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129
datasets available to search
ShareScore release 0.9.0
Dataset results
129 results for “Gain-of-Function”
Genome-wide gain-of-function screening characterized lncRNAs as tumor immune response regulators [CRISPR_screen]
GEO Series GSE202130. Homo sapiens. 5 samples. Type: Other.
A gain-of-function p53 mutant oncogene promotes cell fate plasticity and myeloid leukemia through the pluripotency factor Foxh1
GEO Series GSE125097. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
TLR7 gain-of-function genetic variation causes human lupus
GEO Series GSE196316. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Twist1 gain-of-function studied in 2 normal gastric fibroblast lines
GEO Series GSE62739. Homo sapiens. 8 samples. Type: Expression profiling by array.
RNA-sequencing of fetal thymic epithelial cells (TECs), in control, loss-of-function and gain-of-function Notch mutants
GEO Series GSE100314. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Mutant p53 gain-of-function impact is repressed in the presence of other major oncogenic drivers
GEO Series GSE239817. Homo sapiens. 72 samples. Type: Expression profiling by high throughput sequencing.
Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex
GEO Series GSE65555. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The CD33 short isoform is a gain-of-function variant that enhances Aß1-42 phagocytosis in microglia II
GEO Series GSE172527. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Prevalent p53 gain-of-function mutants co-opt epigenetic pathways to drive cancer growth
GEO Series GSE59176. Homo sapiens; Mus musculus. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Pathogenic DICER1 RNase IIIb Hotspot Mutation Induces 3p-miRNA Gain-of-Function via Argonaute Strand Switch [miR-seq]
GEO Series GSE279556. Mus musculus; Homo sapiens. 26 samples. Type: Non-coding RNA profiling by high throughput sequencing.
A Stat1 gain-of-function mutant disrupts normal Stat4 innate lymphocyte programs during viral infection [RNA-seq]
GEO Series GSE284176. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Only the loss-of-function but not the gain-of-function properties of mutant TP53 are critical for the sustained proliferation, survival and metastasis of a broad range of cancer cells [breast cancer]
GEO Series GSE181010. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice
GEO Series GSE269531. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Human Germline Heterozygous Gain-of-Function STAT6 Variants Cause Severe Allergic Disease [scRNAseq]
GEO Series GSE215405. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Pulmonary gain-of-function toxicity in alpha-1 antitrypsin deficiency
GEO Series GSE227210. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Ascl5 variant alters gene expression in postnatal maxillary molars through potential gain-of-function effect
GEO Series GSE296465. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gain-of-function RNA Polymerase II partitioning is a shared feature of diverse oncogenic fusions
GEO Series GSE267717. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptome characterization of CHOPS syndrome, a novel genetic disorder caused by gain-of-function mutations of AFF4
GEO Series GSE64031. Homo sapiens. 10 samples. Type: Expression profiling by array.
Gain-of-function genetic alterations of G9a drive oncogenesis
GEO Series GSE147429. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
A Gain-of-Function Genomic Screen Identifies the Orphan Nuclear Receptor TLX as an Enhancer of STAT1-mediated Transcription and Immunity to Toxoplasma gondii
GEO Series GSE55751. Homo sapiens. 16 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.