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Dataset results
1,084 results for “substrate”
Yeast cell-based transport assay for the functional characterization of human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 substrates and inhibitors
<p>Data to Kantipudi & Fotiadis (2021), <em>Front. Mol. Biosci. </em>(2021) <strong>8</strong>, 676854.</p>
Unraveling the roles of coastal bacterial consortia in degradation of various lignocellulosic substrates
<p>Lignocellulose, as the abundant natural organic carbon on earth, plays a key role in regulating the global carbon cycle, but there are only few studies in marine ecosystems. Little information is available about the extant lignin-degrading bacteria in coastal wetlands, limiting our understanding of their ecological roles and traits in lignocellulose degradation. We utilized<em> in situ </em>lignocellulose enrichment experiments coupled with 16S rRNA amplicon and shotgun metagenomics sequencing to identify and characterize bacterial consortia attributed to different lignin/lignocellulosic substrates in the southern-east intertidal zone of East China Sea. We found the consortia enriched on woody lignocellulose showed higher diversity than those on the herbaceous substrate. The substrate-dependent taxonomic groups were, hence, revealed. A time-dissimilarity pattern with increased alpha diversity over time was observed. Additionally, this study showed a comprehensive set of genes associated with lignin degradation potential, containing 23 gene families involved in lignin depolymerization, and 371 gene families involved in aerobic/anaerobic lignin-derived aromatic compound pathways, challenging the traditional view of lignin stability within marine ecosystems. In contrast to similar cellulase genes among the lignocellulose substrates, the significantly different ligninolytic gene groups were observed between consortia under woody and herbaceous substrates. Importantly, we not only observed synergistic degradation of lignin and hemi-/cellulose, but also pinpointed the potential biological actors at the levels of taxa and functional genes, which indicates that the alternation of aerobic and anaerobic catabolism could facilitate lignocellulose degradation. Our study advances the understanding of coastal bacterial community assembly and metabolic potential for lignocellulose substrates.</p>
Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate
ClinicalTrials.gov study NCT06405750. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake
ClinicalTrials.gov study NCT02568592. IPD Sharing: NO. Countries: 1. Publications: 0.
Non-invasive Substrate Evaluation in Atrial Fibrillation
ClinicalTrials.gov study NCT04496336. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of the Use of Energy Substrates and Hormonal Regulation of Blood Sugar During Exercise of Increasing Intensity Between Children With Type 1 Diabetes and Non-diabetic Control Children.
ClinicalTrials.gov study NCT03139864. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prediction of Drug Interactions With CYP2C9 Substrates
ClinicalTrials.gov study NCT00226538. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Dextromethorphan (CYP2D6 Substrate) in Healthy Participants
ClinicalTrials.gov study NCT07241065. IPD Sharing: YES. Countries: 0. Publications: 0.
Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis
ClinicalTrials.gov study NCT05891119. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol
ClinicalTrials.gov study NCT03547024. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Rectal Short Chain Fatty Acids Combinations and Substrate and Energy Metabolism
ClinicalTrials.gov study NCT01983046. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reversal of Atrial Substrate to Prevent Atrial
ClinicalTrials.gov study NCT03682991. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Relacorilant on the Pharmacokinetics of the Sensitive P-glycoprotein Substrate Dabigatran Etexilate in Healthy Participants
ClinicalTrials.gov study NCT05347979. IPD Sharing: NO. Countries: 1. Publications: 0.
SUbstrate Ablation in Persistent Atrial Fibrillation for Elimination of Recurrences (SUPAFER).
ClinicalTrials.gov study NCT06291506. IPD Sharing: NO. Countries: 1. Publications: 0.
Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s
ClinicalTrials.gov study NCT03457597. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation
ClinicalTrials.gov study NCT03347227. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants
ClinicalTrials.gov study NCT07223671. IPD Sharing: YES. Countries: 1. Publications: 0.
Gender and Neural Substrates of Stress and Craving
ClinicalTrials.gov study NCT00756925. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise
ClinicalTrials.gov study NCT02605291. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates for Drug Metabolism and Transport
ClinicalTrials.gov study NCT05334108. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.