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1,693 results for “Hypoxia”
Effects of hypoxia and spawning on mitochondrial metabolism and bioenergetics of the blue mussel Mytilus spp. from the Baltic Sea
<p>We studied the effect of short-term hypoxia (7 days) and spawning (pre-spawning, and 3 h and 72 h post-spawning) on mitochondrial respiration, reactive oxygen species (ROS) production, and energy budget of the mussels Mytilus edulis. The data set reports oxygen consumption, efflux of reactive oxygen species (H2O2), fractional electrol leak (ratio of H2O2 efflux to O2 consumption) in isolated mitochondria, as well as the biochemical composition and energy content of the gills and the digestive gland tissues, tissue energy demand (measured as the activity to the electron transport system) and cellular energy allogation (CEA) in the tissues of the mussels.</p>
Mitochondrial responses to long-term and cyclic hypoxia depend on the oxidized fuel in a hypoxia-tolerant marine bivalve Crassostrea gigas
<p>These are the metadata for a publication "Mitochondrial responses to long-term and cyclic hypoxia depend on the oxidized fuel in a hypoxia-tolerant marine bivalve <em>Crassostrea gigas"</em> under consideration for publication in the Scientific reports. Sessile benthic organisms like oysters inhabits intertidal zone transitioning between aquatic and terrestrial condition during tidal movements exposing the organisms to alternating hypoxia and reoxygenation (H/R) episodes thereby altering the respiratory chain activities and metabolome compositions. Our study investigated the effects of constant long-term H/R stress (90 min at ~0% O<sub>2, </sub>and 10 min reoxygenation) and constant cyclic H/R stress (5 cycles of 15 min at ~0% O<sub>2, </sub>and 10 min reoxygenation) on isolated mitochondria from the gill and the digestive gland of <em>C. gigas</em> respiring on different substrates (pyruvate, palmitate, and succinate). Both gill and the digestive gland mitochondria exposed to constant long-term H/R suppressed OXPHOS respiration especially during Complex I oxidation with no change in ROS efflux but an increase FEL. In the gill mitochondria oxidizing Complex I substrates, exposure to constant cyclic H/R prompted a significant drop after the first H/R cycle. In contrast, succinate-driven respiration only showed significant decline after the fifth H/R cycle. ROS efflux and FEL however saw little to no change after constant cyclic H/R. This observation from our study further suggests succinate as a potential stress fuel under H/R stress and might assist in post-hypoxic recovery of oysters mitigating oxidative stress and supporting rapid ATP re-synthesis during oxygen fluctuations such as commonly observed in intertidal zones. Additionally, our study revealed that constant long-term hypoxia is more damaging than constant cyclic hypoxia. </p>
Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm
ClinicalTrials.gov study NCT01875159. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Hypoxia on Type 2 Diabetes and Weight Loss
ClinicalTrials.gov study NCT05147116. IPD Sharing: YES. Countries: 1. Publications: 0.
Rapid Acclimatization to Hypoxia at Altitude
ClinicalTrials.gov study NCT01702025. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
ClinicalTrials.gov study NCT03101904. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hypoxia-inducible Factor-1 (HIF-1) Regulated Circulating Angiogenic Cells (CACs) Recruitment in Burn Wound Healing
ClinicalTrials.gov study NCT00796627. IPD Sharing: NO. Countries: 1. Publications: 1.
Wireless Disposable SpO2 Sensor Hypoxia Testing
ClinicalTrials.gov study NCT06211530. IPD Sharing: NO. Countries: 1. Publications: 5.
Using Capnography to Reduce Hypoxia During Pediatric Sedation
ClinicalTrials.gov study NCT01463527. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Intermittent Hypoxia in Upper and Lower Limb Functions in Persons With Incomplete Spinal Cord Injury
ClinicalTrials.gov study NCT05491837. IPD Sharing: NO. Countries: 1. Publications: 9.
Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
ClinicalTrials.gov study NCT04854057. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Prognostic Value of Tumor Hypoxia, as Measured by 18F-FMISO Breath Hold PET/CT, in Non-Small-Cell-Lung Cancer (NSCLC) Patients
ClinicalTrials.gov study NCT02016872. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia
ClinicalTrials.gov study NCT02482571. IPD Sharing: NO. Countries: 1. Publications: 2.
MRI and PET/FMISO In Assessing Tumor Hypoxia in Patients With Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00902577. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Respiratory and Autonomic Plasticity Following Intermittent Hypoxia
ClinicalTrials.gov study NCT00860743. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Dose Escalation Using Hypoxia-adjusted Radiotherapy
ClinicalTrials.gov study NCT06087614. IPD Sharing: NO. Countries: 1. Publications: 18.
Intermittent Hypoxia and Caffeine in Infants Born Preterm
ClinicalTrials.gov study NCT03321734. IPD Sharing: YES. Countries: 1. Publications: 4.
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
ClinicalTrials.gov study NCT02323698. IPD Sharing: NO. Countries: 1. Publications: 6.
Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury
ClinicalTrials.gov study NCT03071393. IPD Sharing: NO. Countries: 1. Publications: 6.
Accuracy of ScanWatch Pulse Oximeter With Profound Hypoxia
ClinicalTrials.gov study NCT04380389. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.