Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
844
datasets available to search
ShareScore release 0.9.0
Dataset results
844 results for “germline”
IG receptor germline set for species: Human set_name: IGH_VDJ
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: C57BL/6 set_name: C57BL/6 IGH
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
IG receptor germline set for species: Mouse subgroup: PWD/PhJ set_name: PWD/PhJ IGH
<p>Germline Reference set published on the Open Germline Receptor Database (OGRDB)</p>
Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline
<p>Large blocks of tandemly repeated DNAs—satellite DNAs (satDNAs)—play important roles in heterochromatin formation and chromosome segregation. We know little about how satDNAs are regulated, however their misregulation is associated with genomic instability and human diseases. We use the <i>Drosophila melanogaster</i> germline as a model to study the regulation of satDNA transcription and chromatin. Here we show that complex satDNAs (>100-bp repeat units) are transcribed into long noncoding RNAs and processed into piRNAs (PIWI interacting RNAs). This satDNA piRNA production depends on the Rhino-Deadlock-Cutoff complex and the transcription factor Moonshiner—a previously-described non-canonical pathway that licenses heterochromatin-dependent transcription of dual-strand piRNA clusters. We show that this pathway is important for establishing heterochromatin at satDNAs. Therefore, satDNAs are regulated by piRNAs originating from their own genomic loci. This novel mechanism of satDNA regulation provides insight into the role of piRNA pathways in heterochromatin formation and genome stability.</p>
Data and results for "Germline-encoded specificities and the predictability of the B cell response"
<p>Data and results for Vieira et al., <a href="https://www.biorxiv.org/content/10.1101/2022.09.16.508315v4">Germline-encoded specificities and the predictability of the B cell response</a></p> <p>Code for the analyses is available at <a href="https://github.com/cobeylab/v_gene_selection/">https://github.com/cobeylab/v_gene_selection/</a></p> <p> </p>
Supporting data for "Software pipelines for RNA-Seq, ChIP-Seq and Germline Variant calling analyses in Common Workflow Language (CWL)"
<p>Datasets produced during the validation of CWL-based pipelines, designed for the analysis of data from RNA-Seq, ChIP-Seq and germline variant calling experiments. Specifically, the workflows were tested using publicly available High-throughput (HTS) data from published studies on Chronic Lymphocytic Leukemia (CLL) (accession numbers: E-MTAB-6962, GSE115772) and Genome in a Bottle (GIAB) project samples (accession numbers: SRR6794144, SRR22476789, SRR22476790, SRR22476791).</p> <p>The supporting data include:</p> <ul> <li>Differential transcript and gene expression results produced during the analysis with the CWL-based RNA-Seq pipeline</li> <li>Bigwig and narrowPeak files, differential binding results, table of consensus peaks and read counts of EZH2 and H3K27me3, produced during the analysis with the CWL-based ChIP-Seq pipeline</li> <li>VCF files containing the detected and filtered variants, along with the respective hap.py () results regarding comparisons against the GIAB golden standard truth sets for both CWL-based germline variant calling pipelines</li> </ul>
Assessment of the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.
ClinicalTrials.gov study NCT02000622. IPD Sharing: YES. Countries: 19. Publications: 1.
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
ClinicalTrials.gov study NCT02032823. IPD Sharing: YES. Countries: 24. Publications: 3.
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous
ClinicalTrials.gov study NCT04497844. IPD Sharing: YES. Countries: 33. Publications: 1.
Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received a
ClinicalTrials.gov study NCT02282020. IPD Sharing: YES. Countries: 13. Publications: 4.
Talazoparib For Neoadjuvant Treatment Of Germline BRCA1/2 Mutation Patients With Early Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer
ClinicalTrials.gov study NCT03499353. IPD Sharing: YES. Countries: 1. Publications: 2.
Trial of Rucaparib in Patients With Metastatic Hormone-Sensitive Prostate Cancer Harboring Germline DNA Repair Gene Mutations
ClinicalTrials.gov study NCT03413995. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: Attractive male sticklebacks carry more oxidative DNA damage in the soma and germline
Open the record for dataset details and reuse information.
Germline proliferation trades off with lipid metabolism in Drosophila
Open the record for dataset details and reuse information.
Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline
Open the record for dataset details and reuse information.
Data from: Trade-off between somatic and germline repair in a vertebrate supports the expensive germ line hypothesis
Open the record for dataset details and reuse information.
Numeric data from: Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells
Open the record for dataset details and reuse information.
Integrin restriction by miR-34 protects germline progenitors from cell death during aging
Open the record for dataset details and reuse information.
Data from: SMAD4 promotes somatic-germline contact during murine oocyte growth
Open the record for dataset details and reuse information.
prg-1 longevity germline nucleoli: Piwi mutant germ cells transmit a form of heritable stress that promotes longevity
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.