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460 results for “Immunoglobulin A”
Figure 1 in Variation in leukocyte indices and immunoglobulin levels according to host density, sex, flea burden and tularemia prevalence in the common vole Microtus arvalis
Figure 1: Relationship between the a) neutrophil-to-lymphocyte (N:L) ratio and immunoglobulin (Ig) levels according to vole sex, and between the b) proportion of eosinophils and Ig levels. Grey shaded areas show the 95 % confidence intervals of the predicted curves.
Extreme genomic volatility characterises the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes
The evolution of the adaptive immune system has provided vertebrates with a uniquely sophisticated immune toolkit, enabling them to mount precise immune responses against a staggeringly diverse range of antigens. Like other vertebrates, teleost fishes possess a complex and functional adaptive immune system; however, our knowledge of the complex antigen-receptor genes underlying its functionality has been restricted to a small number of experimental and agricultural species, preventing a systematic investigation of how these crucial gene loci evolve. Here, we analyse the genomic structure of the immunoglobulin heavy chain (IGH) gene loci in the cyprinodontiforms, a diverse and important group of teleosts present in many different habitats across the world. We reconstruct the complete IGH loci of the turquoise killifish (Nothobranchius furzeri) and the southern platyfish (Xiphophorus maculatus) and analyse their in vivo gene expression, revealing the presence of species-specific splice isoforms of transmembrane IGHM. We further characterise the IGH constant regions of ten additional cyprinodontiform species, including guppy, amazon molly, mummichog and mangrove killifish. Phylogenetic analysis of these constant regions suggests multiple independent rounds of duplication and deletion of the teleost-specific antibody class IGHZ in the cyprinodontiform lineage, demonstrating the extreme volatility of IGH evolution. Focusing on the cyprinodontiforms as a model taxon for comparative evolutionary immunology, this work provides novel genomic resources for studying adaptive immunity and sheds light on the evolutionary history of the adaptive immune system.
A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis
ClinicalTrials.gov study NCT02398994. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Add-on Intravenous Immunoglobulins in Early Myositis
ClinicalTrials.gov study NCT05832034. IPD Sharing: NO. Countries: 1. Publications: 7.
Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock.
ClinicalTrials.gov study NCT04182737. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Convalescent Plasma (PC) and Human Intravenous Anti-COVID-19 Immunoglobulin (IV Anti COVID-19 IgG) in Patients Hospitalized for COVID-19.
ClinicalTrials.gov study NCT04395170. IPD Sharing: NO. Countries: 1. Publications: 8.
Specific IgG Antibody in Patients With Primary Antibody Deficiencies Treated With Subcutaneous Immunoglobulin
ClinicalTrials.gov study NCT00661401. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Treatment of Early Immunoglobulin A Nephropathy by Angiotensin Converting Enzyme Inhibitor - A Randomized Controlled Trial
ClinicalTrials.gov study NCT01225445. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease
ClinicalTrials.gov study NCT04078568. IPD Sharing: NO. Countries: 1. Publications: 1.
Immunoglobulins in Multiple Myeloma Patients Receiving a BCMA-Directed T Cell Engager
ClinicalTrials.gov study NCT07094048. IPD Sharing: UNDECIDED. Countries: 1. Publications: 18.
Preventing Intravenous Immunoglobulin-associated Adverse Reactions
ClinicalTrials.gov study NCT00675805. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
ClinicalTrials.gov study NCT02961166. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Outpatient Treatment With Anti-Coronavirus Immunoglobulin
ClinicalTrials.gov study NCT04910269. IPD Sharing: YES. Countries: 13. Publications: 1.
Intravenous Immunoglobulins for the Treatment of Covid-19 Patients: a Clinical Trial
ClinicalTrials.gov study NCT04548557. IPD Sharing: NO. Countries: 1. Publications: 11.
rATG Versus rATG Combined With Intravenous Immunoglobulin (IVIG) Induction Immunosuppression in HLA Incompatible Transplantation (INHIBIT)
ClinicalTrials.gov study NCT04302805. IPD Sharing: NO. Countries: 1. Publications: 1.
Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial
ClinicalTrials.gov study NCT02111161. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy and Safety of Xepol (Human Immunoglobulin) in Subjects With Post-Polio Syndrome (PPS)
ClinicalTrials.gov study NCT00160082. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Clinical Study of CM338 in the Treatment of Immunoglobulin A Nephropathy
ClinicalTrials.gov study NCT05775042. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Feasibility and Safety of Immunoglobulin (Ig) Treatment in COPD Outpatients With Frequent Exacerbations: Pilot Study 1
ClinicalTrials.gov study NCT03018652. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Diaplacental Transfer of Anti-HCMV- and Anti-VZV-immunoglobulin G (IgG) -Antibodies at Premature and Mature Newborns
ClinicalTrials.gov study NCT02689700. IPD Sharing: NO. Countries: 1. Publications: 4.
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