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314 results for “Toxoplasma gondii”
Fig. 4 in Role of landscape context in Toxoplasma gondii infection of invasive definitive and intermediate hosts on a World Heritage Island
Fig. 4. Model averaged coefficients of variables (GLM) explaining seroprevalence and OD values of black rats. Bars indicate 95% confidence intervals.
Fig. 2 in Role of landscape context in Toxoplasma gondii infection of invasive definitive and intermediate hosts on a World Heritage Island
Fig. 2. Model averaged coefficients of variables (GLM) explaining seroprevalence and OD values of cats. Bars indicate 95% confidence intervals.
Fig. 3 in Role of landscape context in Toxoplasma gondii infection of invasive definitive and intermediate hosts on a World Heritage Island
Fig. 3. Anti-Toxoplasma gondii seroprevalence and OD values of cats as a function of the number of cattle barns within 1 ha or individual body weight. Gray areas indicate 95% confidence intervals. Dots represent individuals. The color becomes darker with increasing sample size.
Fig. 1 in Role of landscape context in Toxoplasma gondii infection of invasive definitive and intermediate hosts on a World Heritage Island
Fig. 1. Map showing the study area. Open circles and black triangles in the map indicate, respectively, capture sites of cats and black rats.
Fig. 1 in Sero-prevalence and risk factors of Toxoplasma gondii infection in wild cervids in Denmark
Fig. 1. The geographical distribution of wild cervids included in the study and the number of animals tested positive for antibodies against Toxoplasma gondii in the hunting season 2017–2018 in Denmark (n = 428). Shown by region and proportion of species sampled (roe deer, fallow deer or red deer) in each region. Pie charts indicate proportion of samples from each cervid species. Note Sika deer was only sampled in Mid-Jutland (n = 14), and hence not included in the map. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2. Geometric mean ratio and 95 in Associations between Toxoplasma gondii infection and steroid hormone levels in spotted hyenas
Fig. 2. Geometric mean ratio and 95% CI estimates from separate sex stratified models of the relationship between T. gondii infection and plasma cortisol. The red dashed line represents the null, and estimates are based on percentile bootstrapping (2000 simulations).
Fig. 1. Geometric mean ratio and 95 in Associations between Toxoplasma gondii infection and steroid hormone levels in spotted hyenas
Fig. 1. Geometric mean ratio and 95% CI estimates from separate sex and age stratified models of the relationship between T. gondii infection and plasma testosterone. The red dashed line represents the null, and estimates are based on percentile bootstrapping (2000 simulations).
Fig. 1 in Comparison of a commercial ELISA and indirect hemagglutination assay with the modified agglutination test for detection of Toxoplasma gondii antibodies in giant panda (Ailuropoda melanoleuca)
Fig. 1. Receiver operating characteristics (ROC) analysis of the ELISA. ROC analysis shows an area under the curve (AUC) of 0.861 (95% CI: 0.712–1.000) for ELISA (a), 0.894 (95% CI: 0.791–0.997) for ELISA (b), and 0.902 (95% CI: 0.799–1.000) for ELISA (c).
Fig. 2 in High prevalence rates of Toxoplasma gondii in cat-hunted small mammals - Evidence for parasite induced behavioural manipulation in the natural environment?
Fig. 2. Immunohistochemical stained histological section of the heart of a European water vole (Arvicola amphibius s.l.) (ID B42) showing a T. gondii tissue cyst measuring ~20 μm.
Fig. 1 in High prevalence rates of Toxoplasma gondii in cat-hunted small mammals - Evidence for parasite induced behavioural manipulation in the natural environment?
Fig. 1. Spatial distribution of cat-hunted and trap-captured small mammals in Switzerland Map of Switzerland showing the number of sampled small mammals in each location and the distribution of the different groups used in the study. Groups 1–3: "cat-hunted"; Group 4 ′′trap-captured".
Fig. 1 in Toxoplasma gondii and Neospora caninum in invasive wild boars (Sus scrofa) and hunting dogs from Brazil
Fig. 1. Map highlighting the cities where wild boar and hunting dog samples were obtained, Brazil, 2024.
Suppl. files to: Cellular and molecular targets of nucleotide-tagged trithiola-to-bridged arene ruthenium complexes in the protozoan para-sites Toxoplasma gondii and Trypanosoma brucei
<p>These are supplementary files for the manuscript entitled:</p> <p>Cellular and molecular targets of nucleotide-tagged trithiolato-bridged arene ruthenium complexes in the protozoan parasites <em>Toxoplasma gondii</em>and <em>Trypanosoma brucei</em></p> <p>submitted to International Journal of Molecular Sciences</p> <p>by: <strong>Nicoleta Anghel<sup>1¥</sup>, Joachim Müller<sup>1¥*</sup>, Mauro Serricchio<sup> 2</sup>, Jennifer Jelk <sup>2</sup>, Peter Bütikofer<sup>2</sup>, Ghalia Boubaker<sup>1</sup>, Dennis Imhof<sup>1</sup>, Jessica Ramseier<sup>1</sup>, Oksana Desiatkina<sup>3</sup>, Emilia Păunescu<sup>3</sup>, Sophie Braga-Lagache<sup>4</sup>, Manfred Heller<sup>4</sup>, Julien Furrer<sup>3</sup>, Andrew Hemphill<sup>1*</sup></strong></p>
Fig. 2. A in A large-scale study on the seroprevalence of Toxoplasma gondii infection in humans in Iran
Fig. 2. A GIS map of IgM seroprevalence of Toxoplasma gondii (Nicolle et Manceaux, 1908) in different provinces of Iran, during 2015–2020 (ND – no data).
Fig 2 in Soluble total antigen derived from Toxoplasma gondii RH strain prevents apoptosis, but induces anti-apoptosis in human monocyte cell line
Fig 2. This schematic overview suggests signaling pathways of apoptosis. Apoptosis is induced through either the extrinsic pathway or intrinsic pathway. Toxoplasma gondii can prevent cell apoptosis via inhibition of cytochrome c release from the mitochondria into the cytosol, inhibition of cas-3, -6, -7, and -9 via blocking the mitochondrial pathway, and blocking cas-8 by external pathways. The parasite may also suppress pro-apoptotic protein (Bax) and induce anti-apoptotic Bcl-2 proteins and is able to activate transcription factors STAT6 and STAT3-miR-17-92-Bim pathway to inhibit apoptosis. Some proteins of T. gondii such as ROP18 plays a role in Fas/ CD95-mediated apoptosis to inhibit this process. Similarly ROP16 phosphorylates STAT3 and STAT6 to inhibit cell death. Original (S. Nemati).
Fig 1 in Soluble total antigen derived from Toxoplasma gondii RH strain prevents apoptosis, but induces anti-apoptosis in human monocyte cell line
Fig 1. The comparison of the expression levels of Bcl-2 (A), Mcl-1 (B), Cas-7 (C), Cas-3 (D), and Bax (E) in THP-1 cell line regarding different concentrations of the soluble total antigen of Toxoplasma gondii (Nicolle et Manceaux, 1908) STAg. NS: not significant; * P value <0.05; ** P value <0.01; *** P value <0.001.
Fig. 3. A in A large-scale study on the seroprevalence of Toxoplasma gondii infection in humans in Iran
Fig. 3. A GIS map of IgG seroprevalence of Toxoplasma gondii (Nicolle et Manceaux, 1908) in different provinces of Iran, during 2015–2020.
Fig. 1 in Seroprevalence of Toxoplasma gondii infection from water buffaloes (Bubalus bubalis) in northeastern and southern Thailand
Fig. 1. Epidemiological seroprevalence of Toxoplasma gondii (Nicolle et Manceaux, 1908) in water buffaloes from northeastern and southern Thailand. Figures in parentheses are seroprevalence/number of farms/number of samples/population size.
Fig. 1 in A large-scale study on the seroprevalence of Toxoplasma gondii infection in humans in Iran
Fig. 1. The seroprevalence plot of Toxoplasma gondii (Nicolle et Manceaux, 1908) in Iran in different age groups (m-month; y-year).
Fig. 1 in Infection with Toxoplasma gondii can promote chronic liver diseases in HIV-infected individuals
Fig. 1. Frequency of different liver pathologies in deceased patients from cohorts seropositive and seronegative to Toxoplasma gondii (Nicolle et Manceaux, 1908). * – difference between the indices for the entire cohort of seropositive patients and for the group of deceased patients from this cohort (p <0.05); ^ – difference between the indices for the entire cohort of seronegative patients and for the group of deceased patients from this cohort (p <0.05)
A single-parasite transcriptional atlas of Toxoplasma gondii reveals novel control of antigen expression
Toxoplasma gondii, a protozoan parasite, undergoes a complex and poorly understood developmental process that is critical for establishing a chronic infection in its intermediate hosts. Here, we applied single-cell RNA-sequencing (scRNA-seq) on >5,400 Toxoplasma in both tachyzoite and bradyzoite stages using three widely studied strains to construct a comprehensive atlas of cell-cycle and asexual development, revealing hidden states and transcriptional factors associated with each developmental stage. Analysis of SAG1-related sequence (SRS) antigenic repertoire reveals a highly heterogeneous, sporadic expression pattern unexplained by measurement noise, cell cycle, or asexual development. Furthermore, we identified AP2 IX-1 as a transcription factor that controls the switching from the ubiquitous SAG1 to rare surface antigens not previously observed in tachyzoites. In addition, comparative analysis between Toxoplasma and Plasmodium scRNA-seq results reveals concerted expression of gene sets, despite fundamental differences in cell division. Lastly, we built an interactive data-browser for visualization of our atlas resource.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.