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565 results for “RAS”
FIGURE 2 in Notes on holotypes of hermit crabs (Decapoda: Anomura: Paguroidea) deposited in the collection of Zoological Museum of RAS (Saint-Petersburg, Russia) with remarks on hermit crab diversity along the Russian coast of the Sea of Japan
FIGURE 2. Areopaguristes hirsutimanus (Kobjakova, 1971) comb. nov., Posjeta Bay, the Sea of Japan, alive coloration: a—male; b—non-ovigerous female; c—non-mature male; d—front of carapace of female.
Figs 59-70 in New and little known Epilamprinae (Dictyoptera: Blaberidae) from the collections of the Muséum d'histoire naturelle de Genève and the Zoological Institute RAS, Saint Petersburg. Part 2
Figs 59-70. Gurneya rothi sp. nov., male, holotype. (59) Facial part of head. (60) Pronotum, dorsal view. (61) Abdominal apex, dorsal view. (62) The same, ventral view. (63) Hypandrium, ventral view. (64) Right phallomere, dorsal view. (65) The same, ventral view. (66) Sclerite L2D, dorsal view. (67) Caudal part of sclerite L2D, seen from outside. (68) The same, dorsal view. (69, 70) Apex of sclerite L3. Dotted areas show dark colour (60) or membranous parts (62-70). Abbreviations: b.L3, b.o., c.p.R1T, f.s., par., r.scl., R2, R3, R5 - see chapter "abbreviation used in figures", for details see text. Scale bars 1 mm: a = 59, b = 60, c = 61, d = 62, e = 63, f = 64, 65, g = 66, h = 67, 68, i = 69, 70.
Figs 1-15 in New and little known Epilamprinae (Dictyoptera: Blaberidae) from the collections of the Muséum d'histoire naturelle de Genève and the Zoological Institute RAS, Saint Petersburg. Part 2
Figs 1-15. Africalolampra erubescens (Gerstaecker, 1883), male. (1) Facial part of head. (2) Pronotum, dorsal view. (3) First abdominal tergite, dorsal view. (4) Abdominal apex, dorsal view. (5) The same, caudal view. (6) The same, hypandrium and genitalia removed, ventral view. (7) Hypandrium, ventral view. (8) Right phallomere, dorsal view. (9) The same, ventral view. (10) Sclerite L2D, dorsal view. (11) Caudal part of sclerite L2D, dorsal view. (12) Sclerites L3 and L4U. (13-15) Apex of sclerite L3. Dotted areas show membranous parts. Abbreviations: ap.scl., bul., f.s., L4U, out., pl.s., R1T, R2, R3, R4?, R5, s.t., tub. - see chapter "abbreviation used in figures", for details see text. Scale bars 1 mm: a = 1, b = 2, c = 3, d = 4, e = 5, f = 6, g = 7, h = 8, 9, i = 10, j = 11, k = 12, l = 13-15.
Figs 24-37 in New and little known Epilamprinae (Dictyoptera: Blaberidae) from the collections of the Muséum d'histoire naturelle de Genève and the Zoological Institute RAS, Saint Petersburg. Part 2
Figs 24-37. Africalolampra punctipennis (Saussure, 1895), male. (24) Facial part of head. (25) Pronotum, dorsal view. (26) Abdominal apex, dorsal view. (27) Paraprocts, ventral view. (28) Hypandrium, ventral view. (29) Right phallomere, dorsal view. (30) The same, ventral view. (31) Sclerite L2D, dorsal view. (32, 33) Caudal part of sclerite L2D. (34) The same, caudal view. (35-37) Apex of sclerite L3. Dotted areas show membranous parts. Abbreviations: f.s., pl.s., R2, R3, R4?, R5 - see chapter "abbreviation used in figures", for details see text. Scale bars 1 mm: a = 24, b = 25, c = 26, d = 27, e = 28, f = 29, 30, g = 31, h = 32-34, i = 35-37.
Figs 16-23 in New and little known Epilamprinae (Dictyoptera: Blaberidae) from the collections of the Muséum d'histoire naturelle de Genève and the Zoological Institute RAS, Saint Petersburg. Part 2
Figs 16-23. Females of Africalolampra erubescens (Gerstaecker, 1883) (16-19) and Audreia carinulata (Saussure, 1895), paralectotype (20-23). (16, 20) Abdominal apex, dorsal view. (17, 21) Genital plate, ventral view. (18, 22) Abdominal apex, ventral view, genital plate removed. (19, 23) Basal part of ovipositor, view from within. Dotted areas show membranous parts. Abbreviations: aa., bsv., gg., l.scl., m.pl., par., teVIII., teIX., v.I., v.III., vs. - see chapter "abbreviation used in figures", for details see text. Scale bars 1 mm: a = 16, b = 17, c = 18, d = 19, e = 20, f = 21, g = 22, h = 23.
Figs 71-84 in New and little known Epilamprinae (Dictyoptera: Blaberidae) from the collections of the Muséum d'histoire naturelle de Genève and the Zoological Institute RAS, Saint Petersburg. Part 2
Figs 71-84. Pinaconota bifasciata (Saussure, 1862), male, lectotype. (71) Facial part of head. (72) Pronotum, dorsal view. (73) Abdominal apex, dorsal view. (74) The same, ventral view. (75) Hypandrium, ventral view. (76) Hypandrium and genitalia, dorsal view. (77) Right phallomere, dorsal view. (78) The same, ventral view. (79) Caudal part of sclerite L2D and adjacent structures, ventral view. (80) Caudal part of sclerite L2D, dorsal view. (81) Sclerite L3. (82-84) Apex of sclerite L3. Dash lines show black maculae (71, 75). Dotted lines show yellowish maculae (71). Dotted areas show dark colour (72) or membranous parts (74-84). Abbreviations: a.R4, ap.scl., b.L2, b.L3, b.pr., c.p.R1T, ch.a., hge, L3, L4U, ml., R2, R3, R4, R5, scl. - see chapter "abbreviation used in figures", for details see text. Scale bars 1 mm: a = 71, b = 72, c = 73, d = 74, e = 75, f = 76, g = 77, 78, h = 79, i = 80, j = 81, k = 82-84.
Machine Learning and Radiomics analysis by Computed Tomography in colorectal liver metastases patients for RAS mutational status prediction
<p>We uploaded the Radiomics features raw data of the manuscript "<span>Machine Learning and Radiomics analysis by Computed Tomography in colorectal liver metastases patients for RAS mutational status prediction</span>"</p>
Distribution. Mediterranean, scattered in islands in Aegean and Ionian seas and coasts of Greece and W Turkey, NE Morocco, and NW Algeria; E Atlantic Ocean at Desertas Is (Madeira Is group) and Ras Nouadhibou (= Cabo Blanco/Cap Blanc Peninsula) on the border between Western Sahara and Mauritania; occasionally recorded in Canary Is, Mauritania (Banc d'Arguin), Tunisia (La Gallite), Libya (Cyrenaic coast), and the Adriatic coast in Croatia. in Phocidae
Distribution. Mediterranean, scattered in islands in Aegean and Ionian seas and coasts of Greece and W Turkey, NE Morocco, and NW Algeria; E Atlantic Ocean at Desertas Is (Madeira Is group) and Ras Nouadhibou (= Cabo Blanco/Cap Blanc Peninsula) on the border between Western Sahara and Mauritania; occasionally recorded in Canary Is, Mauritania (Banc d'Arguin), Tunisia (La Gallite), Libya (Cyrenaic coast), and the Adriatic coast in Croatia.
Structure-guided discovery of potent antifungals that prevent Ras signaling by inhibiting protein farnesyltransferase
<p>Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and emerging resistances. Next-generation antifungals therefore are needed urgently. We have developed compounds that prevent farnesylation of <em>Cryptoccoccus</em> <em>neoformans</em> Ras protein by inhibiting protein farnesyltransferase with 3–4 nanomolar affinities. Farnesylation directs Ras to the cell membrane and is required for infectivity of this lethal pathogenic fungus. Our high-affinity compounds inhibit fungal growth with 3–6 micromolar minimum inhibitory concentrations, 4- to 8-fold better than Fluconazole, an antifungal commonly used in the clinic. Compounds bound with distinct inhibition mechanisms at two alternative, partially overlapping binding sites, accessed via different inhibitor conformations. We showed that antifungal potency depends critically on the selected inhibition mechanism, because this determines the efficacy of an inhibitor at low <em>in</em> <em>vivo</em> levels of enzyme and farnesyl substrate. We elucidated how chemical modifications of the antifungals encode the desired inhibitor conformation and concomitant inhibitory mechanism.</p>
SASDM95 – Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25
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SASDM85 – GTP-binding domain of Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25
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SASDM75 – Ras-like protein 1 guanine nucleotide exchange factor region of Candida albicans cell division control protein 25
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Figs 5–6 in New findings of Cryptophagidae (Coleoptera: Clavicornia) from Baltic amber in the unbiased collection of the Paleontological Institute of RAS
Figs 5–6. Photo of a new specimen of A. groehni from Baltic amber: 5 — dorsal view; 6 — dorsolateral view. Рис. 5–6. ВнеШний вид A. groehni иЗ балтийского ЯнтарЯ: 5 — сверху; 6 — сверху и сбоку.
Figs 1–4 in New findings of Cryptophagidae (Coleoptera: Clavicornia) from Baltic amber in the unbiased collection of the Paleontological Institute of RAS
Figs 1–4. Photo of a new specimen of M. sarnensis from Baltic amber: 1 — dorsal view; 2 — lateral view; 3 — ventral view; 4 — head and pronotum, ventrolateral view. Рис. 1–4. ВнеШний вид M. sarnensis иЗ балтийского ЯнтарЯ: 1 — габитус, сверху; 2 — габитус, сбоку; 3 — габитус,сниЗу; 4 — голова и переднеспинка, сниЗу и сбоку.
Diffusion-Weighted MRI and Diffusion Kurtosis Imaging to Detect RAS Mutation in Colorectal Liver Metastasis
<p>We uploaded dataset including apparent diffusion coefficient (ADC), basal signal (S0), pseudo-diffusion coefficient (DP), perfusion fraction (FP), tissue diffusivity (DT) and DKI data (mean of diffusion coefficient (MD) and mean of diffusional Kurtosis (MK)) of 52 patients of the manuscript: Diffusion-Weighted MRI and Diffusion Kurtosis Imaging to Detect RAS Mutation in Colorectal Liver Metastasis. Granata V, Fusco R, Risi C, Ottaiano A, Avallone A, De Stefano A, Grimm R, Grassi R, Brunese L, Izzo F, Petrillo A. Diffusion-Weighted MRI and Diffusion Kurtosis Imaging to Detect RAS Mutation in Colorectal Liver Metastasis. Cancers (Basel). 2020 Aug 26;12(9):2420. doi: 10.3390/cancers12092420. PMID: 32858990; PMCID: PMC7565693.</p>
PLATE 1 in Holotypes of ostracods of Order Podocopida from the collection of the Museum of A.V.Zhirmunsky Institute of Marine Biology FEB RAS (Vladivostok)
PLATE 1. SEM images of ostracod valves. 1, Trapezicandona taurica, RV f, holotype; 2, Heterocythereis reticulata, LV f, holotype; 3–6, Semicytherura calamitica: RV and LV f, holotype; 5, 6, LV m (No. 13416) and f (No. 13418), tuberculate variation, paratypes, the Black Sea near Crimea; 7–10, Semicytherura virgata: 7, 8, RV and LV f, holotype; 9, 10, RV and LV m, paratype (No. 13419), the Black Sea near Crimea, Planerskoye Village, 25 m depth, muddy sand. Scale 60 µm.
Data and Code from "Structure-based prediction of Ras-effector binding affinities and design of 'branchegetic' interface mutations"
<p>Data, data generation and data analysis for manuscript "Structure-based prediction of Ras-effector binding affinities and design of ‘branchegetic’ interface mutations", currently available as a preprint <a href="https://doi.org/10.1101/2022.09.04.506480">here</a>.</p> <p>Contains the following directories:</p> <ul> <li>01_models: Contains all scripts for model generation and selection, as well as some of the generated and selected models. <ul> <li>01_inputs: The different inputs for the homology modelling pipeline. This includes AlphaFold single and complex templates, PDB templates and sequence alignments.</li> <li>02_validation: Model generation and initial selection for validation models, based on AF2 single models and PDB complex models.</li> <li>03_production1: Model generation and initial selection for Ras effector complexes, based on AF2 single models and PDB complex models.</li> <li>04_production2: Model generation and initial selection for Ras effector complexes, based on AF2 single models and AF2 complex models.</li> <li>05_selection_optics: Code and analysis for selection by unsupervised learning using OPTICS.</li> </ul> </li> <li>02_selected_models: The three representative models selected for each complex.</li> <li>03_affinity_prediction: Contains code and data for the prediction of binding affinities for Ras effector complexes.</li> <li>04_branch_pruning: Contains code and data for branch pruning analysis.</li> <li>05_systems_analysis: Contains code and data for the analysis of Ras effector systems based on affinities derived from affinity prediction and branch pruning analysis.</li> <li>06_visualization: Information on where in the raw data the panels for the figures in the manuscript can be found.</li> </ul>
Hydraulic model (HEC-RAS) of the Upper San Saba River between Fort McKavett and Menard, TX
<p>This is a 2D Hydraulic model (HEC-RAS) for the Upper San Saba River between Fort McKavett and Menard, TX. Model geometry is based on USGS 3DEP data (2018), with underwater bathymetry "burned" in using cross-sections sampled in the field in 2018. The model was calibrated based on water surface and velocities measured during data collection.</p>
RAS Mutation Testing in the Circulating Blood of Patients With Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT02502656. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
ClinicalTrials.gov study NCT03919292. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.