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172 results for “P450”
Cytochrome P450's Pharmacogenomics in Chronic Pain Patients
ClinicalTrials.gov study NCT03411759. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Cytochrome P450 gene Cyp337 and heritability of fitness traits in the Glanville fritillary butterfly
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Data from: Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga
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Data from: Analysis of cytochrome P450 contribution to evolved plant toxin resistance in Drosophila sechellia
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Data from: Genetic mapping identifies a major locus spanning P450 clusters associated with pyrethroid resistance in kdr-free Anopheles arabiensis from Chad
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Data from: Cytochrome P450 diversification and hostplant utilization patterns in specialist and generalist moths: birth, death, and adaptation
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Data from: Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus
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Annotation and analysis of the secondary structure elements in the Cytochrome P450 protein family
<p>We collected all currently available structures for proteins in the Cytochrome P450 family and annotated their secondary structure elements using SecStrAnnotator software (https://webchem.ncbr.muni.cz/Wiki/SecStrAnnotator). We used 2nnjA as the template domain for the annotation. Based on these annotations, we analysed the occurrence, length distribution, amino acid sequence, and presence of structural irregularities (β-bulges, 3<sub>10</sub>-helices, π-helices) of each secondary structure element class. We also statistically compared the bacterial vs eukaryotic structures. For the secondary structure element classes with sufficient sequence conservation, the most conserved residue is annotated as the reference residue.</p> <p>Main files:</p> <ul> <li><strong>set_ALL.json</strong> - Set-ALL: list of 1012 protein domains belonging to the Cytochrome P450 family (CATH accession 1.10.630.10 + Pfam accession PF00067, accessed on 7 July 2020, one domain per PDB entry)</li> <li><strong>set_NR.json</strong> - Set-NR: non-redundant list of 183 domains (one domain per UniProt ID)</li> <li><strong>domain_lists_table.tsv</strong> - Overview of Set-ALL and Set-NR and separation into subsets Set-NR-Bact (bacterial), Set-NR-Euka (eukaryotic), Set-NR-Arch (archaeal), Set-NR-Viru (viral)</li> <li><strong>structures/template_2NNJ-template.sses.json</strong> - Manually prepared annotation template (domain 2nnjA)</li> <li><strong>structures/template_2NNJ.cif</strong> - Structure of the template domain (2nnjA)</li> <li><strong>annotations_with_reference_residues_ALL.json, annotations_with_reference_residues_ALL.tsv</strong> - Annotation of secondary structure elements for Set-ALL</li> <li><strong>annotations_with_reference_residues_NR.json, annotations_with_reference_residues_NR.tsv</strong> - Annotation of secondary structure elements for Set-NR</li> <li><strong>aligments_NR</strong> - Multiple sequence alignments for each SSE class (Set-NR)</li> <li><strong>logos_NR</strong> - Sequence logos for each SSE class (Set-NR)</li> <li><strong>plots</strong> - Plots of SSE occurrence, length distribution, contained helix types and beta-bulge occurrence (Set-NR), some plots show the comparison between Set-NR-Bact and Set-NR-Euka</li> <li><strong>statistical_tests.ods</strong> - Comparison of SSE occurrence between Set-NR-Bact and Set-NR-Euka by the test of equal proportions and the Fisher test, comparision of the SSE length by the Kolmogorov-Smirnov test and the two-sample Wilcoxon test</li> </ul>
A Study to Assess the Effects of Nemolizumab on Cytochrome P450 Substrates in Participants With Moderate-to-Severe Atopic Dermatitis
ClinicalTrials.gov study NCT04562116. IPD Sharing: Not stated. Countries: 2. Publications: 0.
The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4（CYP3A4）-Metabolized and Cytochrome P450 Isoenzyme 3A4（CYP3A4）-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction
ClinicalTrials.gov study NCT02411903. IPD Sharing: Not stated. Countries: 0. Publications: 3.
An Open-label, DDI Study to Investigate the Effects of Amlitelimab on the PK of Selected Cytochrome P450 Substrates
ClinicalTrials.gov study NCT06686628. IPD Sharing: YES. Countries: 1. Publications: 0.
TAK-438_110 Drug Interaction With Cytochrome P450 3A4 (CYP3A4) Inhibitor Clarithromycin
ClinicalTrials.gov study NCT02774902. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Dengue virus susceptibility in Aedes aegypti tied to natural cytochrome P450 variants
GEO Series GSE279387. Aedes aegypti. 32 samples. Type: Expression profiling by high throughput sequencing.
Molecular bases of P450-mediated resistance to the neonicotinoid insecticide imidacloprid in the mosquito Ae. aegypti
GEO Series GSE174009. Aedes aegypti. 9 samples. Type: Expression profiling by high throughput sequencing.
Metabolic Engineering of Doxorubicin Biosynthesis: Advancing P450 Catalysis through Redox Partner Optimization and Structural Analysis of DoxA
GEO Series GSE289319. Streptomyces peucetius. 36 samples. Type: Expression profiling by high throughput sequencing.
Developmental effects of maternal dietary vitamin A deficiency and P450 cytochrome 1b1 deletion in mice
GEO Series GSE87844. Mus musculus. 24 samples. Type: Expression profiling by array.
Arylhydrocarbon receptor and the cytochrome P450 enzyme CYP1B1 prevent exacerbation of allergic airway inflammation
GEO Series GSE158715. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
The expression profile of cytochromes P450 (CYPs) and aldo-keto reductases (AKRs) in post-treatment breast carcinomas
GEO Series GSE56259. Homo sapiens. 111 samples. Type: Expression profiling by RT-PCR.
A cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
GEO Series GSE224014. Digitalis lanata. 12 samples. Type: Expression profiling by high throughput sequencing.
Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450, family 21, subfamily A, polypeptide 2 (CYP21A2) expression in the bovine corpus luteum
GEO Series GSE128706. Bos taurus. 12 samples. Type: Expression profiling by array.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.