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684 results for “Influenza A virus”
Data from: Inferring epidemiologic dynamics from viral evolution: 2014–2015 Eurasian/North American highly pathogenic avian influenza viruses exceed transmission threshold, R0 = 1, in wild birds and poultry in North America
Highly pathogenic avian influenza virus (HPAIV) is a multi-host pathogen with lineages that pose health risks for domestic birds, wild birds, and humans. One mechanism of intercontinental HPAIV spread is through wild bird reservoirs and wild birds were the likely sources of a Eurasian (EA) lineage HPAIV into North America in 2014. The introduction resulted in several reassortment events with North American (NA) lineage low pathogenic avian influenza viruses and the reassortant EA/NA H5N2 went on to cause one of the largest HPAIV poultry outbreaks in North America. We evaluated three hypotheses about novel HPAIV introduced into wild and domestic bird hosts: (i) transmission of novel HPAIVs in wild birds was restricted by mechanisms associated with highly-pathogenic phenotypes; (ii) the HPAIV poultry outbreak was not self-sustaining and required viral input from wild birds; (iii) reassortment of the EA H5N8 generated reassortant EA/NA AIVs with a fitness advantage over fully Eurasian lineages in North American wild birds. We used a time-rooted phylodynamic model that explicitly incorporated viral population dynamics with evolutionary dynamics to estimate the basic reproductive number (R0) and viral migration among host types in domestic and wild birds, as well as between the EA H5N8 and EA/NA H5N2 in wild birds. We did not find evidence to support hypothesis (i) or (ii) as our estimates of the transmission parameters suggested that the HPAIV outbreak met or exceeded the threshold for persistence in wild birds (R0 > 1) and poultry (R0 ≈ 1) with minimal estimated transmission among host types. There was also no evidence to support hypothesis (iii) because R0 values were similar among EA H5N8 and EA/NA H5N2 in wild birds. Our results suggest that this novel HPAIV and reassortments did not encounter any transmission barriers sufficient to prevent persistence when introduced to wild or domestic birds.
Data from: Molecular analysis of H7 avian influenza viruses from Australia and New Zealand: genetic diversity and relationships from 1976 to 2007
Full genome sequencing of 11 Australian and one New Zealand subtype H7 avian influenza A isolates has enabled the comparison of sequences from each of the genome segments to other sequenced subtype H7 avian influenza A. The inference of phylogenetic relationships for each segment has been used to develop a model of the natural history of these viruses in Australia. The Australian H7 hemagglutinins form a monophyletic clade, consistent with the long-term, independent evolution due to geographic isolation. Based on the analysis of the other available H7 hemagglutinins sequences, the three other geographic regions for which similar monophyletic clades have been observed were confirmed; these regions are Eurasia (Africa, Europe and Asia), North America and South America. Analysis of datasets of H7N1, H7N3, H7N7 neuraminidase sequences revealed congruent relationships indicating a similar pattern of geographically constrained independent evolution for each of the neuraminidase subtype datasets. This pattern of evolution in geographic isolation is supported by analysis of each of the six remaining segments of the Australian isolates. These data in combination with the occurrence of five different combinations of neuraminidase subtypes (H7N2, H7N3, H7N4, H7N6, H7N7) among the 11 Australian isolates suggests a single maintenance network of hosts, probably comprising several avian species, for subtype H7 avian influenza A in Australia. A clear time based evolution of the hemagglutinins sequences despite the occurrence of multiple neuraminidase types suggest a genetic pool from which a variety of reassorants arise rather than the presence of a small number of stable viral clones. This pattern of evolution is likely to occur in each of the regions mentioned above as well as possibly a new region comprising of New Zealand, based on the apparent genetic isolation of the isolate analyzed in this study.
Data from: Association between the severity of influenza A(H7N9) virus infections and length of the incubation period
Background: In early 2013, a novel avian-origin influenza A(H7N9) virus emerged in China, and has caused sporadic human infections. The incubation period is the delay from infection until onset of symptoms, and varies from person to person. Few previous studies have examined whether the duration of the incubation period correlates with subsequent disease severity. Methods and Findings: We analyzed data of period of exposure on 395 human cases of laboratory-confirmed influenza A(H7N9) virus infection in China in a Bayesian framework using a Weibull distribution. We found a longer incubation period for the 173 fatal cases with a mean of 3.7 days (95% credibility interval, CrI: 3.4–4.1), compared to a mean of 3.3 days (95% CrI: 2.9–3.6) for the 222 non-fatal cases, and the difference in means was marginally significant at 0.47 days (95% CrI: -0.04, 0.99). There was a statistically significant correlation between a longer incubation period and an increased risk of death after adjustment for age, sex, geographical location and underlying medical conditions (adjusted odds ratio 1.70 per day increase in incubation period; 95% credibility interval 1.47–1.97). Conclusions: We found a significant association between a longer incubation period and a greater risk of death among human H7N9 cases. The underlying biological mechanisms leading to this association deserve further exploration.
Datasets for: Inactivation mechanisms of Influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS.
<p>Datasets associated with the publication '<strong>Inactivation mechanisms of Influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS</strong>', published by mSphere [DOI: <a href="http://dx.doi.org/10.1128/msphere.00226-23">10.1128/msphere.00226-23</a>]</p> <p>Data included here encompasses infectivity (IAV and VSV), RT-qPCR , and HDX-MS datasets. </p> <p>The raw mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD037176.</p>
Genetic variation data derived from ferret transmission experiments of avian H3N8 influenza viruses
<p>Supplementary Dataset 1. Genetic variation data derived from ferret transmission experiment of HN/4-10 virus<br> Supplementary Dataset 2. Genetic variation data derived from ferret transmission experiment of CS/1000 virus<br> Supplementary Dataset 3. Genetic variation data derived from ferret transmission experiment of CK/FE12 virus<br> Supplementary Dataset 4. Genetic variation data derived from ferret transmission experiment of CK/F0316 virus</p>
ADC189 Tablets on Influenza A Virus Infection/Influenza B Virus Infection
ClinicalTrials.gov study NCT06342921. IPD Sharing: NO. Countries: 1. Publications: 1.
Influenza A VIRus and Destabilization of Atherosclerotic Carotid Plaques
ClinicalTrials.gov study NCT06217471. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Study of Immune Responses in Healthy Adults Receiving Live Influenza Virus Vaccines
ClinicalTrials.gov study NCT01674205. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Immunogenicity of Two Doses of Monovalent Inactivated Influenza Vaccine That is Adjuvanted With MF59C.1 (MF59) and Uses a Surface Antigen From a Potential Pandemic Virus Strain Candidate (H
ClinicalTrials.gov study NCT00841646. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immunogenicity, Safety and Tolerability of a Plant-Derived Seasonal Virus-Like-Particle Quadrivalent Influenza Vaccine in Adults
ClinicalTrials.gov study NCT02233816. IPD Sharing: Not stated. Countries: 1. Publications: 1.
To Assess the Efficacy of GP681 Tablet Versus Placebo in Patients With Acute Uncomplicated Influenza Virus Infection
ClinicalTrials.gov study NCT05474755. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Study on the Immune Response Characteristics of Novel Coronavirus and Influenza Virus Infection
ClinicalTrials.gov study NCT06667063. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
The RAPID Trial: Assessing Point-of-care Influenza and Other Respiratory Virus Diagnostics
ClinicalTrials.gov study NCT03756753. IPD Sharing: NO. Countries: 1. Publications: 1.
Influenza Virus - A Multicenter Registry
ClinicalTrials.gov study NCT01256255. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Influenza Virus Challenge Study to Test Monoclonal Antibody TCN-032 as a Treatment for Influenza
ClinicalTrials.gov study NCT01719874. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 2, Double-blind Study to Evaluate Intranasal Trivalent Influenza Virus Vaccine in Healthy Adult
ClinicalTrials.gov study NCT03784885. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Phase I Open-Label Study of Recombinant DNA Plasmid Vaccine, VRC-AVIDNA036-00-VP, Encoding for Influenza Virus H5 Hemagglutinin Protein Given Intradermally
ClinicalTrials.gov study NCT00489931. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Safety and Immunogenicity of a Live Attenuated H7N9 Influenza Virus Vaccine in Healthy Adults
ClinicalTrials.gov study NCT01995695. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Tobacco Products on Live Attenuated Influenza Virus (LAIV) Infections in Human Volunteers
ClinicalTrials.gov study NCT02019745. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Immunogenicity Study of a H5N1 Influenza Vaccine (Vero Cell-Derived, Whole Virus) in Healthy Infants, Children and Adolescents
ClinicalTrials.gov study NCT01052402. IPD Sharing: Not stated. Countries: 4. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.