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73
datasets available to search
ShareScore release 0.9.0
Dataset results
73 results for “multiplexed imaging”
Processed CODEX multiplexed imaging data of cellular microenvironment around T cell stimulating hydrogels
Open the record for dataset details and reuse information.
Multiplexed protein and drug imaging by super-resolution ion beam imaging
GEO Series GSE141138. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Thermal-plex: fluidic-free, rapid sequential multiplexed imaging with DNA-encoded thermal channels
<div> <div> <p>Multiplexed fluorescence imaging is typically limited to three- to five-plex on standard setups. Sequential imaging methods based on iterative labeling and imaging enable practical higher multiplexing, but generally require a complex fluidic setup with several rounds of slow buffer exchange (tens of minutes to an hour for each exchange step). We report the thermal-plex method, which removes complex and slow buffer exchange steps and provides fluidic-free, rapid sequential imaging. Thermal-plex uses simple DNA probes that are engineered to fluoresce sequentially when, and only when, activated with transient exposure to heating spikes at designated temperatures (thermal channels). Channel switching is fast (<30 s) and is achieved with a commercially available and affordable on-scope heating device. We demonstrate 15-plex RNA imaging (five thermal × three fluorescence channels) in fixed cells and retina tissues in less than 4 min, without using buffer exchange or fluidics. Thermal-plex introduces a new labeling method for efficient sequential multiplexed imaging.</p> </div> </div> <div> <div></div> </div>
The datasets for Precise immunofluorescence canceling enables highly multiplexed imaging
<p>Cell states are regulated by responsive signal pathways upon ligand-binding to the receptor and inter-cellular interactions. Thus, high-resolution imaging has been attempted to explore the dynamics of signaling. Recently, multiplexed imaging has been introduced to profile cell state by acquisition of comprehensive spatial protein information in the cells. However, it is still challenging to compromise resolution for visualizing activated signals. Here we developed ‘Precise Emission Canceling Antibody (PECAb)’ attached with erasable fluorescent labeling. PECAbs allow high-resolution sequential imaging using 206 antibodies and it allowed reconstruction of the spatiotemporal dynamics of signaling pathways. Additionally, combining this approach with seq-smFISH can effectively classify cells and identify their signal activation states in human tissue. Overall, the PECAb system serves as a comprehensive platform for analyzing complex cell processes.</p>
Evaluating the roLe of Multiplexed PET Imaging in the Detection and Staging of hepatocellulaR Carcinoma and gAstro-entero-pancreatic Tumors
ClinicalTrials.gov study NCT07178587. IPD Sharing: NO. Countries: 1. Publications: 0.
Brain Alterations Based on Multiplex MR Imaging in Nasopharyngeal Carcinoma Patients After Treatment, and Their Correlation With Clinical Cognitive Scores.
ClinicalTrials.gov study NCT07011329. IPD Sharing: NO. Countries: 1. Publications: 0.
Multichrome encoding-based multiplexed, spatially resolved imaging reveals single-cell RNA epigenetic modifications heterogeneity
GEO Series GSE280639. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Precise immuno-fluorescence canceling enables highly multiplexed imaging [scRNA-seq]
GEO Series GSE242814. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Precise immuno-fluorescence canceling enables highly multiplexed imaging [RNA-seq]
GEO Series GSE242886. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Remodeled single-cell landscape in the metastatic bone marrow in human neuroblastoma unraveled by multi-omics and deep multiplex imaging
GEO Series GSE172184. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
Multiplexed imaging of nucleome architectures in single cells of mammalian tissue
GEO Series GSE148072. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Spatial Immune Associations of Immunotherapy Response in Non-Small Cell Lung Cancer by Multiplexed Tissue Imaging
Open the record for dataset details and reuse information.
Precise immuno-fluorescence canceling enables highly multiplexed imaging
GEO Series GSE242887. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.