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72
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ShareScore release 0.9.0
Dataset results
72 results for “immune marker”
Single-cell immune profiling reveals markers of emergency myelopoiesis that distinguish severe from mild respiratory syncytial virus (RSV) disease in infants
GEO Series GSE246622. Homo sapiens. 533 samples. Type: Expression profiling by array.
Profile of new early pregnancy markers identified by transcriptomic analysis in peripheral blood immune cells in beef heifers
GEO Series GSE136102. Bos indicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma
Open the record for dataset details and reuse information.
Switched Memory B-cells as a Marker for Humoral Immune System Recovery in Patients With Secondary Antibody Deficiency Due to Hematological Malignancies
ClinicalTrials.gov study NCT05612607. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Immunological Markers in Adult Patients With Immune Thrombocytopenic Purpura
ClinicalTrials.gov study NCT04056507. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of Intralipid Versus Olive Oil Infusions on Endothelial Function, Immune Function, Inflammatory Markers
ClinicalTrials.gov study NCT00989339. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effect of Enteral Immunonutrition on Immune, Inflammatory Markers and Nutritional Status in Patients Undergoing Gastrectomy for Gastric Cancer
ClinicalTrials.gov study NCT03730545. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Selecting specific bio-markers and researching mechanisms of immune regulation from inhalation injury (ILI) and traumatic lung injury (TLI) based on single cell RNA sequencing technology
GEO Series GSE220699. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in human with alpha-gal syndrome
GEO Series GSE308814. Homo sapiens. 43 samples. Type: Expression profiling by high throughput sequencing; Other.
Leukocyte CD antibody microarray profiling reveals immune markers associated with aging and gender (datasets 1 and 2)
GEO Series GSE25755. Homo sapiens. 120 samples. Type: Protein profiling by protein array.
Data set from the article Massaccesi L, Galliera E, Galimberti D, Fenoglio C, Arcaro M, Goi G, Barassi A, Corsi Romanelli MM. Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform. Immun Ageing. 2019 Apr 1;16:7. doi: 10.1186/s12979-019-0147-x. PMID: 30984280; PMCID: PMC6444862.
<p>Data set from the article: Massaccesi L, Galliera E, Galimberti D, Fenoglio C, Arcaro M, Goi G, Barassi A, Corsi Romanelli MM. Lag-time in Alzheimer's disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform. Immun Ageing. 2019 Apr 1;16:7. doi: 10.1186/s12979-019-0147-x. PMID: 30984280; PMCID: PMC6444862.</p> <p>This is the astract:</p> <p>In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's Disease (AD) development and recent evidence correlated oxidative stress with vascular lesion in the pathogenesis of AD, but the mechanism still need to be fully clarified. The etiology of AD is still not completely understood and is influenced by several factors including Apolipoprotein E (ApoE) genotype. In particular, the Apo ε4 isoform is considered a risk factor for AD development. This study was aimed to evaluate the possible relationship between three plasmatic OS marker and Apo ε4 carrier status. Plasmatic soluble receptor for advanced glycation end products (sRAGE) levels, plasma antioxidant total defenses (by lag-time method) and plasmatic Reactive Oxygen species (ROS) levels were evaluated in 25 AD patients and in 30 matched controls. ROS were significantly higher while plasma antioxidant total defenses and sRAGE levels were significantly lower in AD patients compared to controls. In AD patients lag-time values show a significant positive linear correlation with sRAGE levels and a (even not significant) negative correlation with ROS levels. Lag-time is significantly lower in ε4 carrier (<em>N</em> = 13) than in ε4 non-carrier (<em>N</em> = 12). Our result confirms the substantial OS in AD. Lag-time levels showed a significant positive correlation with sRAGE levels and a significant association with ε4 carrier status suggesting that plasmatic lag-time evaluation can be considered as a potential useful OS risk marker in AD.</p> <p> </p>
Dataset related to article "Tumor heterogeneity, hypoxia, and immune markers in surgically resected non-small-cell lung cancer"
<p>This record contains raw data related to article "Tumor heterogeneity, hypoxia, and immune markers in surgically resected non-small-cell lung cancer"</p> <p>OBJECTIVES:</p> <p>This study aimed to determine the prognostic role of textural features and their association with metabolic parameters, hypoxia, and cancer-related immune markers in non-small-cell lung cancer (NSCLC) patients.</p> <p>PATIENTS AND METHODS:</p> <p>The trial was registered at http://www.clinicaltrials.gov (<a href="http://clinicaltrials.gov/show/NCT02519062">NCT02519062</a>). From January 2010 to May 2014, 44 patients (male : female=33 : 11; median age: 69.5 years), referred to our Institution for NSCLC resection, were enrolled. Tumor specimens were assessed for HIF-1α, CD68-TAMs, CD8-TILs, PD-1-TILs, and PD-L1 expressions. All patients underwent fluorine-18-fluorodeoxyglucose (F-FDG) PET before surgery. Semiquantitative parameters included maximum standardized uptake value (SUVmax), SUVpeak, SUVmean, metabolic tumor volume, and total lesion glycolysis, whereas for heterogeneity, we considered tumor sphericity, skewness, kurtosis, entropy, and energy. Parameters were correlated with disease-free survival (DFS) considering a median follow-up of 22.7 months.</p> <p>RESULTS:</p> <p>SUVmax (cutoff: 7.9; P=0.015), SUVpeak (cutoff: 6.7; P=0.013), SUVmean (cutoff: 5.5; P=0.028), metabolic tumor volume (cutoff: 3.6 cm; P=0.027), and entropy (cutoff: 1.89; P=0.045) showed a statistically significant association with DFS. Also, a high expression of cytoplasmic HIF-1α (score 3) was associated with DFS (hazard ratio: 0.09; P=0.003). All F-FDG PET variables differed significantly in tumors with high or low entropy (≤1.89). Also, a significantly higher level of mean CD8-TILs was observed in tumors with higher entropy (P=0.041).Using identified prognostic factors, we developed a scoring system, which was confirmed to be associated with DFS (P<0.004). On receiver operating characteristics analysis, a score above 3 was defined as the optimal cutoff point.</p> <p>CONCLUSION:</p> <p>Tumor heterogeneity, metabolic parameters, and high expression of hypoxia were found to be prognostic factors in NSCLC patients who were candidates for surgery. Higher levels of entropy appear to be associated with increased density of CD8-TILs. The combination of investigated prognostic factors enabled the development of a potential scoring system associated with DFS</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.