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495
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ShareScore release 0.9.0
Dataset results
495 results for “brain development”
Label-free three-photon imaging of intact human cerebral organoids: Tracking early events in brain development and deficits in Rett Syndrome
<p>Human cerebral organoids are unique in their development of progenitor-rich zones akin to ventricular zones from which neuronal progenitors differentiate and migrate radially. Analyses of cerebral organoids thus far have been performed in sectioned tissue or in superficial layers due to their high scattering properties. Here, we demonstrate label-free three-photon imaging of whole, uncleared intact organoids (~2 mm depth) to assess early events of early human brain development. Optimizing a custom-made three-photon microscope to image intact cerebral organoids generated from Rett Syndrome patients, we show defects in the ventricular zone volumetric structure of mutant organoids compared to isogenic control organoids. Long-term imaging of live organoids reveals that shorter migration distances and slower migration speeds of mutant radially migrating neurons are associated with more tortuous trajectories. Our label-free imaging system constitutes a particularly useful platform for tracking normal and abnormal development in individual organoids, as well as for screening therapeutic molecules via intact organoid imaging.</p>
DeepCellMap: a Deep Learning Approach Coupled to Spatial Statistics to unravel Microglial Spatial Organization in the Developing Human Brain
<p>DeepCellMap is a deep-learning-assisted tool that integrates multi-scale image processing with advanced spatial and clustering statistics. This pipeline is designed to map microglial organization during normal and pathological brain development but can be adapted to any cell type.} Using DeepCellMap, we can capture the morphological diversity of microglia, identify strong coupling between proliferative and phagocytic phenotypes, and show that distinct spatial clusters rarely overlap as human brain development progresses. Additionally, we uncover a novel association between microglia and blood vessels in fetal brains exposed to maternal SARS-CoV-2. These findings offer insights into whether various microglial phenotypes form networks in the developing brain to occupy space, and in conditions involving haemorrhages, whether microglia respond to, or influence changes in blood vessel integrity. DeepCellMap is available as open-source software and is a powerful tool for extracting spatial statistics and analyzing cellular organization in large tissue sections, accommodating various imaging modalities. </p>
Understanding brain waste: Unequal opportunities for skills development between highly skilled women and men, migrants and nonmigrants
<p>Brain waste studies seldom analyse the skills development of tertiary-educated</p> <p>workers according to gender and country of origin. Combining statistical analyses,</p> <p>participatory workshops and 77 qualitative interviews on employment trajectories</p> <p>with highly skilled workers in Switzerland, I offer three contributions. An</p> <p>intersectional perspective reveals unequal opportunities of skills development:</p> <p>Swiss-born men have the highest rates of employment, income and jobs commensurate</p> <p>with their education, followed by foreign-born men, then Swiss-born women</p> <p>and lastly foreign-born women. Second, a multiscalar perspective shows how actions</p> <p>by individuals, families, employers and the state favour or constrain skills advancement</p> <p>among women and men. Individual perceptions of gender roles and unequal</p> <p>childcare responsibilities within couples constrain women's skills development. Further</p> <p>constraints are set by the state and employers' policies and practices regarding</p> <p>migration, childcare, taxation and hiring. Third, a spatial–temporal perspective unveils</p> <p>that gender inequalities arise at particular moments (migration and childbirth) and</p> <p>places (lacking childcare services and limited employment).</p>
Early Brain Development in Twins
ClinicalTrials.gov study NCT01409746. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Creating a Calmer NICU: Optimizing Growth and Brain Development in Preterm Infants
ClinicalTrials.gov study NCT04911452. IPD Sharing: NO. Countries: 1. Publications: 5.
Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development
ClinicalTrials.gov study NCT02058225. IPD Sharing: NO. Countries: 1. Publications: 3.
Characterization of the Functional and Structural Development of the Human Neonatal Brain From 30 Wks to 45 Wks ga
ClinicalTrials.gov study NCT02170142. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Orchestra in Class, a Novel Booster for Executive Functions and Brain Development in Young Primary School Children
ClinicalTrials.gov study NCT05912270. IPD Sharing: NO. Countries: 1. Publications: 1.
Brain Development Research Program
ClinicalTrials.gov study NCT00305305. IPD Sharing: Not stated. Countries: 1. Publications: 19.
Prenatal Drug Exposure: Effects on the Adolescent Brain and Behavior Development
ClinicalTrials.gov study NCT01020669. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effects of Music Intervention on the Brain Development of Preschool Children
ClinicalTrials.gov study NCT01275001. IPD Sharing: Not stated. Countries: 1. Publications: 7.
A Study of the Impact of Hemophilia and Its Treatment on Brain Development, Thinking and Behaviour in Children With Hemophilia
ClinicalTrials.gov study NCT03660774. IPD Sharing: YES. Countries: 1. Publications: 2.
Infant Nutrition and Brain Development
ClinicalTrials.gov study NCT03111927. IPD Sharing: NO. Countries: 1. Publications: 1.
Community Kangaroo Mother Care for Improving Child Survival and Brain Development in Low Birth Weight Newborns
ClinicalTrials.gov study NCT02631343. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments (CameraCue)
ClinicalTrials.gov study NCT01840111. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Effectiveness of Taking Choline Supplements During Pregnancy for Improving Infant Brain Development
ClinicalTrials.gov study NCT00332124. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Determining the Impact of Air Pollution on the Developing Brain
ClinicalTrials.gov study NCT04574414. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease
ClinicalTrials.gov study NCT00005902. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Comparison of Two Approaches to Developing Brain Health Programs
ClinicalTrials.gov study NCT04822129. IPD Sharing: YES. Countries: 1. Publications: 1.
Developing Therapies for Traumatic Brain Injury
ClinicalTrials.gov study NCT01420939. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.