Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
697
datasets available to search
ShareScore release 0.7.1
Dataset results
697 results for “Staphylococcus aureus”
Evolution under vancomycin selection drives divergent collateral sensitivity patterns in <em>Staphylococcus aureus</em>
Open the record for dataset details and reuse information.
Staphylococcus aureus phenol soluble modulin aggregation kinetics
Open the record for dataset details and reuse information.
mGEMS Staphylococcus aureus reference dataset
<p>This dataset contains the <em>S. aureus</em> sequences (assembled with shovill v0.9.0), their sequence type 22 clades, and accession numbers used in the mGEMS publication as the reference dataset.</p>
Data from: Ecological overlap and horizontal gene transfer in Staphylococcus aureus and Staphylococcus epidermidis
The opportunistic pathogens Staphylococcus aureus and Staphylococcus epidermidis represent major causes of severe nosocomial infection, and are associated with high levels of mortality and morbidity worldwide. These species are both common commensals on the human skin and in the nasal pharynx, but are genetically distinct, differing at 24% average nucleotide divergence in 1,478 core genes. To better understand the genome dynamics of these ecologically similar staphylococcal species, we carried out a comparative analysis of 324 S. aureus and S. epidermidis genomes, including 83 novel S. epidermidis sequences. A reference pan-genome approach and whole genome multilocus-sequence typing revealed that around half of the genome was shared between the species. Based on a BratNextGen analysis, homologous recombination was found to have impacted on 40% of the core genes in S. epidermidis, but on only 24% of the core genes in S. aureus. Homologous recombination between the species is rare, with a maximum of nine gene alleles shared between any two S. epidermidis and S. aureus isolates. In contrast, there was considerable interspecies admixture of mobile elements, in particular genes associated with the SaPIn1 pathogenicity island, metal detoxification, and the methicillin-resistance island SCCmec. Our data and analysis provide a context for considering the nature of recombinational boundaries between S. aureus and S. epidermidis and, the selective forces that influence realized recombination between these species.
Data from: Low prevalence of methicillin-resistant Staphylococcus aureus among men who have sex with men attending an STI clinic in Amsterdam, a cross-sectional study
Objective: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is common among men who have sex with men (MSM) in the USA. It is unknown whether this is also the case in Amsterdam, the Netherlands. Design: Cross-sectional study. Setting: Sexually transmitted infection outpatient low- threshold clinic, Amsterdam, the Netherlands. Participants: Between October 2008 and April 2010, a total of 211 men were included, in two groups: (1) 74 MSM with clinical signs of a skin or soft tissue infection (symptomatic group) and (2) 137 MSM without clinical signs of such infections (asymptomatic group). Primary outcome measures: S aureus and MRSA infection and/or colonisation. Swabs were collected from the anterior nasal cavity, throat, perineum, penile glans and, if present, from infected skin lesions. Culture for S aureus was carried out on blood agar plates and for MRSA on selective chromagar plates after enrichment in broth. If MRSA was found, the spa- gene was sequenced. Secondary outcome measures: Associated demographic characteristics, medical history, risk factors for colonisation with S aureus and high-risk sexual behaviour were collected through a self- completed questionnaire. Results: The prevalence of S aureus colonisation in the nares was 37%, the pharynx 11%, the perianal region 12%, the glans penis 10% and in skin lesions 40%. In multivariable analysis adjusting for age, anogenital S aureus colonisation was significantly associated with the symptomatic group (p=0.01) and marginally with HIV ( p=0.06). MRSA was diagnosed in two cases: prevalence 0.9% (95% CI 0.1% to 3.4%)). Neither had CA-MRSA strains. Conclusions: CA-MRSA among MSM in Amsterdam is rare. Genital colonisation of S aureus is not associated with high-risk sexual behaviour.
Evaluation of different methods to extract DNA from serum seeded with methicillin-resistant Staphylococcus aureus
Open the record for dataset details and reuse information.
Source data for: Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections
<p class="CxSpFirst">Implant-associated <i>Staphylococcus aureus</i> infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here we show that mAbs targeting common surface components of <i>S. aureus</i> can recognize clinically relevant biofilm types. The mAbs were also shown to bind a collection of clinical isolates derived from different biofilm-associated infections (endocarditis, prosthetic joint, catheter). We identify two groups of antibodies: one group that uniquely binds <i>S. aureus </i>in biofilm state and one that recognizes <i>S. aureus </i>in both biofilm and planktonic state. Furthermore, we show that a mAb recognizing wall teichoic acid (WTA; clone 4497) specifically localizes to a subcutaneously implanted pre-colonized catheter in mice. In conclusion, we demonstrate the capacity of several human mAbs to detect <i>S. aureus</i> biofilms<i> in vitro</i> and <i>in vivo</i>.</p>
Dataset Staphylococcus aureus screening and dynamics in BSF larvae rearing
Open the record for dataset details and reuse information.
5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice
<p>Data underlying the figures in the publication “5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice”, published in <em>Nucleic Acids Research</em>, <strong>2021</strong>, gkab251. <a href="https://doi.org/10.1093/nar/gkab251">https://doi.org/10.1093/nar/gkab251</a></p> <p>Table of contents:</p> <p><strong>1. Dataset</strong>; Excel file with the numerical values for figures of screen (publicly available hit compounds) and hit validation <em>in vitro</em> and <em>in vivo</em>. Dataset of <em>Figures 2, 3, 4, 5, 6</em> and <em>S2</em> & <em>S4</em>.</p>
Raw data for Characterization of the genetic switch from phage ɸ13 important for human colonization by Staphylococcus aureus
<p>Raw data for the manuscript with the title "Characterization of the genetic switch from phage ɸ13 important for human colonization by <em>Staphylococcus aureus". </em>All data produced in the study can be found in this Excel file.</p>
Genome mining reveals the prevalence and extensive diversity of toxin-antitoxin systems in Staphylococcus aureus
<p>Staphylococcus aureus (S. aureus) is a ubiquitous Gram-positive bacterium that is highly pathogenic and adaptive, showing great persistence in the environment. The toxin-antitoxin (TA) system is considered a valuable strategy for bacterial pathogens to survive in stressed environments and plays a crucial role in the defense system. Numerous studies have wildly explored the distribution and function of TA systems in clinical pathogens. However, little is known about the diversity of the TA systems and their evolutionary dynamics in S. aureus. In this study, we performed a comprehensive in silico screening of 621 isolates recovered from public databases. We identified 44 TA groups belonging in S. aureus genomes using bioinformatic search and prediction tools, including SLING, TADB2.0 and TASmania. There was a median of 7 TA systems in each genome, and 3 type II TA groups which were found in more than 80% of the strains, including HD, HD_3, and YoeB, others were more sporadic. The majority of predicted TA genes are chromosomally encoded. The Staphylococcal cassette chromosome mec (SCCmec) genomic islands also harbored TA genes. Further functional characterization of the putative TA system could reveal how these widespread prevalent gene modules potentially influence the ecology, virulence, and disease management practices of S. aureus. Our study opens the prospect of characterizing these putative TA genes and the design of more targeted antimicrobial agents in the future.</p>
Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa
<p>Most bacteria exist and interact within polymicrobial communities. These interactions produce unique compounds, increase virulence and augment antibiotic resistance. One community associated with negative healthcare outcomes consists of <em>Pseudomonas aeruginosa</em> and <em>Staphylococcus aureus</em>. When co-cultured, virulence factors secreted by <em>P. aeruginosa</em> reduce metabolism and growth in <em>S. aureus</em>. When grown in vitro, this allows <em>P. aeruginosa</em> to drive <em>S. aureus</em> toward extinction. However, when found <em>in vivo</em>, both species can co-exist. Previous work has noted that this may be due to altered gene expression or mutations. However, little is known about how the growth environment could influence the co-existence of both species. Using a combination of mathematical modeling and experimentation, we show that changes to bacterial growth and metabolism caused by differences in the growth environment can determine the final population composition. We found that changing the carbon source in growth media affects the ratio of ATP to growth rate for both species, a metric we call absolute growth. We found that as a growth environment increases the absolute growth for one species, that species will increasingly dominate the co-culture. This is due to interactions between growth, metabolism, and metabolism-altering virulence factors produced by <em>P. aeruginosa</em>. Finally, we show that the relationship between absolute growth and the final population composition can be perturbed by altering the spatial structure in the community. Our results demonstrate that differences in growth environment can account for conflicting observations regarding the co-existence of these bacterial species in the literature, provides support for the intermediate disturbance hypothesis, and may offer a novel mechanism to manipulate polymicrobial populations.</p>
Effect of Herbal Extracts on the Survival of Staphylococcus aureus in Goats' Raw Milk Cheese
<p>Presented as e-Poster Flash Presentation; and in Book of Abstracts of the International Seminar ArtiSaneFood - Biopreservation and Risk Modelling Approaches. Bragança, Portugal (24-25 May 2023) (Page 54).</p>
Figure 7: Antibiotic sensitivity and resistance pattern of Staphylococcus Aureus
<p><strong>Figure 7: Antibiotic sensitivity and resistance pattern of Staphylococcus Aureus </strong></p>
Aerosolized Vancomycin in Methicillin-Resistant Staphylococcus Aureus Pneumonia Under Mechanical Ventilation
ClinicalTrials.gov study NCT01925066. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Staphylococcus Aureus Network Adaptive Platform Trial
ClinicalTrials.gov study NCT05137119. IPD Sharing: YES. Countries: 10. Publications: 8.
Phage Therapy in Prosthetic Joint Infection Due to Staphylococcus Aureus Treated With DAIR.
ClinicalTrials.gov study NCT05369104. IPD Sharing: NO. Countries: 1. Publications: 0.
Studying the Distribution of Accessory Gene Regulator (Agr) Quorum Sensing System and the Prevalence of Linezolid and Mupirocin Resistance in Biofilm Producer/Non Producer Staphylococcus Aureus in Soh
ClinicalTrials.gov study NCT06291181. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Prospective Cohort Pilot Study of the Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at the Time of Group B Streptococcal Screening in a Large Urban Medical Center in
ClinicalTrials.gov study NCT00532324. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The Foot in Your Nose Study: Links Between Nasal Staphylococcus Aureus Colonies and Diabetic Foot Lesion Infections
ClinicalTrials.gov study NCT01212120. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.