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861 results for “collagen I”
Highly Conductive Collagen by Low-Temperature Atomic Layer Deposition of Platinum
<p>In modern biomaterial-based electronics, conductive and flexible biomaterials are gaining increasing attention for their wide range of applications in biomedical and wearable electronics industries. The ecofriendly, biodegradable, and self-resorbable nature of these materials makes them an excellent choice in fabricating green and transient electronics. Surface functionalization of these biomaterials is required to cater to the need of designing electronics based on these substrate materials. In this work, a low-temperature atomic layer deposition (ALD) process of platinum (Pt) is presented to deposit a conductive thin film on collagen biomaterials, for the first time. Surface characterization revealed that a very thin ALD-deposited seed layer of TiO2 on the collagen surface prior to Pt deposition is an alternative for achieving a better nucleation and 100% surface coverage of ultrathin Pt on collagen surfaces. The presence of a pure metallic Pt thin film was confirmed from surface chemical characterization. Electrical characterization proved the existence of a continuous and conductive Pt thin film (∼27.8 ± 1.4 nm) on collagen with a resistivity of 295 ± 30 μΩ cm, which occurred because of the virtue of TiO2. Analysis of its electronic structures showed that the presence of metastable state due to the presence of TiO2enables electrons to easily flow from valence into conductive bands. As a result, this turned collagen into a flexible conductive biomaterial.</p>
Chemical evidence of preserved collagen in a 54-million-year-old fish vertebrae
<p>Collagens are the most abundant protein in the animal kingdom. <span>Collagens form </span><span>the structural framework of connective tissues such as bones, tendons and skin and play important biomechanical role in supporting tissue functions. The preservation of collagen in deep time is a topic of intense debate. Here we provide </span>indisputable evidence of the presence of collagen in Early Eocene fish vertebrae using online pyrolysis-comprehensive two dimensional gas chromatography-time-of-flight mass spectrometry and immunofluorescence studies. The presence of cyclic dipeptides such as <span>diketodipyrrole, </span>2,5-diketopiperazine of proline-proline and 2,5-diketopiperazine of proline-glycine along with other nitrogen-bearing molecules in the pyrolysis products of the studied fossils unequivocally demonstrate that collagen can withstand degradation and diagenetic alteration. Immunofluorescence study also confirms the presence of collagen-I in the fossilized fish vertebrae. The present findings suggest, contrary to common opinion, that the preservation of collagen in fossilized soft tissues is not rare. We propose that one of the essential factors controlling preservation of collagen is the establishment of a suitable microenvironment within the fossil inhibiting diagenetic alteration including microbial decay.</p>
Raw data of journal paper of Effects of Mineralisation on the Hierarchical Organisation of Collagen – a Synchrotron X-ray Scattering and Polarised Second Harmonic Generation Study
<p>Both raw data of pSHG and XRD are stored in .mat format, which includes the I2 values, SHG intensity, D-period, intermolecular spacing, fibril dispersion, molecular dispersion and supramolecular twist. </p>
The comparison of marine collagen peptides and soy peptide supplementation on skeletal muscular Calpain-1/2 mRNA expressions and micro-injury in rats
<p>Dataset of a research article named 'The comparison of marine collagen peptides and soy peptide supplementation on skeletal muscular Calpain-1/2 mRNA expressions and micro-injury in rats'.</p>
Histology, TNF-alpha, and collagen score, body weight, and ulcer size
<p><strong>Background: </strong>Areca nut (<em>Areca catechu</em> L.) i<span>s the seed of the fruit of the oriental palm that is commonly </span>used among Southeast Asian communities. Chrysanthemum (<em>Dendrathema grandiflora</em>) is a flowering plant originating from East Asia and dominantly grows in China. Both of these plants have strong antioxidant activities. To investigate the mechanism of their wound healing activities, we prepared areca nut and chrysanthemum polyethylene oral gel and performed several <em>in vivo</em> assays using Sprague-Dawley rats.</p> <p><strong>Methods: </strong>Sprague Dawley rats were divided into five groups: Negative control group (rats with base gel treatment), positive control group (rats treated with triamcinolone acetonide), F1 (treatment with 20% areca nut:80% chrysanthemum), F2 (treatment with 50% areca nut:50% chrysanthemum), and F3 (treatment with 80% areca nut:20% chrysanthemum). Traumatic ulcers were performed on the buccal mucosa of all experimental animals that received topical oral gel and triamcinolone acetonide twice a day for seven days. The clinical and histological characteristics were analyzed and scored.</p> <p><strong>Results:</strong> During the six days, the ulcerated area receded linearly over time and was completely cicatrized in F2 and positive control group (Dependent t-test, p<0.05). There were a significant increase in body weight in F2 and positive control groups. There were no significant differences between groups in histology examination (Kruskal Wallis test, p<0.05). The moderate score of TNF-α levels was seen in F2 and positive control groups (ANOVA/Tukey test). Similar results were seen in the collagenases assay.</p> <p><strong>Conclusions: </strong>A balanced combination of areca nut and chrysanthemum extract in the oral gel can optimize the healing of traumatic oral ulcers in rats through the increase of TNF-α and collagen deposition.</p>
Self-generated gradients steer collective migration on viscoelastic collagen networks
<p>Minimal Raw Data Set for:</p> <p>Self-generated gradients steer collective migration on viscoelastic collagen networks</p> <p>Clark et al, 2022</p>
Data for collagen ruptures
<p>Data for rupture simulations of tropocollagen for the paper: "Chemical bonds in collagen rupture selectively<br> under tensile stress". The data set contains the simulations for GPP and GPO repeats, the data for interrupted sequences, and Gly to Ala mutants. For these systems, only the relevant rupture data is provided. Structures for these were obtained from data sets published on zenodo (https://doi.org/10.5281/zenodo.7107608, https://doi.org/10.5281/zenodo.7107558, https://doi.org/10.5281/zenodo.5578060). <br> Additional data is provided for the crosslinking and fibre-like segments. For these sets, the initial GMIN optimisations to obtain minima are included alongside the rupture simulations.<br> <br> The folder RAW_COUNTS contains the rupture data, and a summary spreadsheet used to produce the plots in the paper.</p>
Economic analysis for the production of gelatine and hydrolyzed collagen from fish by-products and carotenoids, coffee oil and polyphenols from spent coffee grounds
<p>The most relevant economic data of the processes were considered in a cost-benefit analysis for the production of gelatine and hydrolyzed collagen from fish by-products and carotenoids, coffee oil and polyphenols from spent coffee grounds in the Pilot 1 of WaysTUP! project.</p>
Raw data for the article "In vitro culture of leukemic cells in collagen scaffolds and carboxymethylcellulose-polyethylene glycol gel"
<p>Uncropped original micrographs and raw numerical data of figures and tables from the article submitted to PeerJ. </p>
Dataset to "Collagen I Increases Palmitate-Induced Lipotoxicity in HepG2 Cells via Integrin-Mediated Death"
Open the record for dataset details and reuse information.
Data from: Ancient collagen reveals evolutionary history of the endemic South American 'ungulates'
Since the late eighteenth century, fossils of bizarre extinct creatures have been described from the Americas, revealing a previously unimagined chapter in the history of mammals. The most bizarre of these are the 'native' South American ungulates thought to represent a group of mammals that evolved in relative isolation on South America, but with an uncertain affinity to any particular placental lineage. Many authors have considered them descended from Laurasian 'condylarths', which also includes the probable ancestors of perissodactyls and artiodactyls, whereas others have placed them either closer to the uniquely South American xenarthrans (anteaters, armadillos and sloths) or the basal afrotherians (e.g. elephants and hyraxes). These hypotheses have been debated owing to conflicting morphological characteristics and the hitherto inability to retrieve molecular information. Of the 'native' South American mammals, only the toxodonts and litopterns persisted until the Late Pleistocene–Early Holocene. Owing to known difficulties in retrieving ancient DNA (aDNA) from specimens from warm climates, this research presents a molecular phylogeny for both Macrauchenia patachonica (Litopterna) and Toxodon platensis (Notoungulata) recovered using proteomics-based (liquid chromatography–tandem mass spectrometry) sequencing analyses of bone collagen. The results place both taxa in a clade that is monophyletic with the perissodactyls, which today are represented by horses, rhinoceroses and tapirs.
Data set for "The effects of glycine to alanine mutations on the struc-ture of GPO collagen model proteins"
<p>Data set for "The effects of glycine to alanine mutations on the struc-ture of GPO collagen model proteins"</p> <p>The README files contain a description of all files and scripts in this repo.</p>
Hypoxia preconditioned mesenchymal stem cells prevent cardiac fibroblast activation and collagen production via leptin
<p><strong>Aims</strong>: Activation of cardiac fibroblasts into myofibroblasts constitutes a key step in cardiac remodeling after myocardial infarction (MI), due to interstitial fibrosis. Mesenchymal stem cells (MSCs) have been shown to improve post-MI remodeling an effect that is enhanced by hypoxia preconditioning (HPC). Leptin has been shown to promote cardiac fibrosis. The expression of leptin is significantly increased in MSCs after HPC, but it is unknown whether leptin contributes to MSC therapy or the fibrosis process. The objective of this study was to determine whether leptin secreted from MSCs modulates cardiac fibrosis.</p> <p><strong>Methods</strong>: Cardiac fibroblast (CF) activation was induced by hypoxia (0.5% O<sub>2</sub>). The effects of MSCs on fibroblast activation were analyzed by co-culturing MSCs with CFs and detecting the expression of a-SMA, SM22a, and collagen IaI in CFs by western blot, immunofluorescence and Sirius red staining. In vivo MSCs antifibrotic effects on left ventricular remodeling were investigated using an acute MI model involving permanent ligation of the left anterior descending coronary artery.</p> <p><strong>Results</strong>: Co-cultured MSCs decreased fibroblast activation and HPC enhanced the effects. Leptin deficit MSCs from Ob/Ob mice did not decrease fibroblast activation. Consistent with this, H-MSCs significantly inhibited cardiac fibrosis after MI and mediated decreased expression of TGF-b/Smad2 and MRTF-A in CFs. These effects were again absent in leptin-deficient MSCs.</p> <p><strong>Conclusion</strong>: Our data demonstrate that activation of cardiac fibroblast was inhibited by MSCs in a manner that was leptin-dependent. The mechanism may involve blocking TGF-b/Smad2 and MRTF-A signal pathway.</p>
3D rendering (left) and 2D orthoslice (rigth) of a virtual longitudinal section in the chorda tendinea insertion into the papillary muscle allowing to visualize the transition from collagen to muscle fibers
<p>The white square on the 3D rendering indicates the region-of-interest shown on the right. At the beginning of the video, the yellow and<br> blue arrows indicated the presence of adipocytes and a vessel filled with blood.</p>
Three-dimensional Bone Regeneration Using Custom-made Meshes With and Without Collagen Membrane
ClinicalTrials.gov study NCT04286334. IPD Sharing: YES. Countries: 1. Publications: 0.
Connective Tissue Graft Versus Collagen Matrix.
ClinicalTrials.gov study NCT04678804. IPD Sharing: NO. Countries: 1. Publications: 4.
Poly Tetra Fluro Ethylene vs Native Collagen Membrane for Gbr in Anterior Maxilla
ClinicalTrials.gov study NCT03839615. IPD Sharing: UNDECIDED. Countries: 1. Publications: 27.
Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men
ClinicalTrials.gov study NCT04596553. IPD Sharing: NO. Countries: 1. Publications: 7.
Value of PET/MR Enterography in the Assessment of Crohn's Disease Using a Collagen-binding Radiotracer.
ClinicalTrials.gov study NCT06252493. IPD Sharing: NO. Countries: 1. Publications: 6.
Biological Bone Markers and Hydrolyzed Collagen Supplement in Menopausal Healthy Women
ClinicalTrials.gov study NCT01293045. IPD Sharing: Not stated. Countries: 1. Publications: 4.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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