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630 results for “Mycobacterium tuberculosis”
Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis Infection
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Evaluating the contributions of purifying selection and progeny-skew in dictating within-host Mycobacterium tuberculosis evolution
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iValiD-TB: A fully characterized Mycobacterium tuberculosis dataset for antimicrobial resistance bioinformatics workflow validations
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Lipidomic profiling of Mycobacterium tuberculosis treated with JCP276, BMB034, or THL
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Evolutionary rate covariation reveals novel protein networks in Mycobacterium tuberculosis
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Data from: Risk factors associated to a high Mycobacterium tuberculosis complex seroprevalence in wild boar (Sus scrofa) from a low bovine tuberculosis prevalence area
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Mycobacterium tuberculosis-specific antibodies detect progression to active tuberculosis in South African adolescents
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Data from: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread worldwide. Some key antituberculosis antibiotics are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway in which resistance mutations have now been observed. The first-of-its-kind molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethionamide-resistant infection in mice, it also increases the basal sensitivity of bacteria to ethionamide.
Activity-based protein profiling for target identification of JCP276 in Mycobacterium tuberculosis
<p><span><span><span><span><span><span><span><span><span><span><span>The increasing incidence of antibiotic-resistant <i>Mycobacterium tuberculosis </i>infections is a growing global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis of the mycobacterial cell envelope. We screened a library of small molecules containing serine-reactive electrophiles and identified a series of narrow spectrum inhibitors of <i>M. tuberculous </i>growth. Using these lead molecules we performed competitive activity-based protein profiling and identified SH targets, including enzymes with uncharacterized functions. Lipidomic analyses of compound-treated cultures revealed an accumulation of free lipids and a substantial decrease in lipooligosaccharides, linking SH inhibition to defects in cell envelope biogenesis. Mutant analysis revealed a path to resistance via the synthesis of mycocerates, but not through mutations to target enzymes. We conclude that simultaneous inhibition of multiple SH enzymes is likely to be an effective therapeutic strategy.</span></span></span></span></span></span></span></span></span></span></span></p>
Unedited photographs of Mycobacterium tuberculosis colonies to practice an image processing protocol
<p>Unedited raw photographs in TIFF file format of <em>Mycobacterium tuberculosis </em>(Mtb) colonies grown in 7H10 agar plates inside a BSL-3 facility. To assay the bactericidal effect of different drug treatments, serial dilutions were performed per treatment in plate quadrants to ensure a countable range of colony-forming units (CFU). Each treatment has three replicates and a control without the antibacterial treatment. The plates were incubated until colonies grew to about 1–2 mm in size. Photographed using a Sony Alpha 7R II full-frame mirrorless color camera (7974 x 5316 pixels) under ambient laboratory lighting at a distance of 12–18 inches from the plates after placing the plates on a black background and behind the glass of the biosafety cabinet.</p>
MVA85A Aerosol vs Intramuscular Vaccination in Adults With Latent Mycobacterium Tuberculosis (M. tb) Infection
ClinicalTrials.gov study NCT02532036. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase IIb Clinical Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10
ClinicalTrials.gov study NCT02336542. IPD Sharing: NO. Countries: 0. Publications: 6.
Clinical Study of Recombinant Mycobacterium Tuberculosis Allergen ESAT6-CFP10 on Healthy People Aged 18-65(III-healthy)
ClinicalTrials.gov study NCT02795260. IPD Sharing: NO. Countries: 0. Publications: 4.
Activity-based protein profiling for target identification of JCP276 in Mycobacterium tuberculosis
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Data from: Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis
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Data from: Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
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Data from: Construction of a virtual Mycobacterium tuberculosis consensus genome and its application to data from a next generation sequencer
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Data from: Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
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Fluorescent in situ hybridization of Mycobacterium tuberculosis rRNA species for analysis of ribosomal synthesis as a marker of bacterial growth of individual bacilli in distinct lesional microenvironments of lung granulomas from C3HeB/FeJ mice
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Mycobacterium tuberculosis transcriptional response to Pretomanid
GEO Series GSE165671. Mycobacterium tuberculosis. 27 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.