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453 results for “sting”
ARID1A suppresses R-loop mediated STING-Type I Interferon pathway activation of anti-tumor immunity
<p>Clinical trials have identified ARID1A mutations as enriched among patients who respond favorably to Immune Checkpoint Blockade (ICB) in several solid tumor types independent of microsatellite instability. We show that ARID1A loss in murine models is sufficient to induce anti-tumor immune phenotypes observed in ARID1A mutant human cancers, including increased CD8+ T cell infiltration and cytolytic activity. ARID1A deficient cancers upregulated an interferon (IFN) gene expression signature, the ARID1A-IFN signature, associated with increased R-loops and cytosolic single stranded DNA (ssDNA). Overexpression of the R-loop resolving enzyme, RNASEH2B, or cytosolic DNase, TREX1, in ARID1A deficient cells prevented cytosolic ssDNA accumulation and ARID1A-IFN gene upregulation. Further, the ARID1A-IFN signature and anti-tumor immunity were driven by STING dependent Type I IFN signaling, which was required for improved responsiveness of ARID1A mutant tumors to ICB treatment. These findings define a molecular mechanism underlying anti-tumor immunity in ARID1A mutant cancers.</p>
Figure 2 in Superimposition of the sting morphological characters on the dendrogram of Apoidea with emphasis on Crabronidae s. str. (Insecta: Hymenoptera): first steps
Figure 2. Sting parts of Lestica alata. (a) – lateral parts of tergite 9, dorsal view; (b) – lateral sclerite of tergite 9, medial view; (c) – furcula, lateral view; (d) – 2nd valvula, lateral view; (e) – the 2nd ramus, fused with the rostral process of the 2nd valvifer, laterofrontal view; (f) – the 3rd valvula, lateral view; (g) – apical cone-shaped process of the 3rd valvula, laterodorsal view; (h) – the 1st valvula+1st ramus +1st valvifer, medial view; I–valvillus, medial view; (j) – the 1st and 2nd valvulae, lateral view. A, C, D – LM; B, E-J – SEM. Arrowheads indicate regions of interest. Scale bars: 200 µm in A and D; 100 µm – in B, F, H; 50 µm – in C; 20 µm – in E, G, I, J. l – lateral direction; p – posterior direction; v–ventral direction.
Figure 1 in Superimposition of the sting morphological characters on the dendrogram of Apoidea with emphasis on Crabronidae s. str. (Insecta: Hymenoptera): first steps
Figure 1. Sting parts of Bembicinus hungaricus. (a) – the lateral parts of tergite 9, dorsal view, LM; (b) – lateral part of tergite 9, medial view; (c) – furcula, lateral view; (d) – the 2nd valvula, ventrolateral view; (e) – the 2nd ramus, fused with the rostral process of the 2nd valvifer, laterofrontal view; (f) – the 3rd valvula, lateral view; (g) – apical cone-shaped process of the 3rd valvula, ventral view; (h) – the 1st valvula + the 1st ramus + the 1st valvifer, medial view, scale bar; I–valvillus, medial view; J – the 1st valvula, lateral view. B-J – SEM. Arrowheads indicate regions of interest. Scale bars: 200 µm in A and D; 100 µm – in B, F, H; 50 µm – in C; 20 µm – in E, G, I, J. l – lateral direction; p – posterior direction; v– ventral direction.
Figure 5 in Superimposition of the sting morphological characters on the dendrogram of Apoidea with emphasis on Crabronidae s. str. (Insecta: Hymenoptera): first steps
Figure 5. The character states, symbolically superimposed on the simplified dendrogram, resultant from a combination of molecular phylogenies provided by previous students. (Peters et al. 2017; Sann et al. 2018). The dark shading indicates tentative synapomorphies.
Figure 4 in Superimposition of the sting morphological characters on the dendrogram of Apoidea with emphasis on Crabronidae s. str. (Insecta: Hymenoptera): first steps
Figure 4. Sting parts of Sceliphron curvatum. (a) – lateral parts of tergite 9, dorsal view; (b) – lateral sclerite of tergite 9, medial view; (c) – furcula, lateral view; (d) – 2nd valvula, lateral view; (e) – the 2nd ramus, fused with the rostral process of the 2nd valvifer, laterofrontal view; (f) – the 3rd valvula, lateral view; (g) – apical cone-shaped process of the 3rd valvula, ventral view; (h) – the 1st valvula+1st ramus +1st valvifer, lateral view; (i)–valvillus, lateral view; (j) – the 1st and 2nd valvulae, lateroventral view. A, C, D – LM; B, E-J – SEM. Arrowheads indicate regions of interest. Scale bars: 200 µm in A and D; 100 µm – in B, F, H; 50 µm – in C; 20 µm – in E, G, I, J. l – lateral direction; p – posterior direction; v– ventral direction.
Figure 3 in Superimposition of the sting morphological characters on the dendrogram of Apoidea with emphasis on Crabronidae s. str. (Insecta: Hymenoptera): first steps
Figure 3. Sting parts of Crabro scutellatus. (a) – lateral parts of tergite 9, dorsal view; (b) – lateral sclerite of tergite 9, medial view; (c) – furcula, lateral view; (d) – 2nd valvula, lateral view, scale bar; (e) – the 2nd ramus, fused with the rostral process of the 2nd valvifer, laterofrontal view; (f) – the 3rd valvula, lateral view; (g) – apical cone-shaped process of the 3rd valvula, laterodorsal view; (h) – the 1st valvula +1st ramus+1st valvifer+2ndramus+2nd valvifer; (i)–valvillus, medial view; (j) – the 1st and 2nd valvulae, lateral view. A-D – LM; E-J – SEM. Arrowheads indicate regions of interest. Scale bars: 200 µm in A and D; 100 µm – in B, F, H; 50 µm – in C; 20 µm – in E, G, I, J. l – lateral direction; p – posterior direction; v– ventral direction.
FIGURE 4. Cnidoscolus mcvaughii. A. Fertile Branch. B. Aciculiform stinging hairs. C in Synopsis of Cnidoscolus (Euphorbiaceae) in midwestern Brazil, including taxonomic updates, a new species, and a reestablishment of C. neglectus
FIGURE 4. Cnidoscolus mcvaughii. A. Fertile Branch. B. Aciculiform stinging hairs. C. Stipules in frotal view. D. Stipules in dorsal view. E. Details of basilaminar glands. F. Bracts. G. Staminate bud. H. Staminate flowers. I. Androecium. J. Pistillate bud. K. Pistillate flowers. L. Detachment of the tepals of the pistillate flowers. M. Gynoecium. N. Fruit. O. Columella. P. Seeds in frontal view, and Q. Seeds, dorsal view. (A–Q: C. C. Oliveira 516. UB)
Prevention of Jellyfish Stings
ClinicalTrials.gov study NCT00114894. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Sting Challenge and Serological Responses to Jack Jumper Venom Immunotherapy With Inulin as Adjuvant (Jumpvax)
ClinicalTrials.gov study NCT03066986. IPD Sharing: YES. Countries: 1. Publications: 0.
Curcumin, Resveratrol, and Stinging Nettle as Treatments for GWI
ClinicalTrials.gov study NCT05377242. IPD Sharing: NO. Countries: 1. Publications: 3.
Decrease in Temperature as a Pagtonomic Sign by Scorpion Sting
ClinicalTrials.gov study NCT03622125. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Open Label Clinical Trial of Anascorp® in Pediatric Patients With Scorpion Sting Envenomation
ClinicalTrials.gov study NCT01599936. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Open Label Study of Alacramyn® in Pediatric Patients With Scorpion Sting Envenomation
ClinicalTrials.gov study NCT01599923. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Treatment Protocol for Use of Anascorp™ in Patients With Scorpion Sting Envenomation
ClinicalTrials.gov study NCT00624078. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Management and Outcome of Scorpion Sting in Children
ClinicalTrials.gov study NCT06615440. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Direct and indirect trade-offs between resistance, growth, and reproduction in the Japanese stinging nettle Urtica thunbergiana
Open the record for dataset details and reuse information.
Data from: Eudicot pollen-feeding in a Cretaceous stinging wasp (Angiospermae; Hymenoptera: Aculeata)
<p>Angiosperms and their insect pollinators form a foundational symbiosis, evidence for which from the Cretaceous is mostly indirect, based on fossils of insect taxa that today are anthophilous, and of fossil insects and flowers that have apparent anthophilous and entomophilous specializations, respectively. We present exceptional direct evidence preserved in mid-Cretaceous Burmese amber, 100 mya, for feeding on pollen in the eudicot genus <i>Tricolporoidites</i> by a basal new aculeate wasp, <i>Prosphex anthophilos</i>, gen. et sp. nov., in the lineage that contains the ants, bees, and other stinging wasps. Plume of hundreds of pollen grains wafts from its mouth and an apparent pollen mass was detected by micro-CT in the buccal cavity: clear evidence that the wasp was foraging on the pollen. Eudicots today comprise nearly three-quarters of all angiosperm species. <i>Prosphex</i> feeding on <i>Tricolporoidites</i> supports the hypothesis that relatively small, generalized insect anthophiles were important pollinators of early angiosperms.</p>
Supplementary material 1 from: Graf S, Willsch M, Ohl M (2021) Comparative morphology of the musculature of the sting apparatus in Ampulex compressa (Hymenoptera, Ampulicidae) and Sceliphron destillatorium (Hymenoptera, Sphecidae). Deutsche Entomologische Zeitschrift 68(1): 21-32. https://doi.org/10.3897/dez.68.58217
Table S1. Detailed list of specimens and their collection/rearing data
Supplementary material 2 from: Graf S, Willsch M, Ohl M (2021) Comparative morphology of the musculature of the sting apparatus in Ampulex compressa (Hymenoptera, Ampulicidae) and Sceliphron destillatorium (Hymenoptera, Sphecidae). Deutsche Entomologische Zeitschrift 68(1): 21-32. https://doi.org/10.3897/dez.68.58217
Table S2. Overview of all muscles with HAO URIs and the proposed homologies
Figure 4 from: Graf S, Willsch M, Ohl M (2021) Comparative morphology of the musculature of the sting apparatus in Ampulex compressa (Hymenoptera, Ampulicidae) and Sceliphron destillatorium (Hymenoptera, Sphecidae). Deutsche Entomologische Zeitschrift 68(1): 21-32. https://doi.org/10.3897/dez.68.58217
Figure 4 The musculature interconnecting T9 and the second valvifer. Lateral view, anterior to the right, line drawing from dissections. A.Ampulex compressa; B.Sceliphron destillatorium. dT9-2vf a and b – dorsal tergum 9-second valvifer muscle, portion a and b respectively; vT9-2vf – ventral T9 second valvifer muscle; pT9-2vf – posterior tergum 9-second valvifer muscle.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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International Brain Laboratory public data
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