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Dataset results
187 results for “cannabinoids”
PET Imaging of Cannabinoid CB1 Receptors Using [18F]FMPEP-d2
ClinicalTrials.gov study NCT00598286. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3
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Modeling cannabinoids from a large-scale sample of Cannabis sativa chemotypes
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Figure 3 from: Nocheva H, Sabit Z, Bakalov D, Grigorov E (2021) Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception. Pharmacia 68(1): 109-115. https://doi.org/10.3897/pharmacia.68.e49219
Figure 3 Bidirectional effects of (A) DPAT, (B) AEA, and (C) AEA+DPAT in intact animals and after 1h HS.
Figure 2 from: Nocheva H, Sabit Z, Bakalov D, Grigorov E (2021) Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception. Pharmacia 68(1): 109-115. https://doi.org/10.3897/pharmacia.68.e49219
Figure 2 Effects of CB1-agonist (AEA) and 5НТ1А-agonists (DPAT) alone administration on nociceptive (PP) thresholds in (A) intact animals (int) and (B) animals subjected to 1 hour of heat stress (1h HS) without and after pretreatment with CB1- and 5НТ1А-antagonists (AM and NAN, respectively). PP-thresholds are represented as mean values ± S.E.M. in arbitrary units (AU). ***p < 0.001, **p < 0.01, *p < 0.05 vs. controls. A. +++p < 0.001, ++p < 0.01 vs. int+AEA+DPAT. int+NAN+DPAT were compared to int+DPAT – xxxp < 0.001, xxp < 0.01; int+AM+AEA were compared to int+AEA – $$$ p < 0.001. B. +++p < 0.001, ++p < 0.01 vs. 1h HS; xxxp < 0.001, xxp < 0.01 vs. 1h HS+AEA+DPAT. 1h HS+NAN+DPAT were compared to 1h HS+DPAT – $$$p < 0.001, $$p < 0.01; 1h HS+AM+AEA were compared to 1h HS+AEA – &&&p < 0.001.
Figure 1 from: Nocheva H, Sabit Z, Bakalov D, Grigorov E (2021) Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception. Pharmacia 68(1): 109-115. https://doi.org/10.3897/pharmacia.68.e49219
Figure 1 Effects of CB1- and 5НТ1А-agonists (AEA+DPAT) administration on nociceptive (PP) thresholds in (A) intact animals (int) and (B) animals subjected to 1 hour of heat stress (1 h HS) without and after pretreatment with CB1- and 5НТ1А-antagonists (AM and NAN, respectively). PP-thresholds are represented as mean values ± S.E.M. in arbitrary units (AU). ***p < 0.001, **p < 0.01 vs. controls. A. +++p < 0.001, ++p < 0.01 vs. int+AEA+DPAT. B. +++p < 0.001 vs. 1 h HS; xxxp < 0.001, xxp < 0.01 vs. 1 h HS+AEA+DPAT.
Figure 3 from: Suleymanoglu Y, Bakalov D, Sabit Z, Vodenicharov V, Tafradjiiska-Hadjiolova R, Nocheva H (2024) The endogenous cannabinoid and the adrenergic systems in modulation of stress-response. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e115659
Figure 3 A. Stress (and its many sensory inputs) activates different areas in the brain – the prefrontal cortex (PFC), the thalamus (Thal), the limbic system (LS, comprising the amygdala, hippocampus and hypothalamus), with subsequent adverse effects for the whole organism: fear‐related behaviour, depressive-like conditions, anxiety, helplessness and hopelessness, sleep and feeding disorders; B. Endocannabinoids modulate the activity of pyramidal glutamate neurons and prefrontal glutamatergic plasticity, and have been proved beneficial in decreasing anxiety and depressive-like symptoms, alleviation of fear-conditioned memories, improvement of sleep and feeding.
Figure 2 from: Suleymanoglu Y, Bakalov D, Sabit Z, Vodenicharov V, Tafradjiiska-Hadjiolova R, Nocheva H (2024) The endogenous cannabinoid and the adrenergic systems in modulation of stress-response. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e115659
Figure 2 Effects on r-SIA (1 h RS) estimated by PP-test after A. Clonidine (Clo); B. Desipramine (Des); and C. Yohimbine (Yoh) administrations alone or in combination with anandamide (AEA) / AM251 (AM). Mean values ± S.E.M. are presented in arbitrary units (AU) on the 10th, 20th, 30th, and 40th min after substances administration. A–C ***p < 0.001 vs. controls; +++p < 0.001vs. 1 h RS; xxxp < 0.001vs. A. 1 h RS+Clo; B. 1 h RS+Des; C. 1 h RS+Yoh; xp < 0.05 vs. B. 1 h RS+Des; $$$p < 0.001vs. A. 1 h RS+Clo+AEA; B. 1 h RS+Des+AEA; C. 1 h RS+Yoh+AEA; $p < 0.05 vs. C. 1 h RS+Yoh+AEA.
Figure 1 from: Suleymanoglu Y, Bakalov D, Sabit Z, Vodenicharov V, Tafradjiiska-Hadjiolova R, Nocheva H (2024) The endogenous cannabinoid and the adrenergic systems in modulation of stress-response. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e115659
Figure 1 Effects of AEA on r-SIA estimated by PP-test after one hour of restraint (1 h RS) in rats. Mean values ± S.E.M. are presented in arbitrary units (AU) on the 10th, 20th, 30th, and 40th min after substances administration. ***p < 0.001 vs. controls; +++p < 0.001vs. RS.
Fig. 1 in Cannabinoid-like meroterpenoids from Peperomia incana
Fig. 1. Structures of compounds 1–10 isolated from P. incana.
Fig. 2 in Cannabinoid-like meroterpenoids from Peperomia incana
Fig. 2. COSY, key HMBC, and NOE correlations of compounds 1–10.
A photoswitchable cannabinoid for precision treatment of refractory seizures in a mouse epilepsy model
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Cannabinoids vs. whole metabolome: Relevance of cannabinomics in analyzing Cannabis varieties
<p><em>Cannabis sativa</em> has a long history of domestication both for its bioactive compounds and its fibers. This has produced hundreds of varieties, usually characterized in the literature by chemotypes, with Δ<sup>9</sup>-THC and CBD content as the main markers. However, chemotyping could also be done based on minor compounds (phytocannabinoids and others). In this work, a workflow, which we propose to name cannabinomics, combines mass spectrometry of the whole metabolome and statistical analysis to help differentiate <em>C. sativa</em> varieties and deciphering their characteristic markers. By applying this cannabinomics approach to the data obtained from 20 varieties of <em>C. sativa</em> (classically classified as chemotype I, II, or III), we compared the results with those obtained by a targeted quantification of 11 phytocannabinoids. Cannabinomics can be considered as a complementary tool for phenotyping and genotyping, allowing the identification of minor compounds playing a key role as markers of differentiation.</p>
Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults
ClinicalTrials.gov study NCT03944954. IPD Sharing: NO. Countries: 1. Publications: 0.
Sublingual Tablets With Cannabinoid Combinations for the Treatment of Dysmenorrhea
ClinicalTrials.gov study NCT04091789. IPD Sharing: NO. Countries: 1. Publications: 15.
A Direct-to-Consumer Study Investigating the Effect of Specific Cannabinoid Products on Motivation, Energy Level, Focus, and Appetite in Healthy Adults
ClinicalTrials.gov study NCT06213064. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Improvement of Quality of Life by Cannabinoids in Oncologic Patients
ClinicalTrials.gov study NCT06097533. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
CANnabinoids in Pediatric ONCology
ClinicalTrials.gov study NCT05754840. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Opioid and Cannabinoid Interactions
ClinicalTrials.gov study NCT03705559. IPD Sharing: NO. Countries: 1. Publications: 0.
Brain Imaging of Cannabinoid Receptors
ClinicalTrials.gov study NCT03204305. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.