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984 results for “Extracellular Vesicles”
Extracellular Vesicles as Stroke Biomarkers
ClinicalTrials.gov study NCT05370105. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Characterization of Extracellular Vesicles From the Cord Blood of Extremely Preterm New Borns and Their Correlation With Severe Morbidity and Mortality
ClinicalTrials.gov study NCT07273643. IPD Sharing: Not stated. Countries: 0. Publications: 39.
Extracellular Vesicles for the Treatment of Syringomyelia
ClinicalTrials.gov study NCT07295067. IPD Sharing: NO. Countries: 1. Publications: 4.
ATTR Amyloid Cardiomyopathy: Characterization of Extracellular Vesicles as Potential Disease Stratifiers and Prognostic Biomarkers
ClinicalTrials.gov study NCT07314268. IPD Sharing: Not stated. Countries: 1. Publications: 23.
Treatment of Non-ischemic Cardiomyopathies by Intravenous Extracellular Vesicles of Cardiovascular Progenitor Cells
ClinicalTrials.gov study NCT05774509. IPD Sharing: YES. Countries: 1. Publications: 5.
Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure
ClinicalTrials.gov study NCT06002841. IPD Sharing: NO. Countries: 1. Publications: 19.
Safety and Efficacy of Stem Cell Small Extracellular Vesicles in Patients With Retinitis Pigmentosa
ClinicalTrials.gov study NCT06242379. IPD Sharing: NO. Countries: 1. Publications: 22.
Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury
ClinicalTrials.gov study NCT06871800. IPD Sharing: NO. Countries: 1. Publications: 4.
Impact of Exercise-derived Extracellular Vesicle in Blood and Physical Fitness Data in Overweight/Obesity Individuals
ClinicalTrials.gov study NCT07312344. IPD Sharing: NO. Countries: 1. Publications: 7.
The Modulatory Role of Internet MBCT on Extracellular Vesicles and Distress in Cancer Patients - Study Protocol
ClinicalTrials.gov study NCT04727593. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Extracellular Vesicles as Biomarkers for Chronic Renal Failure
ClinicalTrials.gov study NCT04700631. IPD Sharing: NO. Countries: 1. Publications: 1.
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections
ClinicalTrials.gov study NCT04761562. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Saliva and Extracellular Vesicles for Parkinson's Disease
ClinicalTrials.gov study NCT05320250. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Data from: Effect of pancreatic cancer-derived extracellular vesicles on bone marrow-derived macrophages
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Towards establishing extracellular vesicle-associated RNAs as biomarkers for HER2+ breast cancer
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Data from: Profiling extracellular long RNA transcriptome in human plasma and extracellular vesicles for biomarker discovery
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Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend healthspan in mouse models of aging.
<p>Source data file</p>
Data from: Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor.
Extracellular vesicles (EVs) are membrane enclosed nanostructures released by cells into the extracellular environment. As major actors of physiological intercellular communication, they have been shown to be pathogenic mediators of several liver diseases. EVs also appear to be potential actors of drug-induced liver injury, but nothing is known concerning environmental pollutants. We aimed to study the impact of polycyclic aromatic hydrocarbons (PAHs), major contaminants, on hepatocyte-derived EV production, with a special focus on hepatocyte death. Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Treatment of primary rat and WIF-B9 hepatocytes by all three PAHs increased the release of EVs, mainly comprised of exosomes, in parallel with modifying exosome protein marker expression and inducing apoptosis. Moreover, PAH treatment of rodents for three months also led to increased EV levels in plasma. The EV release involved CYP metabolism and the activation of the transcription factor, the AhR, for BP and DBA and another transcription factor, the constitutive androstane receptor (CAR), for PYR. Furthermore, all PAHs increased cholesterol levels in EVs but only BP and DBA were able to reduce the cholesterol content of total cell membranes. All cholesterol changes very likely participated in the increase in EV release and cell death. Finally, we studied changes in cell membrane fluidity caused by BP and DBA due to cholesterol depletion. Our data showed increased cell membrane fluidity, which contributed to hepatocyte EV release and cell death.
Reciprocal Communication between FAPs and Muscle Cells via Distinct Extracellular Vesicle miRNAs in Muscle Regeneration
<p>1 Metadata: Introduction of experimental design and protocol</p> <p>2 Known-miRNA map-MCEVPs: Small RNA reads from MC-EVPs were mapped against miRBase to identify known miRNAs.</p> <p>3 Known-miRNA map-FAPEVPs: Small RNA reads from FAP-EVPs were mapped against miRBase to identify known miRNAs.</p> <p>4 Readcount-TMP-1: The expression of known miRNAs was normalized by TPM (Transcripts per million).</p> <p>5 FAP-EVPs vs MCEVPs. differential analysis: Differential expressed miRNAs were analyzed by DEGseq and filtered with qvalue<0.01 &&|log2(foldchange)|>1.</p>
Extracellular Vesicles Serum, Plasma, CSF Multiplex Dataset
<p>This example dataset for MPAPASS software (v1.02) contains deidentified tetraspanin stained EV multiplex data from plasma, serum, CSF data. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.