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3,584 results for “Fibroblasts”
A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations
ClinicalTrials.gov study NCT04083976. IPD Sharing: YES. Countries: 15. Publications: 1.
Data from: The induction of the fibroblast extracellular senescence metabolome is a dynamic process
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Data from: Novel roles of chloroquine and hydroxychloroquine in Graves’ orbitopathy therapy by targeting orbital fibroblasts
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Data from: Mouse gingival single cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis
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Dermal fibroblast cultures recapitulate differences between deermice and mice in responses to a Toll-like receptor agonist
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Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts
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Data from: Controlled release of basic fibroblast growth factor from a peptide biomaterial for bone regeneration
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Data from: Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model
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Data from: Single-cell transcriptomic analysis of tumor-derived fibroblasts and normal tissue-resident fibroblasts reveals fibroblast heterogeneity in breast cancer
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Differentially expressed genes of Peromyscus leucopus fibroblast cultures treated with lipopolysaccharide or buffer alone
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Data from: Exposure effects beyond the epithelial barrier: trans-epithelial induction of oxidative stress by diesel exhaust particulates in lung fibroblasts in an organotypic human airway model
<p><i>In vitro</i> bronchial epithelial monoculture models have been pivotal in defining the adverse effects of inhaled toxicant exposures; however, they are only representative of one cellular compartment and may not accurately reflect the effects of exposures on other cell types. Lung fibroblasts exist immediately beneath the bronchial epithelial barrier and play a central role in lung structure and function, as well as disease development and progression. We tested the hypothesis that <i>in vitro</i> exposure of a human bronchial epithelial cell barrier to the model oxidant diesel exhaust particulates caused trans-epithelial oxidative stress in the underlying lung fibroblasts using a human bronchial epithelial cell and lung fibroblast co-culture model. We observed that diesel exhaust particulates caused trans-epithelial oxidative stress in underlying lung fibroblasts as indicated by intracellular accumulation of the reactive oxygen species hydrogen peroxide, oxidation of the cellular antioxidant glutathione, activation of NRF2, and induction of oxidative stress responsive genes. Further, targeted antioxidant treatment of lung fibroblasts partially mitigated the oxidative stress response gene expression in adjacent human bronchial epithelial cells during diesel exhaust particulate exposure. This indicates that exposure induced oxidative stress in the airway extends beyond the bronchial epithelial barrier and that lung fibroblasts are both a target and a mediator of the adverse effects of inhaled chemical exposures despite a lack of direct exposure to the inhaled material. These findings illustrate the value of co-culture models and suggest that trans-epithelial exposure effects should be considered in inhalation toxicology research and testing.</p>
Data from: Primary dermal fibroblasts and pectoralis muscle show similar patterns of oxidative stress in tropical and temperate birds despite differing life-histories
<p><span>Tropical birds have a "slower pace of life," with lower rates of whole-animal metabolism, smaller metabolically active organs, and lower cellular metabolic rates than their temperate counterparts. Oxidative stress is a physiological mechanism that may dictate differing life-histories such as those found between tropical and temperate birds. <span>Oxygen is required to make ATP, resulting in the production of reactive oxygen species (ROS)</span>. If left unchecked, ROS can structurally alter proteins, induce mutations in DNA, and damage structural lipids. To combat accumulating oxidative damage, organisms have evolved an elaborate and costly antioxidant system that serves to sequester ROS before they wreak cellular havoc. We examined whether oxidative stress would differ between tropical and temperate birds. We used isolated primary dermal fibroblasts and pectoralis muscle tissue for measurements. We measured four aspects of oxidative stress in primary fibroblasts – reduced glutathione (GSH) concentration, ROS production, mitochondrial content, and lipid peroxidation (LPO) damage. We found no significant differences in the four variables between temperate and tropical birds.. In muscle tissue, we measured catalase (CAT), superoxide dismutase (SOD) glutathione peroxidase (GPx) activity, peroxyl and hydroxyl scavenging capacity, and LPO damage. We found that peroxyl scavenging capacity was significantly higher in tropical birds compared with temperate birds. </span></p>
Integrated single-cell RNA-sequencing data of unwounded and wounded mouse skin and fibroblasts.
<p>This repository contains the .h5ad files that store the integrated scRNA-seq data we generated for the work, Almet et al. (2023), "Fibroblasts evolve in single-cell state to drive extracellular matrix and signaling changes across wound healing", to be published in the Journal of Investigative Dermatology.</p><p>The integrated* files contain both raw counts, normalized counts, as well as unspliced and spliced count estimates that were obtained using kallisto|bustools and velocyto. We integrated the data from the following published datasets:</p><ol><li><a href=" https://doi.org/10.7554/eLife.60066">Phan et al. (2021)</a>: Unwounded P21 mice and small wound P21 + 7 mice</li><li><a href="https://doi.org/10.1016/j.celrep.2020.02.091">Haensel et al. (2020)</a>: Unwounded P49 mice and small wound P49 + 4 mice</li><li><a href="https://doi.org/10.1038/s41467-018-08247-x)">Guerrero-Juarez et al. (2019)</a>: Large wound day 12 mice</li><li><a href="https://doi.org/10.1016/j.stem.2020.07.008">Abbasi et al. (2020)</a>: Large wound day 14 mice</li><li><a href="https://doi.org/10.1126/sciadv.aay3704">Gay et al. (2020)</a>: Large wound fibrotic (hairless) and regenerative (hair follicle neogenesis) day 18 mice</li></ol><p>The unwounded_* files were used to briefly integrated unwounded skin scRNA-seq from mouse models of different ages that have been used to analyze wound healing in <a href="https://doi.org/10.1016/j.celrep.2020.02.091">Haensel et al. (2020),</a> <a href=" https://doi.org/10.7554/eLife.60066">Phan et al. (2021)</a>, and <a href="https://doi.org/10.1016/j.celrep.2022.111155">Vu et al. (2022)</a>, which generated scRNA-seq for unwounded skin from mice aged P21, P49, and P616, respectively. </p><p>The data can be loaded using the Python package Scanpy or AnnData, but you can also load it in R if you use zellkonverter. </p>
Lymphocytes migration beneath fibroblasts
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Fibroblast Growth Factor receptor signaling in cardiomyocytes is protective in the acute phase following ischemia-reperfusion injury
<p>Suplemental echocardiographic images</p>
Spatial regulation of substrate adhesion directs fibroblast morphotype and phenotype
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Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation
<p>Fibroblast single-cell processed expression data and annotations used in the study "Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation"</p>
Data from: A study on genetic variants of Fibroblast Growth Factor Receptor 2 (FGFR2) and the risk of breast cancer from North India
Genome-Wide Association Studies (GWAS) have identified Fibroblast growth factor receptor 2 (FGFR2) as a candidate gene for breast cancer with single nucleotide polymorphisms (SNPs) located in intron 2 region as the susceptibility loci strongly associated with the risk. However, replicate studies have often failed to extrapolate the association to diverse ethnic regions. This hints towards the existing heterogeneity among different populations, arising due to differential linkage disequilibrium (LD) structures and frequencies of SNPs within the associated regions of the genome. It is therefore important to revisit the previously linked candidates in varied population groups to unravel the extent of heterogeneity. In an attempt to investigate the role of FGFR2 polymorphisms in susceptibility to the risk of breast cancer among North Indian women, we genotyped rs2981582, rs1219648, rs2981578 and rs7895676 polymorphisms in 368 breast cancer patients and 484 healthy controls by Polymerase chain reaction-Restriction fragment length polymorphism (PCR-RFLP) assay. We observed a statistically significant association with breast cancer risk for all the four genetic variants (P<0.05). In per-allele model for rs2981582, rs1219648, rs7895676 and in dominant model for rs2981578, association remained significant after bonferroni correction (P<0.0125). On performing stratified analysis, significant correlations with various clinicopathological as well as environmental and lifestyle characteristics were observed. It was evident that rs1219648 and rs2981578 interacted with exogenous hormone use and advanced clinical stage III (after Bonferroni correction, P<0.000694), respectively. Furthermore, combined analysis on these four loci revealed that compared to women with 0–1 risk loci, those with 2–4 risk loci had increased risk (OR = 1.645, 95%CI = 1.152–2.347, P = 0.006). In haplotype analysis, for rs2981578, rs2981582 and rs1219648, risk haplotype (GTG) was associated with a significantly increased risk compared to the common (ACA) haplotype (OR = 1.365, 95% CI = 1.086–1.717, P = 0.008). Our results suggest that intron 2 SNPs of FGFR2 may contribute to genetic susceptibility of breast cancer in North India population.
Hypoxia preconditioned mesenchymal stem cells prevent cardiac fibroblast activation and collagen production via leptin
<p><strong>Aims</strong>: Activation of cardiac fibroblasts into myofibroblasts constitutes a key step in cardiac remodeling after myocardial infarction (MI), due to interstitial fibrosis. Mesenchymal stem cells (MSCs) have been shown to improve post-MI remodeling an effect that is enhanced by hypoxia preconditioning (HPC). Leptin has been shown to promote cardiac fibrosis. The expression of leptin is significantly increased in MSCs after HPC, but it is unknown whether leptin contributes to MSC therapy or the fibrosis process. The objective of this study was to determine whether leptin secreted from MSCs modulates cardiac fibrosis.</p> <p><strong>Methods</strong>: Cardiac fibroblast (CF) activation was induced by hypoxia (0.5% O<sub>2</sub>). The effects of MSCs on fibroblast activation were analyzed by co-culturing MSCs with CFs and detecting the expression of a-SMA, SM22a, and collagen IaI in CFs by western blot, immunofluorescence and Sirius red staining. In vivo MSCs antifibrotic effects on left ventricular remodeling were investigated using an acute MI model involving permanent ligation of the left anterior descending coronary artery.</p> <p><strong>Results</strong>: Co-cultured MSCs decreased fibroblast activation and HPC enhanced the effects. Leptin deficit MSCs from Ob/Ob mice did not decrease fibroblast activation. Consistent with this, H-MSCs significantly inhibited cardiac fibrosis after MI and mediated decreased expression of TGF-b/Smad2 and MRTF-A in CFs. These effects were again absent in leptin-deficient MSCs.</p> <p><strong>Conclusion</strong>: Our data demonstrate that activation of cardiac fibroblast was inhibited by MSCs in a manner that was leptin-dependent. The mechanism may involve blocking TGF-b/Smad2 and MRTF-A signal pathway.</p>
Endogenous hsa-circ_0007113 binds hsa-miR-515-5p to regulate senescence in human embryonic lung fibroblasts
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.