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Dataset results
76 results for “Genome-wide selection”
Genome-wide and Cell-type Selective Profiling of In Vivo Small Noncoding RNA:Target RNA Interactions by Chimeric RNA Sequencing
GEO Series GSE263988. Mus musculus. 12 samples. Type: Other.
(2-Benzimidazolyl)acetonitrile derivative for the highly selective la-beling 5-formyluracil and its application in genome-wide mapping in tissues
GEO Series GSE115918. Homo sapiens; Mus musculus. 6 samples. Type: Other.
Genome-wide mapping of human DNA-replication origins: levels of transcription at Orc1 sites regulate origin selection and replication timing
GEO Series GSE37583. Homo sapiens. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide gene expression in soleus muscle of rats artificially selected for high and low running capacity
GEO Series GSE10527. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
Genome-wide occupation of AR, FOXA1, and H3K27AC in LNCaP cells treated with selective PARP2 inhibitor UPF-1069
GEO Series GSE114274. Homo sapiens. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide liver transcriptomic profiles from chow-fed, high fat diet (HFD) fed, and HFD + AC261066 (Retinoic Acid Receptor Beta-2 Selective Agonist) fed mice
GEO Series GSE165855. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Detection of genome-wide copy number variations in two chicken lines divergently selected for abdominal fat content
GEO Series GSE58551. Gallus gallus. 475 samples. Type: Genome variation profiling by SNP array.
Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei
GEO Series GSE81765. Trypanosoma brucei. 10 samples. Type: Expression profiling by high throughput sequencing; Other.
Combining Genome-wide Gene Expression Analysis (RNA-seq) and Gene Editing Platform (CRISPR-Cas9) to Uncover the Selectively Pro-oxidant Activity of Aurone Compound against Candida albicans
GEO Series GSE158472. Candida albicans. 9 samples. Type: Expression profiling by high throughput sequencing.
Genome-Wide Study Based On Abasic Site Revealed Selective RNA Oxidation In Neuro 2a Cells
GEO Series GSE39641. Mus musculus. 16 samples. Type: Expression profiling by array.
Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide [ChIP-Seq]
GEO Series GSE234319. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide
GEO Series GSE234320. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide selection and testing of superior reference genes for quantitative gene expression normalization in tobacco (Nicotiana tabacum)
GEO Series GSE73440. Nicotiana tabacum. 21 samples. Type: Expression profiling by array.
Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide [RNA-Seq]
GEO Series GSE234318. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide Characterization of Selection Signatures and Runs of Homozygosity in Ugandan Goat Breeds
<p><strong>ABSTRACT</strong></p> <p>Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation across breeds and/or a strong reduction in genetic diversity in regions associated with traits under intense selection pressure. In this study, we evaluated selection signatures and genomic inbreeding coefficients, based on runs of homozygosity (ROH), in six Ugandan goat breeds: Boer (n = 13), and the indigenous breeds Karamojong (n = 15), Kigezi (n = 29), Mubende (n = 29), Small East African (n = 29) and Sebei (n = 29). After genotyping quality control, 45,294 autosomal single nucleotide polymorphisms (SNPs) remained for further analyses. A total of 394 and 6 breed-specific putative selection signatures were identified across all breeds, based on the fixation index ( -values) and hapFLK statistics respectively. These regions were enriched with genes involved in signalling pathways associated directly or indirectly with environmental adaptation, such as immune response (e.g. <em>IL10RB</em> and <em>IL23A</em>), growth and fatty acid composition (e.g. <em>FGF9</em> and <em>IGF1</em>), and thermo-tolerance (e.g. <em>MTOR</em> and <em>MAPK3</em>). The study revealed little overlap in genomic regions under selection and generally did not display the typical classic selection signatures as expected due to the complex nature of the traits. In the Boer breed, candidate genes associated with production traits, such as body size and growth (e.g. <em>GJB2</em> and <em>GJA3</em>) were also identified. Furthermore, analysis of ROH in indigenous goat breeds showed very low levels of genomic inbreeding (with the mean per breed ranging from 0.8% to 2.4%), as compared to higher inbreeding in Boer (mean = 13.8%). And, short ROH were more frequent than long ROH, except in Karamojong, providing insight in the developmental history of these goat breeds. This study provides important insights into the effects of long-term selection in Boer and indigenous Ugandan goat breeds and its genetic. Our findings are of great relevance to the implementation of breeding programs and conservation of genetic resources, as well as their sustainable use and management.</p> <p> </p> <p> </p> <p> </p>
Genome-wide H3K9me2 mapping in single deletions of the selected chromatin modulating genes, histone H3 mutants and ccp1Δepe1Δ double mutant
GEO Series GSE119589. Schizosaccharomyces pombe. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.