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429 results for “multiple genes”
An AAV Gene Therapy Computes Over Multiple Cellular Inputs to Enable Precise Targeting of Multifocal Hepatocellular Carcinoma in Mice
<p>Data underlying the figures in the publication “An AAV gene therapy computes over multiple cellular inputs to enable precise targeting of multifocal hepatocellular carcinoma in mice”, published in <em>Sci. Transl. Med.</em>, <strong>2021</strong>, 13, eabh4456.</p> <p><a href="https://doi.org/10.1126/scitranslmed.abh4456">DOI: 10.1126/scitranslmed.abh4456</a></p> <p>Table of contents:</p> <p><strong>1. Supplementary Material</strong>: File containing Materials and Methods, <em>Fig S1-S8</em>, <em>Table S1</em>, Legend for <em>Table S2</em>, Legends for data files <em>S1</em> and <em>S2</em> and References (63-65).</p> <p><strong>2. Dataset 1.xlsx</strong>: Raw data points used to create the main figures of the paper (<em>1C, 1D, 2B, 2C, 2E, 2G, 2H, 2I, 2K, 3A, 3B, 3C, 4B, 4C, 51, 6A, 7A, 7B, 8B, 8C </em>and<em> 8F</em>) arranged in worksheets panel by panel. The processing steps are described in the methods section of the manuscript and in the supplementary material.</p> <p><strong>3. Dataset 2.xlsx:</strong> Raw data points used to create the supplementary figures of the paper (<em>S1A, S1B, S1C, S3D, S3E, S4A, S4B, S5B, S8A, S8B </em>and <em>S8C</em>) arranged in worksheets panel by panel. The processing steps are described in the methods section of the manuscript and in the supplementary material.</p> <p><strong>4. Table S2</strong>: Experimental data for <em>Table S2.</em></p>
Figure 2 in Gene Flow Patterns of the Aedes aegypti (Diptera: Culicidae) Mosquito in Colombia: a Continental Comparison Suggests Multiple Invasion Routes and Gene Exchange
Figure 2. Haplotype network for the mitochondrial ND4 gene from natural A. aegypti populations from: A. American continent, including sequences for Colombia; B. Colombia. In both haplotype networks, the size of each circle is proportional with the haplotypic frequency. The number next to each circle indicates the haplotype number.
Data from: Plasticity and epistasis strongly affect bacterial fitness after losing multiple metabolic genes
Many bacterial lineages lack seemingly essential metabolic genes. Previous work suggested selective benefits could drive the loss of biosynthetic functions from bacterial genomes when the corresponding metabolites are sufficiently available in the environment. However, the factors that govern this 'genome streamlining' remain poorly understood. Here we determine the effect of plasticity and epistasis on the fitness of Escherichia coli genotypes from whose genome biosynthetic genes for one, two, or three different amino acids have been deleted. Competitive fitness experiments between auxotrophic mutants and prototrophic wild type cells in one of two carbon environments revealed that plasticity and epistasis strongly affected the mutants' fitness individually and interactively. Positive and negative epistatic interactions were prevalent, yet on average cancelled each other out. Moreover, epistasis correlated negatively with the expected effects of combined auxotrophy-causing mutations, thus producing a pattern of diminishing returns. Moreover, computationally analysing 1,432 eubacterial metabolic networks revealed that most pairs of auxotrophies co-occurred significantly more often than expected by chance, suggesting epistatic interactions and/ or environmental factors favoured these combinations. Our results demonstrate that both the genetic background and environmental conditions determine the adaptive value of a loss-of-biochemical-function mutation and that fitness gains decelerate, as more biochemical functions are lost.
Data from: Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Adult-onset hearing loss is very common but we know little about the underlying molecular pathogenesis, impeding development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly-generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response. We review here the findings from this screen. Thirty-eight unexpected genes associated with raised thresholds were detected from our unbiased sample of 1,211 genes tested, suggesting extreme genetic heterogeneity. A wide range of auditory pathophysiologies was found, and some mutant lines showed normal development followed by deterioration of responses, revealing new molecular pathways involved in progressive hearing loss. Several of the genes were associated with the range of hearing thresholds in the human population and one, SPNS2, was involved in childhood deafness. The new pathways required for maintenance of hearing discovered by this screen present new therapeutic opportunities.
FIGURE 4 in A multiple gene genealogy reveals phylogenetic placement of Rhopalostroma lekae
FIGURE 4. Stromatal HPLC-UV profiles of major metabolites in Rhopalostroma lekae.
Pomalidomide in Gene Expression Profiling (GEP)-Defined High-risk Multiple Myeloma
ClinicalTrials.gov study NCT01177735. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Follow-up of Breast Cancer and Multiple Myeloma Patients Previously Enrolled in NIH Gene Therapy Studies
ClinicalTrials.gov study NCT00427726. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis
ClinicalTrials.gov study NCT06290453. IPD Sharing: Not stated. Countries: 0. Publications: 9.
Data from: Molecular phylogenetics of Braconidae (Hymenoptera: Ichneumonoidea) based on multiple nuclear genes and implications for classification
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Alu-Mediated MEN1 Gene Deletion and Loss of Heterozygosity in a Patient with Multiple Endocrine Neoplasia Type 1
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Data from: Exploring data interaction and nucleotide alignment in a multiple gene analysis of Ips (Coleoptera: Scolytinae)
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Data from: Mouse screen reveals multiple new genes underlying mouse and human hearing loss
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Data from: The plasticity of NBS resistance genes in sorghum is driven by multiple evolutionary processes
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Data from: Plasticity and epistasis strongly affect bacterial fitness after losing multiple metabolic genes
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Data from: Current methods for automated filtering of multiple sequence alignments frequently worsen single-gene phylogenetic inference
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Genome wide identification, genomic organization, and expression profiling of the CONSTANS-like (COL) gene family in petunia under multiple stresses
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Multiple genes recruited from hormone pathways partition maize diterpenoid defences.
GEO Series GSE120135. Zea mays. 8 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of multiple sclerosis pathology identifies early patterns of demyelination surrounding chronic active lesions
GEO Series GSE108000. Homo sapiens. 40 samples. Type: Expression profiling by array.
Deep Multiple-omics Profiling of Brain Tumors Identifies Signaling Networks Downstream of Cancer Driver Genes
GEO Series GSE114331. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Identification of NOTCH-driven matrisome-associated genes as prognostic indicators of multiple myeloma patient survival
GEO Series GSE221038. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.