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153
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153 results for “diffusion MRI”
Comparison Study Between PET/CT and Whole-Body Diffusion Weighted MRI in the Detection of Distant Malignancies
ClinicalTrials.gov study NCT06205901. IPD Sharing: Not stated. Countries: 0. Publications: 4.
UNDISTORT Correction of Distortions in Diffusion MRI V1.0
ClinicalTrials.gov study NCT03151512. IPD Sharing: NO. Countries: 1. Publications: 0.
Diffusion MRI for Pancreatic Adenocarcinoma
ClinicalTrials.gov study NCT02896946. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Data from: Diffantom: whole-brain diffusion MRI phantoms derived from real datasets of the Human Connectome Project
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Data from: Data for evaluation of fast kurtosis imaging, b-value optimization and exploration of diffusion MRI contrast
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Data from: Longitudinal diffusion MRI as surrogate outcome measure for myelopathy in adrenoleukodystrophy
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Data from: Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma
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Longitudinal white-matter abnormalities in sports-related concussion: a diffusion MRI study of the NCAA-DoD CARE Consortium
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White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
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Voxel-wise co-analysis of macro- and microstructural brain alteration in Mild Cognitive Impairment and Alzheimer's disease using anatomical and diffusion MRI
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Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI
Purpose: To investigate the feasibility of using diffusion MRI (dMRI) and dynamic contrast-enhanced (DCE) MRI to evaluate the treatment response of metronomic chemotherapy (MCT) in the 4T1 mammary tumor model of locally advanced breast cancer. Methods: Twelve Balb/c mice with metastatic breast cancer were divided into treated and untreated (control) groups. The treated group (n=6) received five treatments of anti-metabolite agent 5-Fluorouracil (5FU) in the span of two weeks. dMRI and DCE-MRI were acquired for both treated and control groups before and after MCT. Immunohistochemically staining and measurements were performed after the post-MRI measurements for comparison. Results: The control mice had significantly ( p <0.005) larger tumors than the MCT treated mice. The DCE-MRI analysis showed a decrease in contrast enhancement for the control group, whereas the MCT mice had a more stable enhancement between the pre-chemo and post-chemo time points. This confirms the antiangiogenic effects of 5FU treatment. Comparing amplitude of enhancement revealed a significantly (p<0.05) higher enhancement in the MCT tumors than in the controls. Moreover, the MCT uptake rate was significantly (p<0.001) slower than the controls. dMRI analysis showed the MCT ADC values were significantly larger than the control group at the post-scan time point. Conclusion: dMRI and DCE-MRI can be used as potential biomarkers for assessing the treatment response of MCT. The MRI and pathology observations suggested that in addition to the cytotoxic effect of cell kills, the MCT with a cytotoxic drug, 5FU, induced changes in the tumor vasculature similar to the anti-angiogenic effect.
ENIGMA Pediatric msTBI diffusion MRI supplemental data
<p><b>Objective</b>: Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine associations between WM organization and neurobehavioral outcomes.</p> <p><b>Methods</b>: Data from ten previously enrolled, existing cohorts recruited from local hospitals and clinics were shared with the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric msTBI working group. We conducted a coordinated analysis of diffusion MRI (dMRI) data using the ENIGMA dMRI processing pipeline.</p> <p><b>Results</b>: Five hundred and seven children and adolescents (244 with complicated mild to severe TBI [msTBI] and 263 controls) were included. Patients were clustered into three post-injury intervals: acute/subacute - <2 months, post-acute - 2-6 months, chronic - 6+ months. Outcomes were dMRI metrics and post-injury behavioral problems as indexed by the Child Behavior Checklist (CBCL). Our analyses revealed altered WM diffusion metrics across multiple tracts and all post-injury intervals (effect sizes ranging between <i>d</i>=-0.5 to -1.3). Injury severity is a significant contributor to the extent of WM alterations but explained less variance in dMRI measures with increasing time post-injury. We observed a sex-by-group interaction: females with TBI had significantly lower fractional anisotropy in the uncinate fasciculus than controls (𝞫=0.043), which coincided with more parent-reported behavioral problems (𝞫=-0.0027).</p> <p><b>Conclusions</b>: WM disruption after msTBI is widespread, persistent, and influenced by demographic and clinical variables. Future work will test techniques for harmonizing neurocognitive data, enabling more advanced analyses to identify symptom clusters and clinically-meaningful patient subtypes.</p>
Dataset related to article "Apparent Diffusion Coefficient standardization: multi-center and multi-vendor validation study across 1.5T and 3T scanners in a diffusion MRI phantom"
<p>The dataset includes ADC measurements collected for MRI harmonisation across centers and vendors, performed as part of the multicenter RESPECT project, using the QIBA-NIST diffusion MRI phantom.</p> <p>The dataset includes the following sheets:</p> <p>"ADC" sheet: ADC measurements (averaged over 4 repeated measures) for each scanner, comprising both first and second acquisition and 3 imaging planes. </p> <p>"temperature" sheet: temperature measurement of the phantom for each acquisition session.</p> <p>"repeatability" sheet: ADC measurements of the 4 repeated measures for the first acquisition. Average values and CVs are also reported.</p>
High Resolution 3D Diffusion-weighted Breast MRI
ClinicalTrials.gov study NCT01315106. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of 3 Tesla Diffusion Weighted Magnetic Resonance Imaging (DW-MRI) for Diagnosis Bladder Cancer Grade and Stage
ClinicalTrials.gov study NCT03138837. IPD Sharing: YES. Countries: 1. Publications: 0.
Longitudinal MRI Assessment in Patients With Diffuse Low-grade Gliomas
ClinicalTrials.gov study NCT04346472. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
DWI Breast MRI in Dense Breast: A Clinical Trial to Assess the Efficacy and Diagnostic Accuracy of Diffusion Weighted Imaging in Dense Breast Tissue
ClinicalTrials.gov study NCT06836089. IPD Sharing: NO. Countries: 1. Publications: 0.
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
ClinicalTrials.gov study NCT04472325. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of Primovist-enhanced MRI, Diffusion Weighted MRI and Multidetector CT of Colorectal Liver Metastases
ClinicalTrials.gov study NCT01255007. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Diagnostic Performance of 18F-FDG-PET and Diffusion-weighted MRI in the Assessment of Stage IB to IIB2 Cervical Squamous-cell Carcinoma Response to Concomitant Radiochemotherapy and Brachytherapy
ClinicalTrials.gov study NCT01663753. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.