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Files from TCGA-KIRC Study for Body Part Regression Tutorial
<p>The data here are in whole based upon data generated by the TCGA Research Network: <a href="https://cancergenome.nih.gov/">http://cancergenome.nih.gov/</a>.</p> <p><br> The DICOM files from the <a href="https://wiki.cancerimagingarchive.net/display/Public/TCGA-KIRC#580038695f8cd691bda43dda71b4093c69c7318">TCGA-KIRC </a>study were converted to nifti files. Moreover, the nifti files with greater size than 35 MB and smaller size than 5 MB were removed (to reduce the size of the dataset and to remove the files with few slices). Furthermore, the metadata from the DICOM files is saved in a separate excel-file.</p>
DeepCytometer pipeline parameter files, Klf14 mouse white adipose tissue histology and hand-traced training contours
<p>Latest description of this data set: <a href="https://github.com/MRC-Harwell/cytometer/blob/main/DATA.md">Data.md at cytometer project</a></p> <pre># Publications related to the data The data associated to the DeepCytometer project (https://github.com/MRC-Harwell/cytometer) is available from Zenodo (doi: 10.5281/zenodo.5137433 and 10.5281/zenodo.5149005). The histology and mouse measures were generated as part of the Small et al. 2018 study: > Small et al. "Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition". Nature Genetics, 50:572–580, 2018. The hand traced data set, colour maps, and automatic segmentations were generated for the Casero et al. 2021 paper: > Casero et al. "Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks". bioRxiv, 2021. doi: [10.1101/2021.06.03.444997](https://www.biorxiv.org/content/10.1101/2021.06.03.444997v1.full). # Data protocols ## Histology and laboratory measures To develop and evaluate our methods we used Klf14tm1(KOMP)Vlcg C57BL/6NTac (B6NTac) mice tissue samples and additional data generated as part of the Small et al. 2018 study(Small et al. 2018). It should be noted that the single exon Klf14 gene is imprinted and only expressed from the maternally inherited allele(Parker-Katiraee et al. 2007). This was taken into account by (Small et al. 2018) by crossing a Het parent with a WT parent, so that each offspring inherited a WT allele from the WT parent, and the Klf14 gene knockout or a WT allele from the other parent (from the father, PAT, or the mother, MAT). We also take Klf14 imprinting into account by using as controls the PAT mice and comparing them to the MAT WT and MAT Het (or functional KO, FKO) mice. We used a total of 76 Klf14-B6NTac mice (nfemale=nmale=38), of which 20 mice from the Control and FKO groups were used for training and testing the DeepCytometer pipeline, as well as the hand traced population experiment (summary in Table MICE). The histopathology screen involved fixing, processing and embedding in wax, sectioning and staining with Hematoxylin and Eosin (H&E) both inguinal subcutaneous and gonadal adipose depots. For paraffin-embedded sections, all samples were fixed in 10% neutral buffered formalin (Surgipath) for at least 48 hours at RT and processed using an Excelsior™ AS Tissue Processor (Thermo Scientific). Samples were embedded in molten paraffin wax and 8 μm sections were cut through the respective depots using a Finesse™ ME+ microtome (Thermo Scientific). Sampling was conducted at 2sxns per slide, 3 slides per depot block onto simultaneous charged slides, stained with haematoxylin Gill 3 and eosin (Thermo scientific) and scanned using an NDP NanoZoomer Digital pathology scanner (RS C10730 Series; Hamamatsu). Body weight (BW) and depot weight (DW) were measured with Satorius BAL7000 scales. ## White adipose tissue segmentation For cell area quantification, we applied DeepCytometer v8 to 75 inguinal subcutaneous and 72 gonadal whole histology slides with DeepCytometer (with the Corrected method), including the 20 slides sampled for the hand-traced data set, corresponding to 73 females and 74 males, to produce 2,560,067 subcutaneous and 2,467,686 gonadal cells (on average, 34,134 and 34,273 cells per slide, respectively). Full segmentation of all whole slides was performed with script [klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py). In this case, the segmentation contours were grouped by tiles in the output AIDA annotation `.json` file (one contour per cell, one file per slide). Non-white adipocyte contours were filtered out, and white adipocyte contours were aggregated into an AIDA annotation `.json` file with a single tile with script [klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py) (one contour per cell, one file per slide). # List of directories and files ## Casero et al. (2021) "DeepCytometer pipeline parameter files, Klf14 mouse white adipose tissue histology and hand-traced training contours" (doi: 10.5281/zenodo.5137433) ### `deepcytometer_pipeline_v8.zip` (60.6 MB) Weights, colourmaps, etc. necessary to run the pipeline (v8, with mode colour correction). This is the version of the pipeline described in the paper. There are 10 weight files per convolutional neural network (CNN), corresponding to 10-fold cross-validation * `klf14_b6ntac_exp_0086_cnn_dmap_model_fold_[0..9].h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0089_cnn_segmentation_correction_overlapping_scaled_contours_model_fold_[0..9].h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0091_cnn_contour_after_dmap_model_fold_[0..9].h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0095_cnn_tissue_classifier_fcn_model_fold_[0..9].h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) * `klf14_b6ntac_exp_0094_generate_extra_training_images.pickle`: training dataset description * **'file_list'**: list of SVG files with hand-traced contours for network training. Each SVG file has a corresponding TIFF file with the histology used for segmentation * **'idx_test'**: 10 lists with file indices for testing in 10-fold cross-validation * **'idx_train'**: 10 lists with file indices for training in 10-fold cross-validation * **'fold_seed'**: seed number used for the random number generator to assign file indices to folds * `klf14_b6ntac_exp_0098_filename_area2quantile.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0098_full_slide_size_analysis_v7.py` using the whole Klf14 data set with v7 of the pipeline, and used in earlier experiments, including some where v8 of the pipeline was used for segmentation. * `klf14_b6ntac_exp_0106_filename_area2quantile_v8.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py` using the whole Klf14 data set with v8 of the pipeline, and used in later experiments. * `klf14_training_colour_histogram.npz`: statistics from Klf14 histology images to be used in colour correction * **'xbins_edge'**, **'xbins'**: edges and centres of the bins used for histogram calculations * **'hist_r_q1'**, **'hist_r_q2'**, **'hist_r_q3'** * **'hist_g_q1'**, **'hist_g_q2'**, **'hist_g_q3'** * **'hist_b_q1'**, **'hist_b_q2'**, **'hist_b_q3'**: density quartiles (Q1, Q2, Q3) for RGB channels for each bin the histogram * **'mode_r'**, **'mode_g'**, **'mode_b'**: modes for RGB channels (this corresponds to the most typical background colour in the histology images) * **'mean_l'**, **'mean_a'**, **'mean_b'**: mean intensity for L*a*b channels of the image * **'std_l'**, **'std_a'**, **'std_b'**: intensity standard deviations for L*a*b channels of the image * `klf14_exp_0112_training_colour_histogram.npz`: other statistics from Klf14 histology images to be used in colour correction * **'p'**: vector of quantile values used in ECDF calculations * **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'**: all intensity values for the RGB channels of Klf14 training images that contain at least a white adipocyte * **'f_ecdf_to_val_r_klf14'**, **'f_ecdf_to_val_g_klf14'**, **'f_ecdf_to_val_b_klf14'**: linear interpolation function that maps ECDF quantiles to intensity values in the Klf14 training data set. These functions can be used together with intensity->quantile interpolation functions calculated for a new histology image to perform histogram matching colour correction * **'mean_klf14'**, **'std_klf14'**: mean and standard deviation of the **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'** vectors There are also weight files for the pipeline trained with all the data, instead of the 10-fold cross-validation partition. These were not used for the paper, but could be useful for future experiments * `klf14_b6ntac_exp_0101_cnn_dmap_model.h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0104_cnn_segmentation_correction_overlapping_scaled_contours_model.h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0102_cnn_contour_after_dmap_model.h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0103_cnn_tissue_classifier_fcn_model.h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) ### `histology.7z` (29.1 GB) 165 H&E histology whole slides from Hamamatsu scanner (`.ndpi`). ### `klf14.7z` (2.3 GB) Mice metadata, training/testing data sets for the pipeline, intermediate files created during training, and neural network weights for multiple experiments. * `klf14_b6ntac_meta_info.csv`: Klf14 mice metadata * **Animal Identifier**, **id:** unique ID for each mouse * **ko_parent:** heterozygous parent of origin for the KO allele (father, PAT or mother, MAT) * **sex:** female or male * **genotype:** wild type (KLF14-KO:WT) or heterozygous (KLF14-KO:Het) * **BW:** body weight (g) * **SC:** subcutaneous depot weight (g) * **gWAT:** gonadal depot weight (g) * **Liver:** livel weight (g) * **cull_age:** age at time of culling (days) * **BW_alive:** body weight measured before culling * **BW_alive_date:** age at time of BW_alive measure * **mother:** unique ID for mouse's mother * **mother_genotype:** mouse's mother genotype * `klf14_b6ntac_training`: Directory with hand-traced segmentations of training histology windows. 131 windows sampled from 20 whole slides, plus hand-traced contours that were used for training DeepCytometer and compute population distributions. These segmentations were used for CNN training, but note that there's a cleaned-up version of these data below, and it was the cleaned-up version that was used for the paper experiments * `ndpifile_row_YYYYYY_col_XXXXXX[.tif/.xcf/.svg]`: * **ndpifile:** name of the whole slide file (e.g. `KLF14-B6NTAC 36.1c PAT 98-16 C1 - 2016-02-11 10.45.00`) * **row_YYYYYY:** Y-coordinate of the top-left corner of the sampling window, in pixels * **col_XXXXXX:** X-coordinate of the top-left corner of the sampling window, in pixels * **.tif:** TIFF file with the histology sampling window * **.xcf:** Gimp file with the histology and hand-traced contours (the contours were drawn in Gimp) * **.svg:** SVG (Scalable Vector Graphics) that contains the hand-traced contours in the XCF file * `klf14_b6ntac_training_v2`: Same as `klf14_b6ntac_training`, but the hand-traced data set was cleaned up to remove small contours of dubious cells, or cells that are fully overlapped by others * `klf14_b6ntac_training_non_overlap`: Directory with intermediate images to train the networks. These images are generated by script [`klf14_b6ntac_training_non_overlap`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0077_generate_non_overlap_training_images.py) * `klf14_b6ntac_training_augmented`: Directory with intermediate images used to train the networks (using augmentation to reduce overfitting). These images are generated by script [`klf14_b6ntac_exp_0078_generate_augmented_training_images.py`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0078_generate_augmented_training_images.py) * `klf14_b6ntac_seg`: Deprecated. Directory to store whole slide coarse segmentations in old experiments (e.g. `klf14_b6ntac_exp_0076_generate_training_images.py`). Of little interest for most users * `klf14_b6ntac_results`: Deprecated. Directory to store miscellanea output from some experiments. Of little interest for most users ## Casero et al. (2021). "Klf14 mouse white adipose tissue histology DeepZoom files and AIDA annotations for visualisation of DeepCytometer white adipocyte segmentations" (doi: 10.5281/zenodo.5149005) ### `aida_data_Klf14_v8_images.7z` (16.9 GB) Histology images converted to DeepZoom so that they can be visualised with [AIDA](https://github.com/alanaberdeen/AIDA). To use this, decompress this file and put the resulting `images` directory in your `AIDA/dist/data/` directory. ### `aida_data_Klf14_v8_annotations.7z` (18 GB) White adipocyte segmentations in AIDA annotation `.json` files (one contour per cell, one file per whole slide). Each slide has the following files: * `SLIDENAME.json`: Soft link to the annotations file that we want to associate to slide `SLIDENAME.ndpi`, e.g. `SLIDENAME` = `KLF14-B6NTAC-PAT-39.2d 454-16 B1 - 2016-03-17 12.16.06` * `SLIDENAME.lock`: Empty file used to tell the pipeline that `SLIDENAME.ndpi` has already been processed or is being currently processed * `SLIDENAME_coarse_mask.npz`: File with the coarse tissue segmentation of `SLIDENAME.ndpi` and the internal state of the pipeline (execution times, steps, etc) * `SLIDENAME_exp_0106_auto.json`: Annotations (all segmentations without filtering from the Auto algorithm, i.e. segmentation without object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_auto_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Auto algorithm. All contours aggregated into a single tile * `SLIDENAME_exp_0106_corrected.json`: Annotations (all segmentations without filtering from the Corrected algorithm, i.e. segmentation with object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_corrected_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Corrected algorithm. All contours aggregated into a single tile To use this, decompress this file and put the resulting `annotations` directory in your `AIDA/dist/data/` directory. </pre>
Klf14 mouse white adipose tissue histology DeepZoom files and AIDA annotations for visualisation of DeepCytometer white adipocyte segmentations
<p>Latest description of this data set: <a href="https://github.com/MRC-Harwell/cytometer/blob/main/DATA.md">Data.md at cytometer project</a></p> <pre># Publications related to the data The data associated to the DeepCytometer project (https://github.com/MRC-Harwell/cytometer) is available from Zenodo (doi: 10.5281/zenodo.5137433 and 10.5281/zenodo.5149005). The histology and mouse measures were generated as part of the Small et al. 2018 study: > Small et al. "Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition". Nature Genetics, 50:572–580, 2018. The hand traced data set, colour maps, and automatic segmentations were generated for the Casero et al. 2021 paper: > Casero et al. "Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks". bioRxiv, 2021. doi: [10.1101/2021.06.03.444997](https://www.biorxiv.org/content/10.1101/2021.06.03.444997v1.full). # Data protocols ## Histology and laboratory measures To develop and evaluate our methods we used Klf14tm1(KOMP)Vlcg C57BL/6NTac (B6NTac) mice tissue samples and additional data generated as part of the Small et al. 2018 study(Small et al. 2018). It should be noted that the single exon Klf14 gene is imprinted and only expressed from the maternally inherited allele(Parker-Katiraee et al. 2007). This was taken into account by (Small et al. 2018) by crossing a Het parent with a WT parent, so that each offspring inherited a WT allele from the WT parent, and the Klf14 gene knockout or a WT allele from the other parent (from the father, PAT, or the mother, MAT). We also take Klf14 imprinting into account by using as controls the PAT mice and comparing them to the MAT WT and MAT Het (or functional KO, FKO) mice. We used a total of 76 Klf14-B6NTac mice (nfemale=nmale=38), of which 20 mice from the Control and FKO groups were used for training and testing the DeepCytometer pipeline, as well as the hand traced population experiment (summary in Table MICE). The histopathology screen involved fixing, processing and embedding in wax, sectioning and staining with Hematoxylin and Eosin (H&E) both inguinal subcutaneous and gonadal adipose depots. For paraffin-embedded sections, all samples were fixed in 10% neutral buffered formalin (Surgipath) for at least 48 hours at RT and processed using an Excelsior™ AS Tissue Processor (Thermo Scientific). Samples were embedded in molten paraffin wax and 8 μm sections were cut through the respective depots using a Finesse™ ME+ microtome (Thermo Scientific). Sampling was conducted at 2sxns per slide, 3 slides per depot block onto simultaneous charged slides, stained with haematoxylin Gill 3 and eosin (Thermo scientific) and scanned using an NDP NanoZoomer Digital pathology scanner (RS C10730 Series; Hamamatsu). Body weight (BW) and depot weight (DW) were measured with Satorius BAL7000 scales. ## White adipose tissue segmentation For cell area quantification, we applied DeepCytometer v8 to 75 inguinal subcutaneous and 72 gonadal whole histology slides with DeepCytometer (with the Corrected method), including the 20 slides sampled for the hand-traced data set, corresponding to 73 females and 74 males, to produce 2,560,067 subcutaneous and 2,467,686 gonadal cells (on average, 34,134 and 34,273 cells per slide, respectively). Full segmentation of all whole slides was performed with script [klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py). In this case, the segmentation contours were grouped by tiles in the output AIDA annotation `.json` file (one contour per cell, one file per slide). Non-white adipocyte contours were filtered out, and white adipocyte contours were aggregated into an AIDA annotation `.json` file with a single tile with script [klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py](https://github.com/MRC-Harwell/cytometer/blob/39358ed1d79df07d1d522b98728c7efd745513f7/scripts/klf14_b6ntac_exp_0106_annotations_postprocessing_v8.py) (one contour per cell, one file per slide). # List of directories and files ## Casero et al. (2021) "DeepCytometer pipeline parameter files, Klf14 mouse white adipose tissue histology and hand-traced training contours" (doi: 10.5281/zenodo.5137433) ### `deepcytometer_pipeline_v8.zip` (60.6 MB) Weights, colourmaps, etc. necessary to run the pipeline (v8, with mode colour correction). This is the version of the pipeline described in the paper. There are 10 weight files per convolutional neural network (CNN), corresponding to 10-fold cross-validation * `klf14_b6ntac_exp_0086_cnn_dmap_model_fold_[0..9].h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0089_cnn_segmentation_correction_overlapping_scaled_contours_model_fold_[0..9].h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0091_cnn_contour_after_dmap_model_fold_[0..9].h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0095_cnn_tissue_classifier_fcn_model_fold_[0..9].h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) * `klf14_b6ntac_exp_0094_generate_extra_training_images.pickle`: training dataset description * **'file_list'**: list of SVG files with hand-traced contours for network training. Each SVG file has a corresponding TIFF file with the histology used for segmentation * **'idx_test'**: 10 lists with file indices for testing in 10-fold cross-validation * **'idx_train'**: 10 lists with file indices for training in 10-fold cross-validation * **'fold_seed'**: seed number used for the random number generator to assign file indices to folds * `klf14_b6ntac_exp_0098_filename_area2quantile.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0098_full_slide_size_analysis_v7.py` using the whole Klf14 data set with v7 of the pipeline, and used in earlier experiments, including some where v8 of the pipeline was used for segmentation. * `klf14_b6ntac_exp_0106_filename_area2quantile_v8.npz`: quantile colour maps calculated in `klf14_b6ntac_exp_0106_full_slide_pipeline_v8.py` using the whole Klf14 data set with v8 of the pipeline, and used in later experiments. * `klf14_training_colour_histogram.npz`: statistics from Klf14 histology images to be used in colour correction * **'xbins_edge'**, **'xbins'**: edges and centres of the bins used for histogram calculations * **'hist_r_q1'**, **'hist_r_q2'**, **'hist_r_q3'** * **'hist_g_q1'**, **'hist_g_q2'**, **'hist_g_q3'** * **'hist_b_q1'**, **'hist_b_q2'**, **'hist_b_q3'**: density quartiles (Q1, Q2, Q3) for RGB channels for each bin the histogram * **'mode_r'**, **'mode_g'**, **'mode_b'**: modes for RGB channels (this corresponds to the most typical background colour in the histology images) * **'mean_l'**, **'mean_a'**, **'mean_b'**: mean intensity for L*a*b channels of the image * **'std_l'**, **'std_a'**, **'std_b'**: intensity standard deviations for L*a*b channels of the image * `klf14_exp_0112_training_colour_histogram.npz`: other statistics from Klf14 histology images to be used in colour correction * **'p'**: vector of quantile values used in ECDF calculations * **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'**: all intensity values for the RGB channels of Klf14 training images that contain at least a white adipocyte * **'f_ecdf_to_val_r_klf14'**, **'f_ecdf_to_val_g_klf14'**, **'f_ecdf_to_val_b_klf14'**: linear interpolation function that maps ECDF quantiles to intensity values in the Klf14 training data set. These functions can be used together with intensity->quantile interpolation functions calculated for a new histology image to perform histogram matching colour correction * **'mean_klf14'**, **'std_klf14'**: mean and standard deviation of the **'val_r_klf14'**, **'val_g_klf14'**, **'val_b_klf14'** vectors There are also weight files for the pipeline trained with all the data, instead of the 10-fold cross-validation partition. These were not used for the paper, but could be useful for future experiments * `klf14_b6ntac_exp_0101_cnn_dmap_model.h5`: Keras weights for the **EDT CNN** (Histology to Euclidean Distance Transform regression) * `klf14_b6ntac_exp_0104_cnn_segmentation_correction_overlapping_scaled_contours_model.h5`: Keras weights for the **Correction CNN** (Segmentation Correction regression) * `klf14_b6ntac_exp_0102_cnn_contour_after_dmap_model.h5`: Keras weights for the **Contour CNN** (EDT to Contour detection) * `klf14_b6ntac_exp_0103_cnn_tissue_classifier_fcn_model.h5`: Keras weights for the **Tissue CNN** (Pixel-wise tissue classifier) ### `histology.7z` (29.1 GB) 165 H&E histology whole slides from Hamamatsu scanner (`.ndpi`). ### `klf14.7z` (2.3 GB) Mice metadata, training/testing data sets for the pipeline, intermediate files created during training, and neural network weights for multiple experiments. * `klf14_b6ntac_meta_info.csv`: Klf14 mice metadata * **Animal Identifier**, **id:** unique ID for each mouse * **ko_parent:** heterozygous parent of origin for the KO allele (father, PAT or mother, MAT) * **sex:** female or male * **genotype:** wild type (KLF14-KO:WT) or heterozygous (KLF14-KO:Het) * **BW:** body weight (g) * **SC:** subcutaneous depot weight (g) * **gWAT:** gonadal depot weight (g) * **Liver:** livel weight (g) * **cull_age:** age at time of culling (days) * **BW_alive:** body weight measured before culling * **BW_alive_date:** age at time of BW_alive measure * **mother:** unique ID for mouse's mother * **mother_genotype:** mouse's mother genotype * `klf14_b6ntac_training`: Directory with hand-traced segmentations of training histology windows. 131 windows sampled from 20 whole slides, plus hand-traced contours that were used for training DeepCytometer and compute population distributions. These segmentations were used for CNN training, but note that there's a cleaned-up version of these data below, and it was the cleaned-up version that was used for the paper experiments * `ndpifile_row_YYYYYY_col_XXXXXX[.tif/.xcf/.svg]`: * **ndpifile:** name of the whole slide file (e.g. `KLF14-B6NTAC 36.1c PAT 98-16 C1 - 2016-02-11 10.45.00`) * **row_YYYYYY:** Y-coordinate of the top-left corner of the sampling window, in pixels * **col_XXXXXX:** X-coordinate of the top-left corner of the sampling window, in pixels * **.tif:** TIFF file with the histology sampling window * **.xcf:** Gimp file with the histology and hand-traced contours (the contours were drawn in Gimp) * **.svg:** SVG (Scalable Vector Graphics) that contains the hand-traced contours in the XCF file * `klf14_b6ntac_training_v2`: Same as `klf14_b6ntac_training`, but the hand-traced data set was cleaned up to remove small contours of dubious cells, or cells that are fully overlapped by others * `klf14_b6ntac_training_non_overlap`: Directory with intermediate images to train the networks. These images are generated by script [`klf14_b6ntac_training_non_overlap`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0077_generate_non_overlap_training_images.py) * `klf14_b6ntac_training_augmented`: Directory with intermediate images used to train the networks (using augmentation to reduce overfitting). These images are generated by script [`klf14_b6ntac_exp_0078_generate_augmented_training_images.py`](https://github.com/MRC-Harwell/cytometer/blob/main/scripts/klf14_b6ntac_exp_0078_generate_augmented_training_images.py) * `klf14_b6ntac_seg`: Deprecated. Directory to store whole slide coarse segmentations in old experiments (e.g. `klf14_b6ntac_exp_0076_generate_training_images.py`). Of little interest for most users * `klf14_b6ntac_results`: Deprecated. Directory to store miscellanea output from some experiments. Of little interest for most users ## Casero et al. (2021). "Klf14 mouse white adipose tissue histology DeepZoom files and AIDA annotations for visualisation of DeepCytometer white adipocyte segmentations" (doi: 10.5281/zenodo.5149005) ### `aida_data_Klf14_v8_images.7z` (16.9 GB) Histology images converted to DeepZoom so that they can be visualised with [AIDA](https://github.com/alanaberdeen/AIDA). To use this, decompress this file and put the resulting `images` directory in your `AIDA/dist/data/` directory. ### `aida_data_Klf14_v8_annotations.7z` (18 GB) White adipocyte segmentations in AIDA annotation `.json` files (one contour per cell, one file per whole slide). Each slide has the following files: * `SLIDENAME.json`: Soft link to the annotations file that we want to associate to slide `SLIDENAME.ndpi`, e.g. `SLIDENAME` = `KLF14-B6NTAC-PAT-39.2d 454-16 B1 - 2016-03-17 12.16.06` * `SLIDENAME.lock`: Empty file used to tell the pipeline that `SLIDENAME.ndpi` has already been processed or is being currently processed * `SLIDENAME_coarse_mask.npz`: File with the coarse tissue segmentation of `SLIDENAME.ndpi` and the internal state of the pipeline (execution times, steps, etc) * `SLIDENAME_exp_0106_auto.json`: Annotations (all segmentations without filtering from the Auto algorithm, i.e. segmentation without object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_auto_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Auto algorithm. All contours aggregated into a single tile * `SLIDENAME_exp_0106_corrected.json`: Annotations (all segmentations without filtering from the Corrected algorithm, i.e. segmentation with object overlap). Contours are grouped by the tile they were processed in * `SLIDENAME_exp_0106_corrected_aggregated.json`: Filtered annotations (non-white adipocytes removed) of the Corrected algorithm. All contours aggregated into a single tile To use this, decompress this file and put the resulting `annotations` directory in your `AIDA/dist/data/` directory.</pre>
LamaH-CE: LArge-SaMple DAta for Hydrology and Environmental Sciences for Central Europe – files
<p><strong>Version 1.0 - This version is the final revised one.</strong></p> <p>This is the LamaH-CE dataset accompanying the paper: Klingler et al., LamaH-CE | LArge-SaMple DAta for Hydrology and Environmental Sciences for Central Europe, published at Earth System Science Data (ESSD), 2021 (<a href="https://doi.org/10.5194/essd-13-4529-2021">https://doi.org/10.5194/essd-13-4529-2021</a>).</p> <p>LamaH-CE contains a collection of runoff and meteorological time series as well as various (catchment) attributes for 859 gauged basins. The hydrometeorological time series are provided with daily and hourly time resolution including quality flags. All meteorological and the majority of runoff time series cover a span of over 35 years, which enables long-term analyses with high temporal resolution.<br> LamaH is in its basics quite sililar to the well-known CAMELS datasets for the contiguous United States (<a href="https://doi.org/10.5194/hess-21-5293-2017">https://doi.org/10.5194/hess-21-5293-2017</a>), Chile (<a href="https://doi.org/10.5194/hess-22-5817-2018">https://doi.org/10.5194/hess-22-5817-2018</a>), Brazil (<a href="https://doi.org/10.5194/essd-12-2075-2020">https://doi.org/10.5194/essd-12-2075-2020</a>), Great Britain (<a href="https://doi.org/10.5194/essd-12-2459-2020">https://doi.org/10.5194/essd-12-2459-2020</a>) and Australia (<a href="https://doi.org/10.5194/essd-13-3847-2021">https://doi.org/10.5194/essd-13-3847-2021</a>), but new features like additional basin delineations (intermediate catchments) and attributes allow to consider the hydrological network and river topology in further applications.</p> <p>We provide two different files to download: 1) Hydrometeorological time series with daily and hourly resolution, which requires decompressed about 70 GB of free disk space. 2) Hydrometeorological time series only with daily resolution, which requires 5 GB. Beyond the temporal resolution of the time series, there are no differences.</p> <p><strong>Note: </strong>It is recommended to read the supplementary info file before using the dataset. For example, it clarifies the time conventions and that <strong>NAs</strong> are indicated by the number<strong> -999</strong> in the <strong>runoff time series</strong>.</p> <p><strong>Disclaimer:</strong> We have created LamaH with care and checked the outputs for plausibility. By downloading the dataset, you agree that we nor the provider of the used source datasets (e.g. runoff time series) cannot be liable for the data provided. The runoff time series of the German federal states Bavaria and Baden-Württemberg are retrospective checked and updated by the hydrographic services. Therefore, it might be appropriate to obtain more up-to-date runoff data from Bavaria (<a href="https://www.gkd.bayern.de/en/rivers/discharge/tables">https://www.gkd.bayern.de/en/rivers/discharge/tables</a>) and Baden-Württemberg (<a href="https://udo.lubw.baden-wuerttemberg.de/public/p/pegel_messwerte_leer">https://udo.lubw.baden-wuerttemberg.de/public/p/pegel_messwerte_leer</a>). Runoff data from the Czech Republic may not be used to set up operational warning systems (<a href="https://www.chmi.cz/files/portal/docs/hydro/denni_data/Podminky_uziti.pdf">https://www.chmi.cz/files/portal/docs/hydro/denni_data/Podminky_uziti.pdf</a>).</p> <p><strong>License: </strong>This work is licensed with CC BY-SA 4.0 (<a href="https://creativecommons.org/licenses/by-sa/4.0/">https://creativecommons.org/licenses/by-sa/4.0/</a>). This means that you may freely use and modify the data (even for commercial purposes). But you have to give appropriate credit (associated ESSD paper, version of dataset and all sources which are declared in the folder "Info"), indicate if and what changes were made and distribute your work under the same public license as the original.</p> <p><strong>Additional references: </strong>We ask kindly for compliance in citing the following references when using LamaH, as an agreement to cite was usually a condition of sharing the data: BAFU (2020), CHMI (2020), GKD (2020), HZB (2020), LUBW (2020), BMLFUW (2013), Broxton et al. (2014), CORINE (2012), EEA (2019), ESDB (2004), Farr et al. (2007), Friedl and Sulla-Menashe (2019), Gleeson et al. (2014), HAO (2007), Hartmann and Moosdorf (2012), Hiederer (2013a, b), Linke et al. (2019), Muñoz Sabater et al. (2021), Muñoz Sabater (2019a), Myneni et al. (2015), Pelletier et al. (2016), Toth et al. (2017), Trabucco and Zomer (2019), and Vermote (2015). These references are listed in detail in the accompanying <a href="https://doi.org/10.5194/essd-13-4529-2021">paper</a>.</p> <p><strong>Supplements: </strong>We have created additional files after publication (therefore non peer-reviewed):<br> 1) Shapefiles for reservoirs (points) and cross-basin water transfers (lines) including several attributes as well as tables with information about the accumulated storage volume and effective catchment area (considerung artificial in- and outflows) for every runoff gauge.<br> 2) Water quality data (e.g. dissolved oxygen, water temperature, conductivity, NO3-N), which are suitable to the gauges. The data for water quality may not be used for commercial purposes.<br> If you are interessted, just send us an email with your name, affiliation and the intended purpose for the requested files to the address listed below. If you find any errors in the dataset, feel free to send us an email to: christoph.klingler@boku.ac.at</p>
Replication files for: Strongmen Cry Too: The Effect of Aerial Bombing on Voting for The Incumbent in Competitive Autocracies
<p>The NATO bombing of Yugoslavia, which lasted from March 24, 1999 until June 10, 1999, was the largest air campaign in Europe since the bombing of Britain and Germany in World War II. The air raids lasted for 78 days and hit 108 out of 160 municipalities, excluding Kosovo and Montenegro. The bombing was spread out and largely aimed at military barracks, industrial facilities, transportation networks, and communication lines. This repo provides a novel dataset with information on over 1,000 targets in the Federal Republic of Yugoslavia, including the date, location, target type, and fatalities. Included is also R code for the replication of my article "Strongmen Cry Too: The Effect of Aerial Bombing on Voting for The Incumbent in Competitive Autocracies" that was accepted for publication at Journal of Peace Research.</p>
Censored Books during the Portuguese Estado Novo: Transcription Dataset of the Censorship Commission's Card Files (1934-74)
<p>This spreadsheet contributes to a new bibliography of censored books under the Portuguese Estado Novo dictatorial regime.</p> <p>It contains the transcription of the data fields of 1,015 card files of censored books, which are indexed by author surname in letters A and B. These files are available at the Arquivo Nacional da Torre do Tombo, in Lisbon, Portugal (PT/TT/SNI-DSC/7, "Fichas de Autores de Obras Proibidas e Autorizadas", <a href="https://digitarq.arquivos.pt/details?id=4326912">https://digitarq.arquivos.pt/details?id=4326912</a>).</p> <p>The card files document data about the books censored by the Estado Novo Censorship Commission (1934-74). Data fields include file number, book report number, decision, date, author, title, origin, destination, observations, notices, and author or book process number.</p> <p>All card files have been photographed from very poor-quality photocopies and manually transcribed by Álvaro Seiça during 2020/21. Letters C-Z are ongoing work and will be added to this dataset.</p> <p>This project received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 793147, ARTDEL.</p> <p>More info at https://artdel.net</p>
GNPS Drug Library spectral files and metadata
<p>Global Natural Product Social Molecular Networking (GNPS) Drug Library: a centralized collection of reference spectra for drugs and their metabolites/analogs along with structured pharmacologic metadata including exposure source, pharmacologic class, therapeutic indication, and mechanism of action. </p> <p>Two MS/MS reference libraries: </p> <ul> <li>GNPS_Drug_Library_Spectra_Drugs_and_Metabolites.mgf: Reference spectra for drugs and drug metabolites collected from the GNPS Spectral Library and MSnLib.</li> <li>GNPS_Drug_Library_Spectra_Drug_Analogs.mgf: MS/MS spectra analogs of drugs in publicly accessible untargeted metabolomics data derived from spectral alignment strategies.</li> </ul> <p>Two metadata files:</p> <ul> <li><span>GNPS_Drug_Library_Metadata_Drugs.csv: Controlled-vocabulary pharmacologic metadata on the drugs. </span></li> <li><span>GNPS_Drug_Library_Metadata_Drug_Analogs.csv: Metadata on the drug analogs, including connections to parent drugs, mass offsets, and pharmacologic metadata based on the parent drugs.</span></li> </ul> <p><span>Publication:</span></p> <p><span>https://www.biorxiv.org/content/10.1101/2024.10.07.617109v1</span></p>
Set of CFT files from EBSD maps
<p>Set of .ctf files from EBSD maps (treated data) used in the articles Demouchy et al., submitted at European Journal Mineralogy.</p> <p>Demouchy, S., Thieme, M., Barou F., Beausir B., Taupin V., Cordier P., (2022-2023). Dislocation and disclination densities in experimentally deformed polycrystalline olivine. Submitted to <em>Eur. J. Min</em>., in revision (minor revision), dec 2022.</p>
TBPos: Dataset for Large-Scale Precision Visual Localization (database files)
<p>Large-scale dataset for visual localization, provided in the format of the well-known InLoc dataset (Taira et al, 2018). Contains co-registered RGB point clouds and a script for generating the rest of the 'database' files for visual localization by the InLoc algorithm. Note: query images are provided in a separate repository.</p>
Si data files for Galaxy materials science tutorials
<p>This is a training dataset for use in Galaxy materials science tutorials. These files can be used to demonstrate the AIRSS (Ab-Initio Random Structure Searching) method for finding muon stopping sites, using the UEP (Unperturbed Electrostatic Potential) technique for the optimisation stage of that method.</p> <p>The files included are:</p> <ul> <li><strong>Si.cell:</strong> structure file containing atom locations</li> <li><strong>Si.den_fmt:</strong> electron density data, generated with CASTEP</li> <li><strong>Si.castep:</strong> CASTEP log file for the electron density calculation</li> <li><strong>Si-muairss-uep.yaml:</strong> configuration file for the AIRSS / UEP workflow</li> </ul>
Supplemental data files: Beyond the reference: gene expression variation and transcriptional response to RNAi in C. elegans
<p>This dataset holds all non-GEO-hosted supplemental data files for manuscript "Beyond the reference: gene expression variation and transcriptional response to RNAi in <em>C. elegans</em>". Please see the linked preprint/publication for full details.</p> <p>The PDF _guide_to_datafiles.pdf gives details on the format and content of each of the included files.</p>
ELWar Expert Survey Trend File
<p>This repository contains the combined data from the 2018, 2020, and 2022 ELWar expert surveys on parties’ political ideology, policy positions, and behavior in six countries in South-East Europe: Bosnia and Herzegovina, Croatia, Kosovo, North Macedonia, Montenegro, and Serbia. The survey is part of the project “Electoral Legacies of War: Political Competition in Postwar Southeast Europe" (ELWar).</p>
SEVN parameter file from the paper "Binary neutron star populations in the Milky Way" by Sgalletta et al., 2023
<p>The repository contains the runtime parameters used in the SEVN simulations analysed in the paper "Binary neutron star populations in the Milky Way" by Sgalletta et al., 2023.</p> <p><strong>Repository content: </strong></p> <p>- <em>used_params_Sgalletta2023.txt<br> </em>The file contains all the runtime parameters used in the SEVN simulations. The parameters that have been varied in different runs are indicated with **** and the explored values are reported in the comment. See the SEVN userguide (<a href="https://gitlab.com/sevncodes/sevn/-/blob/SEVN/resources/SEVN_userguide.pdf">https://gitlab.com/sevncodes/sevn/-/blob/SEVN/resources/SEVN_userguide.pdf</a>) for the description of each parameter </p> <p> </p>
Additional file 1 of Medium development and production of carotenoids and exopolysaccharides by the extremophile Rhodothermus marinus DSM16675 in glucose-based defined media
<p>The biodegradative capacity of bacteria in their natural habitats is affected by water availability. In this work, we have examined the activity and effector specificity of the transcriptional regulator XylR of the TOL plasmid pWW0 of Pseudomonas putida mt-2 for biodegradation of m-xylene when external water potential was manipulated with polyethylene glycol PEG8000. By using non-disruptive luxCDEAB reporter technology, we noticed that the promoter activated by XylR (Pu) restricted its activity and the regulator<br> became more effector-specific towards head TOL substrates when cells were grown under water subsaturation. Such a tight specificity brought about by water limitation was relaxed when intracellular osmotic stress was counteracted by the external addition of the compatible solute glycine betaine. With these facts in hand, XylR variants isolated earlier as effectorspecificity responders to the non-substrate 1,2,4-trichlorobenzene under high matric stress were re-examined and found to be unaffected by water potential in vivo. All these phenomena could be ultimately explained as the result of water potential-dependent conformational changes in the A domain of XylR and its effector-binding pocket, as suggested by AlphaFold prediction of protein structures. The consequences of this scenario for the evolution of specificities in regulators and the emergence of catabolic pathways are discussed.</p>
Data and simulation files for "Constraints on the intergalactic magnetic field using Fermi-LAT and H.E.S.S. blazar observations"
<p>In this repository, we provide data files in connection to our paper “Constraints on the intergalactic magnetic field using Fermi-LAT and H.E.S.S. blazar observations” accepted for publication in the Astrophysical Journals and soon available on Arxiv.</p> <p>In the publication, we perform a joint analysis of observations of five blazars with the Fermi Large Area Telescope (LAT) and the High Energy Stereoscopic System (H.E.S.S.) in order to search for signatures of a gamma-ray halo around these sources. The non-detection of such extended emission allows us to place lower limits on the intergalactic magnetic field (IGMF).</p> <p>In this repository, we provide our data analysis products of both H.E.S.S. and LAT data for the case when a template for the halo flux is <em>not</em> included in the data. Furthermore, we provide files that contain the log likelihood profiles as functions of the IGMF in case the halo emission <em>is</em> included. Lastly, we also provide our template files for the halo, generated with <a href="https://crpropa.github.io/CRPropa3/">CRPropa 3</a>.</p> <p>Below, we provide minimal code examples to demonstrate how to read in the specific files.</p> <p><strong>H.E.S.S. observational results</strong></p> <p>We provide the best-fit spectral parameters as well as the flux points (spectral energy distribution; SED) for the H.E.S.S. observations of the five blazars under consideration. The corresponding files are:</p> <ul> <li>hess_fit_result_*.fits which contain the best-fit parameters,</li> <li>hess_sed_file_*.fits which contain the flux points.</li> </ul> <p>In the file names above, the '*' should be replaced with a the corresponding source name, e.g. 1ES0229+200. The files can be read in using astropy:</p> <pre><code class="language-python">from astropy.table import Table src = "1ES0229+200" best_fit_pars = Table.read("hess_fit_result_1ES0229+200.fits") sed = Table.read("hess_sed_file_1ES0229+200.fits")</code></pre> <p><strong>Fermi observational results</strong></p> <p>For Fermi-LAT, we provide the SED files as well as the best-fit models for the region of interests. These files are called:</p> <ul> <li>fermi_avg_file_*.npy provides the best-fit ROI model</li> <li>fermi_sed_file_*.npy provides the SED.</li> </ul> <p>Both of these files are generated with <a href="https://fermipy.readthedocs.io/en/latest/">fermipy</a> and can be read-in the following way:</p> <pre><code class="language-python">import numpy as np # first a little helper function since the # fermipy analysis was run under python 2.7 def convert(data): if isinstance(data, bytes): return data.decode('ascii') if isinstance(data, dict): return dict(map(convert, data.items())) if isinstance(data, tuple): return map(convert, data) return data # Load the ROI fit roi_fit_file = "fermi_avg_file_1ES0229+200.npy" roi_fit = np.load(avg_file, allow_pickle=True, encoding="latin1").flat[0] # if you want to inspect the dictionaries in python 3, you need to run the convert function. # For example, to inspect the central source of the ROI # you would first get the source name src_fgl_name = roi_fit['config']['selection']['target'] # and then you can get the dictionary for the central source src_dict = convert(roi_fit['sources'])[src_fgl_name] # Load the SED sed_file = "fermi_sed_file_1ES0229+200.npy" sed = np.load(sed_file, allow_pickle=True, encoding='latin1').flat[0] # to plot the SED, you can use the SEDPlotter class from fermipy from fermipy.plotting import SEDPlotter SEDPlotter.plot_sed(sed)</code></pre> <p><strong>Likelihood profiles</strong></p> <p>The likelihood profiles as function of the IGMF strengths are provided in the files logl_profile_*_*yr.npz. Their are provided for all five sources and all tested blazar activity times of 10, 10<sup>4</sup>, and 10<sup>7</sup> years. They can be read in with the following code snippet:</p> <pre><code class="language-python">import numpy as np logl = dict(np.load("logl_profile_1ES0229+200_1.0e+07yr.npz")) b_fields = np.array([1.00000e-16, 3.16228e-16, 1.00000e-15, 3.16228e-15, 1.00000e-14, 3.16228e-14, 1.00000e-13]) for k, v in logl.items(): print(k,v)</code></pre> <p>As the print command shows, the python dictionary contains 3 entries: "fermi_only" are the likelihood values for the Fermi data as a function of magnetic field, "combined" are the likelihood values from Fermi and H.E.S.S. combined, and "ps" is the likelihood value of the Fit without halo to the H.E.S.S. data only.</p> <p><strong>Halo simulations</strong></p> <p>Lastly, we also provide the output simulations files from CRPropa. For details how the simulations were run, please consult the accompanying paper, in particular Section 3.1 and Appendix C. For each source redshift, a tar file is provided, which in itself contains 7 hdf5 files with the simulation outputs for each tested magnetic field strength. The name of the files is casc_file_z*.tar.gz. After unpacking the files, they can be read in with your favorite hdf5 library; in python you would need to install h5py. We recommend that you check out <a href="https://github.com/me-manu/simCRpropa">this github repository</a> which provides an advanced python wrapper for CRPropa and functions to read in the files. In particular, you can use <a href="https://github.com/me-manu/simCRpropa/blob/b3f39b5c77c6b97d19f7db387427d857690444d2/simCRpropa/cascmaps.py#L28">this function</a> to read in the files. It also writes a new hdf5 file with parallel transport applied. The written data is also returned together with the configuration dictionary.</p> <pre><code class="language-python">from simCRpropa.cascmaps import stack_results_lso data, config = stack_results_lso("casc_file_z0.140_B1.00e-16.hdf5", "casc_file_z0.140_B1.00e-16_theta_obs0.0.hdf5" )</code></pre> <p>You can provide arbitrary angles between the observer and the jet angles using the theta_obs keyword. Note, however, that the simulations used a jet opening angle of 3 degrees and going beyond that value will return zero halo photons.</p>
FOAMS: Processed Audio Files
<p>The processed audio files included in the Free Open-Access Misophonia Stimuli (FOAMS) project to curate a freely available database of sound stimuli intended for misophonia research.</p> <p>If you use this database, please credit it as follows:</p> <p>Orloff, D. M., Benesch, D., & Hansen, H. A. (2023). Curation of FOAMS: a Free Open-Access Misophonia Stimuli Database. <em>Journal of Open Psychology Data</em>, <em>11</em>(1).</p>
Results files for Land-free Bioenergy From Circular Agroecology -- A Diverse Option Space and Trade-offs
<p>This is the open data repository to support and reproduce results in the paper "<em>Land-free Bioenergy From Circular Agroecology -- A Diverse Option Space and Trade-offs</em>." There are <strong>three types </strong>of files here:</p> <p> </p> <p> </p> <p><strong>1. Ready-to-use final results files of all strategies and scenarios referred to in the paper. </strong>They can be downloaded and used directly without running any codes. They all have the same naming format for strategies/scenarios: `Org` = organic share, `ConcRed` = concentrate feeding reduction share, `WasteRed` = waste reduction share, and numbers refer to the share. E.g., `Org0_ConcRed50_WasteRed75` is a strategy with 0% organic share, 50% concentrate feeding reduction, and 75% waste reduction.</p> <p> </p> <ul> <li>`NationalAncillaryBioenergyPotential_EJ.csv`: The national potential of ancillary bioenergy in 2050 from all scenarios. (Units: EJ). Same in both pathways.</li> <li>`GlobalPotentialEnvironmentalImpacts_NutrientFirst.csv`: Environmental impacts of all scenarios from the pathway `<em>NutrientFirst</em>.` The first three rows refer to the combination of agroecological practices in places, which allow you to explore environmental impacts grouped by, e.g., different organic shares.</li> <li>`GlobalPotentialEnvironmentalImpacts_NegFirst.csv`: Same structure as the file above, but from another pathway, `<em>NegativeFirst</em>`.</li> </ul> <p> </p> <p><strong>2. `SOLmOutputs` contains all original output files from our model <a href="https://orgprints.org/id/eprint/38778/">SOLmV6</a>. </strong></p> <p> </p> <p><strong>3. `DataCleaningKit` has the Python codes and additional dataset of heat values to process 2. `SOLmOutputs` and spit 1. </strong>(Tip: One should adjust the `input_path` and `output_path` before running `DataCleaning.py.`)</p> <p> </p> <p> </p> <p>Fei Wu (fei.wu@usys.ethz.ch)</p> <p>Delft, August, 2023</p> <p> </p>
Supplementary CIF files for "Shedding Light on the Enigmatic TcO2 ⋅ xH2O Structure with Density Functional Theory and EXAFS Spectroscopy"
<p>Optimized geometries from the paper "Shedding Light on the Enigmatic TcO2 ⋅ <em>x</em>H2O Structure with Density Functional Theory and EXAFS Spectroscopy" (<a href="https://doi.org/10.1002/chem.202202235">https://doi.org/10.1002/chem.202202235</a>), provided in CIF format.</p> <p>All structures were fully optimized (lattice vectors and atomic coordinates) using AMS/BAND (<a href="https://www.scm.com/">https://www.scm.com/</a>) with the PBE density functional, scalar relativistic effects (ZORA), and numerical atomic orbitals (NAOs) augmented with a triple-zeta polarized (TZP) set of Slater-type basis functions. For the chains, D3 dispersion corrections were also included.</p> <p> </p>
Aligned bam files for "Phylogenetic modeling of enhancer shifts in mole-rats reveals regulatory changes associated with tissue-specific traits"
<p>Aligned bam files used for analysis in "Phylogenetic modeling of enhancer shifts in mole-rats reveals regulatory changes associated with tissue-specific traits".</p> <p>This is an accompanying dataset to Datasets and code for "Phylogenetic modeling of enhancer shifts in mole-rats reveals regulatory changes associated with tissue-specific traits" (https://zenodo.org/record/7442105).</p>
MESA model files and data for: 'Stellar Neutrino Emission Across The Mass-Metallicity Plane'
<p>Example MESA model files and stellar evolution tracks for download from "Stellar Neutrino Emission Across The Mass-Metallicity Plane".</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.