Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
13,113
datasets available to search
ShareScore release 0.9.0
Dataset results
13,113 results for “Resistivity”
Identifying functional impacts of heat-resistant fungi on boreal forest recovery after wildfire
<p>Fungi play key roles in carbon (C) dynamics of ecosystems: saprotrophs decompose organic material and return C in the nutrient cycle, and mycorrhizal species support plants that accumulate C through photosynthesis. The identities and functions of extremophile fungi present after fire can influence C dynamics, particularly because plant-fungal relationships are often species-specific. However, little is known about the function and distribution of fungi that survive fires. We aim to assess the distribution of heat-resistant soil fungi across burned stands of boreal forest in the Northwest Territories, Canada, and understand their functions in relation to decomposition and tree seedling growth. We cultured and identified fungi from heat-treated soils and linked sequences from known taxa with high throughput sequencing fungal data (Illumina MiSeq, ITS1) from soils collected in 47 plots. We assessed functions under controlled conditions by inoculating litter and seedlings with heat-resistant fungi to assess decomposition and effects on seedling growth, respectively, for black spruce (Picea mariana), birch (Betula papyrifera), and jack pine (Pinus banksiana). We also measured litter decomposition rates and seedling densities in the field without inoculation. We isolated seven taxa of heat-resistant fungi and found their relative abundances were not associated with environmental or fire characteristics. Under controlled conditions, Fayodia gracilipes and Penicillium arenicola decomposed birch, but no taxa decomposed black spruce litter significantly more than the control treatment. Seedlings showed reduced biomass and/or mortality when inoculated with at least one of the fungal taxa. Penicillium turbatum reduced growth and/or caused mortality of all three species of seedlings. In the field, birch litter decomposed faster in stands with greater pre-fire proportion of black spruce, while black spruce litter decomposed faster in stands experiencing longer fire-free intervals. Densities of seedlings that had germinated since fire were positively associated with ectomycorrhizal richness while there were fewer conifer seedlings with greater heat-resistant fungal abundance. Overall, our study suggests that extremophile fungi present after fires have multiple functions and may have unexpected negative effects on forest functioning and regeneration. In particular, heat-resistant fungi after fires may promote shifts away from conifer dominance that are observed in these boreal forests.</p> <p> </p> <p> </p>
In silico prediction of ARB resistance: A first step in creating personalized ARB therapy
<p><strong>AT1R Model preparation</strong><br> The crystal structure of human AT1R bound to olmesartan (PDB: 4ZUD) was downloaded from the RCSB Protein Data Bank. 4ZUD contains apocytochrome b562RIL fused to the amino terminus, and many of the flexible regions, as well as helix 8, are not resolved. In order to generate an appropriate starting structure, olmesartan and the apocytochrome b562RIL fusion were removed from 4ZUD, and the missing regions were added to the protein with MOE software (Chemical Computing Group ULC, Montreal, Canada). Specifically, the N-Terminus (residues 1 to 25), intracellular loop 2 (residues 134 to 140), extracellular loop 2 (residues 186 to 188), intracellular loop 3 (residues 223 to 234), and helix 8 (residues 305 to 316) were added to the AT1R in accordance to the human AT1R sequence and PDB:4YAY. The remaining carboxyl-tail of the AT1R (residues 317 to 359) was not modeled. The AT1R model then underwent an energy minimization within MOE using the Amber10:Extended Huckel Theory (EHT) force field.</p> <p><strong>Molecular dynamic (MD) simulations and analysis</strong><br> The MOE minimized AT1R was loaded into CHARMM-GUI. An 80 Å by 80 Å lipid bi-layer composed of 13% cholesterol and 87% Phosphatidylcholine (POPC) was generated around the receptor. Water was packed 17.5 Å above and below the lipid bi-layer, and 150 mM Na+ and Cl- ions were added to the system via Monte-Carlo ion placing. The all-atom CHARMM C36 force field for proteins and ions, and the CHARMM TIP3P force field for water were selected. A hard non-bonded cutoff of 8.0 angstroms was utilized. All molecular dynamics simulations were performed using the PMEMD module of the AMBER16 package with support for MPI multi-process control and GPU acceleration code. Orthorhombic periodic boundary conditions with a constant pressure of 1 atm was set via the NPT ensemble and temperature was set to 310.15°K (37°C) using Langevin dynamics. The SHAKE algorithm was used to constrain bonds containing hydrogens. The dynamics were propagated using Langevin dynamics with Langevin damping coefficient of 1 ps-1 and a time step of 2 fs. Before the production run, the AT1R model was minimized for 5000 steps using the steepest descent method and then equilibrated for 600 ps. The protein coordinates were saved in 10 ps intervals. The production run lasted 150 ns, at which point all three replicas were stable for at least the last 20 ns.</p>
Loss and fragmentation of fire-resistent primary forest cover in Sumatra and Kalimantan
<p>Here we share primary forest loss and fire occurrence in Sumatra and Kalimantan covering 2001 through 2019 period. The datasets include primary forest cover fraction and active fire detection counts at 1km spatial resolution and annual time step.</p> <p>For details on the datasets see included README file and the following open access publication:</p> <p>Nikonovas <em>et al</em>., Near-complete loss of fire-resistant primary tropical forest cover in Sumatra and Kalimantan,<em> Communs Earth and Environ., <strong>1</strong>, (2020).</em></p> <p>Usage Notes</p> <p>Contact Tadas Nikonovas (tadas.nik@gmail.com) for questions on usage or additional details.</p> <p> </p> <p>Acknowledgements</p> <p>This study forms part of the Towards a Fire Early Warning System for Indonesia (ToFEWSI) project (Oct. 2017- Oct. 2021), which is funded through the UK’s National Environment Research Council – Newton Fund on behalf of UK Research & Innovation (NE/P014801/1), Indonesia Endowment Fund for Education and the Indonesian Science Fund (Principal Investigators: Allan Spessa (UK) and Muhammad Ali Imron (Indonesia)). The ToFEWSI project is developing a suite of climate, hydrological- and agent-based models to predict the incidence of peat forest fires in Indonesia, plus new evidence-based proposals for managing fires in Indonesia.</p> <p> </p>
Allopatric divergence of cooperators confers cheating resistance and limits the effects of a defector mutation
<p>Studies of microbial social defectors that 'cheat' on cooperative genotypes generally focus on interactions with their cooperative parents, yet in nature defectors may meet diverse cooperators. Genotype-by-genotype interactions may constrain the ranges of cooperators upon which particular defectors can cheat, limiting the cheaters' spread and potentially the overall equilibrium frequency of cheaters. The bacterium Myxococcus xanthus undergoes cooperative multicellular development upon starvation, but some developmental defectors can cheat on cooperators, outcompeting them within mixed groups. We show that a defector disrupted at the signaling gene csgA has a narrow cheating range among diverse natural cooperators owing to antagonisms not specifically targeted at defectors. More strikingly, lab-evolved cooperators only slightly differentiated from the defector have allopatrically evolved beyond its cheating range by accumulating fewer than 20 mutations when development was not directly under selection. Cooperators might diversify not only with respect to which defectors cheat on them, but also in the potential for a particular mutation to reduce expression of cooperative trait or generate a cheating phenotype. We tested this by constructing a new csgA mutation in several highly diverged cooperators. The mutation generated very different sporulation phenotypes – from a complete defect to no defect – indicating that genetic background effects can limit the set of genomes for which a given mutation creates a defector and potentiates cheating. Our results suggest that natural populations feature geographic mosaics of cooperators diversified in susceptibility to cheating by any given defector and in the social phenotypes generated by any given mutation in a cooperation gene.</p>
Data and MATLAB Code for the paper entitled "A modified Chezy formula for one-dimensional unsteady frictional resistance in open channel flow"
<p>This link includes the data and MATLAB code files for the research paper entitled "A modified Chezy formula for one-dimensional unsteady frictional resistance in open channel flow" by Zhou, J.W.; Bro, W.M.; Tick*, G.R.; Mofatakari, H.; Li, Y.; and Cheng, L., which has been submitted to the Journal of Fluids Engineering. These files are edited under the GB18030 character set standard.</p>
Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome
<p><strong>The dataset from the article </strong><strong>Putative mobilized colistin resistance (mcr) genes co-occurring with other antibiotic resistance genes are widespread in the human gut microbiome</strong></p>
Data from: Independently evolved and gene flow‐accelerated pesticide resistance in two‐spotted spider mites
<p>Pest species are often able to develop resistance to pesticides used to control them, depending on how rapidly resistance can emerge within a population or spread from another resistant population. We examined the evolution of bifenazate resistance in China in the two‐spotted spider mite (TSSM) <em>Tetranychus</em> <em>uticae</em> Koch (Acari: Tetranychidae), one of the most resistant arthropods, by using bioassays, detection of mutations in the target <em>cytb</em> gene, and population genetic structure analysis using microsatellite markers. Bioassays showed variable levels of resistance to bifenazate. The <em>cytb</em> mutation G126S, which confers medium resistance in TSSM to bifenazate, had previously been detected prior to the application of bifenazate and was now widespread, suggesting likely resistance evolution from standing genetic variation. G126S was detected in geographically distant populations across different genetic clusters, pointing to the independent origin of this mutation in different TSSM populations. A novel A269V mutation linked to a low‐level resistance was detected in two southern populations. Widespread resistance associated with a high frequency of the G126S allele was found in four populations from the Beijing area which were not genetically differentiated. In this case, a high level of gene flows likely accelerated the development of resistance within this local region, as well as into an outlying region distant from Beijing. These findings, therefore, suggest patterns consistent with both local evolution of pesticide resistance as well as an impact of migration, helping to inform resistance management strategies in TSSM.</p>
The target of selection matters: an established resistance – development-time negative genetic trade-off is not found when selecting on development time.
<p>Trade-offs are fundamental to evolutionary outcomes and play a central role in eco-evolutionary theory. They are often examined by experimentally selecting on one life-history trait and looking for negative correlations in other traits. For example, populations of the moth Plodia interpunctella selected to resist viral infection show a life-history cost with longer development times. However, we rarely examine whether the detection of such negative genetic correlations depends on the trait on which we select. Here we examine a well-characterised negative genotypic trade-off between development time and resistance to viral infection in the moth Plodia interpunctella and test whether selection on a phenotype known to be a cost of resistance (longer development time) leads to the predicted correlated increase in resistance. If there is tight pleiotropic relationship between genes that determine development time and resistance underpinning this trade-off, we might expect increased resistance when we select on longer development time. However, we show that selecting for longer development time in this system selects for reduced resistance when compared to selection for shorter development time. This shows how phenotypes typically characterised by a trade-off can deviate from that trade-off relationship, and suggests little genetic linkage between the genes governing viral resistance and those that determine response to selection on the key life-history trait. Our results are important for both selection strategies in applied biological systems and for evolutionary modelling of host-parasite interactions.</p>
Impacts of Food Limitation on Resistance of <i>Bombus impatiens</i> (Hymenoptera: Apidae) to the Gut Parasite <i>Crithidiai</i> (Trypanosomatida: Trypansomatidae)
<p>Data and R scripts for Conroy et al. experiment testing effects of nectar and pollen limitation on parasite load and survival of bumble bees (Bombus impatiens) infected with Crithidia</p>
Antimicrobial resistance - Salmonella, E. Coli, prevalence ESBL data
<p>The database contains the evidence presented by the Data Visualization tool (available on EFSA website) accompanying the publication of the 2015 European Union Summary Report on antimicrobial resistance (AMR). Data correspond to occurrence of resistance in Salmonella from animals and humans, occurrence of resistance in E. Coli in animals and prevalence of ESBL-producing E.coli in animals and meat, in EU Member States.</p> <p>Format XLSX; Contact zoonoses_support@efsa.europa.eu (EFSA); FWD@ecdc.europa.eu (ECDC)</p> <p> </p>
"Reversible on-surface wiring of resistive circuits", raw data used in figures.
<p>Supporting information associated with the publication "Reversible on-surface wiring of resistive circuits", <em>Chem. Sci.</em>, <strong>2017</strong>, DOI: 10.1039/c7sc00599g. Files contain the raw data used in preparation of the figures.</p>
Antimicrobial resistance - Salmonella, E. Coli, prevalence ESBL data
<p>The database contains the evidence presented by the Data Visualization tool (available on EFSA website) accompanying the publication of the 2015 European Union Summary Report on antimicrobial resistance (AMR). Data correspond to occurrence of resistance in Salmonella from animals and humans, occurrence of resistance in E.Coli in animals and prevalence of ESBL-producing E.coli in animals and meat, in EU Member States.</p> <p> </p> <p><strong>Format XLSX; Contact zoonoses_support@efsa.europa.eu (EFSA); FWD@ecdc.europa.eu (ECDC)</strong></p>
Data for: A fundamental tradeoff among resilience, resistance, efficiency, and redundancy in tidal wetlands
<p>We filtered the raw NASA-MODIS (MOD13Q1) Enhanced Vegetation Index (EVI) dataset to only inlcude pixels with high tidal wetland class purity and Quality Assurance (QA) reliability scores. We filtered 782,693 tidal wetland pixels with coverage spanning the entire contiguous United States to only include those with greater than 90% tidal wetland class purity. We then further filtered these pixels to only include those where data dropouts in the EVI or QA layer occured fewer than 10% of the time. In the end, we used 145,871 pixels in our analysis. Tidal wetland GPP was calculated by pixel for the dates 3/5/2000 to 12/2/2020 at 16-day intervals using the algorithms published in: </p> <p>R. A. Feagin, I. Forbrich, T.P. Huff, J.G. Barr, J. Ruiz-plancarte, J.D Fuentes, R.G. Najjar, R. Vargas, A. Vazquez-lule, L. Windham-Myers, K. Kroeger, E.J. Ward, G.W. Moore, M. Leclerc, K.W. Krauss, C.L. Stagg, M. Alber, S.H. Knox, K.V.R. Schafer, T.S., Bianchi, J.A. Hutchings, H.B. Nahrawi, A. Noormets, B. Mitra, A. Jaimes, A.L. Hinson, B. Bergamaschi, J. King, and G. Miao., Tidal wetland gross primary production across the continental United States, 2000–2019. Global Biogeochemical Cycles 34, e2019GB006349 (2020).</p> <p>The file named "SWR_90percentFinal.csv" contains the filtered SWR database used to calculate GPP. File named "temp_90percentFinal_rounded.csv" contains the filtered air temperature database used to calculate GPP. The file named "EVI(gapped_filled)_90percentFinal.csv" contains the final gap-filled EVI time series database used to calculate GPP. File named "QA_90%Final.csv" contains the filtered quality assurance (QA) values. Dates in the EVI database where QA = 3 were determined to be of poor quality, removed from the database, and replaced with "NA". Single NA gaps in the EVI database were gap-filled by taking the mean of the dates flanking the NA gap. File named "myGPP(gap_filled)_FINAL.csv" contains the calculated GPP estimates used throughout the study analysis. </p> <p>File named "rawEVI.csv" contains the raw EVI database prior to filtering and gap-filling. File named "rawSWR.csv" contains the raw SWR database prior to filtering. File named "rawAirTemp.csv" contains the air temperature database prior to filtering. File named "rawQA.csv" contains the QA layer of the MOD13 satellite product prior to filtering. These files contain the raw data for all 782,693 tidal wetland pixel locations. These raw files can also be accessed at daac.ornl.gov. </p>
Putative mutations associated with tetracycline resistance detected in Treponema spp.- an analysis of 4,355 Spirochaetales genomes
<p>Supplementary Table 1–4, , as well as multiple sequence alignment files for 16S rRNA, rpsC, and rpsJ loci, have been deposited.</p> <p>Additionally, the archive contains a <code>scripts.txt</code> file that includes all custom Bash scripts used for:</p> <ul> <li> <p>rRNA gene detection and quantification using <em>Barrnap</em></p> </li> <li> <p>Genome quality assessment using <em>CheckM</em></p> </li> <li> <p>Gene-by-gene schema creation, allele calling, and cgMLST extraction using <em>chewBBACA</em></p> </li> <li> <p>GFF merging and wide-format transformation for summarizing rRNA copy number per genome</p> </li> </ul> <p>These materials are provided to ensure reproducibility of the analyses and to support further investigations into antimicrobial resistance in <em>Spirochaetales</em>.</p>
Data from: Resurrected seeds from herbarium specimens reveal rapid evolution of drought resistance in a selfing annual
<p>Premise of study: Increased aridity and drought associated with climate change are exerting unprecedented selection pressures on plant populations. Whether populations can rapidly adapt, and which life history traits might confer increased fitness under drought, remain outstanding questions. </p> <p>Methods: We utilized a resurrection ecology approach, leveraging dormant seeds from herbarium collections to assess whether populations of <em>Plantago patagonica</em> from the semi-arid Colorado Plateau have rapidly evolved in response to approximately ten years of intense drought in the region. We quantified multiple traits associated with drought escape and drought resistance and assessed the survival of ancestors and descendants under simulated drought. </p> <p>Key Results: Descendant populations displayed a significant shift in resource allocation, in which they invested less in reproductive tissues and relatively more in both above- and below-ground vegetative tissues. Plants with greater leaf biomass survived longer under terminal drought; moreover, even after accounting for the effect of increased leaf biomass, descendant seedlings survived drought longer than their ancestors. </p> <p>Conclusions: Our results document rapid adaptive evolution in response to climate change in a selfing annual and suggest that shifts in tissue allocation strategies may underlie adaptive responses to drought in arid or semi-arid environments. This work also illustrates a novel approach, documenting that under specific circumstances, seeds from herbarium specimens may provide an untapped source of dormant propagules for future resurrection experiments.</p>
Single-cell datasets for cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2- breast tumor cells
<p>There are 7 files uploaded in the data.</p><p>tumor_preprocessed.h5ad: Full primary tumor dataset post-feature selection and standardization across three treatment conditions (0, 10, and 100 nM palbociclib). AnnData object format. 14 cell cycle features, phase labels and other cell metadata, and two PHATE dimensions for manifold visualization.</p><p>T47D_preprocssed.h5ad: Full dataset of main text T47D dataset post-feature selection and standardization across three treatment conditions (0, 10, and 100 nM palbociclib). AnnData object format. 14 cell cycle features, phase labels and other cell metadata, and two PHATE dimensions for manifold visualization.</p><p>sketched_integrated.h5ad: After downsample 6,000 (2,000 per condition) from T47D_preprocessed and tumor_preprocessed, we integrate the two datasets into one joint latent space using TRANSACT. Now included in the data are the consensus component columns ('0',..,'13'). AnnData object.</p><p>sketched_integrated_df.csv: sketched_integrated.h5ad in .csv format.</p><p>T47D_replicate_preprocessed: Replicate experimental dataset of T47D for supplementary analysis post-feature selection and standardization across three treatment conditions (0, 10, and 100 nM palbociclib). 15 cell cycle features (same 14 but with CDK6).</p><p>sketched_rep.h5ad: Representative downsample of the T47D_replicate_preprocessed. Selecting 6,000 cells (2,000 for each of the three treatment conditions) using kernel herding sketching. AnnData object.</p><p>sketched_rep_df.csv: Same data as sketched_rep.h5ad in csv format.</p><p>T47D_triplicate_preprocessed.h5ad: T47D biological replicate sample collected in triplicate form (three wells for 0, 10, and 100 nM of palbociclib). Wells were joined and the data were sketched down to 20,000 per condition.</p><p>T47D_triplicate_preprocessed.h5ad: T47D triplicate in .csv form.</p><p>tumor_2_preprocessed.h5ad: An additional tumor sample from a new patient with the same treatment conditions of palbociclib. Sketched down to 2,000 cells per condition.</p><p>tumor_2_preprocessed.csv: The additional tumor sample in .csv form.</p><p> </p><p>Further description of sketched_integrated: This is the joint dataset between the T47D and primary tumor, after subsampling using kernel herding sketching. This is a dataset consisting of T47D and primary tumor cells resected from a consented patient. The samples were imaged using iterative indirect immunofluorescent imaging (4i) to get proteomic measurements on a single-cell level. The T47D and tumor samples were gathered, cultured, and imaged separately. Each sample was treated with three conditions of CDK4/6 inhibitor palbociclib (control, 10 nM, and 100 nM). Then, we used kernel sketching to representatively downsample each dataset, selecting 2,000 from each of the three treatment conditions (6,000 cells from each of the two sources). We used an integration method called TRANSACT to integrate the two datasets into one shared, latent space. The dataset here is consisting of these 12,000 cells. The columns ('0','1',...'13') are the principal vectors of the joint latent space. After that, there are the columns of the standardized proteomic measurements of different cell cycle effectors, and biological annotations of interest. The standardization is done for each data source separately. Well refers to the treatment condition. 'prb_ratio' is a marker of if a cell is still proliferating or arrested, found by selecting the upper modality of pRB/RB values. 'phase' are cell cycle phase labels found by unsupervised clustering done on a handful of known cell cycle markers.</p>
Negative Differential Resistance, Instability, and Critical Transition in Lightning Leader
<p>There is a challenging issue of die out and restrike of leaders in a burst of lightning event, such as multiplicity of strokes in grounded flash or recoil leader in cloud flash, although the argument involves the effects of channel characteristic of negative differential resistance instability, there is internal consistency about the instability, the bi-stability of insulation and induction and their critical transition from the view of bifurcation theory of nonlinear dynamics. In this paper, we examined the differential resistance characteristics of the leader-streams lighting system, we associate the leader-streamer channel differential resistance characteristics and sign change with channel state and instability transitions. The critical current and potential difference conditions for the stable transition of the leader-streamer channel are investigated. It is found that the necessary current required for the stable development of the channel is increased with the length of the leader channel, while the internal channel electric field of the leader decreases accordingly.</p>
Phage selection drives resistance-virulence trade-offs in Ralstonia solanacearum plant pathogenic bacterium irrespective of the growth temperature
<p><span>While temperature has been shown to affect the survival and growth of bacteria and their phage parasites, it is unclear if trade-offs between phage resistance and other bacterial traits depend on the temperature. Here, we experimentally compared the evolution of phage resistance-virulence trade-offs and underlying molecular mechanisms in phytopathogenic <em>Ralstonia</em> <em>solanacearum</em> bacterium at 25 °C and 35 °C temperature environments. We found that experimental growth conditions selected for small colony variants (SCVs) with increased growth rate and mutations in the quorum-sensing (QS) signalling receptor gene, <em>phcS</em>. Interestingly, SCVs were also phage-resistant and reached higher frequencies in the presence of phages in both temperature environments. Evolving phage resistance was costly in terms of reduced carrying capacity, biofilm formation and reduced virulence i<em>n planta</em> possibly due to loss of QS-mediated expression of key virulence genes. We also observed mucoid phage-resistant colonies that showed loss of virulence and reduced twitching motility likely due to parallel mutations in prepilin peptidase gene pilD. Moreover, phage-resistant SCVs from 35 °C-phage treatment had parallel mutations in genes encoding type II secretion system (T2SS) genes (<em>gspE</em> and <em>gspF</em>), indicating that defects in pseudopilus made bacterium resistant to the phage. Additional transcriptomic analysis revealed upregulation of CBASS and type Ⅰ restriction-modification phage defence systems in response to phage exposure, which coincided with reduced expression of motility and virulence-associated genes, including <em>pilD</em> and type II and III secretion systems. Together, these results suggest that phage resistance-virulence trade-offs are not affected by the growth temperature but can be mediated through both pre- and post-infection phage resistance mechanisms.</span></p>
Auxiliary files for invasion resistance in multispecies systems based on the replicator equation
<p>In this study we propose a replicator equation framework to model multi-species dynamics. In this replicator equation, the coefficients describe pairwise invasion fitnesses between constituent members, and an explicit quadratic term represents the systemic invasion resistance. This invasion resistance (<em>system trait</em>) is dependent on species frequencies and can be linked with specific structures of their pairwise invasion fitness matrix. Within this replicator framework, mean invasion fitness arises, evolves dynamically, and may undergo critical shifts with global environmental changes (e.g. mean growth rate, mean propensity for co-colonization). In the paper, extending an analogy with an SIS epidemiological model, we derive the conceptual mechanistic link between such replicator equation and <em>N </em>microbial species' growth and interaction traits, stemming from micro-scale environmental modification. We also study several specific invasion matrix structures in detail, their role for the quality of species dynamics and also for systemic invasion resistance. In this Dryad repository, we provide some auxiliary files and links to simulation codes, used and presented in our paper, to aid a mathematical understanding of invasion resistance using the replicator equation. We propose the framework can be applied to study colonization resistance in a wide range of microbial ecosystems. </p>
SUPPLEMENTARY (For MD) An integrative pan-genome and subtractive proteomics approach for the identification of potential novel therapeutic drug target against antibiotic resistant honeybee pathogen Paenibacillus larvae
<p><strong>Parameters</strong></p><p>Force field: AMBER ff19SB</p><p>Water type: TIP3P</p><p>Ions: NaCl </p><p>Ligand topology force field: GAFF2</p><p>Temperature: 298k</p><p>Pressure: 1 bar</p><p>minimization step: 20000 on 5 nanoseconds</p><p>initial velocity is changed by changing "ntx" and "ig"</p><p>C2: ntx = 5 , ig = 8</p><p>C3: ntx = 2 , ig = 5</p><p> </p><p><strong>Uploads</strong>- </p><p>1. Zip file of all 3 main files</p><p>2. Unzip file of C1 (Trajectory, PDB complex after each 10 ns run, and Mp4 video of Complex)</p><p>3. Zip file of C1</p><p>4. Unzip file of C2 (Trajectory, PDB complex after each 10 ns run, and Mp4 video of Complex)</p><p>5. Zip file of C2</p><p>6. Unzip file of C3 (Trajectory, PDB complex after each 10 ns run, and Mp4 video of Complex)</p><p>7. Zip file of C3</p><p>8. Zip and unzip file of <strong>Initial</strong> PDB of complex prior to MD simulation with <strong>Post</strong> MD PDB (C1, C2, C3)</p><p>9. Zip file of <strong>topology</strong> files for C1, C2, and C3</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.