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694 results for “Stiffness”
Data rom: Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment
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Stiffness reprogrammable magnetorheological metamaterials inspired by the spine for multi-bit visual mechanical information processing
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Data from: Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current
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At matched loads, aging does not alter ankle, muscle, or tendon stiffness
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Data from: Nanoindentation methods for viscoelastic characterization of stiff porous materials
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Database for Study: Shear-wave elastography for assessment of trapezius muscle stiffness: reliability and association with low-level muscle activity
<p>This is the database for the study entitled <strong>Shear-wave elastography for assessment of trapezius muscle stiffness: reliability and association with low-level muscle activity. </strong>In this study, we explored the reliability of shear-wave elastography for assessment of the trapezius muscle stiffness and its relationship with low-level muscle activity.Twenty participants were included in a two-session experiment. Measurements of shear modulus and muscle activity were performed at rest and during low-level activity, induced by shoulder abduction without additional external resistance. Good to excellent intra-session repeatability (ICC > 0.80) and moderate inter-rater and inter-session reproducibility (ICC = 0.66-0.74) were observed. Typical errors were acceptable only for intra-session measurements in resting conditions. Inverse relationships between shear modulus and muscle activity at 40° and 60° of shoulder abduction (r = -0.53 and -0.57) were observed on a group level. We also found lower shear modulus in females, for perpendicular probe position and for the non-dominant side of the body. Previous studies have demonstrated positive within-individual relationships between muscle activity and shear modulus. Our results suggested that, at least when the activity levels are low, an inverse relationship exists between muscle activity and shear modulus on a group level, suggesting inherent passive stiffness could account for a larger portion of the variance (compared to muscle activity) in shear modulus when the muscle activity is low. Our results imply that shear-wave elastography can be used in research exploring muscle stiffness, however, caution is needed since only intra-session examination in resting conditions showed acceptable within-participant typical errors.</p>
Differential tissue stiffness of body column facilitates locomotion of Hydra on solid substrates
The bell-shaped members of Cnidaria typically move around by swimming, whereas the Hydra polyp can perform locomotion on solid substrates in an aquatic environment. To address the biomechanics of locomotion on rigid substrates, we studied the 'somersaulting' locomotion in Hydra. We applied atomic force microscopy to measure the local mechanical properties of Hydra's body column and identified the existence of differential Young's modulus between the shoulder region versus rest of the body column at 3:1 ratio. We show that somersault primarily depends on differential tissue stiffness of the body column and is explained by computational models that accurately recapitulate the mechanics involved in this process. We demonstrate that perturbation of the observed stiffness variation in the body column by modulating the extracellular matrix (ECM) polymerization impairs the 'somersault' movement. These results provide mechanistic basis for the evolutionary significance of differential extracellular matrix properties and tissue stiffness.
Particle Stiffness and Surface Topography Determine Macrophage-Mediated Removal of Surface Adsorbed Particles
<p>Cellular surface recognition and behavior are driven by a host of physical and chemical features which have been exploited to influence particle–cell interactions. Mechanical and topographical cues define the physical milieu which plays an important role in defining a range of cellular activities such as material recognition, adhesion, and migration through cytoskeletal organization and signaling. In order to elucidate the effect of local mechanical and topographical features generated by the adsorption of particles to an underlying surface on primary human monocyte‐derived macrophages (MDM), a series of poly(<em>N</em>‐isopropylacrylamide) (pNIPAM) particles with differing rigidity are self‐assembled to form a defined particle‐decorated surface. Assembly of particle‐decorated surfaces is facilitated by modification of the underlying glass to possess a positive charge through functionalization using 3‐aminopropyltriethoxysilane (APTES) or coating with poly(L‐lysine) (PLL). MDMs are noted to preferentially remove particles with higher degrees of crosslinking (stiffer) than those with lower degrees of crosslinking (softer). Alterations to the surface density of particles enabled a greater area of the particle‐decorated surface to be cleared. Uniquely, the impact of particle adsorption is evinced to have a direct impact on topographical recognition of the surface, suggesting a novel approach for controllably affecting cell‐surface recognition and response.</p>
Data from: Reduction in arterial stiffness and vascular age by naltrexone-induced interruption of opiate agonism
Objective: To prospectively assess if opiate antagonist treatment or the opiate-free status could reverse opiate-related vasculopathy. Design: Longitudinal Open Observational, Serial "N of One", over 6.5 years under various treatment conditions: opiate dependence, naltrexone and opiate-free. Setting: Primary care, Australia. Participants: 20 opiate dependent patients (16 males: 16 cases of buprenorphine 4.11+1.17mg, two of methadone 57.5+12.5mg and two of heroin 0.75+0.25g). Intervention: Studies of Central Arterial Stiffness and vascular reference age (RA) were performed longitudinally by SphygmoCor Pulse Wave Analysis (AtCor, Sydney). Primary Outcomes: Primary outcome was vascular age and arterial stiffness accrual under different treatment conditions. Results: The mean chronological age (CA) was 33.62+2.03 years. The opiate-free condition was associated with a lower apparent vascular age both in itself (males: P=0.0402, females: P=0.0360) and in interaction with time (males: P=0.0001; females: P=0.0004), and confirmed with other measures of arterial stiffness. The mean modelled RA was 38.82, 37.73 and 35.05 years in the opiate, naltrexone and opiate-free conditions respectively. The opiate-free condition was superior to opiate agonism after full multivariate adjustment (P=0.0131), with modelled RA/CA of 1.0173, 0.9563, and 0.8985 (reductions of 6.1% and 11.9% respectively). Conclusions: Data demonstrate that opiate-free status improves vascular age and arterial stiffness in previous chronic opiate users.. The role of opiate antagonist treatment in achieving these outcomes requires future clarification and offers hope of novel therapeutic remediation.
Data from: Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation
The adverse effect induced by carbon ion radiation (CIR) is still an unavoidable hazard to the treatment object. Thus, evaluation of its adverse effects on the body is a critical problem with respect to radiation therapy. We aimed to investigate the change between the configuration and mechanical properties of erythrocytes induced by radiation and found differences in both the configuration and the mechanical properties with involving in morphological remodeling process. Syrian hamsters were subjected to whole-body irradiation with carbon ion beams (1, 2, 4, and 6 Gy) or X-rays (2, 4, 6, and 12 Gy) for 3, 14 and 28 days. Erythrocytes in peripheral blood and bone marrow were collected for cytomorphological analysis. The mechanical properties of the erythrocytes were determined using atomic force microscopy, and the expression of the cytoskeletal protein spectrin-α1 was analyzed via western blotting. The results showed that dynamic changes were evident in erythrocytes exposed to different doses of carbon ion beams compared with X-rays and the control (0 Gy). The magnitude of impairment of the cell number and cellular morphology manifested the subtle variation according to the irradiation dose. In particular, the differences in the size, shape and mechanical properties of the erythrocytes were well exhibited. Furthermore, immunoblot data showed that the expression of the cytoskeletal protein spectrin-α1 was changed after irradiation, and there was a common pattern among its substantive characteristics in the irradiated group. Based on these findings, the present study concluded that CIR could induce a change in mechanical properties during morphological remodeling of erythrocytes. According to the unique characteristics of the biomechanical categories, we deduce that changes in cytomorphology and mechanical properties can be measured to evaluate the adverse effects generated by tumor radiotherapy. Additionally, for the first time, the current study provides a new strategy for enhancing the assessment of the curative effects and safety of clinical radiotherapy, as well as reducing adverse effects.
Stiffness Regulates Breast Cancer Antitumor Immunity via COX2-FGF2 Pathway
<p>The code for spatial analysis done with subset of samples form publication: Bassiouni R, Idowu MO, Gibbs LD, Robila V, Grizzard PJ, Webb MG, Song J, Noriega A, Craig DW, Carpten JD. Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast Cancer. Cancer Res. 2023 Jan 4;83(1):34-48. doi: 10.1158/0008-5472.CAN-22-2682. PMID: 36283023; PMCID: PMC9812886.</p> <p> </p>
CSAPSO-BPNN based modeling of end airbag stiffness of nursing transfer robot
<p>The use of nursing transfer robots is a vital solution to the problem of daily mobility difficulties for semi-disabilities. However, the fact that care-receivers have different physical characteristics leads to force concentration during human-robot interaction, which affects their comfort. To address this problem, this study installs an array of double wedge-shaped airbags onto the end-effector of a robot, and analyses airbag mechanical properties. Firstly, this study performed the mechanical testing and data collection of the airbag, including its external load and displacement, at various gas masses. Then the performance of the Back Propagation (BP) neural network is improved by using chaos (C) theory and simulated annealing particle swarm optimization (SAPSO), resulting in the establishment of the CSAPSO-BP neural network. By this method, a fitting model is developed to determine the mechanical parameters of the wedge-shaped airbag stiffness, and the fitting relation of external load-displacement is obtained. Data analyses show that the wedge-shaped airbag stiffness increases quadratically, linearly, and with a constant rate as the gas mass increases. The airbag stiffness regulation and model describe its 3 distinct phases with quadratic, linear, and linear invariant characteristics as the gas mass changes. These findings contribute to the structural optimization of airbags.</p>
Development of a Pneumatically Actuated Quadruped Robot Using Soft-Rigid Hybrid Variable-Stiffness Rotary Joints
<p>This is a supplementary video for the paper "Development of a Pneumatically Actuated Quadruped Robot Using Soft-Rigid Hybrid Variable-Stiffness Rotary Joints" submitted to Robotics.</p>
Modulation of Arterial Intima Stiffness by Disturbed Blood Flow
<p>Atomic Force Microscopy (AFM) measurements of arterial stiffness (carotids) in mice. </p>
Data: relation between soft tissue energy dissipation and leg stiffness in running at different step frequencies
<p>Data set - paper: <span>Relation between soft tissue energy dissipation and leg stiffness in running at different step frequencies </span></p>
Stiffness of Fluid and Gel Phase Lipid Nanovesicles: Weighting the Contributions of Membrane Bending Modulus and Luminal Pressurization
<p>In the manuscript, Atomic Force Microscopy (AFM) is employed for characterizing the mechanical response of nanosized lipid vesicles presenting membranes with different physical state. Results suggest that the mechanical response of lipid vesicles can be ascribed to two main contributions, i) the luminal pressure and ii) the intrinsic membrane rigidity. By developing a spring-based model, authors were able to rationalize the apparent disagrement between the two most commonly employed models for describing vesicle mechanics.</p>
On following pages: 35. Stiff-spined Spiny-rat (Proechimys echinothrix); 36. Tomes''s Spiny-rat (Proechimys semispinosus); 37. O'Connell's Spiny-rat (Proechimys oconnelli); 38. Napo Spiny-rat (Proechimys quadruplicatus); 39. Steere's Spiny-rat (Proechimys steerei); 40. Goeldi's Spiny-rat (Proechimys goeldii); 41. Guyenne Spiny-rat (Proechimys guyannensis); 42. Robert's Spiny-rat (Proechimys robert); 43. Patton's Spiny-rat (Proechimys pattoni); 44. Kulina Spiny-rat (Proechimys kulinae); 45. Gardner's Spiny-rat (Proechimys gardneri); 46. Boyaca Spiny-rat (Proechimys chrysaeolus); 47. Minca Spiny-rat (Proechimys mincae); 48. Guaira Spiny-rat (Proechimys guairae); 49. Trinidad Spiny-rat (Proechimys trinitatis); 50. Guianan Spiny-rat (Proechimys hoplomyoides); 51. Short-tailed Spiny-rat (Proechimys brevicauda); 52. Long-tailed Spiny-rat (Proechimys longicaudatus); 53. Cuvier's Spiny-rat (Proechimys cuvier). in Echimyidae
On following pages: 35. Stiff-spined Spiny-rat (Proechimys echinothrix); 36. Tomes''s Spiny-rat (Proechimys semispinosus); 37. O'Connell's Spiny-rat (Proechimys oconnelli); 38. Napo Spiny-rat (Proechimys quadruplicatus); 39. Steere's Spiny-rat (Proechimys steerei); 40. Goeldi's Spiny-rat (Proechimys goeldii); 41. Guyenne Spiny-rat (Proechimys guyannensis); 42. Robert's Spiny-rat (Proechimys robert); 43. Patton's Spiny-rat (Proechimys pattoni); 44. Kulina Spiny-rat (Proechimys kulinae); 45. Gardner's Spiny-rat (Proechimys gardneri); 46. Boyaca Spiny-rat (Proechimys chrysaeolus); 47. Minca Spiny-rat (Proechimys mincae); 48. Guaira Spiny-rat (Proechimys guairae); 49. Trinidad Spiny-rat (Proechimys trinitatis); 50. Guianan Spiny-rat (Proechimys hoplomyoides); 51. Short-tailed Spiny-rat (Proechimys brevicauda); 52. Long-tailed Spiny-rat (Proechimys longicaudatus); 53. Cuvier's Spiny-rat (Proechimys cuvier).
On following pages: 35. Stiff-spined Spiny-rat (Proechimys echinothrix); 36. Tomes''s Spiny-rat (Proechimys semispinosus); 37. O'Connell's Spiny-rat (Proechimys oconnelli); 38. Napo Spiny-rat (Proechimys quadruplicatus); 39. Steere's Spiny-rat (Proechimys steerei); 40. Goeldi's Spiny-rat (Proechimys goeldii); 41. Guyenne Spiny-rat (Proechimys guyannensis); 42. Robert's Spiny-rat (Proechimys robert); 43. Patton's Spiny-rat (Proechimys pattoni); 44. Kulina Spiny-rat (Proechimys kulinae); 45. Gardner's Spiny-rat (Proechimys gardneri); 46. Boyaca Spiny-rat (Proechimys chrysaeolus); 47. Minca Spiny-rat (Proechimys mincae); 48. Guaira Spiny-rat (Proechimys guairae); 49. Trinidad Spiny-rat (Proechimys trinitatis); 50. Guianan Spiny-rat (Proechimys hoplomyoides); 51. Short-tailed Spiny-rat (Proechimys brevicauda); 52. Long-tailed Spiny-rat (Proechimys longicaudatus); 53. Cuvier's in Echimyidae
On following pages: 35. Stiff-spined Spiny-rat (Proechimys echinothrix); 36. Tomes''s Spiny-rat (Proechimys semispinosus); 37. O'Connell's Spiny-rat (Proechimys oconnelli); 38. Napo Spiny-rat (Proechimys quadruplicatus); 39. Steere's Spiny-rat (Proechimys steerei); 40. Goeldi's Spiny-rat (Proechimys goeldii); 41. Guyenne Spiny-rat (Proechimys guyannensis); 42. Robert's Spiny-rat (Proechimys robert); 43. Patton's Spiny-rat (Proechimys pattoni); 44. Kulina Spiny-rat (Proechimys kulinae); 45. Gardner's Spiny-rat (Proechimys gardneri); 46. Boyaca Spiny-rat (Proechimys chrysaeolus); 47. Minca Spiny-rat (Proechimys mincae); 48. Guaira Spiny-rat (Proechimys guairae); 49. Trinidad Spiny-rat (Proechimys trinitatis); 50. Guianan Spiny-rat (Proechimys hoplomyoides); 51. Short-tailed Spiny-rat (Proechimys brevicauda); 52. Long-tailed Spiny-rat (Proechimys longicaudatus); 53. Cuvier's
Data sets for "Superionic water with stiffness between molecular ice and liquid"
<p>This is the source data shown in Figs. 1, 3A, and Figs. S2, S3, S4, S5, S6, S7, and S12 for the article "Superionic water with stiffness between molecular ice and liquid" by Kimura and Murakami.</p>
Data sets for "Superionic water with stiffness between molecular ice and liquid"
<p>This is the source data shown in Figs. 1, 3A, and Figs. S2, S3, S4, S5, S6, S7, and S12 for the article "Superionic water with stiffness between molecular ice and liquid" by Kimura and Murakami.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.