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176 results for “Multidrug resistance”
Fosfomycin Versus Meropenem or Ceftriaxone in Bacteriemic Infections Caused by Multidrug Resistance in E.Coli
ClinicalTrials.gov study NCT02142751. IPD Sharing: NO. Countries: 1. Publications: 2.
Strategy to Prevent Transmission of Multidrug-resistant Gram-negative Organisms in ICU
ClinicalTrials.gov study NCT03980197. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluating the Pharmacokinetics, Safety, and Tolerability of Delamanid in Combination With Optimized Multidrug Background Regimen (OBR) for Multidrug-Resistant Tuberculosis (MDR-TB) in HIV-Infected an
ClinicalTrials.gov study NCT03141060. IPD Sharing: YES. Countries: 3. Publications: 0.
Data from: Transmission of multidrug-resistant and drug-susceptible tuberculosis within households: a prospective cohort study
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Tigecycline among clinically significant multidrug resistant pathogens
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Raw data for the article: Risk factors for surgical site infection following cardiac surgery in a region endemic for multidrug resistant organisms
<p><strong>Objectives: </strong>To identify risk factors for surgical site infections following cardiosurgery in an area endemic for multidrug resistant organisms.</p> <p><strong>Design: </strong>Single-center, historical cohort study including patients who underwent cardiosurgery during a 6-year period (2014-2020).</p> <p><strong>Setting: </strong>Joint Commission International accredited, multiorgan transplant center in Palermo, Italy.</p> <p><strong>Main outcome measures: </strong>Surgical site infection was the main outcome.</p> <p><strong>Results: </strong>On a total of 3609 cardiosurgery patients, 184 developed surgical site infection (5.1 %). Intestinal colonization with multidrug resistant organisms was more frequent in patients with surgical site infections (69.6 % vs. 33.3 %; p < 0.001). About half of surgical site infections were caused by Gram-negative bacteria (n = 97; 52.7 %). Fifty surgical site infections were caused by multidrug resistant organisms (27.1 %), with extended-spectrum Beta-lactamase-producing Enterobacterales (n = 16; 8.7 %) and carbapenem-resistant Enterobacterales (n = 26; 14.1 %) being the predominant resistance problem. However, in only 24 of surgical site infections caused by multidrug resistant organisms (48 %), mostly carbapenem-resistant Enterobacterales (n = 22), a pathogen match between the rectal surveillance culture and surgical site infections clinical culture was demonstrated. Nevertheless, multivariate logistic regression analysis identified a rectal swab culture positive for multidrug resistant organisms as an independent risk factor for SSI (odds ratio 3.95, 95 % confidence interval 2.79-5.60). Other independent risk factors were female sex, chronic dialysis, diabetes mellitus, previous cardiosurgery, previous myocardial infarction, being overweight/obese, and longer intubation time.</p> <p><strong>Conclusion: </strong>In an area endemic for carbapenem-resistant Enterobacterales, intestinal colonization with multidrug resistant organisms was recognized as independent risk factor for surgical site infections.</p> <p><strong>Implications for clinical practice: </strong>No causal relationship between colonization with resistant pathogens and subsequent infection could be demonstrated. However, from a broader epidemiological perspective, having a positive multidrug resistant organisms colonization status appeared a risk factor for surgical site infections. Therefore, strict infection control measures to prevent cross-transmission remain pivotal (e.g., nasal decolonization, hand hygiene, and skin antisepsis).</p>
In vitro Effects of Tigecycline in Combination with Other Antimicrobials against Multidrug-Resistant Acinetobacter baumannii Isolates
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Modulation of Multidrug Resistance Protein 1-mediated transport processes by the antiretroviral drug ritonavir
<p>We here provide the structure files, trajectories and topology files for analyzing and reproducing simulations performed in the publication: "<strong>Modulation of Multidrug Resistance Protein 1-mediated transport processes by the antiretroviral drug ritonavir</strong>".</p> <p>Classical molecular dynamics simulation of rat Mrp1 have been performed in complex with native substrates like GSH and GSSG or drug molecules like ritonavir, to study binding modes of different combinations. </p> <p>Structure and trajectory files (all 1 µs long) as well as recorded movies of the time progression are provided for the following simulation systems:</p> <p>1. GSH bound to rat Mrp1</p> <p>2. GSSG bound to rat Mrp1</p> <p>3. Ritonavir bound to rat Mrp1</p> <p>4. GSH + Ritonavir bound to rat Mrp1</p> <p>5. GSSG + Ritonavir bound to rat Mrp1</p> <p>Additionally itp files (GROMACS format) containing parameter information about the ligands GSH, GSSG and Ritonavir are provided for the force field CHARMM36m. </p> <p>Raw data of the homology modeling of rat Mrp1 by I-Tasser as well as Docking results produced via AutoDock4 are uploaded as zip directories. </p> <p> </p>
Figure 3 in Antiadhesion and antibiofilm potential of Fagonia indica from Cholistan desert against clinical multidrug resistant bacteria
Figure 3. Effect of sub-inhibitory concentrations of chloroform extract of Fagonia indica on biofilm formation of MDR bacteria. Biofilms were quantified after 24 and 48 hours of incubation. Cells grown in the absence of extract served as control.
Fig. 1 in Six C21 steroidal glycosides from Cynanchum wallichii Wight roots and their multidrug resistance reversal activities
Fig. 1. Structures of compounds Isolated from Cynanchum wallichii wight roots.
Fig. 2. 1H–1H in Ingenane and jatrophane-type diterpenoids from Euphorbia kansui with multidrug resistance reversal activity
Fig. 2. 1H–1H COSY and key HMBC (A) and ROESY (B) correlations of 1.
Fig. 1 in Ingenane and jatrophane-type diterpenoids from Euphorbia kansui with multidrug resistance reversal activity
Fig. 1. Structures of compounds 1–32 isolated from Euphorbia kansui.
Fig. 5 in Phragmalin and mexicanolide limonoids with reversal of multidrug resistance from the seeds of Chukrasia tabularis A. Juss
Fig. 5. Key HMBC () and ROESY(
Fig. 2 in Phragmalin and mexicanolide limonoids with reversal of multidrug resistance from the seeds of Chukrasia tabularis A. Juss
Fig. 2. Key HMBC() and ROESY()correlations of limonoid 1.
Fig. 1 in Phragmalin and mexicanolide limonoids with reversal of multidrug resistance from the seeds of Chukrasia tabularis A. Juss
Fig. 1. The Structures of undescribed limonoids (1–8).
Fig. 3. X in Phragmalin and mexicanolide limonoids with reversal of multidrug resistance from the seeds of Chukrasia tabularis A. Juss
Fig. 3. X-ray structure of 1.
Fig. 8 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 8. Effects of 15 on the expression of P-gp.
Fig. 3 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 3. Key NOESY correlations () of compounds 1, 2, 4, 5, 6, and 8.
Fig. 1 in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 1. The structures of compounds 1–30 and 8a.
Fig. 4. Single-crystal X in Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells
Fig. 4. Single-crystal X-ray structures of 1, 6, 7, and 8a.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.