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Dataset results
86 results for “polyploidy”
Polyploidy-associated paramutation in Arabidopsis is determined by small RNAs, temperature, and allele structure
GEO Series GSE162241. Arabidopsis thaliana. 20 samples. Type: Non-coding RNA profiling by high throughput sequencing.
CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors [CTClineRNAseq]
GEO Series GSE261192. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion
GEO Series GSE271013. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors [scRNAseq]
GEO Series GSE261194. Homo sapiens. 257 samples. Type: Expression profiling by high throughput sequencing.
Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion
GEO Series GSE272066. Homo sapiens. 4 samples. Type: Expression profiling by RT-PCR.
Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete
GEO Series GSE202255. Borreliella burgdorferi. 50 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
c-Myc supports polyploidy and prevents senescence in the murine placenta [RNA-seq]
GEO Series GSE215380. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast [SNP array]
GEO Series GSE173369. Homo sapiens. 12 samples. Type: Genome variation profiling by SNP array.
c-Myc supports polyploidy and prevents senescence in the murine placenta [scRNA-Seq]
GEO Series GSE215381. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors [docetaxelRNAseq]
GEO Series GSE261193. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Data from: Effective polyploidy causes phenotypic delay and influences bacterial evolvability
Whether mutations in bacteria exhibit a noticeable delay before expressing their corresponding mutant phenotype was discussed intensively in the 1940s to 1950s, but the discussion eventually waned for lack of supportive evidence and perceived incompatibility with observed mutant distributions in fluctuation tests. Phenotypic delay in bacteria is widely assumed to be negligible, despite the lack of direct evidence. Here, we revisited the question using recombineering to introduce antibiotic resistance mutations into E. coli at defined time points and then tracking expression of the corresponding mutant phenotype over time. Contrary to previous assumptions, we found a substantial median phenotypic delay of three to four generations. We provided evidence that the primary source of this delay is multifork replication causing cells to be effectively polyploid, whereby wild-type gene copies transiently mask the phenotype of recessive mutant gene copies in the same cell. Using modeling and simulation methods, we explored the consequences of effective polyploidy for mutation rate estimation by fluctuation tests and sequencing-based methods. For recessive mutations, despite the substantial phenotypic delay, the per-copy or per-genome mutation rate is accurately estimated. However, the per-cell rate cannot be estimated by existing methods. Finally, with a mathematical model, we showed that effective polyploidy increases the frequency of costly recessive mutations in the standing genetic variation (SGV), and thus their potential contribution to evolutionary adaptation, while drastically reducing the chance that de novo recessive mutations can rescue populations facing a harsh environmental change such as antibiotic treatment. Overall, we have identified phenotypic delay and effective polyploidy as previously overlooked but essential components in bacterial evolvability, including antibiotic resistance evolution.
Data from: Effective polyploidy causes phenotypic delay and influences bacterial evolvability
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Development of decidual cell polyploidy and bi-nucleation necessitates mitochondrial activity
GEO Series GSE28917. Mus musculus. 6 samples. Type: Expression profiling by array.
Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast
GEO Series GSE173372. Homo sapiens. 48 samples. Type: Genome variation profiling by SNP array; Expression profiling by high throughput sequencing.
Analysis of polyploidy-associated transcriptional gene silencing (paTGS) mutants
GEO Series GSE17496. Arabidopsis thaliana. 9 samples. Type: Expression profiling by array.
Transcriptomic Drivers of Differentiation, Maturation, and Polyploidy in Human Extravillous Trophoblast [RNA-seq]
GEO Series GSE173323. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy
GEO Series GSE268101. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.
GEO Series GSE261195. Homo sapiens. 320 samples. Type: Expression profiling by high throughput sequencing.
Polyploidy in the adult Drosophila melanogaster brain
GEO Series GSE153165. Drosophila melanogaster. 72 samples. Type: Expression profiling by high throughput sequencing.
Fig. 3 in Canary grasses (Phalaris, Poaceae): Molecular phylogenetics, polyploidy and floret evolution
Fig. 3. ITS phylogram based on Bayesian inference. Parsimony bootstrap values are noted above branches and Bayesian posterior probabilities are below. Shaded section of the tree highlights species with x = 6, and names shown in bold denote polyploid species. Floret types follow Fig. 2. • = unknown chromosome number. A = annual and P = perennial habit.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.