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1,046 results for “anti-inflammatory”
Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans
ClinicalTrials.gov study NCT01375491. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Using the Cholinergic Anti-Inflammatory Pathway to Treat Systemic Lupus Musculoskeletal Pain
ClinicalTrials.gov study NCT02822989. IPD Sharing: NO. Countries: 1. Publications: 1.
Polymodal potassium channel modulation contributes to dual analgesic and anti-inflammatory actions of ancient botanical medicines
Open the record for dataset details and reuse information.
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
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Data from: Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer's disease mortality
Alzheimer disease (AD) mortality risk in a large cohort of subjects treated or not with non-steroidal anti-inflammatory drugs (NSAIDs) is unknown. Our objective was to determine whether NSAIDs use is associated with decreased risk of AD mortality. Methods: In this prospective, population-based study (Neurological Disorders in Central Spain [NEDICES]) of 5,072 people without AD (aged 65 years and older), sociodemographic, comorbidity factors, and current medications were recorded at baseline. Community-dwelling older adults were followed for a median of 12.7 years, after which the death certificates of deceased participants were examined. 2,672 (52.7%) of 5,072 participants died, including 504 (18.9%) NSAIDs users and 2,168 (81.1%) non-users. Of the 2,672 deceased participants, 113 (4.2%) had AD as a cause of death (8 [1.6%] among NSAIDs users and 105 [4.8%] among non-users, chi-square = 10.70, p=0.001). In an unadjusted Cox model, risk of AD mortality was decreased in NSAIDs users (hazard ratio [HR] for AD mortality = 0.35, 95% confidence interval [CI] 0.17–0.72, p=0.004) when compared to non-users. After adjusting for numerous demographic factors and co-morbidities, the HR for AD mortality in NSAIDs users was 0.29, 95% CI 0.12–0.73, p=0.009. Stratified analyses showed a significantly decreased risk of AD mortality with aspirin, whereas non-aspirin NSAIDs only showed a statistical trend toward significance in the adjusted Cox regression models. NSAIDs use was associated with 71% decreased risk of AD mortality in older adults. Our results support the hypothesis that NSAIDs use is a protective factor of developing AD.
Fig. 4 in Biotransformation of betulinic acid by Circinella muscae and Cunninghamella echinulata to discover anti-inflammatory derivatives
Fig. 4. Inhibition against NO production of betulinic acid, 1–4, and 7–10 in LPS-induced RAW 264.7 cells.
Resistance exercise with anti-inflammatory foods attenuate skeletal muscle atrophy induced by chronic inflammation
<p>Supplemental figures and table of "Resistance exercise with anti-inflammatory foods attenuate skeletal muscle atrophy induced by chronic inflammation".</p>
Computational Modeling of the Anti-Inflammatory Complexes of IL37
<p>This repository contains IL37 complex structures that are implicated in anti-inflammation.</p>
Data from: Diosmin and its glycocalyx restorative and anti-inflammatory effects on injured blood vessels
<p>Endothelium, a crucial homeostatic organ, regulates vascular permeability and tone. Under physiological conditions, endothelial stimulation induces vasodilator endothelial nitric oxide (eNO) release and prevents adhesion molecule accessibility and leukocyte adhesion and migration into vessel walls. Endothelium dysfunction is a principal event in cardiovascular disorders, including atherosclerosis. Hence, current therapies focus on endothelium repair to prevent downstream cardiovascular events. However, minimal attention is given to the restoration of mechanotransducer endothelial glycocalyx (GCX), a negatively charged heterogeneous polysaccharide, which covers and protects endothelial cells. Endothelial GCX shedding plays a role in endothelial dysfunction, increasing vascular permeability and decreasing vessel tone. Diosmin, a flavone glycoside of diosmetin, downregulates adhesive molecule expression, decreases inflammation and capillary permeability, and upregulates eNO expression. Due to these pleiotropic effects of diosmin on the vasculature, a possible unidentified mechanism of action is through GCX restoration. Diosmin effect on GCX and endothelial function were assessed in a partial ligation left carotid artery (LCA) mouse model where the right carotid artery was the control for each mouse. Diosmin (50 mg/kg) was administered daily for 7 days, 48 hours after ligation. Within the ligated mice LCAs, diosmin treatment elevated the activated eNO synthase level, inhibited inflammatory cell uptake, decreased vessel wall thickness, increased vessel diameter, and increased GCX coverage of the vessel wall. ELISA showed a decrease in hyaluronan concentration in plasma samples of diosmin-treated mice, signifying reduced GCX shedding. In summary, diosmin supported endothelial GCX integrity, which preserved endothelial function by attenuating expression of inflammatory factors and restoring vascular tone.</p>
Measurement of TNF‐α, CK-MB, LDH, IL‐1 and IL-6 levels for anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p>Measurement of TNF‐α, CK-MB, LDH, IL‐1 and IL-6 levels for anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</p>
The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p>The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</p>
The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study
<p><a href="https://zenodo.org/deposit/7360384">The ARRIVE Essential 10: author checklist – Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: an observational study</a></p>
Underlying data for Evaluation of the antioxidant and anti-inflammatory effect of sublingual glutathione on COPD patients: an observational study
<p>Underlying data for Evaluation of the antioxidant and anti-inflammatory effect of sublingual glutathione on COPD patients: an observational study</p>
FIG. 3 in A potent anti-inflammatory response in bat macrophages may be linked to extended longevity and viral tolerance
FIG. 3. Bat-specific sites under positive selection in the investigated immune genes. Sites that had statistically significant evidence of positive selection acting across eutherian mammals were investigated for any amino acid substitutions unique to the ancestral bat lineage, the vespertilionid lineage or the pteropodid lineage. Bat lineages-specific sites are highlighted in yellow
FIG. 2 in A potent anti-inflammatory response in bat macrophages may be linked to extended longevity and viral tolerance
FIG. 2. Signatures of adaptive evolution in genes involved in sensing of viral infection and activation of antiviral/proinflammatory signalling. Genes under positive selection (site-test) in mammals are highlighted in green. Genes with sites under positive selection in bat lineages are indicated with an asterix
FIG. 1. Myotis myotis and M in A potent anti-inflammatory response in bat macrophages may be linked to extended longevity and viral tolerance
FIG. 1. Myotis myotis and M. musculus macrophages present differential response to LPS and Poly(I:C) challenge. Change in gene expression of A — IFN-β, B — IL-1β, C — TNF, D — Il-10 in response to LPS and Poly(I:C) treatment at 1, 4 and 24 hr time points are presented as changes in delta Ct values normalized to actin-β. Ratios of the fold induction of anti-inflammatory Il-10 to proinflammatory TNF (E) and Il-1β (F) are also presented. G — Literature derived Il-10/TNF ratios for other mammals. H — NO generated by stimulated M. myotis and mouse macrophages. Bars represent the mean of two experimental repeats ± SEM. Presented P -values indicate the significance of the difference between species from analysis of variance (ANOVA)
Fig. 8 in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 8. The inhibition of p-IκK, p-IκBα and p-p65 NF-κB protein expression by compound 4 in LPS induced RAW264.7 cells.
Fig. 6 in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 6. (A)The inhibition of iNOS protein expression by compound 4 in LPS induced RAW264.7 cells; (B) Compound 4 was positioned in the interacting pocket of iNOS (PDB: 3E7G); (C) 2D interaction diagram of compound 4 at the active site of iNOS.
Fig. 4. Main 1H–1H in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 4. Main 1H–1H gCOSY (blue thick lines) and HMBC correlations (red arrows, from 1H to 13C) of 2–5. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2. Main 1H–1H in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 2. Main 1H–1H gCOSY (blue thick lines), HMBC (red arrows, from 1H to 13C) and Key NOESY (blue double arrows) correlations of 1 and 2. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.