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1,200 results for “Meta analysis”
Comments on "Current status and quality of radiomic studies for predicting KRAS mutations in colorectal cancer patients: A systematic review and meta-analysis"
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Influence of elastomeric and steel ligatures on periodontal health during fixed appliance orthodontic treatment: a systematic review and meta-analysis
<p>Dataset for all analyses.</p>
Pre-eclampsia and offspring blood pressure meta-analysis
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Deferred cord clamping to improve neonatal blood values. A systematic review and meta-analysis
<p>Complete data set of extracted studies </p>
Intercropping indices evaluation on grain legume-small grain cereals mixture: a critical meta-analysis review
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Supplementary material 1 from: Gruntman M, Segev U (2024) Effect of residence time on trait evolution in invasive plants: review and meta-analysis. NeoBiota 91: 99-124. https://doi.org/10.3897/neobiota.91.109251
Supplementary information
Imiquimod is Effective in Reducing Cervical Intraepithelial Neoplasia: A Systematic Review and Meta-Analysis
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Immunocompetent mouse models of endometriosis: a systematic review and meta-analysis
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The Influence of Study Quality, Age, and Geographic Factors on Polycystic Ovary Syndrome Prevalence-A Systematic Review and Meta-Analysis (Supplemental data)
<p><strong><span>Supplemnatray data for manuscript tentatively entitled "The Influence of Study Quality, Age, and Geographic Factors on </span></strong><strong><span>Polycystic Ovary Syndrome Prevalence</span></strong><strong><span>-A Systematic Review and Meta-Analysis", including: </span></strong></p> <p><strong><span>Supplementary Table 1.</span></strong><span> Search strategy and its results including studies published until February 29<sup>th</sup> of 2024.</span></p> <p><strong><span>Supplementary Table 2.</span></strong><span> The quality assessment results of studies conducted on adults based on the Polycystic ovary syndrome (PCOS) Epidemiology and Phenotype (PEP) tool. </span></p> <p><strong><span>Supplementary Table 3.</span></strong><span> The quality assessment results of studies conducted on adolescents based on <a name="_Hlk176077530"></a>the Polycystic ovary syndrome (PCOS) Epidemiology and Phenotype (PEP) tool. </span></p> <p><strong><span>Supplementary Table 4.</span></strong><span> The quality assessment results of studies conducted on mixed populations (both adults and adolescents) based on PCOS Epidemiology and Phenotype (PEP) tool. </span></p> <p><strong><span>Supplementary Figure 1 (A-D). </span></strong><span>Forest plots of global PCOS prevalence stratified by diagnostic criteria (regardless of study quality, age group, and geographic region): A) NIH, B) Rotterdam, C) AE-PCOS, D) Self-report: A) NIH, B) Rotterdam, C) AE-PCOS, D) Self-report.</span></p> <p><strong><span>Supplementary Figure 2 (A-C</span></strong><span>). Forest plots of global PCOS prevalence stratified by WHO region and diagnostic criteria (regardless of study quality and age group): A) NIH, B) Rotterdam, C) AE-PCOS.</span></p> <p><strong><span>Supplementary Figure 3 (A-C).</span></strong><span> </span><a name="_Hlk174390393"></a><span>Forest plots of PCOS prevalence stratified by diagnostic criteria and age group (adults vs. adolescent) (regardless of study quality): A) NIH, B) Rotterdam, C) AE-PCOS.</span></p> <p><strong><span>Supplementary Figure 4 (A-C).</span></strong><span> Sensitivity Analysis based on high-quality studies: Impact of individual study exclusion on pooled prevalence</span> <span>(using high-quality studies only)- A) NIH, B) Rotterdam, C) AE-PCOS.</span></p>
Meta-analysis: Drivers of soil health across EU
<p><span>This meta-analysis is conducted as part of SOLO (Soils for Europe), an EU´s Horizon Europe funded project and the results of the outcomes from this analysis is planned to feed into the other work packages to support the development of the co-creation and knowledge developing platforms for each of the eight EU soil mission objectives (soil erosion, land degradation, soil structure, soil sealing, soil organic carbon, soil literacy, soil pollution, and EU global footprint on soil) and with the addition of soil biodiversity. </span><span>The driving force analysis in the SOLO project (Work Package 3) is built upon a comprehensive analytical framework which recognizes driving forces, pressures, state, impact, and response measures (DPSIR) as fundamental components of soil health. </span><span>A scoping literature review is conducted to identify the drivers which will further feed into the analysis of the links between pressures (changes in soil and land management), and states (soil health objectives) and the respective impacts (ecosystem services). The literature review is divided in four parts based on different land use (urban and industrial, agriculture, forest, and nature) and is conducted in accordance with the PRISMA protocol. More than 40000 references have been scanned to filter out 451 relevant studies and to compile a list of drivers for soil and land use changes in the EU. The identified drivers across all land uses have been adjusted and standardised in in-person and online workshops. The set list of drivers is being used to filter the metadata and the presently filtered set of data is sorted according to the EU soil mission’s soil health objectives, land use, and location. The filtered data is compiled in excel to be uploaded in the repository to further support future use in research and publications. <span> </span></span></p>
Difference in rupture risk between familial and sporadic intracranial aneurysms: an individual patient data meta-analysis
<p><b>Objective:</b> We combined <span>individual patient data (IPD) from prospective cohorts of patients with </span>unruptured intracranial aneurysms (UIA) to assess to what extent patients with familial UIA have a higher rupture risk than those with sporadic UIA.<b> </b></p> <p><b>Methods:</b> For this IPD meta-analysis we performed an Embase and Pubmed search for studies published up to December 1, 2020. We included studies that 1) had a prospective study design; 2) included 50 or more patients with UIA; 3) studied the natural course of UIA and risk factors for aneurysm rupture including family history for aneurysmal subarachnoid haemorrhage and UIA; and 4) had aneurysm rupture as an outcome. Cohorts with available IPD were included. All studies included patients with newly diagnosed UIA visiting one of the study centers. The primary outcome was aneurysmal rupture. Patients with polycystic kidney disease and moyamoya disease were excluded. We compared rupture rates of familial versus sporadic UIA using a Cox proportional hazard regression model adjusted for the PHASES score and smoking. We performed two analyses: 1. only studies defining first-degree relatives as parents, children, and siblings and 2. all studies, thus both including and excluding siblings as first-degree relatives.</p> <p><b>Results:</b> We pooled IPD from eight cohorts with a low and moderate risk of bias. First-degree relatives were defined as parents, siblings and children in six cohorts (29% Dutch, 55% Finnish, 15% Japanese), totalling 2,297 patients (17% familial, 399 patients) with 3,089 UIA and 7,301 person-years follow-up. Rupture occurred in 10 familial patients (rupture rate: 0·89%/person-year; 95% CI:0·45-1·59) and 41 sporadic patients (0·66%/person-year; 95% CI:0·48-0·89); adjusted HR for familial patients 2·56 (95% CI: 1·18–5·56). After adding also the two cohorts excluding siblings as first-degree relatives resulting in 9,511 patients the adjusted HR was 1·44 (95% CI: 0·86–2·40).</p> <p><b>Conclusion:</b> The risk of rupture of UIA is two and a half times higher, with a range from a 1.2 to 5 times higher risk, in familial than in sporadic UIA. When assessing the risk of rupture in UIA, family history should be taken into account.</p>
Database of: The Mexican flora as a study case in systematics (Taxonomy, Phylogenetics, and Evolution); GenBank's accession meta-analysis
<p>Result database of The Mexican flora as a study case in systematics (Taxonomy, Phylogenetics, and Evolution); GenBank’s accession meta-analysis.</p>
Rapid evolution of life history traits in response to warming, predation and competition: a meta-analysis
<p>Although studies quantifying evolutionary change in response to the selective pressures that organisms face in the wild have demonstrated that organisms <i>can</i> evolve rapidly, we lack a systematic assessment of the frequency, magnitude and direction of rapid evolutionary change across taxa. To address this gap, we conducted a meta-analysis of 58 studies that document the effects of warming, predation or competition on the evolution of body size, development rate or fecundity in natural or experimental animal populations. We tested whether there was a consistent effect of any selective agent on any trait, whether the direction of these effects align with theoretical predictions, and whether the three agents select in opposing directions on any trait. Overall, we found weak effects of all three selective agents on trait evolution: none of our nine trait by selective agent combinations had an overall effect that differed from zero, only 31% of studies had a significant within-study effect, and attributes of the included studies generally did not account for between-study variation in results. One notable exception was that predation targeting adults consistently resulted in the evolutoin of smaller prey body size. We discuss potential causes of these generally weak responses and consider how our results inform the ongoing development of eco-evolutionary research.</p>
A meta‐analysis of insularity effects on herbivory and plant defences
<p><b>Aim:</b> Plants on islands are often subjected to lower levels of herbivory relative to those at mainland sites. As a consequence, island plants are predicted to exhibit lower levels of physical and chemical defences, which renders them more susceptible to introduced herbivores. Yet, instances of high pressure by superabundant herbivores native to islands have been reported in many insular systems, which presumably would result in heightened plant defences. To date, no quantitative review has been conducted to determine how common these contrasting patterns are and their implications for the evolution of plant defences.</p> <p><b>Location: </b>Islands worldwide</p> <p><b>Taxon:</b> Plants, insects, mammals</p> <p><b>Methods: </b>We conducted a meta-analysis of insularity effects on herbivory and plant defences by including studies that conducted island-mainland comparisons of the same plant species in both environments (90% of cases), or insular endemics vs. mainland congeners (10% of cases). We tested for differences between mammalian and invertebrate herbivory as well as between plant chemical and physical defences by specifying comparisons based on the type of herbivore included in the study.</p> <p><b>Results:</b> Mammalian herbivory was significantly higher on islands than on mainlands. In contrast, no significant effect was observed on invertebrate herbivory. In addition, we found no significant difference in either plant physical or chemical defences between insular and mainland plants, though physical defences tended to be higher for plants on islands.</p> <p><b>Main conclusions:</b> All analysed mammal studies focused on species introduced to islands, suggesting greater susceptibility of insular plants to exotic mammals, whereas the lack of effects in the case of invertebrate herbivory suggests no difference in susceptibility to molluscs and insects between insular and mainland plants. Interestingly, plant trait patterns suggest a trend for increased physical defences by insular plants, possibly due to heightened pressure by exotic mammalian herbivores on islands, whereas chemical defences appear uncorrelated to differences in herbivory. These findings call for further experimental and observational studies measuring defences and herbivory for multiple sympatric plant species occurring at both mainland and island sites within a system, or comparing insular endemics to congeneric mainland species.</p>
Supplementary material 2 from: Miranda-García ML, Muñoz-Pedreros A, Norambuena HV (2021) Waterbird assemblages of inland wetlands in Chile: A meta-analysis. Nature Conservation 45: 41-61. https://doi.org/10.3897/natureconservation.45.74062
Supplementary material 2
Supplementary material 1 from: Miranda-García ML, Muñoz-Pedreros A, Norambuena HV (2021) Waterbird assemblages of inland wetlands in Chile: A meta-analysis. Nature Conservation 45: 41-61. https://doi.org/10.3897/natureconservation.45.74062
Supplementary material 1
Urbanization buffers seasonal change in composition of bird communities: a multi-continental meta-analysis
<p>Aim: Urbanization buffers the seasonality of climate conditions and food availability and, therefore, may cause a seasonal homogenization of animal communities. However, the global effect of urbanization on the seasonal dynamics of animal communities remains unexplored. Our aim was to study the multi-continental relationship between urbanization and the seasonal change in bird composition and explore the influence of climatic factors on the urban-induced reduction of seasonality of bird composition.<br> <br> Location: Multi-continental<br> <br> Methods: We performed a literature review and a meta-analysis. The risk ratio effect size (here referred to as urban seasonality index, USI) was used, considering the number of species seen either in the breeding (spring and/or summer) or the non-breeding (autumn and/or winter) season, and the number of species seen during both seasons between urban and less urbanized sites. Low USI values indicated a decrease in the seasonal change in bird composition in urban areas.<br> <br> Results: A total of 38 USIs were obtained from 34 cities of six continents. Multi-continentally, there are fewer differences in bird composition between seasons in urban than in less urbanized areas, indicating seasonal homogenization due to urbanization. The USI decreased in areas with the lowest maximum temperature and the highest latitude, suggesting the highest decrease in the seasonality of bird composition in urban areas located in regions near the poles and with high seasonal change in temperature. Moreover, studies in the Northern Hemisphere and those that compared suburban versus natural and urban versus rural habitats had a significant decrease of seasonality of bird community in urban areas. <br> <br> Main conclusions: Urbanization induces a seasonal homogenization of bird composition, and this impact seems more pronounced in temperate areas with broad annual temperature range, and located in the Northern Hemisphere. Results indicate that efforts to restore seasonal dynamics in habitats and resources should be made in urban areas of temperate regions.</p>
Data from: Territoriality modifies the effects of habitat complexity on animal behavior: a meta-analysis
<p>Augmenting habitat complexity by adding structure has been used to increase the population density of some territorial species in the wild and to reduce aggression among captive animals. However, it is unknown if all territorial species are affected similarly by habitat complexity, and whether these effects extend to non-territorial species. We conducted a meta-analysis to compare the behavior of a wide range of territorial and non-territorial taxa in complex and open habitats to determine the effects of habitat complexity on<b> </b>1) territory size, 2) population density, 3) rate and time spent on aggression, 4) rate and time devoted to foraging, 5) rate and time spent being active, 6) shyness/boldness, 7) survival rate, and 8) exploratory behavior. Overall, all measures were significantly affected by habitat complexity, but the responses of territorial and non-territorial species differed. As predicted, territorial species were less aggressive, had smaller territories and higher densities in complex habitats, whereas non-territorial species were more aggressive and did not differ in population density. Territorial species were bolder but not more active in complex habitats, whereas non-territorial species were more active but not bolder. While the survival of non-territorial species increased in complex habitats, no such increase was observed for territorial species. The increased safety from predators provided by complex habitats may have been balanced by the higher population densities and bolder behavior in territorial species. Our analysis suggests that territorial and non-territorial animals respond differently to habitat complexity, perhaps due to the strong reliance on visual cues by territorial animals.</p>
Data from: Risk of cancer with angiotensin-receptor blockers increases with increasing cumulative exposure: Meta-regression analysis of randomized trials
<p>Angiotensin-receptor blockers (ARBs) are a class of drugs approved for the treatment of several common conditions, such as hypertension and heart failure. Recently, regulatory agencies have started to identify possibly carcinogenic nitrosamines and azido compounds in a multitude of formulations of several ARBs, resulting in progressive recalls. Furthermore, data from several randomized controlled trials suggested that there is also a clinically increased risk of cancer and specifically lung cancer with ARBs; whereas other trials suggested no increased risk. The purpose of this analysis was to provide additional insight into the ARB-cancer link by examining whether there is a relationship between degree of cumulative exposure to ARBs and risk of cancer in randomized trials. Trial-level data from ARB Trialists Collaboration including 15 randomized controlled trials was extracted and entered into meta-regression analyses. The two co-primary outcomes were the relationship between cumulative exposure to ARBs and risk of all cancers combined and the relationship between cumulative exposure and risk of lung cancer. A total of 74,021 patients were randomized to an ARB resulting in a total cumulative exposure of 172,389 person-years of exposure to daily high dose (or equivalent). 61,197 patients were randomized to control. There was a highly significant correlation between the degree of cumulative exposure to ARBs and risk of all cancers combined (slope=0.07 [95% CI 0.03 to 0.11], p<0.001), and also lung cancer (slope=0.16 [95% CI 0.05 to 0.27], p=0.003). Accordingly, in trials where the cumulative exposure was greater than 3 years of exposure to daily high dose, there was a statistically significant increase in risk of all cancers combined (I<sup>2</sup>=31.4%, RR 1.11 [95% CI 1.03 to 1.19], p=0.006). There was a statistically significant increase in risk of lung cancers in trials where the cumulative exposure was greater than 2.5 years (I<sup>2</sup>=0%, RR 1.21 [95% CI 1.02 to 1.44], p=0.03). In trials with lower cumulative exposure to ARBs, there was no increased risk of all cancers combined or lung cancer. Cumulative exposure-risk relationship with ARBs was independent of background angiotensin-converting enzyme inhibitor treatment or the type of control (i.e. placebo or non-placebo control). Since this is a trial-level analysis. the effects of patient characteristics such as age and smoking status could not be examined due to lack of patient-level data. In conclusion, this analysis, for the first time, reveals that risk of cancer with ARBs (and specifically lung cancer) increases with increasing cumulative exposure to these drugs. The excess risk of cancer with long-term ARB use has public health implications.</p>
VNS and seizure outcomes in pediatric refractory epilepsy: Systematic review and meta-analysis
<p>This data provides supplemental information for the systematic review and Meta-analysis. Supplemental tables report the detailed serach strategy (Supplementary Table <span><span><span><span><span><span><span><span><span>1), details of included studies (</span></span></span></span></span></span></span></span></span>Supplementary Table <span><span><span><span><span><span><span><span><span>2), list of excluded studies (</span></span></span></span></span></span></span></span></span>Supplementary Table <span><span><span><span><span><span><span><span><span>3), 50% Responder Rate in children with Lennox-Gastaut syndrome after VNS insertion (</span></span></span></span></span></span></span></span></span>Supplementary Table <span><span><span><span><span><span><span><span><span>4), 50% Responder Rate in children with Dravet syndrome after VNS insertion (</span></span></span></span></span></span></span></span></span>Supplementary Table 5<span><span><span><span><span><span><span><span><span>), VNS settings and other seizure outcomes reported in the included studies (</span></span></span></span></span></span></span></span></span>Supplementary Table 6<span><span><span><span><span><span><span><span><span>) and Studies reporting a formal Quality of life (QOL) assessment in children post VNS implantation (</span></span></span></span></span></span></span></span></span>Supplementary Table 7<span><span><span><span><span><span><span><span><span>). </span></span></span></span></span></span></span></span></span></p> <p><b>Supplemental figure 1 </b><strong>(S1)</strong> shows the PRISMA flowchart for this systematic review. </p> <p><strong>Supplemental Figure 2</strong><span><span><span><span><span><span><span><span><span> <strong>(S2)</strong>: </span></span></span></span></span></span></span></span></span><span><span><span><span><span><span><span><span><span>Determinants of Seizure Outcomes. Multivariable regression showed 50%-RR at last reported follow-up to increase with increasing age of onset of seizures and decrease with the number of ASMs tried before VNS implantation (A). Higher 50%-RR 1-year after VNS implantation was seen in patients with shorter duration of epilepsy and fewer number of ASM trials (B). Decline in 50%-RR at 1 and 2 year follow-up in studies with a higher proportion of males (C). Proportion of seizure free patients at last reported follow-up also decreases with a greater number of ASM trials before VNS implantation (D). [50%-RR: 50% Responder Rate, ASM: Anti-seizure Medication, VNS: Vagus Nerve Stimulator; Bubbles represent individual effect size for studies, lines represent ordinary least squares regression models, and<a name="_Hlk61802391"> </a>the shading represents 95% confidence regions.</span></span></span></span></span></span></span></span></span></p> <p><strong>Supplemental figure 3 (S3)</strong>: <span>Forest plots for proportion of seizure free patients. </span><span><span><span><span><span><span><span><span><span>Forest plots for proportion of patients with 50% responder rate at 6 months (B), 1 year (C) and 2 years (D) follow-up summarizing the pooled effect estimate and heterogeneity. </span></span></span></span></span></span></span></span></span></p> <p><strong>Supplemental figure 4 (S4)</strong>: <span>Forest plots for proportion of seizure free patients. </span><span><span><span><span><span><span><span><span><span>Forest plots for proportion of seizure free patients at 6 months (B), 1 year (C) and 2 years (D) follow-up summarizing the pooled effect estimate and heterogeneity.</span></span></span></span></span></span></span></span></span></p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.