Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
97
datasets available to search
ShareScore release 0.9.0
Dataset results
97 results for “Synaptic plasticity”
The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons
GEO Series GSE87441. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Sub-chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice
GEO Series GSE245307. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Basic Helix Loop Helix Enhancer 40 Null Mice Have Impaired Synaptic Plasticity, Enhanced Neuronal Excitability, and Decreased Expression of Insulin Degrading Enzyme
GEO Series GSE85959. Mus musculus. 23 samples. Type: Expression profiling by array.
Early life stress in fathers impairs synaptic plasticity in the offspring
GEO Series GSE47848. Mus musculus. 60 samples. Type: Expression profiling by array.
Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity [PRO-Seq]
GEO Series GSE223566. Mus musculus. 4 samples. Type: Other.
HDAC3-mediated regulation of the circadian gene Per1 contributes to age-related impairments in hippocampal memory and synaptic plasticity
GEO Series GSE94832. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Egr1 is a sex-specific regulator of neuronal chromatin, synaptic plasticity, and behaviour [ATAC-Seq]
GEO Series GSE249976. Mus musculus. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity
GEO Series GSE223568. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing; Other.
Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity [RNA-Seq]
GEO Series GSE223567. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Myeloid cell deficiency of the inflammatory transcript factor STAT4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet
GEO Series GSE240045. Mus musculus. 12 samples. Type: Expression profiling by array.
Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and synaptic plasticity
GEO Series GSE107357. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory
GEO Series GSE87675. Mus musculus. 8 samples. Type: Expression profiling by array.
A53T-α-synuclein overexpression mouse model signaling and striatal synaptic plasticity
GEO Series GSE20547. Mus musculus. 54 samples. Type: Expression profiling by array.
miR-101a-3p impairs synaptic plasticity and contributes to synucleinopathy
GEO Series GSE196020. Mus musculus. 15 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Foxp1 expression in forebrain pyramidal neurons controls gene expression required for spatial learning and synaptic plasticity
GEO Series GSE97181. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
GEO Series GSE161540. Rattus norvegicus. 10 samples. Type: Expression profiling by high throughput sequencing.
Early life stress in fathers impairs synaptic plasticity in the offspring - brain collected at rest
GEO Series GSE47846. Mus musculus. 12 samples. Type: Expression profiling by array.
Data set_Network-wide modulation of synaptic plasticity and spike patterns in motor circuits by pallidal deep brain stimulation in a dystonia model
<p>This study utilized deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) to investigate its long-term effects on synaptic activity in motor thalamic and motor cortical neurons in an animal model of generalized dystonia (dtsz hamster). Whole-cell recordings were employed to measure synaptic spike patterns, revealing significant changes in DBS-treated animals compared to sham-treated controls. Specifically, we observed reduced interspike intervals (ISI) and increased postsynaptic current (PSC) frequencies. Fast oscillations were also detected in both thalamic and motor cortical neurons, indicating potential modulation of corticothalamocortical loops by GPi-DBS. Notably, while the overall discharge rates of spontaneous and evoked action potentials remained unchanged, DBS treatment led to increased PSC amplitudes and alterations in inhibitory synaptic currents. These findings suggest that GPi-DBS influences both presynaptic and postsynaptic mechanisms of synaptic plasticity. The results further indicate that GPi-DBS disrupts desynchronized neural activity through axonal and synaptic failures, thereby reorganizing neuronal firing patterns and synaptic connectivity within the motor circuit. This modulation provides mechanistic insights into the therapeutic effects of GPi-DBS in alleviating dystonic symptoms.</p>
microRNA-218-5p Coordinates Scaling of Excitatory and Inhibitory Synapses during Homeostatic Synaptic Plasticity
GEO Series GSE245158. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Circadian protein TIMELESS regulates synaptic plasticity and memory by modulating cAMP signaling
GEO Series GSE208149. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.