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78
datasets available to search
ShareScore release 0.9.0
Dataset results
78 results for “fusion transcript”
Transcriptional profiling of estrogen receptor fusion genes in breast cancer cell lines
GEO Series GSE191158. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
The TAZ-CAMTA1 and YAP-TFE3 fusion proteins modulate the basal TAZ/YAP transcriptional program by recruiting the Ada2a-containing histone acetyltransferase complex [atacseq]
GEO Series GSE152733. Homo sapiens. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Rapid transcriptional changes of ROS1 fusion positive cells in response to crizotinib treatments
GEO Series GSE239844. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12 (ATAC-seq)
GEO Series GSE278066. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming
GEO Series GSE266253. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Pilot-study for a novel universal tool for detection of oncogenic fusion transcripts
GEO Series GSE14435. Homo sapiens. 10 samples. Type: Expression profiling by array.
Prevalent aberrant condensates of onco-fusion transcription factors and their dissolution as potential cancer therapy
GEO Series GSE194374. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Hoxblinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98 fusion transformed leukemia [CTCF-HiChIP-seq]
GEO Series GSE283303. Mus musculus. 2 samples. Type: Other.
The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma
GEO Series GSE78159. Mus musculus. 8 samples. Type: Expression profiling by array.
Pioneer activity of an oncogenic fusion transcription factor at inaccessible chromatin
GEO Series GSE163068. Homo sapiens. 31 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis
GEO Series GSE271858. Homo sapiens; Mus musculus. 49 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis (RNA-Seq)
GEO Series GSE271857. Mus musculus; Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Effect of knockdown PHF8 on the transcriptional regulation of BCR-ABL1 fusion gene on CML cell line K562
GEO Series GSE235463. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
YAP1 fusion proteins drive forebrain ependymoma tumorigenesis via the interaction with TEAD transcription factors
GEO Series GSE110625. Mus musculus. 10 samples. Type: Expression profiling by array.
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis (CLIP-Seq)
GEO Series GSE271855. Homo sapiens. 2 samples. Type: Other.
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis (PRO-Seq)
GEO Series GSE271856. Homo sapiens. 6 samples. Type: Other.
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis (ChIP-Seq)
GEO Series GSE271854. Homo sapiens. 23 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Study of Tumor Recurrence Related to the Expression of the PAX3-FOXO1 Oncogenic Transcription Factor in Fusion-Positive Rhabdomyosarcoma
Alveolar rhabdomyosarcoma (ARMS) is a highly aggressive pediatric soft tissue cancer characterized by a recurrent 2;13 chromosome translocation. This translocation generates a PAX3-FOXO1 (P3F) fusion gene, which encodes a chimeric transcription factor with oncogenic activity. Using a human myoblast system that models targeted therapy directed against P3F, we demonstrated that the expression of the fibroblast growth factor 8 (FGF8), a direct transcriptional target of P3F, is necessary and sufficient for PAX3-FOXO1-independent tumor recurrence in addition to be required for the tumorigenic activity of primary tumors expressing P3F. In addition, we showed that FGF8 is expressed in human rhabdomyosarcoma cell lines that express P3F. We also demonstrated that FGF8 contributes to their proliferation and transformation in vitro, and is sufficient to maintain their oncogenicity after the loss of P3F expression. We suggest that targeting the expression of the PAX3-FOXO1 transcription factor can generate resistance and recommend that additional anticipated therapeutic approaches, such as targeting FGF8 pathway, may avoid this resistance mechanism.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.