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ShareScore release 0.9.0
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68 results for “sudden cardiac death”
An Observational Study to Assess the Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Users of Proton Pump Inhibitors, and Users of Metoclopramide
ClinicalTrials.gov study NCT01907633. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death
ClinicalTrials.gov study NCT04540289. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Medications and the Risk of Sudden Cardiac Death
ClinicalTrials.gov study NCT00241800. IPD Sharing: NO. Countries: 0. Publications: 0.
Personalised Risk scOre For Implantation of Defibrillators in Patients With Reduced LVEF≤35% and a Low Risk for Sudden Cardiac Death
ClinicalTrials.gov study NCT04540354. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Evaluating the Risk of Serious Ventricular Arrhythmia and Sudden Cardiac Death Among Users of Domperidone
ClinicalTrials.gov study NCT00925457. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Subcutaneous ICD Therapy Combined With VT Ablation for the Secondary Prevention of Sudden Cardiac Death
ClinicalTrials.gov study NCT03622307. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death
GEO Series GSE206121. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Clinical Considerations for a Family with Dilated Cardiomyopathy, Sudden Cardiac Death, and a Novel TTN Frameshift Mutation.
<p>Figures from Micaglio E, Monasky MM, Bernardini A, Mecarocci V, Borrelli V, Ciconte G, Locati ET, Piccoli M, Ghiroldi A, Anastasia L, Pappone C. Clinical Considerations for a Family with Dilated Cardiomyopathy, Sudden Cardiac Death, and a Novel <em>TTN</em> Frameshift Mutation. Int J Mol Sci. 2021 Jan 12;22(2):670. doi: 10.3390/ijms22020670. PMID: 33445410; PMCID: PMC7826882.</p> <p>Abstract</p> <p>Dilated cardiomyopathy (DCM) is the leading indication for heart transplantation. <em>TTN</em> gene truncating mutations account for about 25% of familial DCM cases and for 18% of sporadic DCM cases. The clinical relevance of specific variants in <em>TTN</em> has been difficult to determine because of the sheer size of the protein for which <em>TTN</em> encodes, as well as existing extensive genetic variation. Clinicians should communicate novel clinically-relevant variants and genotype-phenotype associations, so that animal studies evaluating the molecular mechanisms are always conducted with a focus on clinical significance. In the present study, we report for the first time the novel truncating heterozygous variant NM_001256850.1:c.72777_72783del (p.Phe24259Leufs*51) in the <em>TTN</em> gene and its association with DCM in a family with sudden death. This variant occurs in the A-band region of the sarcomere, in a known mutational hotspot of the gene. Truncating titin variants that occur in this region are the most common cause of DCM and have been rarely reported in asymptomatic individuals, differently from other pathogenic <em>TTN</em> gene variants. Further studies are warranted to better understand this particular clinically-relevant variant.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.