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77
datasets available to search
ShareScore release 0.9.0
Dataset results
77 results for “SOD1”
Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons
GEO Series GSE210969. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Effect of depletion of SOD1 on gene expression of organoid culture
GEO Series GSE211035. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Microarray analysis identifies the gene signature of surviving motor neurons in human SOD1-related motor neuron disease
GEO Series GSE20589. Homo sapiens. 10 samples. Type: Expression profiling by array.
Single cell RNA-Seq result of spinal cord of SOD1*G93A transgenic mice treated with PF-04457845 or vehicle
GEO Series GSE242939. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq result of Bulk spinal cord of SOD1*G93A transgenic mice treated with PF-04457845 or vehicle
GEO Series GSE242940. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of G93A-SOD1 mouse spinal cord, blood and muscle
GEO Series GSE27933. Mus musculus. 92 samples. Type: Expression profiling by array.
Comparative gene expression analysis of thoracic spinal cord from G93A SOD1 mutant rats and from wild type littermates following mild compression injury
GEO Series GSE22161. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Transcriptomic profiling of electrophysiologically characterized human iPSC-derived motor neurons having SOD1 A4V mutation
GEO Series GSE138120. Homo sapiens. 192 samples. Type: Expression profiling by high throughput sequencing.
Boxer dataset for genome-wide association study of modifiers of risk of canine degenerative myelopathy in dogs homozygous for SOD1 mutation
GEO Series GSE80315. Canis lupus familiaris. 25 samples. Type: SNP genotyping by SNP array.
The Role of the Thymus in ALS development in a SOD1 ALS model
GEO Series GSE286267. Mus musculus. 76 samples. Type: Expression profiling by high throughput sequencing.
Gene expression and gene ontology analysis of the transcriptional changes occurring in spinal cord from the G93A SOD1 gene mutant rat
GEO Series GSE20894. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Spinal cord of SOD1*G93A transgenic mice treated with PF-04457845 or vehicle
GEO Series GSE242942. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
RNA molecular signature profiling in PBMCs of sporadic ALS patients: HSP70 overexpression is associated with nuclear SOD1
GEO Series GSE183204. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Gene expression profile in SOD1-G85R transgenic mice, a mouse model of amyotrophic lateral schelosis
GEO Series GSE167974. Mus musculus. 6 samples. Type: Expression profiling by array.
Amyotrophic lateral sclerosis: SOD1 mouse model
GEO Series GSE2400. Mus musculus. 6 samples. Type: Expression profiling by array.
Dataset related to article " Behavioural and cognitive phenotypes of patients with amyotrophic lateral sclerosis carrying SOD1 mutations" (manuscript submitted)
<p>Clinical and neuropsychological anonymized data of patients involved in the study presented in the submitted article mentioned at title </p>
HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex
<p><strong>The database includes </strong>the raw of the article “HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex”.</p> <p><strong>In detail, the database contains</strong> data obtained by the following evaluations: i) RNA electrophoretic mobility shift assay (REMSA) to detect the formation of a complex between HuD recombinant protein and SOD1 ARE sequences. ii) multiplex qRT-PCR to evaluate if oxidative stress levels, i.e H2O2 treatment, induces a shift in the alternative polyadenylation (APA) site usage in SOD1 3'UTR.</p> <p><strong>Aim of the work</strong> was to investigate the potential involvement of HuD (ELAVL4) one of the neuronal members of the ELAVL family, in SOD1 regulation during oxidative stress and in sporadic ALS patients (sALS).</p> <p>Using differentiated SH-SY5Y cells along with brain tissues from sALS patients, we evaluated HuD-dependent regulation of SOD1 mRNA. By means in vitro binding and mRNA decay assays we observed that HuD specifically binds to SOD1 ARE motifs promoting mRNA stabilization. In SH-SY5Y cells, we faound that the overexpression of full-length HuD increased SOD1 mRNA and protein levels; moreover HuD regulation of SOD1 mRNA we found that this regulation is related to oxidative stress, as shown after H2O2 exposure. H2O2 exposure also induced a shift in the APA site usage in SOD1 3'UTR, increasing the levels of a long variant bearing HuD binding sites. We validated this data using a specific siRNA. In the motor cortex from sALS patients, we found increases in SOD1 and HuD mRNAs and proteins, accompanied by greater HuD binding to this mRNA as confirmed by RNA-immunoprecipitation (RIP) assays.</p> <p><strong>To conclude,</strong> these results point a role of HuD in the post-transcriptional regulation of SOD1 expression in neurons after oxidative stress and in sALS brain tissues, thus suggesting an involvement in ALS pathogenesis.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.