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766 results for “phosphorylation”
Data Archive for Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation, and ssDNA binding kinetics
<p>This archive contains all data communicated in the indicated publication.</p>
Data from: Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche
In the epithelial follicle stem cells (FSCs) of the Drosophila ovary, Epidermal Growth Factor Receptor (EGFR) signaling promotes self-renewal, whereas Notch signaling promotes differentiation of the prefollicle cell (pFC) daughters. We have identified two proteins, Six4 and Groucho (Gro), that link the activity of these two pathways to regulate the earliest cell fate decision in the FSC lineage. Our data indicate that Six4 and Gro promote differentiation towards the polar cell fate by promoting Notch pathway activity. This activity of Gro is antagonized by EGFR signaling, which inhibits Gro-dependent repression via p-ERK mediated phosphorylation. We have found that the phosphorylated form of Gro persists in newly formed pFCs, which may delay differentiation and provide these cells with a temporary memory of the EGFR signal. Collectively, these findings demonstrate that phosphorylated Gro labels a transition state in the FSC lineage and describe the interplay between Notch and EGFR signaling that governs the differentiation processes during this period.
Functional crosstalk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5
<p>Source data underlying Figs 1b, 2b-c, 3b-c, 4a-d, and Supplementary Figs 3b-e, 4b-c, 5a-b</p>
Phosphorylation Regulation Mechanism of β2 Integrin for the Binding of Filamin Revealed by Markov State Model
<p>Datasets of MD and MSM trajectories</p>
Data from: A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1
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Data from: Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche
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Data from: Mek1 down regulates Rad51 activity during yeast meiosis by phosphorylation of Hed1
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Data from: Arabidopsis MKK10-MPK6 mediates red-light-regulated opening of seedling cotyledons through phosphorylation of PIF3
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Data from: Stronger selective constraint on downstream genes in the oxidative phosphorylation pathway of cetaceans
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Tyrosine phosphorylation levels in primary human myometrial cells
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Data from: Meta-analysis of Arabidopsis thaliana phospho-proteomics data reveals compartmentalization of phosphorylation motifs
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Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition
GEO Series GSE119697. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Phosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (ChIP-seq)
GEO Series GSE21939. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Enrichment profiles of Ser-5 phosphorylated RNA polymerase II (PolII S5p) in mouse female ES cells
GEO Series GSE30689. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma
GEO Series GSE162783. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
CDK11 phosphorylates SF3B1 and is essential for constitutive splicing (4sU-seq)
GEO Series GSE185810. Homo sapiens. 12 samples. Type: Other.
Thr4 phosphorylation on RNA Pol II occurs at early transcription regulating 3’-end processing
GEO Series GSE262826. Homo sapiens. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Proximity-dependent biotinylation map of the RNAPII CTD reveals that the primary role of Serine 2 phosphorylation is in the suppression of pervasive antisense transcription and not in RNA 3’ end proce
GEO Series GSE249235. Schizosaccharomyces pombe. 8 samples. Type: Expression profiling by high throughput sequencing.
Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression [Mice]
GEO Series GSE277935. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A high-throughput screen reveals SALL4-induced oxidative phosphorylation vulnerabilities in cancer
GEO Series GSE114808. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.