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303
datasets available to search
ShareScore release 0.9.0
Dataset results
303 results for “cerebrospinal fluid”
A Study in Healthy Participants to Evaluate the Effect of JNJ-54175446 on Amyloid Biomarkers and Cytokine Profiles in Cerebrospinal Fluid and Plasma
ClinicalTrials.gov study NCT02933762. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sonographic Monitoring of Weaning of Cerebrospinal Fluid Drainages
ClinicalTrials.gov study NCT02408757. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Alpha-synuclein in Cerebrospinal Fluid to Differentiate Alzheimer's Disease From Lewy Body Disease.
ClinicalTrials.gov study NCT01876459. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury
ClinicalTrials.gov study NCT04998370. IPD Sharing: UNDECIDED. Countries: 3. Publications: 1.
Evaluation of Internal Nasal Splint-Supported Free Graft Versus Nasoseptal Flap for Endoscopic Skull Base Repair in Cerebrospinal Fluid Leaks
ClinicalTrials.gov study NCT07368348. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Study to Evaluate the Effects of JNJ-54861911 on Amyloid Beta Processing in Cerebrospinal Fluid and Plasma in Patients With Prodromal Alzheimer's Disease
ClinicalTrials.gov study NCT01978548. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients
ClinicalTrials.gov study NCT03823482. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury
ClinicalTrials.gov study NCT02495545. IPD Sharing: Not stated. Countries: 1. Publications: 36.
Data from: Origin and role of the cerebrospinal fluid bidirectional flow in the central canal
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Data from: The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid
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Data from: Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in Cerebrospinal fluid
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Compartmentalization of cerebrospinal fluid inflammation across the spectrum of HIV infection
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Data from: Cerebrospinal fluid dynamics disorders: relationship to Alzheimer biomarkers and cognition
Objectives: To determine the frequency high-convexity tight sulci (HCTS) in a population based sample and whether the presence of HCTS and related features influenced participants' cognitive status and classification within the new Alzheimer-biomarker framework. Methods: We analyzed 684 participants, ≥50, enrolled into the prospective population-based Mayo Clinic Study of Aging, who underwent structural MRI, amyloid PET imaging, and tau- PET imaging. A fully automated machine-learning algorithm that had been developed previously in-house was used to detect neuroimaging features of HCTS. Based on PET and MRI measures, participants were classified as having normal (A−) or abnormal (A+) amyloid, normal (T−) or abnormal (T+) tau, and normal (N−) or abnormal (N+) neurodegeneration. The neuropsychological battery assessed domain-specific and global cognitive scores. Gait speed also was assessed. Analyses were adjusted for age and sex. Results: 45/684 participants (6.6%) were classified with HCTS based on the automated algorithm. Patients with HCTS were older than patients without HCTS (mean [SD], 78.0 [8.3] vs 71.9 [10.8] years; P<.001). More were cognitively impaired after age and sex adjustment (27% vs 9%; P=.005). Amyloid PET status was similar with and without HCTS, but tau PET SUVR was lower for those with HCTS after age and sex adjustment (P<.001). Despite a lower tau SUVR, HCTS patients had lower Alzheimer disease (AD) signature cortical thickness. Using the AT(N) framework, HCTS was overrepresented in the T−(N)+ group, regardless of amyloid status. Conclusions: The HCTS pattern represents a definable subgroup of non-AD pathophysiology (i.e., T−[N]+) that is associated with cognitive impairment. HCTS may confound clinical and biomarker interpretation in AD clinical trials.
Integrative analyses of single-cell transcriptome and immune profiling reveal clonal expansion of T cells in the blood and cerebrospinal fluid of Parkinson's disease
<p>An increasing number of studies has indicated that the immune system plays important roles in the pathogenesis of Parkinson's disease. However, little is known about the contribution of adaptive immune responses in Parkinson's disease. Here, we performed comprehensive integrative analyses of single-cell transcriptome and immune profiling of the blood of 8 Parkinson's patients and 13 healthy controls as well as the cerebrospinal fluid of 6 Parkinson's patients, 4 Alzheimer's patients, 5 mild cognitive impairment (MCI) patients and 9 healthy controls. In total, 22 T cell subsets with distinct functions and clonalities were identified from 121,402 T cells. We observed significant clonal expansion of effector CD8+ T cells in Parkinson's patients, which formed a gradient of transcriptional states from central memory CD8+ T cells to early effector CD8+ T cells followed by terminal effector CD8+ T cells. Shared TCRs in this progression suggest TCRs may be involved in the state transition of CD8+ T cells stimulated by antigens. Notably, we also found that a group of clonally expanded cytotoxic CD4+ T cells were significantly increased in Parkinson's patients compared to controls, suggesting their cytotoxic roles in Parkinson's disease. Finally, we screened putative TCR-antigen pairs that existed in both blood and cerebrospinal fluid of patients with Parkinson's disease. These results reveal an adaptive immune response in the blood and cerebrospinal fluid of Parkinson's disease and provide novel evidence of clonal, antigen-experienced T cells patrolling in the blood and cerebrospinal fluid of Parkinson's disease.</p>
Data from: Analysis of the cerebrospinal fluid proteome in Alzheimer's disease
Alzheimer's disease is a neurodegenerative disorder accounting for more than 50% of cases of dementia. Diagnosis of Alzheimer's disease relies on cognitive tests and analysis of amyloid beta, protein tau, and hyperphosphorylated tau in cerebrospinal fluid. Although these markers provide relatively high sensitivity and specificity for early disease detection, they are not suitable for monitor of disease progression. In the present study, we used label-free shotgun mass spectrometry to analyse the cerebrospinal fluid proteome of Alzheimer's disease patients and non-demented controls to identify potential biomarkers for Alzheimer's disease. We processed the data using five programs (DecyderMS, Maxquant, OpenMS, PEAKS, and Sieve) and compared their results by means of reproducibility and peptide identification, including three different normalization methods. After depletion of high abundant proteins we found that Alzheimer's disease patients had lower fraction of low-abundance proteins in cerebrospinal fluid compared to healthy controls (p<0.05). Consequently, global normalization was found to be less accurate compared to using spiked-in chicken ovalbumin for normalization. In addition, we determined that Sieve and OpenMS resulted in the highest reproducibility and PEAKS was the programs with the highest identification performance. Finally, we successfully verified significantly lower levels (p<0.05) of eight proteins (A2GL, APOM, C1QB, C1QC, C1S, FBLN3, PTPRZ, and SEZ6) in Alzheimer's disease compared to controls using an antibody-based detection method. These proteins are involved in different biological roles spanning from cell adhesion and migration, to regulation of the synapse and the immune system.
Codes and images associated with "Neuronal dynamics orchestrate cerebrospinal fluid perfusion and brain clearance"
<p>MATLAB scripts and representative images associated with the publication. </p>
Assessment of Exposure of BI 409306 in Cerebrospinal Fluid (CSF) Relative to Plasma as Well as to Evaluation of the Effect of Different Doses of BI 409306 on the cGMP (Cyclic Guanosine Monophosphate)
ClinicalTrials.gov study NCT01493570. IPD Sharing: NO. Countries: 1. Publications: 0.
Raltegravir Cerebrospinal Fluid Pharmacodynamic Study in HIV-Infected Individuals
ClinicalTrials.gov study NCT01293123. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS)
ClinicalTrials.gov study NCT07153211. IPD Sharing: NO. Countries: 1. Publications: 0.
The Rilpivirine Cerebrospinal-fluid (CSF) Study
ClinicalTrials.gov study NCT01562886. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.