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210 results for “Ebola”
Data from: Investigating the zoonotic origin of the West African Ebola epidemic
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2-year-old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife surveys, interviews, and molecular analyses of bat and environmental samples. We found no evidence for a concurrent outbreak in larger wildlife. Exposure to fruit bats is common in the region, but the index case may have been infected by playing in a hollow tree housing a colony of insectivorous free-tailed bats (Mops condylurus). Bats in this family have previously been discussed as potential sources for Ebola virus outbreaks, and experimental data have shown that this species can survive experimental infection. These analyses expand the range of possible Ebola virus sources to include insectivorous bats and reiterate the importance of broader sampling efforts for understanding Ebola virus ecology.
ebola: Ebola dataset for Mirador
<p>This dataset includes 157 individuals from Sierra Leone from whom 106 were diagnosed to be Ebola positive during the 2014 Ebola outbreak. Details at http://www.nejm.org/doi/full/10.1056/NEJMoa1411680</p>
ebola: Dataset v1.4
<p>This data comprises a total of 213 cases evaluated for Ebola virus infection at the Kenema Government Hospital in Sierra Leone between May 25 and June 18, 2014. Details in “Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone”, by John S. Schieffelin, et al.</p> <p>Available are raw files (Excel, VCF formats), Mirador project, and single CSV file.</p> <p>Zenodo record (DOI): https://zenodo.org/record/14565</p>
Data from: Ebola cases and health system demand in Liberia
In 2014, a major epidemic of human Ebola virus disease emerged in West Africa, where human-to-human transmission has now been sustained for greater than 12 months. In the summer of 2014, there was great uncertainty about the answers to several key policy questions concerning the path to containment. What is the relative importance of nosocomial transmission compared with community-acquired infection? How much must hospital capacity increase to provide care for the anticipated patient burden? To which interventions will Ebola transmission be most responsive? What must be done to achieve containment? In recent years, epidemic models have been used to guide public health interventions. But, model-based policy relies on high quality causal understanding of transmission, including the availability of appropriate dynamic transmission models and reliable reporting about the sequence of case incidence for model fitting, which were lacking for this epidemic. To investigate the range of potential transmission scenarios, we developed a multi-type branching process model that incorporates key heterogeneities and time-varying parameters to reflect changing human behavior and deliberate interventions in Liberia. Ensembles of this model were evaluated at a set of parameters that were both epidemiologically plausible and capable of reproducing the observed trajectory. Results of this model suggested that epidemic outcome would depend on both hospital capacity and individual behavior. Simulations suggested that if hospital capacity was not increased, then transmission might outpace the rate of isolation and the ability to provide care for the ill, infectious, and dying. Similarly, the model suggested that containment would require individuals to adopt behaviors that increase the rates of case identification and isolation and secure burial of the deceased. As of mid-October, it was unclear that this epidemic would be contained even by 99% hospitalization at the planned hospital capacity. A new version of the model, updated to reflect information collected during October and November 2014, predicts a significantly more constrained set of possible futures. This model suggests that epidemic outcome still depends very heavily on individual behavior. Particularly, if future patient hospitalization rates return to background levels (estimated to be around 70%), then transmission is predicted to remain just below the critical point around Reff = 1. At the higher hospitalization rate of 85%, this model predicts near complete elimination in March to June, 2015.
Phase I Trial to Assess the Safety, Tolerability and Immunogenicity of a Ebola Virus Vaccine (rVSVΔG-ZEBOV-GP)
ClinicalTrials.gov study NCT02283099. IPD Sharing: NO. Countries: 1. Publications: 5.
A Study to Find Out if the New Ebola Vaccine is Safe and Stimulates Immunity That Might Protect Adults in Kilifi, Kenya.
ClinicalTrials.gov study NCT02296983. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Phase I Clinical Trial to Evaluate the Ebola Adenovirus Vector Vaccine (Ad5-EBOV) in Healthy Adults.
ClinicalTrials.gov study NCT02326194. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Experimental Vaccine for Prevention of Ebola Virus Infection
ClinicalTrials.gov study NCT00374309. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Experimental Ebola Vaccine Trial
ClinicalTrials.gov study NCT00072605. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability, and Immunogenicity of the Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO), VRC-EBOADC069-00-VP, in Healthy Adults
ClinicalTrials.gov study NCT02231866. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Phase I Study to Assess Ebola Vaccines cAd3-EBO Z and MVA-EBO Z
ClinicalTrials.gov study NCT02451891. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Persistence of the Immune Response After Immunisation With Ebola Virus Vaccines
ClinicalTrials.gov study NCT03140774. IPD Sharing: NO. Countries: 1. Publications: 2.
Efficacy of Favipiravir Against Ebola (JIKI)
ClinicalTrials.gov study NCT02329054. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Ebola Virus Disease Survivors: Clinical and Immunologic Follow-up
ClinicalTrials.gov study NCT02431923. IPD Sharing: Not stated. Countries: 2. Publications: 5.
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
ClinicalTrials.gov study NCT04723602. IPD Sharing: NO. Countries: 1. Publications: 5.
Ebola and Marburg Virus Vaccines
ClinicalTrials.gov study NCT00605514. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Phase 1 Trial of Ebola Vaccine in Mali
ClinicalTrials.gov study NCT02267109. IPD Sharing: NO. Countries: 1. Publications: 1.
Addressing Medium- to Long-term EBOLA Associated Psychological Distress and Psychosocial Problems in Central Uganda
ClinicalTrials.gov study NCT06093646. IPD Sharing: YES. Countries: 1. Publications: 1.
Evaluating an Ebola and a Marburg Vaccine in Uganda
ClinicalTrials.gov study NCT00997607. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of a 2-dose Ebola Vaccine Regimen of Ad26.ZEBOV Followed by MVA-BN-Filo in Healthy Pregnant Women
ClinicalTrials.gov study NCT04556526. IPD Sharing: YES. Countries: 1. Publications: 2.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.