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642 results for “Oxytocin”
Oxytocin and CBSST for People With Schizophrenia
ClinicalTrials.gov study NCT01752712. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?
ClinicalTrials.gov study NCT01312272. IPD Sharing: Not stated. Countries: 1. Publications: 10.
PK Sampling After IV Oxytocin and Effects on Sensory Function in Healthy Volunteers
ClinicalTrials.gov study NCT03929367. IPD Sharing: NO. Countries: 1. Publications: 1.
Compositional variation in early life parenting structures alters oxytocin and vasopressin 1a receptor development in prairie voles (Microtus ochrogaster)
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Dominance relationships in captive female African lions are ameliorated by oxytocin administration
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The oxytocin-prostaglandins pathways in the horse (Equus caballus) placenta during pregnancy, physiological parturition, and parturition with fetal membrane retention
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Breastfeeding dynamically changes endogenous oxytocin levels and emotion recognition in mothers
<p>Breastfeeding behaviors can significantly change mothers' physiological and psychological states. The hormone oxytocin may mediate breastfeeding and mothers' emotion recognition. This study examined the effects of endogenous oxytocin fluctuation via breastfeeding on emotion recognition in 51 primiparous mothers. Saliva oxytocin was assessed before and after the manipulation (breastfeeding or holding an infant), and emotion recognition tasks were conducted. Among mothers who breastfed daily, mothers with more increased levels of oxytocin after breastfeeding showed greater reduced negative recognition and enhanced positive recognition of adult facial expressions. These oxytocin functions accompanying breastfeeding may support continued nurturing behaviors and also affect the general social cognition of other adults beyond any specific effect on infants.</p>
Supplementary material for: Neural effects of oxytocin and mimicry in frontotemporal dementia: A randomized cross-over study
<p><span>OBJECTIVE: Reduced empathy is one of the hallmark and untreatable symptoms of frontotemporal dementia (FTD). The objective of this study was to determine whether intranasal oxytocin, alone or in combination with instructed mimicry of facial expressions, would augment neural activity in patients with FTD in brain regions associated with empathy, emotion processing and the simulation network, as indexed by blood-oxygen-level dependent (BOLD) signal during functional magnetic resonance imaging (fMRI).</span></p> <p><span>METHODS: In a placebo-controlled, randomized cross-over design, 28 patients with FTD received 72 IU of intranasal oxytocin or placebo and then completed a fMRI facial expression mimicry task. </span></p> <p><span>RESULTS: Oxytocin alone, and in combination with instructed mimicry, increased activity in regions of the simulation network and in limbic regions associated with emotional expression processing. </span></p> <p><span>CONCLUSIONS: The findings demonstrate latent capacity to augment neural activity in affected limbic and other frontal and temporal regions during social cognition in patients with FTD, and support the promise and need for further investigation of these interventions as therapeutics in FTD.</span></p> <p><span><a>CLASSIFICATION OF EVIDENCE:</a> This study provides Class III evidence that a single dose of 72 IU intranasal oxytocin augments BOLD signal in patients with FTD during viewing of emotional facial expressions.</span></p>
Data from: Umbilical vein oxytocin for the treatment of retained placenta (Release Study): a double-blind, randomised controlled trial.
BACKGROUND: Retained placenta is associated with post-partum haemorrhage. Meta-analysis has suggested that umbilical injection of oxytocin could increase placental expulsion without the need for a surgeon or anaesthetic. We assessed the effect of high-dose umbilical vein oxytocin as a treatment for retained placenta. METHODS: In this double-blind, placebo-controlled trial, haemodynamically stable women with a retained placenta for more than 30 min were recruited from 13 sites in the UK, Uganda, and Pakistan. 577 women were randomly assigned by a computer-generated randomisation list stratified by centre to 30 mL saline containing either 50 IU oxytocin (n=292) or 5 mL water (n=285), which was injected into the placenta through an umbilical vein catheter. All trial participants, study workers, and data handlers were masked to individual allocations. The primary outcome was the need for manual removal of the placenta. Analysis was by intention to treat. This study is registered, number ISRCTN 13204258. FINDINGS: The primary outcome was recorded for all participants. We detected no difference between the groups in the need for manual removal of placenta (oxytocin 179/292 [61.3%] vs placebo 177/285 [62.1%]; relative risk 0.98, 95% CI 0.87-1.12; p=0.84). The need for manual removal was higher in the UK (overall 250/361 [69%]) than in Uganda (90/190 [47%]) or Pakistan (16/26 [62%]). Adverse events did not differ between the two groups. INTERPRETATION: Umbilical oxytocin has no clinically significant effect on the need for manual removal for women with retained placenta. FUNDING: WHO, WellBeing of Women, Pakistan Higher Education Commission.
Data from: Stabilising selection on microsatellite allele length at arginine vasopressin 1a receptor and oxytocin receptor loci
The loci arginine vasopressin receptor 1a (avpr1a) and oxytocin receptor (oxtr) have evolutionarily conserved roles in vertebrate social and sexual behavior. Allelic variation at a microsatellite locus in the 5' regulatory region of these genes is associated with fitness in the bank vole Myodes glareolus. Given the low frequency of long and short alleles at these microsatellite loci in wild bank voles, we used breeding trials to determine whether selection acts against long and short alleles. Female bank voles with intermediate length avpr1a alleles had the highest probability of breeding, while male voles whose avpr1a alleles were very different in length had reduced probability of breeding. Moreover, there was a significant interaction between male and female oxtr genotypes, where potential breeding pairs with dissimilar length alleles had reduced probability of breeding. These data show how genetic variation at microsatellite loci associated with avpr1a and oxtr is associated with fitness, and highlight complex patterns of selection at these loci. More widely, these data show how stabilising selection might act on allele length frequency distributions at gene-associated microsatellite loci.
[dataset] Behavioral expression of father-daughter bonds affects sociality and responsiveness to oxytocin and vasopressin treatments in captive juvenile female titi monkeys (Plecturocebus cupreus)
<p>[dataset] Social bonds influence physiology and behavior, which can shape how individuals respond to physical and affective challenges. Coppery titi monkey (<em>Plecturocebus cupreus</em>) offspring form selective bonds with their fathers, making them ideal for investigating how father-daughter bonds influence juveniles’ responses to oxytocin (OT) and vasopressin (AVP) manipulations. We quantified expression of father-daughter bond-related behaviors in females (n = 10) and gave acute intranasal treatments of saline, low/medium/high OT, low/high AVP, or OT receptor antagonist (OTA) to subjects prior to a parent preference test. While females spent more time in proximity to their parents than strangers, we found a large degree of individual variation. Females with greater expression of bonding behaviors responded to OT treatments in a dose-dependent manner. Subjects also spent less time in proximity to strangers when treated with High OT (p = 0.003) and Low OT (p = 0.007), but more time when treated with High AVP (p = 0.007), Low AVP (p = 0.009), and OTA (p = 0.001). Findings from the present study suggest variation in expression of bond-related behaviors may alter responsiveness to OT and AVP, increasing engagement with unfamiliar social others. This enhanced sociality with strangers may promote formation of pair bonds with partners.</p>
Delayed Cord Clamping and Use of Oxytocin
ClinicalTrials.gov study NCT02618499. IPD Sharing: NO. Countries: 1. Publications: 10.
Oxytocin and Pain Sensitivity and Threshold
ClinicalTrials.gov study NCT01988649. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparative Study Between Prader-Willi Patients Who Take Oxytocin Versus Placebo
ClinicalTrials.gov study NCT01038570. IPD Sharing: NO. Countries: 1. Publications: 1.
Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
ClinicalTrials.gov study NCT07119398. IPD Sharing: NO. Countries: 1. Publications: 7.
Oxytocin Administration in the Third Stage of Labour - A Study of Appropriate Route and Dose
ClinicalTrials.gov study NCT00200252. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intramuscular Versus Intravenous Prophylactic Oxytocin for Hemorrhage After Vaginal Delivery
ClinicalTrials.gov study NCT02080104. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Oxytocin to Decrease Blood Loss During Cesarean Section
ClinicalTrials.gov study NCT00891150. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain
ClinicalTrials.gov study NCT03060031. IPD Sharing: UNDECIDED. Countries: 1. Publications: 35.
Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin
ClinicalTrials.gov study NCT04330677. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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