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242 results for “Microfluidics”
Raw research data supporting "Assembly of fillable microrobotic systems by microfluidic loading with dip sealing"
<p>Raw research data supporting Sun, R., Song, X., et al., "Assembly of fillable microrobotic systems by microfluidic loading with dip sealing." Advanced Materials. DOI: 10.1002/adma.202207791.</p>
Imaging Data for: Enabling oxygen-controlled microfluidic cultures for spatiotemporal microbial single-cell analysis
<p>This dataset contains the microfluidic microscopy time-lapse data for the publication <a href="https://www.frontiersin.org/articles/10.3389/fmicb.2023.1198170/">"Enabling oxygen-controlled microfluidic cultures for spatiotemporal microbial single-cell analysis"</a>.</p> <p>The imaging data is recorded as raw 16-bit tif-stacks. The sequences <span>17406 - 17410 and 17411 - </span><span>17415 contain the aerobic and anaerobic conditions, respectively. For details about cultivation conditions and image processing please have a look into our <a href="http://www.frontiersin.org/articles/10.3389/fmicb.2023.1198170/">paper</a> or the public code repository <a href="https://github.com/JuBiotech/Supplement-to-Kasahara-et-al.-2023a">Supplement-to-Kasahara-et-al.-2023a</a>.</span></p>
On-Demand Inkjet Printed Hydrophilic Coatings for Flow Control in 3D-Printed Microfluidic Devices Embedded with Organic Electrochemical Transistors
<p>Dataset of the journal article "On-Demand Inkjet Printed Hydrophilic Coatings for Flow Control in 3D-Printed Microfluidic Devices Embedded with Organic Electrochemical Transistors", article DOI: 10.1002/admt.202300127</p>
The Path from Nasal Tissue to Nasal Mucosa on Chip Part 2- Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing
<p><strong>Abstract: </strong>The nasal mucosa, being accessible and highly vascularized, opens up new opportunities for the systemic administration of drugs. However, due to several protective functions like the mucociliary clearance, this physiological barrier is a difficult obstacle for drug candidates to overcome. For this reason, effective testing procedures are required in the preclinical phase of pharmaceutical development. Based on a recently reported immortalized porcine nasal epithelial cell line, we developed a test platform based on a tissue-compatible microfluidic chip. A biomimetic glass chip equipped with a controlled bidirectional airflow to induce a physiologically relevant wall shear stress on the epithelial cell layer was microfabricated. By developing a membrane transfer technique, the epithelial cell layer could be pre-cultivated in a static holder prior to cultivation in the microfluidic environment. The dynamic cultivation within the chip showed a homogenous distribution of the mucus film on top of the cell layer and a significant increase of cilia formation compared to static cultivation condition. In addition, the recording of the ciliary transport mechanism by micro particle image velocimetry was successful. Using FITC-dextran 4000 as an example, it was shown that this nasal mucosa on a chip is suitable for permeation studies. The obtained permeation coefficient was in the range of values determined by means of other established in vitro and in vivo models. The novel nasal mucosa on chip can in future be automated and used as a substitute for animal testing.</p>
Sperm Selection by Microfluidic Separation Improves Embryo Quality
ClinicalTrials.gov study NCT03085433. IPD Sharing: NO. Countries: 1. Publications: 1.
Microfluidic monitoring of the growth of individual hyphae in confined environments
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Soft, wearable, microfluidic system for fluorometric analysis of loss of amino acids through eccrine sweat
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Microfluidic droplet application for bacterial surveillance in fresh-cut produce wash waters
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Single-cell Herpes simplex virus type-1 infection of neurons using drop-based microfluidics reveals heterogeneous replication kinetics
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Data from: Microfluidic Enrichment Barcoding (MEBarcoding): a new method for high throughput plant DNA barcoding
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Data from: Deterministic cell pairing with simultaneous microfluidic merging and sorting of droplets
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Brine Drying and Salt Precipitation in Porous Media: A Microfluidics Study
<p>This is a dataset for the research "Brine Drying and Salt Precipitation in Porous Media: A Microfluidics Study'', including all the test images, the images used for U-net training, and the data for figures presented.</p>
A novel approach to low-cost, rapid and simultaneous colorimetric detection of multiple analytes using 3D printed microfluidic channels
<p>This research paper presents an inventive technique to swiftly create microfluidic channels on distinct membrane papers, enabling colorimetric drug detection. Using a modified DIY RepRap 3D printer with a syringe pump, microfluidic channels (µPADs) are crafted on a flexible nylon-based substrate. This allows simultaneous detection of four common drugs with a single reagent. An optimized blend of Polydimethylsiloxane (PDMS) dissolved in hexane is used to create hydrophobic channels on various filter papers. The PDMS-hexane mixture infiltrates the paper's pores, forming hydrophobic barriers that confine liquids within the channels. These barriers are cured on the printer's hot plate, controlling channel width and preventing spreading. Capillary action drives fluid along these paths without spreading. This novel approach provides a versatile solution for rapid microfluidic channel creation on membrane papers. The DIY RepRap 3D printer integration offers precise control and faster curing. The PDMS-hexane solution accurately forms hydrophobic barriers, containing liquids within desired channels. The resulting microfluidic system holds potential for portable, cost-effective drug detection and various sensing applications.</p>
Training dataset for label-free microfluidic droplet classification in single cell functional assays
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Supplementary material from: Microfluidic vessel-on-chip platform for investigation of cellular defects in venous malformations and responses to various shear stress and flow conditions
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Rapid microfluidic perfusion system enables controlling dynamics of intracellular pH regulated by Na+/H+ exchanger NHE1
<p>Dataset for manuscript titled "Rapid microfluidic perfusion system enables controlling dynamics of intracellular pH regulated by Na+/H+ exchanger NHE1."</p> <p>Version 2: additional data for Figure 2(e) and (f).</p>
A microfluidic platform to investigate the role of mechanical constraints on tissue reorganization
<p>Movie 1: 40 minutes long timelapse (brightfield) of an aggregate aspired in a channel.<br> <br> Movie 2: 60 minutes long timelapse (two-photon microscopy) of an aggregate aspired in a channel.<br> <br> Movie 3: cell-cell junctions involved in cellular rearrangements in Supplementary Movie 2.<br> <br> Movie 4: aspiration and rapid relaxation experiment (two-photon microscopy).<br> <br> Movie 5: relaxation experiment after a long aspiration (two-photon microscopy).</p>
Wide-range viscoelastic compression forces in microfluidics to probe cell-dependent nuclear structural and mechanobiological responses
<p><span>The cell nucleus plays a critical role in mechanosensing and mechanotransduction processes, by adaptive changes of its envelope composition to external biophysical stimuli such as substrate rigidity and tensile forces. Current measurement approaches lack of precise control in stress application on nuclei, thus significantly impairing a complete mechanobiological study of cells. Here, we present a contactless microfluidic approach capable to exert a wide-range of viscoelastic compression forces (10-103 </span>μ<span>N) -as an alternative to adhesion-related techniques- to induce cell-specific mechano-structural and biomolecular changes. We succeed in monitoring substantial nuclear modifications in Lamin A/C expression and coverage, diffusion processes of probing molecules, YAP shuttling, chromatin re-organization and cGAS pathway activation. As a result, high compression forces lead to a nuclear reinforcement (e.g. up to +20% in Lamin A/C coverage) or deconstruction (e.g. down to -45% in Lamin A/C coverage with a 30% reduction of chromatin condensation state parameter) up to cell death. We demonstrate how wide-range compression on suspended cells can be used as a tool to investigate nuclear mechanobiology and to define specific nuclear signatures for cell mechanical phenotyping. </span></p>
MFMET webinar - 04. Leakage in Microfluidic Devices – detection and quantification
<p><span>This video is shows how leakage testing can be evaluated in microfluidic devices. <br></span></p> <p>The leakage tests include:</p> <ul> <li><span><span>·<span> </span></span></span>Visual inspection test</li> <li><span><span>·<span> </span></span></span>Pressure decay test </li> <li><span><span>·<span> </span></span></span>Flow rate measurement test</li> </ul> <p> </p> <p>Further readings can be found:</p> <p><a href="https://mfmet.eu/publications">https://mfmet.eu/publications</a></p> <p>• Deliverable 1 – Guidelines and a test protocol for flow control evaluating leakage and burst pressure in microfluidic devices. <a href="https://mfmet.eu/publications%20%20%20%20&bull; Deliverable%201%20&ndash;%20Guidelines%20and%20a%20test%20protocol%20for%20flow%20control%20evaluating%20leakage%20and%20burst%20pressure%20in%20microfluidic%20devices.%20Link%20%20%20&bull; A1.2.3%20Documented%20example%20of%20the%20test%20protocol%20for%20leakage%20and%20burst%20pressure.%20Link%20%20%20&bull; The%20MFA%20&%20MFMET%20&ndash;%20Protocols%20for%20leakage%20testing.%20Link%20%20%20&bull; Overcoming%20Technological%20Barriers%20in%20Microfluidics:%20Leakage%20Testing.%20Front.%20Bioeng.%20Biotechnol.%2010:%20958582 https://doi.org/10.3389/fbioe.2022.958582">Link</a></p> <p>• A1.2.3 Documented example of the test protocol for leakage and burst pressure. <a href="https://mfmet.eu/publications%20%20%20%20&bull; Deliverable%201%20&ndash;%20Guidelines%20and%20a%20test%20protocol%20for%20flow%20control%20evaluating%20leakage%20and%20burst%20pressure%20in%20microfluidic%20devices.%20Link%20%20%20&bull; A1.2.3%20Documented%20example%20of%20the%20test%20protocol%20for%20leakage%20and%20burst%20pressure.%20Link%20%20%20&bull; The%20MFA%20&%20MFMET%20&ndash;%20Protocols%20for%20leakage%20testing.%20Link%20%20%20&bull; Overcoming%20Technological%20Barriers%20in%20Microfluidics:%20Leakage%20Testing.%20Front.%20Bioeng.%20Biotechnol.%2010:%20958582 https://doi.org/10.3389/fbioe.2022.958582">Link</a></p> <p>• The MFA & MFMET – Protocols for leakage testing. <a href="https://mfmet.eu/publications%20%20%20%20&bull; Deliverable%201%20&ndash;%20Guidelines%20and%20a%20test%20protocol%20for%20flow%20control%20evaluating%20leakage%20and%20burst%20pressure%20in%20microfluidic%20devices.%20Link%20%20%20&bull; A1.2.3%20Documented%20example%20of%20the%20test%20protocol%20for%20leakage%20and%20burst%20pressure.%20Link%20%20%20&bull; The%20MFA%20&%20MFMET%20&ndash;%20Protocols%20for%20leakage%20testing.%20Link%20%20%20&bull; Overcoming%20Technological%20Barriers%20in%20Microfluidics:%20Leakage%20Testing.%20Front.%20Bioeng.%20Biotechnol.%2010:%20958582 https://doi.org/10.3389/fbioe.2022.958582">Link</a></p> <p>• Overcoming Technological Barriers in Microfluidics: Leakage Testing. Front. Bioeng. Biotechnol. 10: 958582 <a href="https://doi.org/10.3389/fbioe.2022.958582">https://doi.org/10.3389/fbioe.2022.958582</a> </p> <p>The project (20NRM02 MFMET) have received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme.</p>
Raw Data for: Efficient Parahydrogen Induced 13C Hyperpolarization on a Microfluidic Device
<p>Raw data supporting publication entitled "Efficient Parahydrogen Induced 13C Hyperpolarization on a Microfluidic Device". Data have been arranged according to the figures in the publication. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.