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769 results for “deprivation”
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
ClinicalTrials.gov study NCT06644573. IPD Sharing: YES. Countries: 1. Publications: 15.
Triple Vulnerability? Circadian Tendency, Sleep Deprivation and Adolescence
ClinicalTrials.gov study NCT01828320. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation
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Flying on empty: Reduced mitochondrial function and flight capacity in food-deprived monarch butterflies
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Effects of sleep deprivation on susceptibility to parasitic infection
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DO THE TERRORISTS VERITABLY THE DEPRIVED SOULS? EXPLORING THE BITTER TRUTH EMPIRICALLY
<p>This dataset is related to the research conducted by the Authors on the topic "<strong>DO THE TERRORISTS VERITABLY THE DEPRIVED SOULS? EXPLORING THE BITTER TRUTH EMPIRICALLY".</strong></p>
Data from: Parrots consume sodium-rich palms in the sodium-deprived landscape of the Western Amazon Basin
Herbivorous animals face shortages of different minerals in different geographic areas. In the Amazon basin, sodium is often limiting, driving herbivores to seek supplemental sources. In the lowlands of the western Amazon basin, parrots commonly consume sodium-rich soils at clay licks but lick use varies widely among species and to date, parrots in the region have not been reported consuming other supplemental sodium sources. We document 11 species of psittacines consuming sodium-rich leaves and trunks of Attalea butyracea palms growing on sodium-rich soils in lowland Peru. Consumed palms had more sodium and less potassium than uneaten A. butyracea palms and other palm species in the area. Among A. butyracea palm parts, sodium and Na:K ratios were highest in trunks (consumed by parrots in 91% of the 721 foraging bouts recorded) and lowest in leaves (consumed in only 14% of foraging bouts). The low potassium and high Na:K ratio suggest that birds may be seeking not just any sodium sources, but those low in potassium, as potassium is known to exacerbate dietary sodium shortages. Use of the palms and species' abundances in the study area were not correlated. Instead, parrot species that consumed palms the most were those that use relatively few traditional soil clay licks. This finding suggests that parrot species in the region have fundamental differences in preferred strategies for obtaining supplemental sodium and may help explain documented interspecific differences in geophagy. .
Nitrogen and sulfur for phosphorus: Lipidome adaptation for anaerobic sulfate-reducing bacteria in phosphorus-deprived conditions
<p><strong>Abstract </strong></p> <p>Understanding how microbial lipidomes adapt to environmental and nutrient stress is crucial for comprehending microbial survival and functionality. Certain anaerobic bacteria can synthesize glycerolipids with ether/ester bonds, yet the complexities of their lipidome remodeling under varying environmental and nutritional conditions remain largely unexplored. In this study, we thoroughly examined the lipidome adaptations of <em>Desulfatibacillum alkenivorans</em> strain PF2803<sup>T</sup>, a mesophilic anaerobic sulfate-reducing bacterium known for its n-alkene degradation capability, under various cultivation conditions including temperature, pH, salinity, and ammonium and phosphorous concentrations. Employing an extensive analytical and computational lipidomic methodology, we identified nearly 400 distinct lipids for the first time, including a range of glycerol ether/ester lipids and various polar head groups. Information theory-based analysis revealed that temperature fluctuations and phosphate scarcity profoundly influenced the lipidome's composition, leading to enhanced diversity and specificity of novel lipids. Notably, phosphorous limitation led to the creation of novel glucuronosylglycerols and sulfur-containing aminolipids, termed butyramide cysteine glycerols, featuring various ether/ester bonds. This suggests a novel adaptive strategy for anaerobic heterotrophs to thrive in phosphorus-depleted areas of the oceans, characterized by a diverse array of nitrogen- and sulfur-containing polar head groups, moving beyond a reliance on conventional non-phospholipid types.</p> <p><strong>Repository Contents</strong></p> <p><strong>1_SRB_lipidome.zip</strong>: includes all source data and code scripts used for figures in this study. Files are organized as follows and are associated with the corresponding parts of the manuscript: Figure 2A-F, Figure 4A-E, Figure 5A-B, Figure 6A-E, Supplementary Figures 7.</p> <p>Figure 2. The impact of culturing conditions on lipidomic variability. A) The number of intact polar lipid species in different lipid classes putatively identified in this study. B) Principal Component Analysis (PCA) based on peak intensity of intact polar lipid species, showcasing the variation in general lipidomic features across individual experimental conditions. C) Information theory analysis showing lipidome diversity and specificity based on the Shannon entropy of the lipidomic frequency distribution. D) Lipid species specificity across the various culturing conditions. E) Hierarchical clustering heatmap depicting the distribution of major lipid classes across all the culturing conditions. F) Cumulative variability of all intact polar lipid species within each range of growth conditions, calculated as the difference in mean abundance between the standard growth condition and the variable conditions. The variability analysis excludes phosphate 0.015 mM as it is under phosphorous-sufficient condition, which showed a similar lipidome composition as the standard growth condition. Each condition analysis is based on three biological replicates. Abbreviations: Polar head groups –phosphatidylethanolamines (PE), phosphatidylglycerols (PG), cardiolipins (CL), novel N-butyramide cysteine (BACys), glucuronosyl (GlcA); Core lipids – diacylglycerols (DAGs), acyl/ether glycerols (AEGs), dietherglycerols (DEGs), tetraetherglycerols (TetraEGs), triether/monoacyl glycerols (TriEGs), diether/diacyl glycerol (DiEGs), monoether/triacyl glycerol (MonoEGs), and tetraacylglycerols (TetraAGs), demethylmenaquinone (DMK).</p> <p>Figure 4. Variability of major lipid classes across different culturing conditions. A) PG with different ether/ester bond core lipids. B) PE with different ether/ester bond core lipids. C) CL with different ether/ester bond core lipids. D) GlcA with different ether/ester bond core lipids. E) Novel BACys with different ether/ester bond core lipids. Asterisks indicate significant differences between the last condition and the current condition (Student's t tests on pairwise differences, *P < 0.05, **P < 0.01 and ***P < 0.001). The numbers of treatments on the x-axis represent the parameters associated with each condition, ranging from low to high. These parameters include temperature (25°C, 30°C, 40°C), pH levels (6.4, 6.8, 7.8), NaCl concentration (3 g/L, 10 g/L, 25 g/L, 60 g/L), phosphate concentration (0.0005 mM, 0.0015 mM, 0.015 mM, 1.5 mM), and ammonium concentration (0.003 g/L, 0.03g/L, 0.3 g/L).</p> <p><span>Figure 5. Distribution of the relative abundance of major lipid classes and number of lipid species across different culturing conditions. </span><span>A) Relative abundance of major lipid classes. B) Number of lipid species with an abundance exceeding 0.5% of the total lipids. The numbers of treatments on the x-axis represent the parameters associated with each condition, ranging from low to high. These parameters include temperature (25°C, 30°C, 40°C), pH levels (6.4, 6.8, 7.8), NaCl concentration (3 g/L, 10 g/L, 25 g/L, 60 g/L), phosphate concentration (0.0005 mM, 0.0015 mM, 0.015 mM, 1.5 mM), and ammonium concentration (0.003 g/L, 0.03g/L, 0.3 g/L).</span></p> <p><span>Fig</span><span>ure</span><span> 6</span><span>. Adaptation of ether/ester bond lipids, polar headgroups, the averaged carbon chain length and double bond equivalents (DB) of the studied sulfur-reducing bacterial lipidome across different culturing conditions.</span><span> A) The ratio of phospholipids with dialkyl chains and tetraalkyl chains, or the ratio of (PE+PG)/CL, calculated as the summed core lipids within each class. B) The logarithmic ratio of phospholipids/non-phospholipids, phospholipids included both diglyceride phospholipids (PG and PE) and CL. C) The ratio of ether/ester bond lipids. The abundance of ethers in lipids with DEGs is calculated based on their inherent intensity, while the abundance of ethers in lipids containing both ether and ester chains is determined using the ratio of ether% multiplied by the intensity. For instance, in CL-TriEG, which has three ether-bond chains and one ester-bond chain, the abundance of the ether chain is calculated as 0.75 multiplied by the intensity. D) The average DBs of total lipids across different culturing conditions. E) The average chain length of two-chain lipids across different culturing conditions. Asterisks indicate significant differences between the last condition and the current condition (Student’s <em>t </em>tests on pairwise differences, *<em>P </em>< 0.05, **<em>P </em>< 0.01 and ***<em>P </em>< 0.001). These parameters include temperature (25°C, 30°C, 40°C), pH levels (6.4, 6.8, 7.8), NaCl concentration (3 g/L, 10 g/L, 25 g/L, 60 g/L), phosphate concentration (0.0005 mM, 0.0015 mM, 0.015 mM, 1.5 mM), and ammonium concentration (0.003 g/L, 0.03g/L, 0.3 g/L).</span></p> <p><span><span>Fig. S7. The fractional abundance of lipids with (A) different DBs (0-4) and (B) different carbon chain lengths (26-37, 56-68).</span></span><span> The numbers from 26 to 37 represent the summed two-chain carbon atoms, while the numbers from 56 to 68 represent the summed four-chain carbon atoms (from CL). The numbers of treatments </span><span>with different colors</span><span> represent the parameters associated with each condition, ranging from low to high. </span></p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p>
Metabolic depression in sea urchin barrens associated with food deprivation
<p>The proliferation of sea urchins can decimate macroalgal forests in coastal ecosystems, leading to persistent barren seascapes. While kelp forests are among the most productive ecosystems on the planet, productivity in these urchin barrens is dramatically reduced. Moreover, urchins inhabiting these food-depauperate barrens face starvation and many survive in these barrens for years or decades. Urchins in barrens can persist by eating food subsidies from drift algae, pelagic salps, tubeworms, as well as encrusting and filamentous algae, microbial mats, and slow-growing species resistant to herbivory. Despite both food from endogenous production and exogenous subsidies, many urchins in barrens likely experience prolonged food deprivation. This resource limitation may create a trade-off between reproduction and survival; for example, fecundity of purple sea urchins (<em>Strongylocentrotus purpuratus</em>) is 99.9% lower in barrens. Despite food constraints, red sea urchins (<em>Mesocentrotus franciscanus</em>), the dominant urchin species at our study sites, can live in excess of 100 years and barrens in Haida Gwaii, British Columbia (BC), Canada, have persisted for at least 143 years. While these phenomena are widespread and well documented, the bioenergetic adaptations that allow urchins to persist in these food-depauperate barrens remain poorly understood. To quantify habitat-specific differences in metabolic rates and energy reserves (as measured by gonadal mass), we conducted respirometry on and measured gonadal mass in <em>M. franciscanus</em> at three locations in BC inside and outside of adjacent kelp forest and barrens habitat. Here we demonstrate that <em>M. franciscanus</em> in barrens versus kelp forests have substantially lower energy reserves and, importantly, also exhibit dramatic reductions in size-specific resting metabolic rates (RMR), even after standardizing by metabolically active body mass. On average, gonadal mass was 44.6% lower and RMR scaled to metabolically active body mass was 40% lower in barrens urchins than in kelp forest urchins. Such a shift in metabolic rate may provide a mechanism that facilitates barren state stability over long time scales as <em>M. franciscanus</em> can lower energetic demands while they wait for small pulses of food, scrape by on low-productivity resources, and suppress recruitment of macroalgae for months, years, or decades.</p>
Eluding anemone nematocysts: are clownfish deprived of N-acetylated sugars on their surface?
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scRNA-seq dataset from "Glucose deprivation and identification of TXNIP as an immunometabolic modulator of T cell activation in cancer"
<p>Gene expression profiling analysis of single cell RNA-seq data from MLR, anti-CD3/anti-CD28 treated and paired untreated CD4+ T cells samples under high glucose (11 mM) and low glucose (1 mM) conditions.</p> <p>For each sample, cells suspensions in culture medium were recovered, washed once with 0.04% BSA in 1X PBS and processed through 10x Cell Multiplexing Oligo Labeling protocol (10x Genomics, USA) according to the manufacturer’s instructions. ~1,600 cells/µl pooled cell suspensions were prepared with equal number of cells per sample: one for MLR samples, one for non-stimulated T cells samples, and one for anti-CD3/anti-CD28-stimulated T cells samples. Libraries were prepared using the 10x Chromium Single-Cell 3’ v3.1 protocol with Feature Barcode (10x Genomics, USA), according to the manufacturer’s instructions. Sequencing was performed on a NovaSeq 6000 sequencer (Illumina, USA).</p> <p>Cell Ranger (v6.0.1, 10x Genomics Inc) was applied for demultiplexing, reads mapping against the GRCh38 human reference genome, and UMI counting. Seurat package (v4.4.0) was used to generate Seurat objects. Only genes detected in at least 3 cells were kept. Cells with fewer than 200 genes detected or >15% mitochondrial UMI counts were filtered out. Samples were merged in a unique Seurat object then count data normalization and scaling was performed using Seurat with default parameters. The 2000 most highly variable genes were used for Principal Component Analysis (PCA). Harmony (v0.1.1) was applied for batch effect correction then Uniform Manifold Approximation and Projection (UMAP) and clustering using the Louvain algorithm were performed on the harmony reduction. Non-T or -MoDC clusters were removed for further analysis.</p>
Early social deprivation shapes neuronal programming of the social decision-making network in a cooperatively breeding fish
The early social environment an animal experiences may have pervasive effects on its behaviour. The Social Decision-Making network (SDMN), consisting of interconnected brain nuclei from the forebrain and midbrain, is involved in the regulation of behaviours during social interactions. In species with advanced sociality such as cooperative breeders, offspring are exposed to a large number and a great diversity of social interactions every day of their early life, which may have life-long consequences on the development of several neurophysiological systems within the SDMN, although these effects are largely unknown. We studied these life-long effects in a cooperatively breeding fish, Neolamprologus pulcher, focusing on the expression in the SDMN of genes involved in the monoaminergic and stress response systems. N. pulcher fry were raised until an age of two months either with their parents, subordinate helpers and same clutch siblings (+F), or with same clutch siblings only (-F). Analysis of the expression of glucocorticoid receptor (GR), mineralcorticoid receptors (MR), corticotropin releasing factor (CRF), dopamine receptors 1 and 2, serotonin transporter (SERT) and DNA methyltransferase I (DNMT1) genes showed that early social experiences altered the neurogenomic state of the preoptic area (POA) of the hypothalamus. The dopamine receptor 1 gene was up-regulated in the POA of -F fish, compared to +F fish. -F fish also showed up-regulation of GR1 expression in the dorsal medial telencephalon (homologous to the basolateral amygdala). Our results suggest that early social environment has life-long effects on the development of several neurophysiological systems within the SDMN. --
Data from: Water deprivation compromises maternal physiology and reproductive success in a cold and wet adapted snake Vipera berus
<p>Dataset from : <a href="https://doi.org/10.1093/conphys/coab071">https://doi.org/10.1093/conphys/coab071</a></p> <p>Dezetter, M., Le Galliard, J. F., Guiller, G., Guillon, M., Leroux-Coyau, M., Meylan, S., ... & Lourdais, O. (2021). Water deprivation compromises maternal physiology and reproductive success in a cold and wet adapted snake Vipera berus. <em>Conservation Physiology</em>, <em>9</em>(1), coab071.</p>
FIGURE 1 in Unnoticed anomaly in the holotype of Grallaria rufocinerea (Myrmotheridae) deprives romeroana Hernández-Camacho & Rodríguez, 1979 of diagnosability
FIGURE 1. Approximate geographic distribution of Grallaria rufocinerea. Stars represent the type localities of rufocinerea (Sclater & Salvin 1879) and romeroana (Hernández-Camacho & Rodríguez-M. 1979). All adult individuals of this species along its range look as the individual in the inset photograph, from the northern part of its range, in Río Blanco, Caldas (gray dot). Note the solid rufous brown throat that makes a complete hood, and the faint scaling below. Photo by Daniel Uribe Birding Tours Colombia.
FIGURE 2 in Unnoticed anomaly in the holotype of Grallaria rufocinerea (Myrmotheridae) deprives romeroana Hernández-Camacho & Rodríguez, 1979 of diagnosability
FIGURE 2. Four specimens of Grallaria rufocinerea, all from the Central Cordillera of Colombia, and arranged north (top) to south (bottom). A: Holotype of G. rufocinerea (Sclater & Salvin 1879) from Santa Elena, Antioquia (NHMUK 1889.9.20.618). B: An adult male from Páramo de Sonsón, Antioquia (USNM 436486). C: Holotype of G. rufocinerea romeroana (HernándezCamacho & Rodríguez-M. 1979) from Río Bedón, PuracéNational Park, Huila (IAvH-A 525). D: An adult female from Santa Helena at La Cruz, Nariño (MHN-UC AV004534). Note the disarranged throat plumage of the rufocinerea type (A) that makes it look as mottled gray. For this same reason, the erected feathers in the type of romeroana (C) and in the female from Nariño (D) make the upper throat look grayish too. The soft scaling pattern on the belly is not exclusive to romeroana, as it occurs both Antioquia rufocinerea specimens.
FIGURE 3 in Unnoticed anomaly in the holotype of Grallaria rufocinerea (Myrmotheridae) deprives romeroana Hernández-Camacho & Rodríguez, 1979 of diagnosability
FIGURE 3. The plate of Grallaria rufocinerea based on the type specimen (NHM 1889.9.20.618); the illustration, taken from Sclater (1890), is by Joseph Smit. Note that the center of throat is shown as gray from the base of the bill to the breast, in contrast to the characteristic solid rufous brown throat that forms the rufous brown hood in this species. This is likely an artifact of specimen preparation (see text). Extracted from the Biodiversity Heritage Library (https://www.biodiversitylibrary.org/item/34360).
Androgen Deprivation Therapy, External Beam Radiotherapy and Stereotactic Radiosurgery Boost for Prostate Cancer
ClinicalTrials.gov study NCT03322020. IPD Sharing: NO. Countries: 1. Publications: 2.
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery
ClinicalTrials.gov study NCT03541928. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
ClinicalTrials.gov study NCT04270331. IPD Sharing: YES. Countries: 1. Publications: 3.
RADICALS - Radiotherapy and Androgen Deprivation In Combination After Local Surgery
ClinicalTrials.gov study NCT00541047. IPD Sharing: NO. Countries: 2. Publications: 6.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.