika virus (ZIKV) is a mosquito-borne human-pathogenic arbovirus of the <em>Flaviviridae</em> family, genus <em>Flavivirus</em>. Other arboviruses, including dengue (DENV) or chikungunya (CHIKV) virus, can occur in the same regions as ZIKV and are also transmitted by <em>Aedes aegypti</em>. Notably, it has been shown that these viruses can co-infect this mosquito, andco-transmission occurs. Such processes may add to the serious public health issues already linked to those pathogens. Arbovirus infections in mosquitoes are controlled through an immune response called RNA interference (RNAi). It is however unknown whether immune responses changs when a mosquito is exposed to a co-infection of ZIKV with either DENV or CHIKV. In this study, we provide evidence that ZIKV co-infections with CHIKV or DENV are similarly well controlled by RNAi as single infections. These findings give new insights into the dynamics of arboviral co-infections in mosquito vectors that increase our understanding of co-infection scenarios during arbovirus outbreaks.</p>
Impact of household bulky waste collection on the presence of dengue-transmitting mosquito breeding sites_dataset
<p>The objective was to evaluate the impact of a municipal strategy to reduce Ae. aegypti in Asunción focused on the management of household bulky waste. To estimate the result, the Difference in Difference (DID) method was used. For the baseline, a simple random sampling of 324 households was carried out. The intervention implemented by the local government in an area with 180,000 residents, contributed to the collection of the equivalent of 14 kilos of bulky waste per inhabitant, given an idea of the magnitude of the problem. For the evaluation survey, 2.5 to 4 years after the intervention, 120 households were randomly selected, of which 60% had not been intervened (control households) and 40% had been intervened. As a result, a significant reduction was achieved in the total number of large solid waste found in the homes that were the object of the intervention. The differentiated collection was used mainly by those households that had a large number of large solid waste (DID of -55%), but not to get rid of all of these objects, but only a part. The data present no evidence of change in the percentage of households with breeding containers between the intervention and control groups.</p>
A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue Fever
ClinicalTrials.gov study NCT06006559. IPD Sharing: YES. Countries: 6. Publications: 0.
Association of Host Genetics With Vaccine Efficacy and Study of Immune Correlates of Risk From a Tetravalent Dengue Vaccine
ClinicalTrials.gov study NCT02827162. IPD Sharing: YES. Countries: 1. Publications: 2.
Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Co-administered With an Hepatitis A Virus Vaccine
ClinicalTrials.gov study NCT03525119. IPD Sharing: YES. Countries: 1. Publications: 1.
A Phase II Trial of a Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy Adults in Thailand
ClinicalTrials.gov study NCT00370682. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Immunogenicity Study to Assess TDV, a Live Attenuated Tetravalent Vaccine for Prevention of Dengue Fever
ClinicalTrials.gov study NCT01224639. IPD Sharing: Not stated. Countries: 1. Publications: 1.
This Study Will Describe the Burden of DENgue Fever Virus (DENV) Illness Among Household Members Aged 6 Months to 50 Years of Selected Communities in Latin America and Southeast Asia
ClinicalTrials.gov study NCT02766088. IPD Sharing: Not stated. Countries: 2. Publications: 2.
An Epidemiological Surveillance Study to Evaluate the Incidence of Dengue in Brazil
ClinicalTrials.gov study NCT01751139. IPD Sharing: Not stated. Countries: 1. Publications: 1.
GLS-5700 in Dengue Virus-Naïve Adults
ClinicalTrials.gov study NCT02809443. IPD Sharing: NO. Countries: 2. Publications: 1.
Safety and Immunogenicity of the Dengue Virus Vaccine TV005 (TetraVax-DV TV005) in Healthy Adults, Adolescents, and Children in Dhaka, Bangladesh
ClinicalTrials.gov study NCT02678455. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia
ClinicalTrials.gov study NCT01134263. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Trial to Model Primary, Secondary, and Tertiary Dengue Using a Monovalent Vaccine
ClinicalTrials.gov study NCT05691530. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Immunogenicity With Two Different Serotype 2 Potencies of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Adults in Singapore
ClinicalTrials.gov study NCT02425098. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Two-dose Primary Vaccination Study of a Tetravalent Dengue Virus Purified Inactivated Vaccine vs. Placebo in Healthy Adults
ClinicalTrials.gov study NCT01666652. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Safety and Immunogenicity of Various Formulations of Live Attenuated Tetravalent Dengue Vaccine in Healthy US Adults
ClinicalTrials.gov study NCT00350337. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ADVP005; Dengue CVD 12000 - Dengue-1-Virus Live Virus Human Challenge (DENV-1-LVHC)
ClinicalTrials.gov study NCT04786457. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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OpenNeuro
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