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95
datasets available to search
ShareScore release 0.9.0
Dataset results
95 results for “host-pathogen”
Simultaneous host-pathogen transcriptional analysis of Clostridium perfringens murine myonecrosis infections
GEO Series GSE106657. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Spaceflight analogue culture enhances the host-pathogen interaction between Salmonella and a 3-D biomimetic intestinal co-culture model
GEO Series GSE146347. Salmonella enterica subsp. enterica serovar Typhimurium; Homo sapiens. 72 samples. Type: Expression profiling by high throughput sequencing.
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
GEO Series GSE164156. Mycobacterium tuberculosis H37Rv. 123 samples. Type: Other.
Probe-based spatial host-pathogen genes expression to study bacterial pathogenesis and the regulation of bacterial virulence factors in tissue.
GEO Series GSE242471. Mus musculus. 4 samples. Type: Other.
Dual RNA-Sequencing of Vitis vinifera During Lasiodiplodia theobromae Infection Unveils Host-Pathogen Interactions
GEO Series GSE129109. Lasiodiplodia theobromae; Vitis vinifera. 24 samples. Type: Expression profiling by high throughput sequencing.
Host-Pathogen Interactions in the Plasmodium-Infected Mouse Liver at Spatial and Single-Cell Resolution (Spatial Transcriptomics 2k)
GEO Series GSE268018. Plasmodium berghei ANKA; Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing.
Combined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions [mouse tissues 12,24,72 h]
GEO Series GSE83680. Mus musculus. 54 samples. Type: Expression profiling by array.
Dual RNA-seq analysis of Mycobacterium tuberculosis-infected lung macrophages reveals cell-lineage specific host-pathogen dynamics
GEO Series GSE132354. Mus musculus; Mycobacterium tuberculosis. 19 samples. Type: Expression profiling by high throughput sequencing.
Escalation in the host-pathogen arms race: a host resistance response corresponds to a heightened bacterial virulence response
GEO Series GSE142035. Sorghum bicolor; Xanthomonas vasicola. 21 samples. Type: Expression profiling by high throughput sequencing.
Host-pathogen interaction profiling of nontypeable Haemophilus influenzae and Moraxella catarrhalis coinfection of bronchial epithelial cells.
GEO Series GSE283527. Homo sapiens; Moraxella catarrhalis; Haemophilus influenzae. 48 samples. Type: Expression profiling by high throughput sequencing.
Data from: The impact of bottlenecks on microbial survival, adaptation and phenotypic switching in host-pathogen interactions
Microbial pathogens and viruses can often maintain sufficient population diversity to evade a wide range of host immune responses. However, when populations experience bottlenecks, as occurs frequently during initiation of new infections, pathogens require specialized mechanisms to regenerate diversity. We address the evolution of such mechanisms, known as stochastic phenotype switches, which are prevalent in pathogenic bacteria. We analyze a model of pathogen diversification in a changing host environment that accounts for selective bottlenecks, wherein different phenotypes have distinct transmission probabilities between hosts. We show that under stringent bottlenecks, such that only one phenotype can initiate new infections, there exists a threshold stochastic switching rate below which all pathogen lineages go extinct, and above which survival is a near certainty. We determine how quickly stochastic switching rates can evolve by computing a fitness landscape for the evolutionary dynamics of switching rates, and analyzing its dependence on both the stringency of bottlenecks and the duration of within-host growth periods. We show that increasing the stringency of bottlenecks or decreasing the period of growth results in faster adaptation of switching rates. Our model provides strong theoretical evidence that bottlenecks play a critical role in accelerating the evolutionary dynamics of pathogens.
Host-pathogen Interactions During SARS-CoV-2 Infection
ClinicalTrials.gov study NCT04376476. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Modeling Host-Pathogen Interaction Using Lymphoid Organoids
ClinicalTrials.gov study NCT06479837. IPD Sharing: NO. Countries: 1. Publications: 0.
Host-pathogen Interaction in Otitis Media
ClinicalTrials.gov study NCT00847756. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Host-pathogen Interactions in Meningococcal Disease: Finding the Key That Fits the Lock
ClinicalTrials.gov study NCT02727465. IPD Sharing: NO. Countries: 1. Publications: 0.
Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy
ClinicalTrials.gov study NCT04962477. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: The impact of bottlenecks on microbial survival, adaptation and phenotypic switching in host-pathogen interactions
Open the record for dataset details and reuse information.
The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interaction
GEO Series GSE239718. Staphylococcus aureus. 12 samples. Type: Expression profiling by high throughput sequencing.
Dual RNA-sequencing of nontypeable Haemophilus influenzae and host cell transcriptomes reveals new aspects of host-pathogen interface
GEO Series GSE63900. Homo sapiens; Haemophilus influenzae. 24 samples. Type: Expression profiling by high throughput sequencing.
Combined transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions
GEO Series GSE83682. Mus musculus; Candida albicans. 80 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.