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350 results for “antibacterial”
Data from: Photothermal-assisted antibacterial application of GO-Ag nanocomposites against clinical isolated MDR E. coli
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Bacterial mediated green synthesis of silver nanoparticles and their antibacterial and antifungal activities against drug-resistant pathogens
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Rapid synthesis and characterization of silver-loaded graphene oxide nanomaterials and their antibacterial applications
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Drosophila survival after infection and Buletin antibacterial activity data
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Machine learning in mass spectrometry: A MALDI-TOF MS approach to phenotypic antibacterial screening
<p>Dataset relating to the publication:</p> <p>Machine learning in mass spectrometry: A MALDI-TOF MS approach to phenotypic antibacterial screening</p> <p>by Luuk Nico van Oosten and Christian D. Klein</p> <p>Published in the Journal of Medicinal Chemistry, 2020</p> <p><strong>Important notice:</strong></p> <p><strong>The data are free to use for non-commercial, academic purposes, provided that the original source is<br> cited and the authors and the publication are credited in any derivative work.</strong></p> <p><strong>A patent application has been filed for the method described by van Oosten and Klein, which uses mass<br> spectrometry and machine learning to identify the pharmacological or other effects of compounds on cell<br> cultures and other biological systems.</strong></p> <p>Therefore, a license for the commercial use of the method must be negotiated by contacting either</p> <p>Anke Faller<br> Universität Heidelberg<br> Dezernat Forschung<br> Rechts- und Strukturfragen der Forschungsförderung<br> Seminarstraße 2, 69117 Heidelberg<br> Tel. +49 6221 54-12611<br> anke.faller(at)zuv.uni-heidelberg.de</p> <p>or</p> <p>Prof. Dr. C. Klein; c.klein(at)uni-heidelberg.de<br> Medicinal Chemistry<br> Institute of Pharmacy and Molecular Biotechnology IPMB<br> Heidelberg University, INF 364<br> D-69120 Heidelberg<br> Germany<br> Phone: ++49-6221-54-4875<br> FAX : ++49-6221-54-6430</p> <p> </p>
Preparation of Polyacrylonitrile-based fibres with chelated Ag ions for antibacterial applications
<p>The need for an excellent antibacterial material that is sufficiently powerful to never develop bacterial resistance is urgent. In this study, a series of novel polyacrylonitrile-based fibres with chelated Ag ions (referred to as Ag-SH-PANF) were prepared by a two-step chemical modification process: grafting and chelating. The properties of the as-prepared Ag-SH-PANF were characterised by Fourier-transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). The antibacterial activities of Ag-SH-PANF were examined against pathogenic bacteria, and an antibacterial mechanism was explicated based on the release of Ag ions from the fibres' surfaces. The results showed that, although chelation occurred between the Ag ions and the grafted amino and sulfhydryl groups, Ag-SH-PANF retained its fine microstructure and thermal stability. Moreover, Ag-SH-PANF displayed excellent antibacterial ability against pathogenic bacteria as well as good washing durability. In terms of the antibacterial mechanism, Ag ions are the main bactericidal agents in the role of catalysts, and are not consumed in the antibacterial process. Nonetheless, a relatively higher concentration of Ag ions can accelerate the bactericidal process.</p>
Improved antibacterial activity of hemp fibres by covalent grafting of quaternary ammonium groups
<p><span><span>In this study, novel antibacterial hemp fibres grafted with </span></span>quaternary<span><span> ammonium groups, named HF-GTA, were prepared by alkalisation, oxidation, amination, and quaternisation multistage reactions. The chemical structure and micromorphology of the fibres were characterised by Fourier-transform infrared spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and X-ray diffraction. The grafting and reaction mechanisms were proved to be successful, which indicated that the grafting reaction primarily occurred on the </span></span>hydroxyl <span><span>groups of cellulose and hemicellulose in the hemp fibres, where they retained good fibrous morphology, thermal stability and hygroscopicity. The antibacterial activity of HF-GTA exhibited the best antibacterial activity, where the antibacterial ratios against <i><span>E. coli </span></i>and <i><span>S. aureus</span></i> were 95.41% and 99.64%, respectively. <span>E</span><span>ven </span><span>a</span><span>fter 30 times of washing</span><span>, </span><span>the antibacterial activity </span><span>wa</span><span>s</span><span> retained</span><span> at </span><span>89.78% and 91.12%</span><span>,</span><span> indicating that HF-GTA </span><span>wa</span><span>s</span><span> endowed with good washing resistance. </span>The antibacterial mechanism occurred because the electrostatic reaction reduced the electrochemical potential on the cell membrane, leading to the release of cytoplasmic substances and the dissolution of cells, thereby producing antibacterial activity. It would be significantly important to guarantee textile quality and prevent disease transmission. </span></span></p>
Inhibition mechanism and antibacterial activity of natural antibacterial agent citral on bamboo mold and its anti- mildew effect on bamboo
<p><span><span>Bamboo, a natural material, has been widely used in the fields of decoration, architecture and furniture. However, bamboo is easy to mildew and lose its use value. In this paper, inhibition mechanism and antibacterial activity of natural antibacterial agent citral on bamboo mold and its anti- mildew effect on bamboo were studied. The results showed that citral could change the shape of mycelium, destroy the integrity of mycelium structure, cell wall, and cell membrane structure, thereby causing leakage of nucleic acid, protein, and other substances in the cell, as well as destroy the pH balance of the inside and outside of the cell, to inhibit or kill mold. When the concentration of citral is 100mg/mL, the antibacterial rates of citral against <i>Penicillium citrinum </i>(PC), <i>Trichoderma viride</i> (TV), <i>Aspergillus niger</i> (AN) and a hybrid fungi group comprising PC, TV, and AN (Hun) were more than 100%. However, compared with the direct effect of citral on mold, the antibacterial property of bamboo treated with citral was significantly reduced, the mildew proof effect can be achieved only if the concentration of citral to treat bamboo is increased to more than 2 times of the concentration of citral directly acting on mold.</span></span></p>
A superfine glass fiber air filter with rapid response to photocatalytic antibacterial properties under visible light by loading rGO/ZnO
<p class="15"> The development of high-performance air filter has become more and more important to public health. However, it has always been very challenging for developing a multifunctional air filter to simultaneously achieve excellent filtration and antibacterial properties. Herein, a versatile air filter was prepared with loading the reduced graphener and Zinc oxide on the superfine glass fiber with the three-dimensional network structure by in-situ sol-gel process followed by calcination, which aims to achieve synergistic high efficiency air filtration and rapid response to photocatalytic antibacterial under visible light. The air filter showed a three-dimensional network structure based on a rGO/ZnO/s-GF multilayer and exhibited the highest catalytic performance by achieving a 95% degradation effect on Rhodamine B within 2 h and achieving 100% antibacterial inactivation of the Escherichia coli and Staphylococcus aureus within 4 h under visible light when the weight ratio of rGO in rGO/ZnO is 1.6%. The air filtration efficiency can also be maintained at 99% after loading Zno and rGO photocatalytic particles. The spectrum of PL, DRS and ERS indicate that the combination of rGO and ZnO on the s-GF can increase the separation of photo-generated carriers and the specific surface area of the air filter, thereby increasing the photocatalytic response and antibacterial properties of the s-GF air filter under visible light in a short time.</p> <p> </p>
Synthesis of antibacterial gold nanoparticles with different particle size using chlorogenic acid
<p><span>This study proposes a strategy for the rapid and simple synthesis of gold nanoparticles (CGA-AuNPs) with different particle size using trisodium citrate (TSC) as the first reducing agent and chlorogenic acid (CGA) as the second reducing agent. And the antibacterial activity of CGA-AuNPs with different particle size in vitro was verified by measuring the growth curves of <i>Escherichia coli</i> (<i>E. coli ATCC 25922</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus ATCC 25923</i>). The CGA-AuNPs obtained by analysis of transmission electron microscope (TEM) images and UV-visible Spectra were mainly spherical, and the average diameters were 18.94±1.81nm, 30.42±6.32nm, 37.86±3.80nm, 48.72±6.47nm respectively. High-resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SAED) showed that these nanoparticles were polycrystalline gold structures. Both of CGA-AuNPs and CGA have excellent antibacterial activity, and CGA-AuNPs with small particle size has a stronger antibacterial effect than the larger one. UV-visible absorption spectrum data revealed that the synthesized CGA-AuNPs without adding other stabilizing agent were well maintained even after 26 days. This work provides a special idea to regulate the size of CGA-AuNPs with CGA by chemical synthesis, and the strong antibacterial activity of these CGA-AuNPs may be applied in the field of antibacterial in the future.</span></p>
Data from: Spatial and seasonal influences on culturable endophytic mycobiota associated with different tissues of Eugenia jambolana Lam. and their antibacterial activity against MDR strains
Background: Present study focuses on diversity and distribution analysis of endophytic fungi associated with different tissues of Eugenia jambolana. The influence of season and geographical location on diversity and distribution of endophytic fungi has been analyzed. Antibacterial activity of isolated fungal species has also been investigated against MDR bacterial strains. Result: A total of 1896 endophytic fungal isolates were obtained from healthy, surface sterilized tissues of leaf, stem and petiole tissues during summer, monsoon and winter season. Out of 24 fungal species isolated, 20 species belong to class Ascomycetes, 2 to Basidiomycetes and 2 to Zygomycetes. Maximum species diversity was in rainy season whereas colonization frequency was in winter. All the diversity indices showed maximum species diversity at site 5 (Yamunanager), rainy among the seasons and leaf among the tissues studied. Aspergillus genus was most frequently isolated. Aspergillus niger and Alternaria alternata were most dominant species. Three way ANOVA results showed that effect of season was highly significant on species diversity in relation to sites and tissues. 60% endophytic fungal extracts showed significant antibacterial activity against one or more than one MDR bacterial strain. Conclusion: Different fungal species were recovered from different sites but the inter-site comparisons were not significant according to Jaccard similarity coefficient. Diversity of such fungal endophytes indicates that Eugenia jambolana plant acts as an ecosystem facilitating survival of many microbes with impressive antibacterial potential.
Supporting MD trajectories for the paper "In Situ Captured Antibacterial Action of Membrane-Incising Peptide Lamellae"
<p>Source data and molecular dynamic trajectories for the article "In Situ Captured Antibacterial Action of Membrane-Incising Peptide Lamellae"</p> <p>New compounds with unique mechanisms of action are needed to combat the growing issue of antimicrobial resistance. Supramolecular assemblies, which combine the complex membrane attacking mechanisms of natural host defense peptides with the improved biostability of non-natural compounds offer a promising alternative to current small molecule antibiotics. However, for such membrane-targeting compounds the direct visual insight on the toxic agents in bacteria is still lacking. To this end, we employed a design strategy focusing on an inducible assembly mechanism and utilized electron microscopy (EM) to follow the formation of supramolecular peptide structures triggered by bacterial cell surface lipopolysaccharides (LPS). Inspired by the alternating chirality backbone pattern of some effective peptide antimicrobials, we designed lysine-rich heterochiral β3-peptides, termed lamellin-2K and lamellin-3K, with optimal residual spacing for enhanced coordination on the phosphate groups of LPS. Combined molecular dynamics simulations (MD), EM and bacterial assays confirmed that the phosphate-induced conformational change of these lamellins led to the formation of thin, striped lamellar layers, where each stripe represents double arrays of H-bonded peptide molecules that are interconnected by phosphate ions. EM micrographs of Gram-negative bacteria show that the lamellae incised the cell envelope, while leakage and antibacterial activity assays prove that growth inhibition starts already at submicromolar concentrations. Detailed image analysis demonstrated that the lamellae penetrating deep into the bacterial cell have a rather uniform size distribution and, surprisingly, only a few of these supramolecules are sufficient to cause major cell wall damage making them efficient in destroying target cells. Our findings also provide a missing mechanistic link for membrane-targeting agents, connecting how the antibiotic mechanism is built up from individual molecules through on-site formation of the active supramolecules that lead to bactericidal activity.</p> <p>Molecular dynamics trajectories from the production runs of single beta-peptide strands in water + 150 mM NaCl + 50:1 MePO4^(2-):peptide. Altogether 8 runs were performed, each one starting from a different helical conformation (H10, H12 and H14, both positive and negative winding) of the peptide. In the first half (500 ns) of the simulation, the intra-chain hydrogen bonds responsible for the actual helix were kept together by distance restraints. In the second half (again 500 ns), these restraints were instantaneously lifted and the system was left to evolve from the same state. In all cases the helical structure unwound in a very short time (under 100 ns), and did not refold in any helix.</p>
Data from: Effects of poly(vinyl alcohol) blending with Ag/alginate solutions to form nanocomposite fibers for potential use as antibacterial wound dressings
<p>The first set of data comprise FTIR spectra of Ca-alginate, Ag/Ca-alginate, pure PVA, PVA/Ca-alginate, and PVA/Ag/Ca-alginate fibers. The fibers were obtained by extrusion and gelation of the aqueous solutions with following compositions: for Ag/Ca-alginate fibers - 1.27 ± 0.08 w/v Na-alginate and AgNPs at 2.6 mM, for Ca-alginate fibers - 1.27 ± 0.08 w/v Na-alginate, for PVA fibers - 5.7 % w/v PVA, for PVA/Ca-alginate fibers - 5.7 % w/v PVA and 1.27 ± 0.08 w/v Na-alginate, and for PVA/Ag/Ca-alginate fibers - 5.7 % w/v PVA, 1.27 ± 0.08 w/v Na-alginate and AgNPs at 2.6 mM.</p> <p>The second set of data are UV-Visible absorption spectra of the initial PVA/Ag/Na-alginate colloid solution (5.7 % w/v PVA, 1.27 ± 0.08 w/v Na-alginate, 2.6 mM nominal silver concentration) and resulting fibers produced after gelling of alginate after dissolution in 2.28 % w/v sodium citrate solution.</p> <p>The third set of data are force and stroke values over time measured by using a Universal Testing Machine for Ca-alginate fibers obtained from the 1.27 ± 0.08 % w/v Na-alginate solution and PVA/Ca-alginate fibers, obtained from the solution containing 5.67 % w/v PVA and 1.27 ± 0.08 % w/v Na-alginate at the initial time, and after drying and rehydration for 24 h and 48 h in physiological saline solution. </p>
Adhesive Antibacterial Moisturizing Nanostructured Skin Patch for Sustainable Development of Atopic Dermatitis Treatment in Humans [Swelling studies]
<p>Adhesive Antibacterial Moisturizing Nanostructured Skin Patch [Swelling studies]</p>
Supplementary Data for "Molecular Docking, ADMET, Synthesis and Evaluation of New Indomethacin Hydrazide Derivatives as Antibacterial Agents"
<p>This supplementary data file contains additional information supporting the findings presented in the research article "<strong>Molecular Docking, ADMET, Synthesis and Evaluation of New Indomethacin Hydrazide Derivatives as Antibacterial Agents</strong>". The data includes:</p> <ul> <li>Infrared (IR) spectra of the synthesized compounds</li> <li>Proton nuclear magnetic resonance (H NMR) spectra of the synthesized compounds</li> <li>Minimum inhibitory concentration (MIC) and zone of inhibition (ZOI) data for the synthesized compounds against tested microorganisms</li> </ul>
DATASET for the article "Synthesis and Antibacterial Activity of Polymerizable Acryloyloxyalkyltriethyl Ammonium Salts"
<p>The files contains:</p> <p>- A visual description of the experiments performed for the synthesis of a representative polymerizable surfactant (acryloyloxyundecyltriethylammonium bromide, AUTEAB), reported in the paper published in ChemPlusChem 2017, 82, 1235-1244 (in PDF format);</p> <p>- The raw data obtained in the assessment of the biological activity of the polymerizable surfactants synthesized in the paper published in ChemPlusChem 2017, 82, 1235-1244 (in Excel format)</p> <p> </p> <p> </p>
Data described in the article "Design and evaluation of composite films for in situ synthesis and antibacterial activity of allicin vapour"
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Dataset of the paper Antibacterial plant combinations prevent postweaning diarrhea in organically raised piglets challenged with enterotoxigenic Escherichia coli F18
<p>Dataset of the paper: Antibacterial plant combinations prevent postweaning diarrhea in organically raised piglets challenged with enterotoxigenic Escherichia coli F18</p> <p>meta_data: tracking information</p> <p>my_raw_data: raw data</p> <p>my_table: processed data</p> <p> </p>
Fig. 5 in In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds
Fig. 5. Anti-proliferative effect of isolated compounds and standard adriamycin at different concentrations. Growth between 0% and 50% indicated a cytostatic effect, while growth <0% indicated a cytocidal effect. (a) Percent control growth for MCF-7 cell line and (b) percent control growth for MDA-MB-468.
Fig. 2 in In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds
Fig. 2. Percentage scavenging activities of different fractions of P. dulcis at different concentrations. (a) DPPH radical scavenging activity, (b) Scavenging of hydrogen peroxide, (c) Percentage iron chelation, (d) Superoxide radical scavenging activity and (e) Reducing power of different fractions of P. dulcis (in %) at different concentrations. Each value represents as mean ± SD (n = 3). HF, hexane fraction; EF, ethyl acetate fraction; BF, butanol fraction; AqF, aqueous fraction. SD, standard deviation.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.