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113 results for “adult survival”
Blood cell differential count discretization modeling predicts survival in adults reporting to the emergency room: a retrospective cohort study
<p><strong>Objectives</strong>: to assess survival predictivity of baseline blood cell differential count (BCDC), discretized according to two different methods, in adults visiting the Emergency Room (ER) for illness or trauma over one-year. </p> <p><strong>Design</strong>: Retrospective cohort study of hospital records. </p> <p><strong>Setting</strong>: Tertiary care public hospital in northern Italy. </p> <p><strong>Participants</strong>: 11052 patients aged > 18 years, consecutively admitted to the ER in one year, and for whom BCDC collection was indicated by ER medical staff at first presentation.</p> <p><strong>Primary outcome</strong>: Survival was the referral outcome for explorative model development. Automated BCDC analysis at baseline assessed hemoglobin, red cell mean volume (MCV) and distribution-width (RDW), platelet distribution-width (PDW), plateletcrit (PCT), absolute red blood cells, white blood cells, neutrophils, lymphocytes, monocytes, eosinophils, basophils, and platelets. Discretization cutoffs were defined by Benchmark and Tailored methods. Benchmark cutoffs were stated on laboratory reference values (CLSI). Tailored cutoffs for linear, sigmoid-shaped and for U-shaped distributed variables were discretized by Maximally Selected Rank Statistics and by Optimal-Equal Hazard Ratio respectively. Explanatory variables (age, gender, ER admission during SARS-CoV2 surges, in-hospital admission) were analyzed using Cox multivariable regression. ROC curves were drawn by sum of Cox-significant variables for each method.</p> <p><strong>Results</strong>: Of 11052 patients (median age 67 years, IQR 51–81, 48% female), 59% (n=6489) were discharged and 41% (n=4563) were admitted in hospital. After a 306-day median follow up (IQR 208–417 days), 9455 (86%) patients were alive and 1597 (14%) deceased. Increased HRs were associated with age >73-years (HR=4.6 CI=4.0–5.2), in-hospital admission (HR=2.2 CI=1.9–2.4), ER admission during SARS-CoV2 surges (Wave-I HR=1.7 CI=1.5–1.9); Wave-II HR=1.2 CI=1.0–1.3). Gender, hemoglobin, MCV, RDW, PDW, neutrophils, lymphocytes and eosinophils counts were significant in overall. Benchmark-BCDC model included basophils and platelet count (AUROC 0.74). Tailored-BCDC model included monocyte counts and plateletcrit (AUROC 0.79).</p> <p><strong>Conclusions</strong>: baseline discretized BCDC provides meaningful insight regarding Emergency Room patients survival.</p>
The Impact of Time-of-day-Dependent Administration of Nivolumab-Ipilimumab (ICI/ICI) Combination on Overall Survival in Adults With Advanced Kidney Cancer: A Pragmatic Multicenter, Randomized Controll
ClinicalTrials.gov study NCT07338981. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
Retrospective Analysis of Survival in Adult MRD Positive Acute Lymphoblastic Leukemia Patients
ClinicalTrials.gov study NCT02010931. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Establishment of a Lifetime of Cohort of Adults Surviving Childhood Cancer
ClinicalTrials.gov study NCT00760656. IPD Sharing: Not stated. Countries: 1. Publications: 12.
REal World Data in LYmphoma and Survival in Adults
ClinicalTrials.gov study NCT03869619. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Historical Data Analysis of Hematological Remission and Survival in Adults With R/R Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT02003612. IPD Sharing: Not stated. Countries: 8. Publications: 2.
Data from: Anthropogenic host plant expansion leads a nettle-feeding butterfly out of the forest: consequences for larval survival and developmental plasticity in adult morphology
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Data from: Survival of adult Steller sea lions in Alaska: senescence, annual variation and covariation with male reproductive success
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The diversity of maternal-age effects upon pre-adult survival across animal species
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Data from: Effects of food restriction across stages of juvenile and early adult development on body weight, survival, and adult life history
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Data from: Sustainability management of short-lived freshwater fish in human-altered ecosystems should focus on adult survival
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Exceptionally high apparent adult survival in three tropical species of plovers in Madagascar
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Data from: Early-life disease exposure and associations with adult survival, cause of death, and reproductive success in preindustrial humans
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Data from: Experiencing El Niño conditions during early life reduces recruiting probabilities but not adult survival
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Data from: Natal habitat and sex-specific survival rates result in a male-biased adult sex ratio
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Adult survival in migratory caribou is negatively associated with MHC functional diversity
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Blood cell differential count discretization modeling predicts survival in adults reporting to the emergency room: a retrospective cohort study
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Data from: Geographic variation and environmental correlates of apparent survival rates in adult tree swallows Tachycineta bicolor
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Data from: Food availability affects adult survival trajectories depending on early developmental conditions
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Coping with seasonality: dynamics of adult body mass and survival in an alpine hibernator
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.