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459 results for “Mesenchymal stromal cells”
Dataset related to the article "Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile"
<p>This record contains raw data related to the article "Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile". </p> <p><strong>Background:</strong> Left ventricle (LV) and right ventricle (RV) are characterized by well-known physiological differences, mainly related to their different embryological origin, hemodynamic environment, function, structure, and cellular composition. Nevertheless, scarce information is available about cellular peculiarities between left and right ventricular chambers in physiological and pathological contexts. Cardiac mesenchymal stromal cells (C-MSC) are key cells affecting many functions of the heart. Differential features that distinguish LV from RV C-MSC are still underappreciated.</p> <p><strong>Aim:</strong> To analyze the physiological differential amount, function, and transcriptome of human C-MSC in LV versus (vs.) RV.</p> <p><strong>Methods:</strong> Human cardiac specimens of LV and RV from healthy donors were used for tissue analysis of C-MSC number, and for C-MSC isolation. Paired LV and RV C-MSC were compared as for surface marker expression, cell proliferation/death ratio, migration, differentiation capabilities, and transcriptome profile.</p> <p><strong>Results:</strong> Histological analysis showed a greater percentage of C-MSC in RV vs. LV tissue. Moreover, a higher C-MSC amount was obtained from RV than from LV after isolation procedures. LV and RV C-MSC are characterized by a similar proportion of surface markers. Functional studies revealed comparable cell growth curves in cells from both ventricles. Conversely, LV C-MSC displayed a higher apoptosis rate and RV C-MSC were characterized by a higher migration speed and collagen deposition. Consistently, transcriptome analysis showed that genes related to apoptosis regulation or extracellular matrix organization and integrins were over-expressed in LV and RV, respectively. Besides, we revealed additional pathways specifically associated with LV or RV C-MSC, including energy metabolism, inflammatory response, cardiac conduction, and pluripotency.</p> <p><strong>Conclusion:</strong> Taken together, these results contribute to the functional characterization of RV and LV C-MSC in physiological conditions. This information suggests a possible differential role of the stromal compartment in chamber-specific pathologic scenarios.</p>
Dataset related to article "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"
<p>Dataset related to manuscript "A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment"</p> <p>Each excel file contains raw data relative to data shown in Figures</p>
"Ready-to-use" Intra-articular Formulation of Mesenchymal Stromal Cells
ClinicalTrials.gov study NCT05751564. IPD Sharing: YES. Countries: 0. Publications: 1.
Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease
ClinicalTrials.gov study NCT02150551. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease)
ClinicalTrials.gov study NCT04345601. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
ClinicalTrials.gov study NCT04466098. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT03828123. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT03268603. IPD Sharing: NO. Countries: 1. Publications: 0.
Diabetic Kidney Disease Induces Transcriptome Alterations Associated with Angiogenesis Activity in Human Mesenchymal Stromal Cells [mRNA]
GEO Series GSE217709. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
Regional specialization and fate specification of mesenchymal stromal cells in skeletal development [bulk RNA-seq]
GEO Series GSE156634. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Generation and Characterization of an immortalized human mesenchymal stromal cell line model [Illumina adipocyte differentiation]
GEO Series GSE47647. Homo sapiens. 12 samples. Type: Expression profiling by array.
Gene expression profiling of cardiac mesenchymal stromal cell during ageing
GEO Series GSE129656. Mus musculus. 8 samples. Type: Expression profiling by array.
RNA-seq Analysis of bone marrow mesenchymal stromal cells from DPBS-treated vs FAP inhibitor-treated mice
GEO Series GSE145473. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reduce Pseudomonas-biofilm formation and inflammation in CF Bronchial Epithelial Cells
GEO Series GSE295607. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Modulating neutrophil phenotype via mesenchymal stromal cell paracrine signals; insights from human and mouse experiments
GEO Series GSE287432. Mus musculus. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Neonatal bone marrow interstitial fluid supports expansion and osteogenic ability of human bone marrow mesenchymal stromal cells
GEO Series GSE290284. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Generation and Characterization of an immortalized human mesenchymal stromal cell line model [Illumina iMSC#3 and hMSC primary cultures]
GEO Series GSE47648. Homo sapiens. 3 samples. Type: Expression profiling by array.
Generation and Characterization of an immortalized human mesenchymal stromal cell line model [Affymetrix]
GEO Series GSE47646. Homo sapiens. 1 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
GEO Series GSE104259. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Gene expression profile of human mesenchymal stromal cells (MSCs) exposed to hypoxic and pseudohypoxic preconditioning
GEO Series GSE180371. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.