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1,445 results for “attenuation”
Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
<p>Omicron recently emerged sub-lineage BA.5, together with BA.4, caused a 5th wave of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a predominant strain globally due to its high transmissibility. The lethality of BA.5 infection has not been studied in acute hACE2 transgenic (hACE2.Tg) mice models. Here, we investigated tissue-tropism and immuno-pathology induced by BA.5 infection in hACE2.Tg mice. Our data show that intranasal BA.5 infection in hACE2.Tg mice result in attenuated pulmonary infection and pathology with diminished COVID-19-induced clinical and pathological manifestations. BA.5, similar to Omicron (B.1.1.529), infection led to attenuated production of inflammatory cytokines, anti-viral response and effector T cell response as compared to the ancestral strain. Mice recovered from B.1.1.529 infection showed robust protection against BA.5 infection with reduced lung viral load and pathology. Our data provide insights as to why BA.5 infection escapes previous SARS-CoV-2 exposure induced-T cell immunity but may result in milder immuno-pathology and alleviated chances of re-infectivity in Omicron-recovered individuals.</p>
Dataset from 'Klever, L., Islam, J., Võ, M., & Billino, J. (2023). Aging attenuates the memory advantage for unexpected objects in real-world scenes. Heliyon, e20241, doi: 10.1016/j.heliyon.2023.e20241
<p>We provide two files; one data file contains data on which analyses are based, the other one gives the column labels for the data file.</p> <p>___________________________________________<br> For further questions, please contact:<br> jutta.billino[at]psychol.uni-giessen.de</p>
Pivotal Study to Evaluate Safety and Immunogenicity of a Live-Attenuated Chikungunya Virus Vaccine Candidate in Adults
ClinicalTrials.gov study NCT04546724. IPD Sharing: NO. Countries: 1. Publications: 2.
A Multicenter Study to Evaluate Safety and Immunogenicity of a Live-attenuated Chikungunya Vaccine in Adolescents
ClinicalTrials.gov study NCT04650399. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Immunologic Responses to a Live Attenuated Oral Cholera Vaccine
ClinicalTrials.gov study NCT03251495. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) During Malaria Transmission Season in Healthy African Adult Women of Chil
ClinicalTrials.gov study NCT03989102. IPD Sharing: NO. Countries: 1. Publications: 7.
Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging
ClinicalTrials.gov study NCT01336140. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase II Trial of a Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy Adults in Thailand
ClinicalTrials.gov study NCT00370682. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Immunogenicity Study to Assess TDV, a Live Attenuated Tetravalent Vaccine for Prevention of Dengue Fever
ClinicalTrials.gov study NCT01224639. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of ChimeriVax™-JE Live Attenuated Vaccine in Healthy Adults
ClinicalTrials.gov study NCT00981175. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of a Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV™) Compared to CD.JEVAX™ in Toddlers
ClinicalTrials.gov study NCT01396512. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Immunogenicity of Various Formulations of Live Attenuated Tetravalent Dengue Vaccine in Healthy US Adults
ClinicalTrials.gov study NCT00350337. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2
ClinicalTrials.gov study NCT01656200. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal
ClinicalTrials.gov study NCT05114460. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Bridging Study Between V181 (Dengue Quadrivalent Vaccine rDENVΔ30 [Live, Attenuated]) to Butantan Dengue Vaccine (Butantan - DV) in Healthy Adults 18 to 50 Years of Age in Brazil (V181 - 002)
ClinicalTrials.gov study NCT05710224. IPD Sharing: YES. Countries: 1. Publications: 0.
Evaluating the Infectivity, Safety, and Immunogenicity of a Single Dose of a Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccine (D46/NS2/N/ΔM2-2-HindIII) in RSV-Seronegative Infants 6 to
ClinicalTrials.gov study NCT03102034. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Immunogenicity of a Live-attenuated Universal Flu Vaccine Followed by an Inactivated Universal Flu Vaccine
ClinicalTrials.gov study NCT03300050. IPD Sharing: NO. Countries: 1. Publications: 3.
A Randomized, Controlled Trial on the Efficacy and Safety of Live-Attenuated Influenza Vaccine (LAIV) Among Children in Bangladesh
ClinicalTrials.gov study NCT01797029. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Phase I/II Trial of Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naive Infants
ClinicalTrials.gov study NCT00322049. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Evaluating the Infectivity, Safety, and Immunogenicity of Recombinant Live-Attenuated RSV Vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 in RSV-Seronegative Infants 6 to 24 Months of Age
ClinicalTrials.gov study NCT03227029. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.