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322 results for “dopaminergic”
Data from: Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence
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Data from: Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron
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Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice
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Dopaminergic mechanisms underlying normal variation in trait anxiety: supplemental
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Data from: Effect of polygenic load on striatal dopaminergic deterioration in Parkinson's disease
Objective: To investigate the effect of polygenic load on the progression of striatal dopaminergic dysfunction in patients with Parkinson's disease (PD). Methods: Using data from 335 PD patients in the Parkinson's Progression Markers Initiative (PPMI) database, we investigated the longitudinal association of PD-associated polygenic load with changes in striatal dopaminergic activity as measured by 123I-N-3-fluoropropyl-2-beta-carboxymethoxy-3beta-(4-iodophenyl) nortropane (123I-FP-CIT) single photon emission computed tomography (SPECT) over 4 years. PD-associated polygenic load was estimated by calculating weighted genetic risk scores (GRS) using: i) all available 27 PD-risk single nucleotide polymorphisms (SNPs) in the PPMI database (GRS1); and ii) 23 SNPs with minor allele frequency > 0.05 (GRS2). Results: GRS1 and GRS2 were correlated with younger age-at-onset in PD patients (GRS1, Spearman's rho = -0.128, p = 0.019; GRS2, Spearman's rho = -0.109, p = 0.047). Although GRS1 did not show an association with changes in striatal 123I-FP-CIT availability, GRS2 was associated with a slower decline of striatal dopaminergic activity (interactions with disease duration in linear mixed model; caudate nucleus, estimate = 0.399, SE = 0.165, p = 0.028; putamen, estimate = 0.396, SE = 0.137, p = 0.016). Conclusions: Our results suggest that genetic factors for PD risk may have heterogeneous effects on the striatal dopaminergic degeneration, and some factors may be associated with a slower decline of dopaminergic activity. Composition of PD-progression specific GRS may be useful in predicting disease progression in patients.
Data from: Psychostimulant-induced testicular toxicity in mice: evidence of cocaine and caffeine effects on the local dopaminergic system
Several organ systems can be affected by psychostimulant toxicity. However, there is not sufficient evidence about the impact of psychostimulant intake on testicular physiology and catecholaminergic systems. The aim of the present study was to further explore potential toxic consequences of chronic exposure to cocaine, caffeine, and their combination on testicular physiology. Mice were injected with a 13-day chronic binge regimen of caffeine (3x5mg/kg), cocaine (3×10mg/kg), or combined administration. Mice treated with cocaine alone or combined with caffeine showed reduced volume of the seminiferous tubule associated to a reduction in the number of spermatogonia. Cocaine-only and combined treatments induced increased lipid peroxidation evaluated by TBARS assay and decreased glutathione peroxidase mRNA expression. Importantly, caffeine-cocaine combination potentiated the cocaine-induced germ cell loss, and induced pro-apoptotic BAX protein expression and diminished adenosine receptor A1 mRNA levels. We analyzed markers of dopaminergic function in the testis and detected the presence of tyrosine hydroxylase (TH) in the cytoplasm of androgen-producing Leydig cells, but also in meiotic germs cells within seminiferous tubules. Moreover, using transgenic BAC-Drd1a-tdTomato and D2R-eGFP mice, we report for the first time the presence of dopamine receptors (DRs) D1 and D2 in testicular mouse Leydig cells. Interestingly, the presence of DRD1 was also detected in the spermatogonia nearest the basal lamina of the seminiferous tubules, which did not show TH staining. We observed that psychostimulants induced downregulation of DRs mRNA expression and upregulation of TH protein expression in the testis. These findings suggest a potential role of the local dopaminergic system in psychostimulant-induced testicular pathology.
Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons
<p>The tabular dataset for all graphs in Rafiq et al 2024 can be found in the ASAP data repository</p>
Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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Morphological/WB/ELISA/cell counting data of the paper 'Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism'
<p>The files contain the data included in Figure 2B, Figure 2C, Figure 4B, Figure 4C, Figure 6B, Figure 6C, Suppl.Fig.4, Suppl. Figure 5, Suppl. Figure 6I, Suppl. Figure 6J.</p>
Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant Depression
ClinicalTrials.gov study NCT00953745. IPD Sharing: Not stated. Countries: 1. Publications: 0.
PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects
ClinicalTrials.gov study NCT03581305. IPD Sharing: NO. Countries: 1. Publications: 0.
Study Assessing Efficacy and Safety of AKST4290 in Subjects With Parkinson's Disease on Stable Dopaminergic Treatment
ClinicalTrials.gov study NCT04369430. IPD Sharing: NO. Countries: 5. Publications: 0.
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Supplemental Open-Label Arm
ClinicalTrials.gov study NCT06587217. IPD Sharing: NO. Countries: 1. Publications: 0.
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System
ClinicalTrials.gov study NCT04325503. IPD Sharing: NO. Countries: 1. Publications: 0.
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm
ClinicalTrials.gov study NCT06219915. IPD Sharing: NO. Countries: 1. Publications: 0.
DTA (Dopaminergic Therapy for Anhedonia) Study
ClinicalTrials.gov study NCT04723147. IPD Sharing: YES. Countries: 1. Publications: 0.
DESENSITIZE-PD: Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Support Dopaminergic Desensitization in PD
ClinicalTrials.gov study NCT05579379. IPD Sharing: UNDECIDED. Countries: 0. Publications: 6.
Data from: Psychostimulant-induced testicular toxicity in mice: evidence of cocaine and caffeine effects on the local dopaminergic system
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Data from: Effect of polygenic load on striatal dopaminergic deterioration in Parkinson's disease
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Single Cell RNA-seq Study of Midbrain and Dopaminergic Neuron Development in Mouse, Human, and Stem Cells
GEO Series GSE76381. Homo sapiens; Mus musculus. 6179 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.